The molecular basis of the obese mutation in ob(2J) mice

Genomics

Volumn 42, Issue 1, 1997, Pages 152-156

  Moon, Byoung Chon ^a   Friedman, Jeffrey M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; RNA;

ADIPOSE TISSUE; ALLELE; ANIMAL TISSUE; ARTICLE; EXON; GENETIC ORGANIZATION; INTRON; MOUSE; MUTATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPE; POLYADENYLATION; PRIORITY JOURNAL; RECESSIVE INHERITANCE; TRANSPOSON;

EID: 0031570346     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4701     Document Type: Article

References (14)

1. 1. Adachi, M., Watanabe-Fukunaga, R., and Nagata, S. (1993). Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90: 1756-1760.
2. 2. Brulet, P., Kaghad, M., Xu, Y.-S., Croissant, O., and Jacob, F. (1983). Early differential tissue expression of transposon-like repetitive DNA sequences of the mouse. Proc. Natl. Acad. Sci. USA 80: 5641-5645.
3. 3. Chirgwin, J. M., Przybyla, A. A., MacDonald, R. J., and Rutter, W. J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294-5299.
4. 4. Friedman, J. M., and Leibel, R. L. (1992). Tackling a weighty problem. Cell 69: 217-220.
5. 5. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546.
6. 6. He, Y., Chen, H., Quon, M. J., and Reitman, M. (1995). The mouse obese gene. J. Biol. Chem. 48: 28887-28891.
7. 7. Herrmann, B. G., Labeit, S., Poustka, A., King, T. R., and Lehrach, H. (1990). Cloning of the T gene required in mesoderm formation in the mouse. Nature 343: 617-622.
8. 8. Kaghad, M., Maillet, L., and Brulet, P.(1985). Retroviral characteristics of the long terminal repeat of murine E.Tn sequences. EMBO J. 4: 2911-2915.
9. 9. Shell, B. E., Collins, J. T., Elenich, L. A., Szurek, P. F., and Dunnick, W. A. (1990). Two subfamilies of murine retrotransposon ETn sequences. Gene 86: 269-274.
10. 10. Sonigo, P., Wain-Hobson, S., Bougueleret, L., Tiollais, P., Jacob, F., and Brulet, P. (1987). Nucleotide sequence and evolution of ETn elements. Proc. Natl. Acad. Sci. USA 84: 3768-3771.
11. 11. Steinmeyer, K., Klocke, R., Ortland, C., Gronemeier, M., Jockusch, H., Gtunder, S., and Jentsch, T. J. (1991). Inactivation of muscle chloride channel by transposon insertion in myotonic mice. Nature 354: 304-308.
12. 12. Venter, C. J. (1993). "Automated DNA Sequencing and Analysis," Academic Press, New York.
13. 13. Vitale, M., Vashishtha, A., Linzer, E., Powell, D. J., and Fried man, J. M. (1990). Molecular cloning of the mouse CCK gene: Expression in different brain regions and during cortical development. Nucleic Acids Res. 19: 169-177.
14. 14. Zhang, Y., Proenca, P., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.