Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic Acid-I, a potent mGluR agonist

Journal of Medicinal Chemistry

Volumn 41, Issue 10, 1998, Pages 1641-1650

  Kozikowski, Alan P ^a   Steensma, Darryl ^a   Araldi, Gian Luca ^a   Tückmantel, Werner ^a   Wang, Shaomeng ^a   Pshenichkin, Sergey ^a   Surina, Elena ^a   Wroblewski, Jarda T ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEXANE 2,5 DICARBOXYLIC ACID; DICARBOXYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EFFECTOR CELL; HYDROLYSIS; LIGAND BINDING; MOLECULAR RECOGNITION; NERVE DEGENERATION; NONHUMAN; SYNAPTIC TRANSMISSION;

ANIMALS; BICYCLO COMPOUNDS; CALCIUM; CELLS, CULTURED; CEREBELLUM; CHO CELLS; CRICETINAE; CYCLIC AMP; CYCLOLEUCINE; DICARBOXYLIC ACIDS; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; INOSITOL PHOSPHATES; KIDNEY; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NORBORNANES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM;

EID: 0032492989     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970719q     Document Type: Article

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