The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

Nature Medicine

Volumn 5, Issue 8, 1999, Pages 895-899

  Wang, Jiali ^a   Liu, Rong ^a   Liu, LiSen ^a   Chowdhury, Rahena ^a   Barzilai, Nir ^a   Tan, Jianzhen ^a   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; GENE EXPRESSION REGULATION; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0032804218     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/11335     Document Type: Article

References (40)

1. Coleman, D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-148 (1978).
2. Zhang, V. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 42-32 (1994).
3. Wang, J., Liu, R., Hawkins, M., Barzilai, N. & Rossetti, L. A nutrient sensing pathway regulates leptin gene expression in muscle and fat. Nature 393, 684-688 (1998).
4. Bado, A. et al. The stomach is a source of leptin. Nature 394, 790-793 (1998).
5. Masuzaki, H. et al. Nonadipose tissue production of leptin as a novel placenta-derived hormone in humans. Nature Med. 3, 1029-1033 (1997).
6. Campfield, L., Smith, F.J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549 (1995).
7. Frederich, R.C. et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med. 1, 1311-1314 (1995).
8. Flier, J.S. Leptin expression and action: New experimental paradigms. Proc. Natl. Acad. Sci. USA 94, 4242-4245 (1997).
9. Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
10. Halaas, J.L et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
11. Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P. & Baskin, D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98, 1101-1106 (1996).
12. Caro, J.F., Sinha, M.K., Kolaczynski, W., Zhang, P.L. & Considine, R.V. Leptin: the tale of an obesity gene. Diabetes 45, 1455-1462 (1996).
13. Ravussin, E. et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nature Med. 3, 238-240 (1997).
14. Carpenter, L.R. et al. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with ob receptor. Proc. Natl. Acad Sci. USA 95, 6061-6066 (1998).
15. Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1, 619-625 (1998).
16. Boston, B.A., Blaydon, K.M., Varnerin, J. & Cone R.D. Independent and additive effects of central POMC and leptin pathways on murine obesisty. Science 278, 1641-1644 (1997).
17. Chua, S.C.J. et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271, 994-996 (1996).
18. Considine, R.V., Considine, E.L., Williams, C.J., Hyde, T.M. & Caro, J.F. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45, 992-994 (1996).
19. Jacob, R.J. et al. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 46, 150-152 (1997).
20. Bai, Y., Zhang, S., Kim, K.-S., Lee, J.-K. & Kim, K.-H. Leptin inhibits acetyl-CoA carboxylase in 3T3 pre-adipocytes. J. Biol. Chem. 271, 13939-13942 (1996).
21. Lord, G.M. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897-901 (1998).
22. Muoio, D.M., Dohn, G.L., Fiedorek, F.T., Tapscott, E.B. & Coleman, R.A. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46, 1360-1363 (1997).
23. Shimabukuro, M. et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA 94, 4637-4641 (1997).
24. Sierra-Honigmann, M.R. et al. Biological action of leptin as an angiogenic factor. Science 281, 1683-1686 (1998).
25. Kellerer, M. et al. Leptin activates Pl-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40, 1358-1362 (1997).
26. Liu, L. et al. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J. Biol. Chem. 273, 31160-31167 (1998).
27. Rossetti, L., Smith, D., Shulman, G.I., Papachristou, D. & DeFronzo, R.A. Corection of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79, 1510-1515 (1987).
28. Rossetti, L. et al. Short-term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 27758-27763 (1997).
29. Tartaglia, L. et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271 (1995).
30. Zhang, Y. et al. The leptin receptor mediates apparent autocrine regulation of leptin gene expression. Biochem. Biophys. Res. Comm. 240, 492-495 (1997).
31. Saladin, R. et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527-529 (1995).
32. 3-adrenergic agonists, and leptin. J. Biol. Chem. 272, 24129-24132 (1997).
33. Kim, Y.-B., Uotani, S., Flier, J.S. & Kahn, B.B. In vivo administration of leptin rapidly activates phosphoinositide-3-kinase in insulin sensitive tissues. Diabetes 47, A317 (1998).
34. Schwartz, M.W., Peskind, E., Raskind, M., Boyko, E.J. & Porte, D.J. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med. 2, 589-593 (1996).
35. Seeley, R.J. et al. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm. Metab. Res. 28, 664-668 (1996).
36. Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 324-325 (1996).
37. Boden, G., Chen, X., Mozzoli, M. & Ryan, I. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81, 3419-3423 (1996).
38. Kolaczynski, J.W. et al. Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 45, 1511-1515 (1996).
39. Pelleymounter, M.A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995).
40. Schwartz, M.W. et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535 (1996).