The master regulators of allergic inflammation: Dendritic cells in Th2 sensitization

Current Opinion in Immunology

Volumn 15, Issue 6, 2003, Pages 620-626

  Eisenbarth, Stephanie C ^a   Piggott, Damani A ^a   Bottomly, Kim ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CELL RECEPTOR; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CCR7; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN DERIVATIVE; LIPOPOLYSACCHARIDE; PATHOGEN ASSOCIATED MOLECULAR PATTERN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENVIRONMENTAL EXPOSURE; HUMAN; IMMUNOREGULATION; IMMUNOSTIMULATION; INFLAMMATION; LYMPHOID ORGAN; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TISSUE DISTRIBUTION;

EID: 0242491041     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2003.09.003     Document Type: Review

References (55)

1. Masten B.J., Lipscomb M.F. Comparison of lung dendritic cells and B cells in stimulating naive antigen-specific T cells. J. Immunol. 162:1999;1310-1317.
2. Lambrecht B.N. Allergen uptake and presentation by dendritic cells. Curr. Opin. Allergy Clin. Immunol. 1:2001;51-59.
3. Medzhitov R., Janeway C. Jr. Innate immunity. N. Engl. J. Med. 343:2000;338-344.
4. Akira S., Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85:2003;85-95.
5. Cyster J.G. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J. Exp. Med. 189:1999;447-450.
6. + dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen. J. Exp. Med. 181:1995;1275-1283.
7. Reider N., Reider D., Ebner S., Holzmann S., Herold M., Fritsch P., Romani N. Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production. J. Allergy Clin. Immunol. 109:2002;89-95.
8. Jahnsen F.L., Moloney E.D., Hogan T., Upham J.W., Burke C.M., Holt P.G. Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax. 56:2001;823-826.
9. Lambrecht B.N., Salomon B., Klatzmann D., Pauwels R.A. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J. Immunol. 160:1998;4090-4097.
10. Julia V., Hessel E.M., Malherbe L., Glaichenhaus N., O'Garra A., Coffman R.L. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity. 16:2002;271-283.
11. Hammad H., Lambrecht B.N., Pochard P., Gosset P., Marquillies P., Tonnel A.B., Pestel J. Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7. J. Immunol. 169:2002;1524-1534 A humanized severe combined immunodeficiency model of DC adoptive transfer that supports the crucial role of DCs in human disease and also elucidates the need for CCR7-mediated DC migration.
12. Graffi S.J., Dekan G., Stingl G., Epstein M.M. Systemic administration of antigen-pulsed dendritic cells induces experimental allergic asthma in mice upon aerosol antigen rechallenge. Clin. Immunol. 103:2002;176-184.
13. Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196: 2002;1645-1651 This study demonstrates both the need for LPS in the induction of allergic sensitization and the differential effect of LPS dose on adaptive immunity.
14. Stumbles P.A., Thomas J.A., Pimm C.L., Lee P.T., Venaille T.J., Proksch S., Holt P.G. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 188:1998;2019-2031.
15. Lambrecht B.N., De Veerman M., Coyle A.J., Gutierrez-Ramos J.C., Thielemans K., Pauwels R.A. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. 106:2000;551-559.
16. Keane-Myers A., Gause W.C., Linsley P.S., Chen S.J., Wills-Karp M. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J. Immunol. 158:1997;2042-2049.
17. Barton G.M., Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr. Opin. Immunol. 14:2002;380-383.
18. Becker S., Fenton M.J., Soukup J.M. Involvement of microbial components and Toll-like receptors 2 and 4 in cytokine responses to air pollution particles. Am. J. Respir. Cell Mol. Biol. 27:2002;611-618 An in vitro analysis of human alveolar macrophage responsiveness to pollution-derived particulate matter. This paper makes the important point that these inert particles induce macrophage activation only when accompanied by bacteria (both Gram-positive and Gram-negative).
19. Dabbagh K., Dahl M.E., Stepick-Biek P., Lewis D.B. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 168:2002;4524-4530.
20. Shortman K., Liu Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:2002;151-161.
21. Pulendran B., Smith J.L., Caspary G., Brasel K., Pettit D., Maraskovsky E., Maliszewski C.R. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl. Acad Sci. USA. 96:1999;1036-1041.
22. Rissoan M.C., Soumelis V., Kadowaki N., Grouard G., Briere F., de Waal Malefyt R., Liu Y.J. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 283:1999;1183-1186.
23. Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., Liu Y.J. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:2001;863-869.
24. Boonstra A., Asselin-Paturel C., Gilliet M., Crain C., Trinchieri G., Liu Y.J., O'Garra A. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J. Exp. Med. 197:2003;101-109 An important paper describing the ability of various DC subsets to induce Th1 differentiation. Antigen dose dependence and microbial exposure are both explored in the induction of Th1 versus Th2 responses.
25. Edwards A.D., Manickasingham S.P., Sporri R., Diebold S.S., Schulz O., Sher A., Kaisho T., Akira S., Reis e Sousa C. Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J. Immunol. 169:2002;3652-3660 This paper evaluates the role of different pathogen-associated molecular patterns (PAMPs) in DC1 versus DC2 induction and concludes that DC subsets are not pre-committed to either Th1 or Th2 differentiation.
26. Bozza S., Gaziano R., Spreca A., Bacci A., Montagnoli C., di Francesco P., Romani L. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J. Immunol. 168:2002;1362-1371.
27. d'Ostiani C.F., Del Sero G., Bacci A., Montagnoli C., Spreca A., Mencacci A., Ricciardi-Castagnoli P., Romani L. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 191:2000;1661-1674.
28. Vieira P.L., de Jong E.C., Wierenga E.A., Kapsenberg M.L., Kalinski P. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J. Immunol. 164:2000;4507-4512.
29. Whelan M., Harnett M.M., Houston K.M., Patel V., Harnett W., Rigley K.P. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J. Immunol. 164:2000;6453-6460.
30. de Jong E.C., Vieira P.L., Kalinski P., Schuitemaker J.H., Tanaka Y., Wierenga E.A., Yazdanbakhsh M., Kapsenberg M.L. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J. Immunol. 168:2002;1704-1709 A comprehensive paper that specifically addresses the induction of DC1 and DC2 subsets and the factors used by these DCs to influence Th1 and Th2 polarization differentially.
31. Kalinski P., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today. 20:1999;561-567.
32. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:2003;133-146.
33. Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., Yoshimura A., Yoshida H. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170:2003;4886-4890.
34. + T cells. Immunity. 16:2002;779-790.
35. Belladonna M.L., Renauld J.C., Bianchi R., Vacca C., Fallarino F., Orabona C., Fioretti M.C., Grohmann U., Puccetti P. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168:2002;5448-5454.
36. Tanaka H., Demeure C.E., Rubio M., Delespesse G., Sarfati M. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio. J. Exp. Med. 192:2000;405-412.
37. Manickasingham S.P., Edwards A.D., Schulz O., Reis e Sousa C. The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals. Eur. J. Immunol. 33:2003;101-107.
38. Greenwald R.J., McAdam A.J., Van der Woude D., Satoskar A.R., Sharpe A.H. Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J. Immunol. 168:2002;991-995.
39. Jember A.G., Zuberi R., Liu F.T., Croft M. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 193:2001;387-392.
40. Hoshino A., Tanaka Y., Akiba H., Asakura Y., Mita Y., Sakurai T., Takaoka A., Nakaike S., Ishii N., Sugamura K., et al. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur. J. Immunol. 33:2003;861-869.
41. De Smedt T., Smith J., Baum P., Fanslow W., Butz E., Maliszewski C. Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol. 168:2002;661-670.
42. Arestides R.S., He H., Westlake R.M., Chen A.I., Sharpe A.H., Perkins D.L., Finn P.W. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur. J. Immunol. 32:2002;2874-2880.
43. Grewal I.S., Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:1998;111-135.
44. MacDonald A.S., Straw A.D., Dalton N.M., Pearce E.J. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J. Immunol. 168:2002;537-540 Evaluation of the role of CD40 in the induction of Th2 responses to S. mansoni using DC adoptive transfer.
45. MacDonald A.S., Patton E.A., La Flamme A.C., Araujo M.I., Huxtable C.R., Bauman B., Pearce E.J. Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J. Immunol. 168:2002;4643-4649.
46. Ghaemmaghami A.M., Gough L., Sewell H.F., Shakib F. The proteolytic activity of the major dust mite allergen Der p1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level. Clin. Exp. Allergy. 32:2002;1468-1475.
47. Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., Menon S., Clifford T., Hunte B., Lesley R., et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity. 15:2001;985-995.
48. Hurst S.D., Muchamuel T., Gorman D.M., Gilbert J.M., Clifford T., Kwan S., Menon S., Seymour B., Jackson C., Kung T.T., et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol. 169:2002;443-453.
49. Diehl S., Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol. Immunol. 39:2002;531-536.
50. + T cell-mediated suppression by dendritic cells. Science. 299:2003;1033-1036.
51. Dodge I.L., Carr M.W., Cernadas M., Brenner M.B. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J. Immunol. 170:2003;4457-4464.
52. Soumelis V., Reche P.A., Kanzler H., Yuan W., Edward G., Homey B., Gilliet M., Ho S., Antonenko S., Lauerma A., et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3:2002;673-680.
53. Idzko M., la Sala A., Ferrari D., Panther E., Herouy Y., Dichmann S., Mockenhaupt M., Di Virgilio F., Girolomoni G., Norgauer J. Expression and function of histamine receptors in human monocyte-derived dendritic cells. J. Allergy Clin. Immunol. 109:2002;839-846.
54. Gutzmer R., Langer K., Lisewski M., Mommert S., Rieckborn D., Kapp A., Werfel T. Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells. J. Allergy Clin. Immunol. 109:2002;524-531.
55. Drouin S.M., Corry D.B., Hollman T.J., Kildsgaard J., Wetsel R.A. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J. Immunol. 169:2002;5926-5933.