A novel microsatellite polymorphism in the human OB gene: A highly polymorphic marker for linkage analysis

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1398-1401

  Shintani, M ^a   Ikegami, H ^a,b   Yamato, E ^a   Kawaguchi, Y ^a   Fujisawa, T ^a   Nakagawa, Y ^a   Hamada, Y ^a   Ueda, H ^a   Miki, T ^a   Ogihara, T ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Diabetes mellitus; Genetics; Microsatellite; OB gene; Obesity

Indexed keywords

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL;

ALLELES; BASE SEQUENCE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; FEMALE; GENETIC MARKERS; HUMANS; LEPTIN; LINKAGE (GENETICS); MALE; MICROSATELLITE REPEATS; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROTEINS;

EID: 10244222261     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050589     Document Type: Article

References (10)

1. Ghosh S, Nicholas J (1996) Genetic analysis of NIDDM. Diabetes 45: 1-14
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
3. Considine RV, Considine EL, Williams CJ et al. (1995) Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95: 2986-2988
4. Margherita M, Markus S, Marisa B et al. (1996) Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes 45: 679-682
5. Naohi I, Yoshihiro O, Naohisa T et al. (1995) Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 46: 27728-27733
6. Toshiharu N, Hiroyuki M, Yoshikazu T et al. (1996) Molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. Diabetes 45: 675-678
7. Samuel DJ, Carmine F, Deanna P, Joy B, Michael L (1996) Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45: 695-698
8. Karine C, Chad G, Jorg H et al. (1996) Indication for linkage of the human OB gene region with extreme obesity. Diabetes 45: 687-690
9. Danielle RR, Yuan D, Weizhen X, Corinne C, Eric DG, Price RA (1996) Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45: 691-694
10. Kennedy GC, German MS, Rutter WJ (1995) The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet 9: 293-298