C3′-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: Synthesis and SAR studies

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6556-6570

  González, Rosario ^a   Collado, Iván ^a   López De Uralde, Beatriz ^a   Marcos, Alicia ^a   Martín Cabrejas, Luisa M ^a   Pedregal, Concepción ^a   Blanco Urgoiti, Jaime ^b   Pérez Castells, Javier ^b   Fernández, M Alejandro ^c   Andis, Sherri L ^d   Johnson, Bryan G ^d   Wright, Rebecca A ^d   Schoepp, Darryle D ^d   Monn, James A ^d  

^a ELI LILLY AND COMPANY   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

^c UNIVERSITY OF OVIEDO   (Spain)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Carboxycyclopropyl glycine; CCG; Metabotropic glutamate 2 3 receptor

Indexed keywords

2 (2' CARBOXY 3 CYANOCYCLOPROPYL)GLYCINE; 2 (3' AMINOMETHYL 2' CARBOXYCYCLOPROPYL)GLYCINE; 2 (3' AZIDOMETHYL 2' CARBOXYCYCLOPROPYL)GLYCINE; 2 (3' BENZENESULFONYLAMINOMETHYL 2' CARBOXYCYCLOPROPYL)GLYCINE; 2 (3' ETHYL 2' CARBOXYCYCLOPROPYL)GLYCINE; 2 (3' PHENYLCARBAMOYLOXYMETHYL 2' CARBOXYCYCLOPROPYL)GLYCINE; 2 [(3' HYDROXYETHYL) 2' CARBOXYCYCLOPROPYL]GLYCINE; 2 [2' CARBOXY 3' (METHYLAMINOCARBONYL)CYCLOPROPYL]GLYCINE; CARBOXYCYCLOPROPYLGLYCINE DERIVATIVE; FUNCTIONAL GROUP; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; UNCLASSIFIED DRUG; GLYCINE; METABOTROPIC RECEPTOR;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DRUG POTENTIATION; HUMAN; METABOLISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; GLYCINE; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27544473793     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.036     Document Type: Article

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