Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1646-1655

  Schumacher, P A ^a   Siman, R G ^b   Fehlings, M G ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Calpain; Nerve tissue proteins; Neurofilament; Neurotrauma; Spinal cord injury; Treatment

Indexed keywords

CALPAIN; CEP 4143; ENZYME INHIBITOR; NEUROFILAMENT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; LOCOMOTION; NEUROFILAMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SPINAL CORD INJURY;

ANIMALS; AXONS; CALPAIN; CELL COUNT; CYTOSKELETON; ENZYME INHIBITORS; FEMALE; FLUORESCENT DYES; LOCOMOTION; MICROINJECTIONS; NEUROFILAMENT PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; STILBAMIDINES; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0034066304     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741646.x     Document Type: Article

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