2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1- yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 358-378

  Ornstein, Paul L ^a   Bleisch, Thomas J ^a   Arnold, M Brian ^a   Kennedy, Joseph H ^a   Wright, Rebecca A ^a   Johnson, Bryan G ^a   Tizzano, Joseph P ^a   Helton, David R ^a   Kallman, Mary Jeanne ^a   Schoepp, Darryle D ^a   Hérin, Marc ^b  

^a ELI LILLY AND COMPANY   (United States)

^b Eli Lilly Benelux   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROP 1 YL) 3 (9 XANTHYL)PROPANOIC ACID; CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MEMBRANE; BRAIN PROTECTION; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG SYNTHESIS; FOREBRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STEREOISOMERISM;

EID: 14444286701     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970498o     Document Type: Article

References (21)

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