Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2′-carboxy-3′-phenylcyclopropyl)glycine. Focus on (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist

Journal of Medicinal Chemistry

Volumn 39, Issue 11, 1996, Pages 2259-2269

  Pellicciari, Roberto ^a   Marinozzi, Maura ^a   Natalini, Benedetto ^a   Costantino, Gabriele ^a   Luneia, Roberto ^a   Giorgi, Gianluca ^b   Moroni, Flavio ^c   Thomsen, Christian ^d  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2' CARBOXY 3' PHENYLCYCLOPROPYL)GLYCINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CYCLIC AMP; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; MOLECULAR CLONING; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ALTERNATIVE SPLICING; ANIMALS; CELL MEMBRANE; CEREBRAL CORTEX; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; GLYCINE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VARIATION (GENETICS);

EID: 0029956082     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960059+     Document Type: Article

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