-
1
-
-
0028139089
-
Positional cloning of mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of mouse obese gene and its human homologue. Nature. 372:425-431.
-
(1994)
Nature
, vol.372
, pp. 425-431
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
3
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee G-H, Proenca R, Montez JM, et al. 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.-H.1
Proenca, R.2
Montez, J.M.3
-
4
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, et al. 1996 Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1263-1271.
-
(1996)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
5
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
Chua Jr SC, Chung WK, Wu-Peng X-S, et al. 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:994-996.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua Jr., S.C.1
Chung, W.K.2
Wu-Peng, X.-S.3
-
6
-
-
0029895421
-
Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker Fatty (fa/fa) rat
-
Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. 1996 Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker Fatty (fa/fa) rat. Biochem. Biophys. Res. Commun. 222:19-26.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.222
, pp. 19-26
-
-
Iida, M.1
Murakami, T.2
Ishida, K.3
Mizuno, A.4
Kuwajima, M.5
Shima, K.6
-
7
-
-
9344241376
-
Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr)
-
Chua SC Jr, White DW, Wu Peng XS, et al. 1996 Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes. 45:1141-1143.
-
(1996)
Diabetes
, vol.45
, pp. 1141-1143
-
-
Chua Jr., S.C.1
White, D.W.2
Wu Peng, X.S.3
-
8
-
-
0031026234
-
Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity
-
Rönnemaa T, Karonen S-L, Rissanen A, Koskenvuo M, Koivisto VA. 1997 Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann. Intern. Med. 126:26-31.
-
(1997)
Ann. Intern. Med.
, vol.126
, pp. 26-31
-
-
Rönnemaa, T.1
Karonen, S.-L.2
Rissanen, A.3
Koskenvuo, M.4
Koivisto, V.A.5
-
9
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subiects
-
Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subiects. Nat Med. 1:1155-1161.
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
-
10
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine RV, Sinha MK, Heiman ML, et al. 1995 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:292-295.
-
(1995)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
11
-
-
0029893211
-
Leptin concentrations in diabetic and nondiabetic Mexican-Americans
-
Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL. 1996 Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes. 45:822-824.
-
(1996)
Diabetes
, vol.45
, pp. 822-824
-
-
Haffner, S.M.1
Stern, M.P.2
Miettinen, H.3
Wei, M.4
Gingerich, R.L.5
-
12
-
-
0029974877
-
Adipose tissue leptin production and plasma leptin kinetics in humans
-
Klein S, Coppack SW, Mohammed-Ali V, Landt M. 1996 Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes. 45:984-987.
-
(1996)
Diabetes
, vol.45
, pp. 984-987
-
-
Klein, S.1
Coppack, S.W.2
Mohammed-Ali, V.3
Landt, M.4
-
13
-
-
0029050937
-
Overexpression of the obese (ob) gene in adipose tissue of human obese subiects
-
Lönnqvist F, Arner P, Nordfors L, Schalling M. 1995 Overexpression of the obese (ob) gene in adipose tissue of human obese subiects. Nat Med. 1:950-953.
-
(1995)
Nat Med
, vol.1
, pp. 950-953
-
-
Lönnqvist, F.1
Arner, P.2
Nordfors, L.3
Schalling, M.4
-
14
-
-
0029083859
-
Increased obese mRNA expression in omental fat cells from massively obese humans
-
Hamilton BS, Paglia D, Kwan AYM, Deitel M. 1995 Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med. 1:953-956.
-
(1995)
Nat Med
, vol.1
, pp. 953-956
-
-
Hamilton, B.S.1
Paglia, D.2
Kwan, A.Y.M.3
Deitel, M.4
-
15
-
-
0029020677
-
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
-
Considine RV, Considine EL, Williams CJ, et al. 1995 Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest. 95:2986-2968.
-
(1995)
J Clin Invest
, vol.95
, pp. 2986-2968
-
-
Considine, R.V.1
Considine, E.L.2
Williams, C.J.3
-
16
-
-
15844399534
-
Human obese gene. Molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity
-
Niki T, Mori H, Tamori Y, et al. 1996 Human obese gene. Molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. Diabetes. 45:675-78.
-
(1996)
Diabetes
, vol.45
, pp. 675-678
-
-
Niki, T.1
Mori, H.2
Tamori, Y.3
-
17
-
-
15844373886
-
Absence of mutations in the human ob gene in obese/diabetic subjects
-
Maffei M, Stoffel M, Barone M, et al. 1996 Absence of mutations in the human ob gene in obese/diabetic subjects. Diabetes. 45:679-681.
-
(1996)
Diabetes
, vol.45
, pp. 679-681
-
-
Maffei, M.1
Stoffel, M.2
Barone, M.3
-
18
-
-
7844235437
-
Polymorphisms of the ob gene in human obesity
-
Mammes O, Betoulle D, Aubert R, Giraurd V, Tuzet S, Fumeron F. 1997 Polymorphisms of the ob gene in human obesity. Int J Obes Relat Metab Disord 21:s11.
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
-
-
Mammes, O.1
Betoulle, D.2
Aubert, R.3
Giraurd, V.4
Tuzet, S.5
Fumeron, F.6
-
19
-
-
0030705974
-
Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus
-
Shigemoto M, Nishi S, Ogawa Y, et al. 1997 Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus. Eur J Endocrinol. 137:511-513.
-
(1997)
Eur J Endocrinol
, vol.137
, pp. 511-513
-
-
Shigemoto, M.1
Nishi, S.2
Ogawa, Y.3
-
20
-
-
0030994425
-
Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects
-
Oksanen L, Kainulainen K, Heiman M, Mustajoki P, Kauppinen-Mäkelin R, Kontula K. 1997 Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects. Int J Obes Relat Metab Disord. 21:489-494.
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 489-494
-
-
Oksanen, L.1
Kainulainen, K.2
Heiman, M.3
Mustajoki, P.4
Kauppinen-Mäkelin, R.5
Kontula, K.6
-
22
-
-
0345335191
-
Indication for linkage of the human ob gene region with extreme obesity
-
Clement C, Garner C, Hager J, et al. 1996 Indication for linkage of the human ob gene region with extreme obesity. Diabetes. 45:687-690.
-
(1996)
Diabetes
, vol.45
, pp. 687-690
-
-
Clement, C.1
Garner, C.2
Hager, J.3
-
23
-
-
0029938057
-
Extreme obesity may be linked to markers flanking the human ob gene
-
Reed DR, Ding Y, Xu W, Cather C, Green ED, Price A. 1996 Extreme obesity may be linked to markers flanking the human ob gene. Diabetes. 45:675-678.
-
(1996)
Diabetes
, vol.45
, pp. 675-678
-
-
Reed, D.R.1
Ding, Y.2
Xu, W.3
Cather, C.4
Green, E.D.5
Price, A.6
-
24
-
-
9844259470
-
Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents
-
Roth H, Hinney A, Ziegler A, et al. 1997 Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents. Exp Clin Endocrinol Diabetes. 105:341-344.
-
(1997)
Exp Clin Endocrinol Diabetes
, vol.105
, pp. 341-344
-
-
Roth, H.1
Hinney, A.2
Ziegler, A.3
-
25
-
-
0029821904
-
Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians
-
Normann RA, Leibel RL, Chung WK, et al. 1996 Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes. 45:1229-32.
-
(1996)
Diabetes
, vol.45
, pp. 1229-1232
-
-
Normann, R.A.1
Leibel, R.L.2
Chung, W.K.3
-
26
-
-
0029150525
-
Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs
-
Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P. 1996 Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes. 44:999-1001.
-
(1996)
Diabetes
, vol.44
, pp. 999-1001
-
-
Stirling, B.1
Cox, N.J.2
Bell, G.I.3
Hanis, C.L.4
Spielman, R.S.5
Concannon, P.6
-
27
-
-
0028863211
-
Structural organization and chromosomal assignment of the human obese gene
-
Isse N, Ogawa Y, Tamura N, et al. 1995 Structural organization and chromosomal assignment of the human obese gene. J Biol Chem. 270:27728-27733.
-
(1995)
J Biol Chem
, vol.270
, pp. 27728-27733
-
-
Isse, N.1
Ogawa, Y.2
Tamura, N.3
-
28
-
-
0030032754
-
Genomic structure and promoter analysis of the human obese gene
-
Gong D-W, Bi S, Pratley RE, Weintraub BD. 1996 Genomic structure and promoter analysis of the human obese gene. J. Biol. Chem. 271:3971-3974.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 3971-3974
-
-
Gong, D.-W.1
Bi, S.2
Pratley, R.E.3
Weintraub, B.D.4
-
29
-
-
0029954255
-
Apolipoprotein E phenotype modifies metabolic and hemodynamic abnormalities related to central obesity in women
-
Uusitupa MIJ, Karhunen L, Rissanen A, et al. 1996 Apolipoprotein E phenotype modifies metabolic and hemodynamic abnormalities related to central obesity in women. Am J Clin Nutr. 64:131-136.
-
(1996)
Am J Clin Nutr
, vol.64
, pp. 131-136
-
-
Uusitupa, M.I.J.1
Karhunen, L.2
Rissanen, A.3
-
31
-
-
0021965556
-
Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin-dependent) diabetic subjects
-
Uusitupa M, Siitonen O, Aro A, Pyörälä K. 1985 Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin-dependent) diabetic subjects. Diabetologia. 28:22-27.
-
(1985)
Diabetologia
, vol.28
, pp. 22-27
-
-
Uusitupa, M.1
Siitonen, O.2
Aro, A.3
Pyörälä, K.4
-
32
-
-
0026895137
-
Constraints acting on the exon positions of the splice site sequences and local amino acid composition of the protein
-
Fichant GA. 1992 Constraints acting on the exon positions of the splice site sequences and local amino acid composition of the protein. Hum Mol Gen. 1:259-267.
-
(1992)
Hum Mol Gen
, vol.1
, pp. 259-267
-
-
Fichant, G.A.1
-
33
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in human
-
Montague CT, Farooqi IS, Whitehead JP, et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in human. Nature. 387:903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
34
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camoin L, Ozaza M, Strosberg AD. 1998 A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet. 18:213-215.
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozaza, M.4
Strosberg, A.D.5
-
35
-
-
0032010818
-
Leptin receptor gene in a large cohort of massively obese subjects: No indication of the fa/fa rat mutation. Detection of an intronic variant wth no association with obesity
-
Rolland V, Clement K, Dugail I, et al. 1998 Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant wth no association with obesity. Obes Res. 6:122-127.
-
(1998)
Obes Res
, vol.6
, pp. 122-127
-
-
Rolland, V.1
Clement, K.2
Dugail, I.3
-
36
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, et al. 1998 A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
|