Leptin Gene Polymorphisms and Their Phenotypic Associations

Vitamins and Hormones

Volumn 71, Issue , 2005, Pages 373-404

  van der Lende, T ^a   te Pas, M F W ^a   Veerkamp, R F ^a   Liefers, S C ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LEPTIN;

ANIMAL; CATTLE; CHEMISTRY; EXON; GENETIC POLYMORPHISM; GENETICS; HUMAN; INTRON; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHODGKIN LYMPHOMA; OBESITY; PHENOTYPE; PROMOTER REGION; PROSTATE TUMOR; REVIEW; SWINE;

ANIMALS; CATTLE; DIABETES MELLITUS, TYPE 2; DNA, COMPLEMENTARY; EXONS; HUMANS; INTRONS; LEPTIN; LYMPHOMA, NON-HODGKIN; MALE; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; SWINE;

EID: 27744524229     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(05)71013-X     Document Type: Review

References (117)

1. Almeida S.E.M., Almeida E.A., Moraes J.C.F., and Weimer T.A. Molecular markers in the LEP gene and reproductive performance of beef cattle. J. Anim. Breed. Genet. 120 (2003) 106-113
2. Ambrosini G., Nath A.K., Sierra-Honigmann M.R., and Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia: Involvement of hypoxia-inducible factor 1. J. Biol. Chem. 277 (2002) 34601-34609
3. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J.-P., Bortoluzzi M.-N., Moizo L., Lehy T., Guerre-Millo M., Le Marchand-Brustel Y., and Lewin M.J.M. The stomach is a source of leptin. Nature 394 (1998) 790-793
4. Bi S., Gavrilova O., Gong D.-W., Mason M.M., and Reitman M. Identification of a placental enhancer for the human leptin gene. J. Biol. Chem. 272 (1997) 30583-30588
5. Brunner L., Whitebread S., Leconte I., Stricker-Krongrad A., Cumin F., Chiesi M., and Levens N. A peptide leptin antagonist reduces food intake in rodents. Int. J. Obes. 23 (1999) 463-469
6. Buchanan F.C., Fitzsimmons C.J., Van Kessel A.G., Thue T.D., Winkelman-Sim D.C., and Schmutz S.M. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Gen. Sel. Evol. 34 (2002) 105-116
7. Buchanan F.C., Van Kessel A.G., Waldner C., Christensen D.A., Laarveld B., and Schmutz S.M. Hot topic: An association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 86 (2003) 3164-3166
8. Chelikani P.K., Glimm D.R., and Kennelly J.J. Short communication: Tissue distribution of leptin and leptin receptor mRNA in the bovine. J. Dairy Sci. 86 (2003) 2369-2372
9. Chen C.-C., Chang T., and Su H.-Y. Genetic polymorphisms in porcine leptin gene and their association with reproduction and production traits. Austr. J. Agric. Res. 55 (2004) 699-704
10. Comings D.E., Gade R., Muhleman D., Peters W.R., and Mac Murray J.P. The LEP gene and age of menarche: Maternal age as a potential cause of hidden stratification in association studies. Mol. Gen. Metabol. 73 (2001) 204-210
11. Considine R.V. Endocrine regulation of leptin production. In: Henson M.C., and Castracane V.D. (Eds). "Leptin and Reproduction" (2003), Kluwer Academic/Plenum, New York 39-51
12. Considine R.V., Considine E.L., Williams C.J., Nyce M.R., Zhang P., Opentanova I., Ohannesian J.P., Kolaczynski J.W., Bauer T.L., Moore J.H., and Caro J.F. Mutation screening and identification of a sequence variation in the human OB gene coding region. Bioch. Biophys. Res. Comm. 220 (1996) 735-739
13. Cornish J., Callon K.E., Bava U., Lin C., Naot D., Hill B.L., Grey A.B., Broom N., Myers D.E., Nicholson G.C., and Reid I.R. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J. Endocrinol. 175 (2002) 405-415
14. Darlington G.J., Wang N., and Hanson R.W. C/EBP alpha: A critical regulator of genes governing integrative metabolic processes. Curr. Opin. Gen. Dev. 5 (1995) 565-570
15. De Silva A.M., Walder K.R., Aitman T.J., Gotoda T., Goldstone A.P., Hodge A.M., De Courten M.P., Zimmet P.Z., and Collier G.R. Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males. Int. J. Obes. 23 (1999) 816-822
16. Echwald S.M., Rasmussen S.B., Sorensen T.I.A., Andersen T., Tybjærg-Hansen A., Clausen J.O., Hansen L., Hansen T., and Pedersen O. Identification of two novel missense mutations in the human OB gene. Int. J. Obes. 21 (1997) 321-326
17. Ewart-Toland A., Mounzih K., Qiu J., and Chehab F.F. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 140 (1999) 732-738
18. Farooqi S., Rau H., Whitehead J., and O'Rahilly S. ob Gene mutations and human obesity. Proc. Nutr. Soc. 57 (1998) 471-475
19. Flehmig G. Einfluß von Lipoproteinlipase-Gen- und Leptinpromotorgen-Polymorphismen auf die Körperzusammensetzung von adipösen Frauen während eines strukturierten und bilanzierten Diätenprogrammes (1999), University of Potsdam, Germany Diplom Thesis
20. Fukuda H., and Iritani N. Transcriptional regulation of leptin gene promoter in rat. FEBS Lett. 455 (1999) 165-169
21. Gong D.-W., Bi S., Pratley R.E., and Weintraub B.D. Genomic structure and promoter analysis of the human obese gene. J. Biol. Chem. 271 (1996) 3971-3974
22. Grasso P., Leinung M.C., Ingher S.P., and Lee D.W. In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: Localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 (1997) 1413-1418
23. Green E.D., Maffei M., Braden V.V., Proenca R., De Silva U., Zhang Y., Chua Jr. S.C., Leibel R.L., Weissenbach J., and Friedman J.M. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res. 5 (1995) 5-12
24. Grosfeld A., André J., Hauguel-de Mouzon S., Berra E., Pouysségur J., and Guerre-Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J. Biol. Chem. 277 (2002) 42953-42957
25. Haegeman A., Van Zeveren A., and Peelman L.J. New mutation in exon 2 of the bovine leptin gene. Anim. Genet. 31 (2000) 79
26. Hager J., Clement K., Francke S., Dina C., Raison J., Lahlou N., Rich N., Pelloux V., Basdevant A., Guy-Grand B., North M., and Froguel P. A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels. Int. J. Obes. 22 (1998) 200-205
27. Hale C.S., Herring W.O., Johnson G.S., Shibuya H., Lubahn D.B., and Keisler D.H. Evaluation of the leptin gene as a possible marker of carcass traits in Angus cattle. 1998 UMC Animal Sciences Departmental Report (1998) 25-27
28. Haluzik M., Colombo C., Gavrilova O., Chua S., Wolf N., Chen M., Stannard B., Dietz K.R., Le Roith D., and Reitman M.L. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145 (2004) 3258-3264
29. Hamrick M.W., Pennington C., Newton D., Xie D., and Isales C. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 34 (2004) 376-383
30. Hassink S.G., De Lancey E., Sheslow D.V., Smith-Kirwin S.M., O'Connor D.M., Considine R.V., Opentanova I., Dostal K., Spear M.L., Leef K., Ash M., Spitzer A.R., and Funanage V.L. Placental leptin: an important new growth factor in intrauterine and neonatal development?. Pediatrics 100 (1997) e1 (6 pp).
31. He Y., Chen H., Quon M.J., and Reitman M. The mouse obese gene. J. Biol. Chem. 270 (1995) 28887-28891
32. Henson M.C., and Castracane V.D. "Leptin and Reproduction." (2003), Kluwer Academic/Plenum, New York
33. Hinney A., Bornscheuer A., Depenbusch M., Mierke B., Tölle A., Mayer H., Siegfried W., Remschmidt H., and Hebebrand J. Absence of leptin deficiency mutation in extremely obese German children and adolescents. Int. J. Obes. 21 (1997) 1190
34. Hoffstedt J., Eriksson P., Mottagui-Tabar S., and Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm. Metabol. Res. 34 (2002) 355-359
35. Hollenberg A.N., Susulic V.S., Madura J.P., Zhang B., Moller D.E., Tontonoz P., Sarraf P., Spiegelman B.M., and Lowell B.B. Functional antagonism between CCAAT/Enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J. Biol. Chem. 272 (1997) 5283-5290
36. Hossner K.L. Cellular, molecular and physiological aspects of leptin: Potential application in animal production. Can. J. Anim. Sci. 78 (1998) 463-472
37. Hwang C.-S., Mandrup S., Mac Dougald O.A., Geiman D.E., and Lane M.D. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein α. Proc. Natl. Acad. Sci. USA 93 (1996) 873-877
38. Imagawa K., Numata Y., Katsuura G., Sakaguchi I., Morita A., Kikuoka S., Matumoto Y., Tsuji T., Tamaki M., Sasakura K., Teraoka H., Hosoda K., Ogawa Y., and Nakao K. Structure-function studies of human leptin. J. Biol. Chem. 273 (1998) 35245-35249
39. Isse N., Ogawa Y., Tamura N., Masuzaki H., Mori K., Okazaki T., Satoh N., Shigemoto M., Yoshimasa Y., Nishi S., Hosoda K., Inazawa J., and Nakao K. Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270 (1995) 27728-27733
40. Jiang Y., Wilk J.B., Borecki I., Williamson S., De Stefano A.L., Xu G., Liu J., Ellison R.C., Province M., and Myers R.H. Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung and Blood Institute Family Heart Study. Am. J. Hum. Genet. 75 (2004) 220-230
41. Jiang Z.-H., and Gibson J.P. Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mamm. Genome 10 (1999) 191-193
42. Jin L., Zhang S., Burguera B.G., Couce M.E., Osamura R.Y., Kulig E., and Lloyd R.V. Leptin and leptin receptor expression in rat and mouse pituitary cells. Endocrinology 141 (2000) 333-339
43. Karvonen M.K., Pesonen U., Heinonen P., Laakso M., Rissanen A., Naukkarinen H., Valve R., Uusitupa M.I.J., and Koulu M. Identification of new sequence variants in the leptin gene. J. Clin. Endocrinol. Metabol. 83 (1998) 3239-3242
44. Kennes Y.M., Murphy B.D., Pothier F., and Palin M.-F. Characterization of swine leptin (LEP) polymorphisms and their association with production traits. Anim. Genet. 32 (2001) 215-218
45. Kim J.B., Sarraf P., Wright M., Yao K.M., Mueller E., Solanes G., Lowell B.B., and Spiegelman B.M. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Invest. 101 (1998) 1-9
46. Kmieć M., Kulig H., and Konik A. Preliminary results on associations between leptin gene (LEP) and some reproduction performance traits of boars. Arch. Tierz. Dummerstorf 46 (2003) 63-70
47. Korwin-Kossakowska A., Kamyczek M., Cieślak D., Pierzchala M., and Kurył J. The effect of the polymorphism of leptin (LEP), leptin receptor (LEPR) and osteopontin (OPN) genes on selected reproduction traits of synthetic Line 990 sows. Anim. Sci. Pap. Rep. 20 (2002) 159-168
48. Kulig H., Grzesiak W., and Szatkowska I. Effect of leptin gene polymorphism on growth and carcass traits in pigs. Arch. Tierz. Dummerstorf 44 (2001) 291-296
49. Lagonigro R., Wiener P., Pilla F., Woolliams J.A., and Williams J.L. A new mutation in the coding region of the bovine leptin gene associated with feed intake. Anim. Genet. 34 (2003) 371-374
50. Lahlou N., Issad T., Lebouc Y., Carel J.-C., Camoin L., Roger M., and Girard J. Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation. Diabetes 51 (2002) 1980-1985
51. Lakka T.A., Rankinen T., Weisnagel S.J., Chagnon Y.C., Lakka H.-M., Ukkola O., Boulé N., Rice T., Leon A.S., Skinner J.S., Wilmore J.H., Rao D.C., Bergman R., and Bouchard C. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals. The HERITAGE family study. Diabetes 53 (2004) 1603-1608
52. Le Stunff C., Le Bihan C., Schork N.J., and Bougnères P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 49 (2000) 2196-2200
53. Li W.-D., Reed D.R., Lee J.H., Xu W., Kilker R.L., Sodam B.R., and Price R.A. Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women. Ann. Hum. Genet. 63 (1999) 227-234
54. Liefers S.C. Physiology and genetics of leptin in periparturient dairy cows (2004), Wageningen University, The Netherlands Thesis
55. Liefers S.C., Te Pas M.F.W., Veerkamp R.F., and Van der Lende T. Associations between leptin gene polymorphisms and production, live weight, energy balance, feed intake, and fertility in Holstein heifers. J. Dairy Sci. 85 (2002) 1633-1638
56. Liefers S.C., Te Pas M.F.W., Veerkamp R.F., Chilliard Y., Delavaud C., Gerritsen R., and Van der Lende T. Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mamm. Genome 14 (2003) 657-663
57. Lien S., Sundvold H., Klungland H., and Våge D.I. Two novel polymorphisms in the bovine obesity gene (OBS). Anim. Genet. 28 (1997) 245
58. Lord G.M., Matarese G., Howard J.K., Baker R.J., Bloom S.R., and Lechler R.I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394 (1998) 897-901
59. Lucantoni R., Ponti E., Berselli M.E., Savia G., Minocci A., Calò G., De Medici C., Liuzzi A., and Di Blasio A.M. The A19G polymorphism in the 5' untranslated region of the human obese gene does not affect leptin levels in severely obese patients. J. Clin. Endocrinol. Metabol. 85 (2000) 3589-3591
60. Maffei M., Stoffel M., Barone M., Moon B., Dammerman M., Ravussin E., Bogardus C., Ludwig D.S., Flier J.S., Talley M., Auerbach S., and Friedman J.M. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes 45 (1996) 679-682
61. Mammès O., Betoulle D., Aubert R., Giraud V., Tuzet S., Petiet A., Colas-Linhart N., and Fumeron F. Novel polymorphisms in the 5' region of the LEP gene. Association with leptin levels and response to low-calorie diet in human obesity. Diabetes 47 (1998) 487-489
62. Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., and Fumeron F. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann. Hum. Genet. 64 (2000) 391-394
63. Mason M.M., He Y., Chen H., Quon M.J., and Reitman M. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor. Endocrinology 139 (1998) 1013-1022
64. Masuzaki H., Ogawa Y., Isse N., Satoh N., Okazaki T., Shigemoto M., Mori K., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., and Nakao K. Human obese gene expression Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44 (1995) 855-858
65. Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanaka I., Mori T., and Nakao K. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nat. Med. 3 (1997) 1029-1033
66. Mattevi V.S., Zembrzuski V.M., and Hutz M.H. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int. J. Obes. 26 (2002) 1179-1185
67. McGarvey S.T., Forrest W., Weeks D.E., Sun G., Smelser D., Tufa J., Viali S., and Deka R. Human leptin locus (LEP) alleles and BMI in Samoans. Int. J. Obes. 26 (2002) 783-788
68. Meißner U., Östreicher I., Allabauer I., Rascher W., and Dötsch J. Synergistic effects of hypoxia and insulin are regulated by different transcriptional elements of the human leptin promoter. Biochem. Biophys. Res. Comm. 303 (2003) 707-712
69. Miller S.G., De Vos P., Guerre-Millo M., Wong K., Hermann T., Staels B., Briggs M.R., and Auwerx J. The adipocyte specific transcription factor C/EBPα modulates human ob gene expression. Proc. Natl. Acad. Sci. USA 93 (1996) 5507-5511
70. Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., Sewter C.P., Digby J.E., Mohammed S.N., Hurst J.A., Cheetham C.H., Earley A.R., Barnett A.H., Prins J.B., and O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387 (1997) 903-908
71. 2J mice. Genomics 42 (1997) 152-156
72. Morash B., Li A., Murphy P.R., Wilkinson M., and Ur E. Leptin gene expression in the brain and pituitary gland. Endocrinolgy 140 (1999) 5995-5998
73. Nieters A., Becker N., and Linseisen J. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur. J. Nutr. 41 (2002) 210-221
74. Nkrumah J.D., Li C., Basarab J.B., Guercio S., Meng Y., Murdoch B., Hansen C., and Moore S.S. Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition. Can. J. Anim. Sci. 84 (2004) 211-219
75. Oberkofler H., Beer A., Breban D., Hell E., Krempler F., and Patsch W. Human obese gene expression: Alternative splicing of mRNA and relation to adipose tissue localization. Obesity Surgery 7 (1997) 390-396
76. Öhman M., Oksanen L., Kainulainen K., Jänne O.A., Kaprio J., Koskenvuo M., Mustajoki P., Kontula K., and Peltonen L. Testing of human homologues of murine obesity genes as candidate regions in Finnish obese sib pairs. Eur. J. Hum. Gen. 7 (1999) 117-124
77. Ohshiro Y., Ueda K., Nishi M., Ishigame M., Wakasaki H., Kawashima H., Furuta H., Sasaki H., Sanke T., Takasu N., and Nanjo K. A polymorphic marker in the leptin gene associated with Japanese morbid obesity. J. Mol. Med. 78 (2000) 516-520
78. Oksanen L., Kainulainen K., Heiman M., Mustajoki P., Kauppinen-Mäkelin R., and Kontula K. Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects. Int. J. Obes. 21 (1997) 489-494
79. Oksanen L., Palvimo J.J., Jänne O.A., and Kontula K. Functional analysis of the C(-188)A polymorphism of the human leptin promoter. Hum. Genet. 103 (1998) 527-528
80. Onions K.L., Hunt S.C., Rutkowski M.P., Klanke C.A., Su Y.R., Reif M., and Menon A.G. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension 31 (1998) 1230-1234
81. Oprzadek J., Flisikowski K., Zwierzchowski L., and Dymnicki E. Polymorphisms at loci of leptin (LEP), Pit1 and STAT5A and their association with growth, feed conversion and carcass quality in Black-and-White bulls. Anim. Sci. Papers Rep. 21 (2003) 135-145
82. Ozata M., Ozdemir I.C., and Licinio J. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metabol. 84 (1999) 3686-3695
83. Peelman F., Van Beneden K., Zabeau L., Iserentant H., Ulrichts P., Defeau D., Verhee A., Catteeuw D., Elewaut D., and Tavernier J. Mapping of the leptin binding sites and design of a leptin antagonist. J. Biol. Chem. 279 (2004) 41038-41046
84. Peelman F., Waelput W., Iserentant H., Lavens D., Eyckerman S., Zabeau L., and Tavernier J. Leptin: Linking adipocyte metabolism with cardiovascular and autoimmune diseases. Prog. Lipid Res. 43 (2004) 283-301
85. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., and Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
86. Pomp D., Zou T., Clutter A.C., and Barendse W. Rapid communication: Mapping of leptin to bovine chromosome 4 by linkage analysis of a PCR-based polymorphism. J. Anim. Sci. 75 (1997) 1427
87. Qiu J., Ogus S., Mounzih K., Ewart-Toland A., and Chehab F.F. Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes. Endocrinology 142 (2001) 3421-3425
88. Rahmouni K., and Haynes W.G. Leptin and the cardiovascular system. Recent Prog. Horm. Res. 59 (2004) 225-244
89. Rau H., Reaves B.J., O'Rahilly S., and Whitehead J.P. Truncated human leptin (Δ133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. Endocrinology 140 (1999) 1718-1723
90. Raver N., Vardy E., Livnah O., Devos R., and Gertler A. Comparison of R128Q mutations in human, ovine, and chicken leptins. Gen. Comp. Endocrinol. 126 (2002) 52-58
91. Ren W., Zhang SH., Wu J., and Ni Y.-X. Polymorphism of the leptin gene promoter in pedigrees of type 2 diabetes mellitus in Chongqing, China. Chin. Med. J. 117 (2004) 558-561
92. Ribeiro R., Vasconcelos A., Costa S., Pinto D., Morais A., Oliveira J., Lobo F., Lopes C., and Medeiros R. Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate 59 (2004) 268-274
93. Rock F.L., Altmann S.W., Van Heek M., Kastelein R.A., and Bazan J.F. The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond. Horm. Metabol. Res. 28 (1996) 649-652
94. Samson W.K., Murphy T.C., Robison D., Vargas T., Tau E., and Chang J.-K. A 35 amino acid fragment of leptin inhibits feeding in the rat. Endocrinology 137 (1996) 5182-5185
95. Señarís R., Garcia-Caballero T., Casabiell X., Callego R., Castro R., Considine R.V., Dieguez C., and Casanueva F.F. Synthesis of leptin in human placenta. Endocrinology 138 (1997) 4501-4504
96. Shigemoto M., Nishi S., Ogawa Y., Isse N., Matsuoka N., Tanaka T., Azuma N., Masuzaki H., Nishimura H., Yoshimasa Y., Hosoda K., and Nakao K. Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus. Eur. J. Endocrinol. 137 (1997) 511-513
97. Shintani M., Ikegami H., Yamato E., Kawaguchi Y., Fujisawa T., Nakagawa Y., Hamada Y., Ueda H., Miki T., and Ogihara T. A novel microsatellite polymorphism in the human OB gene: A highly polymorphic marker for linkage analysis. Diabetologia 39 (1996) 1398-1401
98. Shintani M., Ikegami H., Fujisawa T., Kawaguchi Y., Ohishi M., Katsuya T., Higaki J., Shimamoto K., and Ogihara T. Leptin gene polymorphism is associated with hypertension independent of obesity. J. Clin. Endocrinol. Metabol. 87 (2002) 2909-2912
99. Skibola C.F., Holly E.A., Forrest M.S., Hubbard A., Bracci P.M., Skibola D.R., Hegedus C., and Smith M.T. Body mass index, leptin and leptin receptor polymorphisms, and non-Hodgkin lymphoma. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 779-786
100. Smith-Kirwin S.M., O'Connor D.M., Johnston J., De Lancey E., Hassink S.G., and Funanage V.L. Leptin expression in human mammary epithelial cells and breast milk. J. Clin. Endocrinol. Metabol. 83 (1998) 1810-1813
101. Steppan C.M., Crawford D.T., Chidsey-Frink K.L., Ke H.Z., and Swick A.G. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul. Pept. 92 (2000) 73-78
102. Stoehr J.P., Byers J.E., Clee S.M., Lan H., Boronenkov I.V., Schueler K.L., Yandell B.S., and Attie A.D. Identification of major quantitative trait loci controlling body weight variation in ob/ob mice. Diabetes 53 (2004) 245-249
103. Stratil A., Peelman L., Van Poucke M., and Čepica S. A HinfI PCR-RFLP at the porcine leptin (LEP) gene. Anim. Genet. 28 (1997) 371-372
104. Strobel A., Issad T., Camoin L., Ozata M., and Strosberg A.D. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 18 (1998) 213-215
105. Szydlowski M., Stachowiak M., Mackowski M., Kamyczek M., Eckert R., Rozycki M., and Switonski M. No major effect of the leptin gene polymorphism on porcine production traits. J. Anim. Breed. Genet. 121 (2004) 149-155
106. Taniguchi Y., Itoh T., Yamada T., and Sasaki Y. Genomic structure and promoter analysis of the bovine leptin gene. IUBMB Life 53 (2002) 131-135
107. Urban T., Kuciel J., and Mikolášová R. Polymorphism of genes encoding for ryanodine receptor, growth hormone, leptin and MYC protooncogene protein and meat production in Duroc pigs. Czech J. Anim. Sci. 47 (2002) 411-417
108. Verploegen S.A.B.W., Plaetinck G., Devos R., Van der Heyden J., and Guisez Y. A human leptin mutant induces weight gain in normal mice. FEBS Lett. 405 (1997) 237-240
109. Wang J., Liu R., Hawkins M., Barzilai N., and Rosetti L. A nutrient-sensing pathway regulates leptin gene expresssion in muscle and fat. Nature 393 (1998) 684-688
110. Wang J., Liu R., Liu L., Chowdhury R., Barzilai N., Tan J., and Rossetti L. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nat. Med. 5 (1999) 895-899
111. Wiesner G., Vaz M., Collier G., Seals D., Kaye D., Jennings G., Lambert G., Wilkinson D., and Esler M. Leptin is released from the human brain: Influence of adiposity and gender. J. Clin. Endocrinol. Metabol. 84 (1999) 2270-2274
112. Wilkins R.J., and Davey H.W. A polymorphic microsatellite in the bovine leptin gene. Anim. Genet. 28 (1997) 376
113. Yiannakouris N., Melistas L., Yannakoulia M., Mungal K., and Mantzoros C.S. The -2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. Hormones 2 (2003) 229-236
114. Zabeau L., Lavens D., Peelman F., Eyckerman S., Vandekerckhove J., and Tavernier J. The ins and outs of leptin receptor activation. FEBS Lett. 546 (2003) 45-50
115. Zhang F., Basinski M.B., Beals J.M., Briggs S.L., Churgay L.M., Clawson D.K., Di Marchi R.D., Furman T.C., Hale J.E., Hsiung H.M., Schoner B.E., Smith D.P., Zhang X.Y., Wery J.-P., and Schevitz R.W. Crystal structure of the obese protein leptin-E100. Nature 387 (1997) 206-209
116. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
117. Zhang Z.J., Yao Z.J., Mou X.D., Chen J.F., Zhu R.X., Liu W., Zhang X.R., Sun J., and Hou G. Association of -2548G/A functional polymorphism in the promoter region of leptin gene with antipsychotic agent-induced weight gain. Chin. Med. J. 83 (2003) 2119-2123