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Volumn 18, Issue 6, 2005, Pages 543-549

Host determinants of antiretroviral drug activity

Author keywords

Antitretroviral drugs; HIV infection; Pharmacogenetics

Indexed keywords

ABACAVIR; ABC TRANSPORTER; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; EFAVIRENZ; ENFUVIRTIDE; GLYCOPROTEIN P; INDINAVIR; LAMIVUDINE; MULTIDRUG RESISTANCE PROTEIN; NEVIRAPINE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; THYMIDINE KINASE; ZIDOVUDINE;

EID: 27744482950     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qco.0000191507.48481.10     Document Type: Review
Times cited : (12)

References (84)
  • 1
    • 0142248431 scopus 로고    scopus 로고
    • British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy
    • Pozniak A, Gazzard B, Anderson J, et al. British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy. HIV Med 2003; 4 (Suppl 1):1-41.
    • (2003) HIV Med , vol.4 , Issue.SUPPL. 1 , pp. 1-41
    • Pozniak, A.1    Gazzard, B.2    Anderson, J.3
  • 2
    • 0036114874 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in HIV infection: Current status and future directions
    • Back D, Gatti G, Fletcher C, et al. Therapeutic drug monitoring in HIV infection: current status and future directions. Aids 2002; 16 (Suppl 1): S5-S37.
    • (2002) Aids , vol.16 , Issue.SUPPL. 1
    • Back, D.1    Gatti, G.2    Fletcher, C.3
  • 3
    • 0347526061 scopus 로고    scopus 로고
    • Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and pharmacogenomics
    • Hoehe MR, Timmermann B, Lehrach H. Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and pharmacogenomics. Curr Pharm Biotechnol 2003; 4:351-378.
    • (2003) Curr Pharm Biotechnol , vol.4 , pp. 351-378
    • Hoehe, M.R.1    Timmermann, B.2    Lehrach, H.3
  • 4
    • 3242808027 scopus 로고    scopus 로고
    • Large-scale copy number polymorphism in the human genome
    • Sebat J, Lakshmi B, Troge J, et al. Large-scale copy number polymorphism in the human genome. Science 2004; 305:525-528.
    • (2004) Science , vol.305 , pp. 525-528
    • Sebat, J.1    Lakshmi, B.2    Troge, J.3
  • 5
    • 0038662719 scopus 로고    scopus 로고
    • Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata
    • Palella FJ Jr, Deloria-Knoll M, Chmiel JS, et al. Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata. Ann Intern Med 2003; 138:620-626.
    • (2003) Ann Intern Med , vol.138 , pp. 620-626
    • Palella Jr., F.J.1    Deloria-Knoll, M.2    Chmiel, J.S.3
  • 6
    • 20444506418 scopus 로고    scopus 로고
    • Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy
    • Boffito M, Acosta E, Burger D, et al. Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy. Antivir Ther 2005; 10:375-392.
    • (2005) Antivir Ther , vol.10 , pp. 375-392
    • Boffito, M.1    Acosta, E.2    Burger, D.3
  • 7
    • 0033790624 scopus 로고    scopus 로고
    • Zidovudine triphosphate and lamivudine triphosphate concentration- response relationships in HIV-infected persons
    • Fletcher CV, Kawle SP, Kakuda TN, et al. Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons. Aids 2000; 14:2137-2144.
    • (2000) Aids , vol.14 , pp. 2137-2144
    • Fletcher, C.V.1    Kawle, S.P.2    Kakuda, T.N.3
  • 8
    • 1242343602 scopus 로고    scopus 로고
    • Cellular issues relating to the resistance of HIV to antiretroviral agents
    • Turriziani O, Scagnolari C, Bellomi F, et al. Cellular issues relating to the resistance of HIV to antiretroviral agents. Scand J Infect Dis Suppl 2003; 35 (Suppl 106):45-48.
    • (2003) Scand J Infect Dis Suppl , vol.35 , Issue.SUPPL. 106 , pp. 45-48
    • Turriziani, O.1    Scagnolari, C.2    Bellomi, F.3
  • 9
    • 0030039293 scopus 로고    scopus 로고
    • Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase
    • Antonelli G, Turriziani O, Verri A, et al. Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase. AIDS Res Hum Retroviruses 1996; 12:223-228.
    • (1996) AIDS Res Hum Retroviruses , vol.12 , pp. 223-228
    • Antonelli, G.1    Turriziani, O.2    Verri, A.3
  • 11
    • 0033773435 scopus 로고    scopus 로고
    • Cellular factors for resistance against antiretroviral agents
    • Fridland A, Connelly MC, Robbins BL. Cellular factors for resistance against antiretroviral agents. Antivir Ther 2000; 5:181-185.
    • (2000) Antivir Ther , vol.5 , pp. 181-185
    • Fridland, A.1    Connelly, M.C.2    Robbins, B.L.3
  • 12
    • 0032879904 scopus 로고    scopus 로고
    • MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    • Schuetz JD, Connelly MC, Sun D, et al. MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 1999; 5:1048-1051.
    • (1999) Nat Med , vol.5 , pp. 1048-1051
    • Schuetz, J.D.1    Connelly, M.C.2    Sun, D.3
  • 13
    • 0037110745 scopus 로고    scopus 로고
    • Impaired 2′,3′-dideoxy-3′-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11
    • Turriziani O, Schuetz JD, Focher F, et al. Impaired 2′,3′- dideoxy-3′-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. Biochem J 2002; 368:325-332.
    • (2002) Biochem J , vol.368 , pp. 325-332
    • Turriziani, O.1    Schuetz, J.D.2    Focher, F.3
  • 14
    • 0035163638 scopus 로고    scopus 로고
    • Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir
    • Hetherington S, McGuirk S, Powell G, et al. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir. Clin Ther 2001; 23:1603-1614.
    • (2001) Clin Ther , vol.23 , pp. 1603-1614
    • Hetherington, S.1    McGuirk, S.2    Powell, G.3
  • 15
    • 0036246069 scopus 로고    scopus 로고
    • Risk factor analysis of hypersensitivity reactions to abacavir
    • Symonds W, Cutrell A, Edwards M, et al. Risk factor analysis of hypersensitivity reactions to abacavir. Clin Ther 2002; 24:565-573.
    • (2002) Clin Ther , vol.24 , pp. 565-573
    • Symonds, W.1    Cutrell, A.2    Edwards, M.3
  • 16
    • 0034798191 scopus 로고    scopus 로고
    • Hypersensitivity related to abacavir in two members of a family
    • Peyrieere H, Nicolas J, Siffert M, et al. Hypersensitivity related to abacavir in two members of a family. Ann Pharmacother 2001; 35:1291-1292.
    • (2001) Ann Pharmacother , vol.35 , pp. 1291-1292
    • Peyrieere, H.1    Nicolas, J.2    Siffert, M.3
  • 17
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002; 359:727-732.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 18
    • 0037197044 scopus 로고    scopus 로고
    • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • Hetherington S, Hughes AR, Mosteller M, et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet 2002; 359:1121-1122.
    • (2002) Lancet , vol.359 , pp. 1121-1122
    • Hetherington, S.1    Hughes, A.R.2    Mosteller, M.3
  • 19
    • 3042634326 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of HLA-B*5701 genotyping in preventing abacavir hypersensitivity
    • Hughes DA, Vilar FJ, Ward CC, et al. Cost-effectiveness analysis of HLA-B*5701 genotyping in preventing abacavir hypersensitivity. Pharmacogenetics 2004; 14:335-342.
    • (2004) Pharmacogenetics , vol.14 , pp. 335-342
    • Hughes, D.A.1    Vilar, F.J.2    Ward, C.C.3
  • 20
    • 12144287198 scopus 로고    scopus 로고
    • Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • Martin AM, Nolan D, Gaudieri S, et al. Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci U S A 2004; 101:4180-4185.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4180-4185
    • Martin, A.M.1    Nolan, D.2    Gaudieri, S.3
  • 21
    • 12144291646 scopus 로고    scopus 로고
    • Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations
    • Hughes AR, Mosteller M, Bansal AT, et al. Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. Pharmacogenomics 2004; 5:203-211.
    • (2004) Pharmacogenomics , vol.5 , pp. 203-211
    • Hughes, A.R.1    Mosteller, M.2    Bansal, A.T.3
  • 22
    • 24044474081 scopus 로고    scopus 로고
    • The management of HIV-1 protease inhibitor pharmacokinetic interactions
    • Winston A, Boffito M. The management of HIV-1 protease inhibitor pharmacokinetic interactions. J Antimicrob Chemother 2005; 56:1-5.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 1-5
    • Winston, A.1    Boffito, M.2
  • 23
    • 0026519541 scopus 로고
    • Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
    • Rettie AE, Korzekwa KR, Kunze KL, et al. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem Res Toxicol 1992; 5:54-59.
    • (1992) Chem Res Toxicol , vol.5 , pp. 54-59
    • Rettie, A.E.1    Korzekwa, K.R.2    Kunze, K.L.3
  • 24
    • 13844320650 scopus 로고    scopus 로고
    • The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation
    • de Leon J, Susce MT, Pan RM, et al. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry 2005; 66:15-27.
    • (2005) J Clin Psychiatry , vol.66 , pp. 15-27
    • De Leon, J.1    Susce, M.T.2    Pan, R.M.3
  • 25
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001; 27:383-391.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 26
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • Ingelman-Sundberg M, Oscarson M, McLellan RA. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol Sci 1999; 20:342-349.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 27
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • RebbeckTR, Jaffe JM, Walker AH, et al. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 1998; 90:1225-1229.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3
  • 28
    • 0034744113 scopus 로고    scopus 로고
    • No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin a through concentrations or rejection incidence in stable renal transplant recipients
    • von Ahsen N, Richter M, Grupp C, et al. No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A through concentrations or rejection incidence in stable renal transplant recipients. Clin Chem 2001; 47:1048-1052.
    • (2001) Clin Chem , vol.47 , pp. 1048-1052
    • Von Ahsen, N.1    Richter, M.2    Grupp, C.3
  • 29
    • 15744390776 scopus 로고    scopus 로고
    • Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype
    • Lee SJ, Bell DA, Coulter SJ, et al. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype. J Pharmacol Exp Ther 2005; 313:302-309.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 302-309
    • Lee, S.J.1    Bell, D.A.2    Coulter, S.J.3
  • 30
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001; 11:399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3
  • 31
    • 4644349582 scopus 로고    scopus 로고
    • Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: Demonstration of phenotypic null alleles
    • Lang T, Klein K, Richter T, et al. Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther 2004; 311:34-43.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 34-43
    • Lang, T.1    Klein, K.2    Richter, T.3
  • 32
    • 0033047411 scopus 로고    scopus 로고
    • Efavirenz in the management of HIV infection
    • Gazzard BG. Efavirenz in the management of HIV infection. Int J Clin Pract 1999; 53:60-64.
    • (1999) Int J Clin Pract , vol.53 , pp. 60-64
    • Gazzard, B.G.1
  • 33
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. Aids 2004; 18:2391-2400. Novel data to improve the management of HIV patients on antiretroviral agents.
    • (2004) Aids , vol.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 34
    • 2942551228 scopus 로고    scopus 로고
    • Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens
    • Tsuchiya K, Gatanaga H, Tachikawa N, et al. Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. Biochem Biophys Res Commun 2004; 319:1322-1326.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 1322-1326
    • Tsuchiya, K.1    Gatanaga, H.2    Tachikawa, N.3
  • 35
    • 17644414659 scopus 로고    scopus 로고
    • Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
    • Rodriguez-Novoa S, Barreiro P, Rendon A, et al. Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects. Clin Infect Dis 2005; 40:1358-1361.
    • (2005) Clin Infect Dis , vol.40 , pp. 1358-1361
    • Rodriguez-Novoa, S.1    Barreiro, P.2    Rendon, A.3
  • 36
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H, et al. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005; 15:1-5.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 37
    • 27744501459 scopus 로고    scopus 로고
    • Relevance of drug transporters and drug metabolism enzymes to nevirapine: Superimposition of host genotype
    • Boston, MA; February. Abstract 650
    • Owen A, Almond L, Hartkoorn R, et al. Relevance of drug transporters and drug metabolism enzymes to nevirapine: superimposition of host genotype. 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA; February 2005. Abstract 650.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Owen, A.1    Almond, L.2    Hartkoorn, R.3
  • 38
  • 39
    • 11944274532 scopus 로고    scopus 로고
    • The influence of age and sex on the clearance of cytochrome P450 3A substrates
    • Cotreau MM, von Moltke LL, Greenblatt DJ. The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet 2005; 44:33-60.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 33-60
    • Cotreau, M.M.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 40
    • 7944235868 scopus 로고    scopus 로고
    • Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate
    • Greenblatt DJ, Harmatz JS, von Moltke LL, et al. Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. Clin Pharmacol Ther 2004; 76:467-479.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 467-479
    • Greenblatt, D.J.1    Harmatz, J.S.2    Von Moltke, L.L.3
  • 41
    • 0037275143 scopus 로고    scopus 로고
    • The influence of sex on pharmacokinetics
    • Schwartz JB. The influence of sex on pharmacokinetics. Clin Pharmacokinet 2003; 42:107-121.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 107-121
    • Schwartz, J.B.1
  • 43
    • 0242333229 scopus 로고    scopus 로고
    • Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals
    • Anderson PL, Kakuda TN, Kawle S, Fletcher CV. Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals. Aids 2003; 17:2159-2168.
    • (2003) Aids , vol.17 , pp. 2159-2168
    • Anderson, P.L.1    Kakuda, T.N.2    Kawle, S.3    Fletcher, C.V.4
  • 47
    • 0036156409 scopus 로고    scopus 로고
    • Pharmacokinetic variability caused by gender: Do women have higher indinavir exposure than men?
    • Burger DM, Siebers MC, Hugen PW, et al. Pharmacokinetic variability caused by gender: do women have higher indinavir exposure than men? J Acquir Immune Defic Syndr 2002; 29:101-102.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 101-102
    • Burger, D.M.1    Siebers, M.C.2    Hugen, P.W.3
  • 48
    • 2342563028 scopus 로고    scopus 로고
    • Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1
    • Pai MP, Schriever CA, Diaz-Linares M, et al. Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1. Pharmacotherapy 2004; 24:592-599.
    • (2004) Pharmacotherapy , vol.24 , pp. 592-599
    • Pai, M.P.1    Schriever, C.A.2    Diaz-Linares, M.3
  • 49
    • 7244243920 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of a double-boosting regimen of saquinavir soft gel plus lopinavir plus minidose ritonavir in human immunodeficiency virus-infected adults
    • Ribera E, Lopez RM, Diaz M, et al. Steady-state pharmacokinetics of a double-boosting regimen of saquinavir soft gel plus lopinavir plus minidose ritonavir in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother 2004; 48:4256-4262.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4256-4262
    • Ribera, E.1    Lopez, R.M.2    Diaz, M.3
  • 50
    • 1842450852 scopus 로고    scopus 로고
    • Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359
    • Fletcher CV, Jiang H, Brundage RC, et al. Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359. J Infect Dis 2004; 189:1176-1184.
    • (2004) J Infect Dis , vol.189 , pp. 1176-1184
    • Fletcher, C.V.1    Jiang, H.2    Brundage, R.C.3
  • 51
    • 0036235089 scopus 로고    scopus 로고
    • Simplifying protease inhibitor therapy with once-daily dosing of saquinavir soft-gelatin capsules/ritonavir (1600/100 mg): HIVNAT 001.3 study
    • Cardiello PG, van Heeswijk RP, Hassink EA, et al. Simplifying protease inhibitor therapy with once-daily dosing of saquinavir soft-gelatin capsules/ritonavir (1600/100 mg): HIVNAT 001.3 study. J Acquir Immune Defic Syndr 2002; 29:464-470.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 464-470
    • Cardiello, P.G.1    Van Heeswijk, R.P.2    Hassink, E.A.3
  • 52
    • 27744450308 scopus 로고    scopus 로고
    • Pharmacokinetics of once-daily saquinavir hard-gel capsule with low-dose ritonavir or full-dose atazanavir in seronegative volunteers: ASPIRE I
    • Boston, MA. Abstract 655
    • Becker S, Tse M, Sterman F, et al. Pharmacokinetics of once-daily saquinavir hard-gel capsule with low-dose ritonavir or full-dose atazanavir in seronegative volunteers: ASPIRE I. 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA; 2005. Abstract 655.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Becker, S.1    Tse, M.2    Sterman, F.3
  • 53
    • 27744448646 scopus 로고    scopus 로고
    • The impact of gender on saquinavir hard gel/ritonavir (1000/100 mg bid) pharmacokinetics and PBMC transporter expression in HIV-1 infected individuals
    • Quebec, Canada; April. Abstract 9
    • Dickinson L, Back D, Chandler B, et al. The impact of gender on saquinavir hard gel/ritonavir (1000/100 mg bid) pharmacokinetics and PBMC transporter expression in HIV-1 infected individuals. 6th International Workshop on Clinical Pharmacology of HIV Therapy, Quebec, Canada; April 2005. Abstract 9.
    • (2005) 6th International Workshop on Clinical Pharmacology of HIV Therapy
    • Dickinson, L.1    Back, D.2    Chandler, B.3
  • 54
    • 0037342870 scopus 로고    scopus 로고
    • The mechanisms that control intracellular penetration of the HIV protease inhibitors
    • Hoggard PG, Owen A. The mechanisms that control intracellular penetration of the HIV protease inhibitors. J Antimicrob Chemother 2003; 51:493-496.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 493-496
    • Hoggard, P.G.1    Owen, A.2
  • 55
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetics study
    • Fellay J, Marzolini C, Meaden ER, et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002; 359:30-36.
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.R.3
  • 56
    • 20044362282 scopus 로고    scopus 로고
    • The implications of P-glycoprotein in HIV: Friend or foe?
    • Owen A, Chandler B, Back DJ. The implications of P-glycoprotein in HIV: friend or foe? Fundam Clin Pharmacol 2005; 19:283-296.
    • (2005) Fundam Clin Pharmacol , vol.19 , pp. 283-296
    • Owen, A.1    Chandler, B.2    Back, D.J.3
  • 57
    • 0034971274 scopus 로고    scopus 로고
    • The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 1 23 from CD56+ natural killer cells
    • Hitzl M, Drescher S, van der Kuip H, et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 1 23 from CD56+ natural killer cells. Pharmacogenetics 2001; 11:293-298.
    • (2001) Pharmacogenetics , vol.11 , pp. 293-298
    • Hitzl, M.1    Drescher, S.2    Van Der Kuip, H.3
  • 58
    • 6344294111 scopus 로고    scopus 로고
    • Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4
    • Owen A, Chandler B, Bray PG, et al. Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J Virol 2004; 78:12022-12029. Novel and interesting scientific data to clarify the complex role of transporters in HIV infection.
    • (2004) J Virol , vol.78 , pp. 12022-12029
    • Owen, A.1    Chandler, B.2    Bray, P.G.3
  • 60
    • 0023690101 scopus 로고
    • Drug binding to human alpha-1-acid glycoprotein in health and disease
    • Kremer JM, Wilting J, Janssen LH. Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 1988; 40:1-47.
    • (1988) Pharmacol Rev , vol.40 , pp. 1-47
    • Kremer, J.M.1    Wilting, J.2    Janssen, L.H.3
  • 61
    • 0027310686 scopus 로고
    • Alpha 1-acid glycoprotein levels in AIDS patients before and after short-term treatment with zidovudine (ZDV)
    • Oie S, Jacobson MA, Abrams DI. Alpha 1-acid glycoprotein levels in AIDS patients before and after short-term treatment with zidovudine (ZDV). J Acquir Immune Defic Syndr 1993; 6:531-533.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 531-533
    • Oie, S.1    Jacobson, M.A.2    Abrams, D.I.3
  • 62
    • 0031815338 scopus 로고    scopus 로고
    • Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: Generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the a variant
    • Herve F, Caron G, Duche JC, et al. Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant. Mol Pharmacol 1998; 54:129-138.
    • (1998) Mol Pharmacol , vol.54 , pp. 129-138
    • Herve, F.1    Caron, G.2    Duche, J.C.3
  • 63
    • 2342436091 scopus 로고    scopus 로고
    • Identification and characterization of polymorphisms at the HAS alpha1-acid glycoprotein (ORM*) gene locus in Caucasians
    • Owczarek CM, Owczarek AL, Board PG. Identification and characterization of polymorphisms at the HAS alpha1-acid glycoprotein (ORM*) gene locus in Caucasians. Genet Mol Res 2002; 1:96-105.
    • (2002) Genet Mol Res , vol.1 , pp. 96-105
    • Owczarek, C.M.1    Owczarek, A.L.2    Board, P.G.3
  • 64
    • 3242880312 scopus 로고    scopus 로고
    • Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: Role of genetic and non genetic factors
    • Rodrigues-Lima F, Dupret JM. Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: role of genetic and non genetic factors. Curr Pharm Des 2004; 10:2519-2524.
    • (2004) Curr Pharm des , vol.10 , pp. 2519-2524
    • Rodrigues-Lima, F.1    Dupret, J.M.2
  • 65
    • 0033760290 scopus 로고    scopus 로고
    • Polymorphisms in UDP glucuronosyltransferase genes: Functional consequences and clinical relevance
    • Mackenzie PI, Miners JO, McKinnon RA. Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance. Clin Chem Lab Med 2000; 38:889-892.
    • (2000) Clin Chem Lab Med , vol.38 , pp. 889-892
    • Mackenzie, P.I.1    Miners, J.O.2    McKinnon, R.A.3
  • 66
    • 20944449543 scopus 로고    scopus 로고
    • Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses?
    • Kinzig-Schippers M, Tomalik-Scharte D, Jetter A, et al. Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses? Antimicrob Agents Chemother 2005; 49:1733-1738.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1733-1738
    • Kinzig-Schippers, M.1    Tomalik-Scharte, D.2    Jetter, A.3
  • 67
    • 2942540524 scopus 로고    scopus 로고
    • Princeton, NJ: Bristol-Myers Squibb
    • Atazanavir (package insert). Princeton, NJ: Bristol-Myers Squibb.
    • Atazanavir (Package Insert)
  • 68
    • 9644268882 scopus 로고    scopus 로고
    • Atazanavir for the treatment of human immunodeficiency virus infection
    • Busti AJ, Hall RG, Margolis DM. Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy 2004; 24:1732-1747.
    • (2004) Pharmacotherapy , vol.24 , pp. 1732-1747
    • Busti, A.J.1    Hall, R.G.2    Margolis, D.M.3
  • 69
    • 0037819284 scopus 로고    scopus 로고
    • Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
    • Guillemette C. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 2003; 3:136-158.
    • (2003) Pharmacogenomics J , vol.3 , pp. 136-158
    • Guillemette, C.1
  • 70
    • 17644415318 scopus 로고    scopus 로고
    • Pharmacogenomics. HIV therapeutics
    • Haas DW, Pharmacogenomics. HIV therapeutics. J Infect Dis 2005; 191:1397-1400.
    • (2005) J Infect Dis , vol.191 , pp. 1397-1400
    • Haas, D.W.1
  • 71
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: Far more than a lipid transport protein
    • Mahley RW, Rall SC Jr. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 2000; 1:507-537.
    • (2000) Annu Rev Genomics Hum Genet , vol.1 , pp. 507-537
    • Mahley, R.W.1    Rall Jr., S.C.2
  • 72
    • 0028881810 scopus 로고
    • Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia
    • Li WW, Dammerman MM, Smith JD, et al. Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest 1995; 96:2601-2605.
    • (1995) J Clin Invest , vol.96 , pp. 2601-2605
    • Li, W.W.1    Dammerman, M.M.2    Smith, J.D.3
  • 73
    • 0027223301 scopus 로고
    • An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphisms
    • Dammerman M, Sandkuijl LA, Halaas JL, et al. An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphisms. Proc Natl Acad Sci U S A 1993; 90:4562-4566.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4562-4566
    • Dammerman, M.1    Sandkuijl, L.A.2    Halaas, J.L.3
  • 74
    • 20244375708 scopus 로고    scopus 로고
    • Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders
    • Tarr PE, Taffe P, Bleiber G, et al. Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders. J Infect Dis 2005; 191:1419-1426. Clear and interesting study clarifying the importance of pharmacogenetics in relation to the development of antiretroviral-related metabolic adverse events.
    • (2005) J Infect Dis , vol.191 , pp. 1419-1426
    • Tarr, P.E.1    Taffe, P.2    Bleiber, G.3
  • 75
    • 0035824763 scopus 로고    scopus 로고
    • An interaction between apo C-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients
    • Fauvel J, Bonnet E, Ruidavets JB, et al. An interaction between apo C-III variants and protease inhibitors contributes to high triglyceride/low HDL levels in treated HIV patients. Aids 2001; 15:2397-2406.
    • (2001) Aids , vol.15 , pp. 2397-2406
    • Fauvel, J.1    Bonnet, E.2    Ruidavets, J.B.3
  • 76
    • 0037131198 scopus 로고    scopus 로고
    • TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy
    • Maher B, Alfirevic A, Vilar FJ, et al. TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. Aids 2002; 16:2013-2018.
    • (2002) Aids , vol.16 , pp. 2013-2018
    • Maher, B.1    Alfirevic, A.2    Vilar, F.J.3
  • 77
    • 0037415033 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha gene - 238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy
    • Nolan D, Moore C, Castley A, et al. Tumour necrosis factor-alpha gene - 238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy. Aids 2003; 17:121-123.
    • (2003) Aids , vol.17 , pp. 121-123
    • Nolan, D.1    Moore, C.2    Castley, A.3
  • 80
    • 20544473465 scopus 로고    scopus 로고
    • An analysis of the correlation between the severity of injection site reactions and the amount of subcutaneous fat in the alliance cohort
    • Boston, MA; February. Poster 838
    • Cooper DA, Group TAI. An analysis of the correlation between the severity of injection site reactions and the amount of subcutaneous fat in the alliance cohort. 12th Conference of Retroviruses and Opportunistic Infections, Boston, MA; February 2005. Poster 838.
    • (2005) 12th Conference of Retroviruses and Opportunistic Infections
    • Cooper, D.A.1    Group, T.A.I.2
  • 81
    • 0037333717 scopus 로고    scopus 로고
    • An objective case definition of lipodystrophy in HIV-infected adults: A case-control study
    • Carr A, Emery S, Law M, et al. An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet 2003; 361:726-735.
    • (2003) Lancet , vol.361 , pp. 726-735
    • Carr, A.1    Emery, S.2    Law, M.3
  • 82
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3
  • 83
    • 0036500559 scopus 로고    scopus 로고
    • HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype
    • Sheppard HW, Celum C, Michael NL, et al. HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype. J Acquir Immune Defic Syndr 2002; 29:307-313.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 307-313
    • Sheppard, H.W.1    Celum, C.2    Michael, N.L.3
  • 84
    • 27144465704 scopus 로고    scopus 로고
    • HIV chemokine receptor inhibitors as novel anti-HIV drugs
    • 5 July [Epub ahead of print]. Comprehensive review on novel anti-HIV agents
    • Princen K, Schols D. HIV chemokine receptor inhibitors as novel anti-HIV drugs. Cytokine Growth Factor Rev 2005; 5 July [Epub ahead of print]. Comprehensive review on novel anti-HIV agents.
    • (2005) Cytokine Growth Factor Rev
    • Princen, K.1    Schols, D.2


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