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Volumn 35, Issue 3, 2005, Pages 183-189

Celiac disease. New therapeutic alternatives based on a better knowledge of molecular pathogenesis;Enfermedad celíaca. Nuevas perspectivas terapéuticas basadas en un mejor conocimiento de su patogenia molecular

Author keywords

Enfermedad cel aca; Inmunomodulaci n; Patogenia; Terapia

Indexed keywords

CELIAC DISEASE; GENETICS; HUMAN; IMMUNOLOGY; REVIEW;

EID: 27544468770     PISSN: 03009033     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (56)
  • 1
    • 0027319208 scopus 로고
    • Gliadin-specific, HLA-DQ (α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
    • Lundin KE, Scott H, Hansen T, et al. Gliadin-specific, HLA-DQ (α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-196.
    • (1993) J Exp Med , vol.178 , pp. 187-196
    • Lundin, K.E.1    Scott, H.2    Hansen, T.3
  • 2
    • 0028828948 scopus 로고
    • Gluten specific, HLA-DQ restricted T cells from celiac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma
    • Nilsen EM, Lundin KE, Krajci P, et al. Gluten specific, HLA-DQ restricted T cells from celiac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995;37:766-776.
    • (1995) Gut , vol.37 , pp. 766-776
    • Nilsen, E.M.1    Lundin, K.E.2    Krajci, P.3
  • 3
    • 0036715684 scopus 로고    scopus 로고
    • Coeliac disease: Dissecting a complex inflammatory disorder
    • Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nature Rev 2002;2:647-655.
    • (2002) Nature Rev , vol.2 , pp. 647-655
    • Sollid, L.M.1
  • 4
    • 0037183951 scopus 로고    scopus 로고
    • Gluten and the gut - Lessons for immune regulation
    • Schuppan D, Hahn EG. Gluten and the gut - lessons for immune regulation. Science 2002; 297:2218-2220.
    • (2002) Science , vol.297 , pp. 2218-2220
    • Schuppan, D.1    Hahn, E.G.2
  • 5
    • 0034695893 scopus 로고    scopus 로고
    • The intestinal T cell response to a-gliadin in adult celiac disease is focused on a single deaminated glutamine targeted by tissue transglutaminase
    • Arentz-Hansen H, Korner R, Molberg O, et al. The intestinal T cell response to a-gliadin in adult celiac disease is focused on a single deaminated glutamine targeted by tissue transglutaminase. J Exp Med 2000;191:603-612.
    • (2000) J Exp Med , vol.191 , pp. 603-612
    • Arentz-Hansen, H.1    Korner, R.2    Molberg, O.3
  • 6
    • 0034066695 scopus 로고    scopus 로고
    • In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as a dominant A-gliadin T-cell epitope
    • Anderson RP, Degano P, Godkin AJ, et al. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as a dominant A-gliadin T-cell epitope. Nat Med 2000;6:337-342.
    • (2000) Nat Med , vol.6 , pp. 337-342
    • Anderson, R.P.1    Degano, P.2    Godkin, A.J.3
  • 7
    • 3242801934 scopus 로고    scopus 로고
    • Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    • Qiao SW, Bergseng E, Molberg O, et al. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol 2004;173:1757-1762.
    • (2004) J Immunol , vol.173 , pp. 1757-1762
    • Qiao, S.W.1    Bergseng, E.2    Molberg, O.3
  • 8
    • 0038501062 scopus 로고    scopus 로고
    • Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
    • Maiuri L, Ciacci C, Ricciardelli I, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003;362:30-37.
    • (2003) Lancet , vol.362 , pp. 30-37
    • Maiuri, L.1    Ciacci, C.2    Ricciardelli, I.3
  • 9
    • 4444251461 scopus 로고    scopus 로고
    • A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    • Hue S, Mention JJ, Monteiro RC, et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004;21:367-377.
    • (2004) Immunity , vol.21 , pp. 367-377
    • Hue, S.1    Mention, J.J.2    Monteiro, R.C.3
  • 10
    • 0037880603 scopus 로고    scopus 로고
    • HLA in coeliac disease: Unravelling the complex genetics of a complex disorder
    • Louka AS, Sollid LM. HLA in coeliac disease: unravelling the complex genetics of a complex disorder. Tissue Antigens 2003;61:105-117.
    • (2003) Tissue Antigens , vol.61 , pp. 105-117
    • Louka, A.S.1    Sollid, L.M.2
  • 11
    • 0037381091 scopus 로고    scopus 로고
    • HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: Results from the European Genetics Cluster on Celiac Disease
    • Karell K, Louka AS, Moodie SJ, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol 2003;64:469-477.
    • (2003) Hum Immunol , vol.64 , pp. 469-477
    • Karell, K.1    Louka, A.S.2    Moodie, S.J.3
  • 12
    • 0031893682 scopus 로고    scopus 로고
    • HLA-DQ2-negative celiac disease in Finland and Spain
    • Polvi A, Arranz E, Fernández-Arquero M, et al. HLADQ2-negative celiac disease in Finland and Spain. Hum Immunol 1998;59:169-175.
    • (1998) Hum Immunol , vol.59 , pp. 169-175
    • Polvi, A.1    Arranz, E.2    Fernández-Arquero, M.3
  • 14
    • 0032198071 scopus 로고    scopus 로고
    • In vivo gluten ingestion in celiac disease
    • Ciclitira PJ, Ellis HJ. In vivo gluten ingestion in celiac disease. Dig Dis Sci 1998;16:337-340.
    • (1998) Dig Dis Sci , vol.16 , pp. 337-340
    • Ciclitira, P.J.1    Ellis, H.J.2
  • 15
    • 0037302594 scopus 로고    scopus 로고
    • Investigation of the putative immunodominant T cell epitopes in celiac disease
    • Ellis HJ, Pollock EC, Engel W, et al. Investigation of the putative immunodominant T cell epitopes in celiac disease. Gut 2003;52:212-217.
    • (2003) Gut , vol.52 , pp. 212-217
    • Ellis, H.J.1    Pollock, E.C.2    Engel, W.3
  • 16
    • 0344234245 scopus 로고    scopus 로고
    • Coeliac disease: In vivo toxicity of the putative immunodominant epitope
    • Fraser JS, Engel W, Ellis HJ, et al. Coeliac disease: in vivo toxicity of the putative immunodominant epitope. Gut 2003;52:1698-1702.
    • (2003) Gut , vol.52 , pp. 1698-1702
    • Fraser, J.S.1    Engel, W.2    Ellis, H.J.3
  • 17
    • 0036724918 scopus 로고    scopus 로고
    • Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
    • Arentz-Hansen H, McAdam SN, Molberg O, et al. Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 2002;123:803-809.
    • (2002) Gastroenterology , vol.123 , pp. 803-809
    • Arentz-Hansen, H.1    McAdam, S.N.2    Molberg, O.3
  • 18
    • 0037183929 scopus 로고    scopus 로고
    • Structural basis for gluten intolerance in celiac sprue
    • Shan L, Molberg O, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002; 297:2275-2279.
    • (2002) Science , vol.297 , pp. 2275-2279
    • Shan, L.1    Molberg, O.2    Parrot, I.3
  • 19
    • 0141872931 scopus 로고    scopus 로고
    • The molecular basis of celiac disease
    • Koning F. The molecular basis of celiac disease. J Mol Recognit 2003;16:333-336
    • (2003) J Mol Recognit , vol.16 , pp. 333-336
    • Koning, F.1
  • 20
    • 14944352764 scopus 로고    scopus 로고
    • Mapping of gluten T cell epitopes in the bread wheat ancestors; implications for celiac disease
    • Molberg O, Uhlen AK, Jensen T, et al. Mapping of gluten T cell epitopes in the bread wheat ancestors; implications for celiac disease. Gastroenterology 2005;128:393-401.
    • (2005) Gastroenterology , vol.128 , pp. 393-401
    • Molberg, O.1    Uhlen, A.K.2    Jensen, T.3
  • 21
    • 0141817727 scopus 로고    scopus 로고
    • Characterization of cereal toxicity for celiac disease patients based on protein homology in grains
    • Vader LW, Stepniak DT, Bunnik EM, et al. Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. Gastroenterology 2003; 125:1105-1113.
    • (2003) Gastroenterology , vol.125 , pp. 1105-1113
    • Vader, L.W.1    Stepniak, D.T.2    Bunnik, E.M.3
  • 22
    • 0031779478 scopus 로고    scopus 로고
    • Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    • Molberg O, McAdam SN, Korner R, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998; 4:713-17.
    • (1998) Nat Med , vol.4 , pp. 713-717
    • Molberg, O.1    McAdam, S.N.2    Korner, R.3
  • 23
    • 0032528813 scopus 로고    scopus 로고
    • Selective deamination by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
    • van de Wal Y, Kooy Y, Van Veelen P, et al. Selective deamination by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998;161:1585-1588.
    • (1998) J Immunol , vol.161 , pp. 1585-1588
    • Van De Wal, Y.1    Kooy, Y.2    Van Veelen, P.3
  • 24
    • 0036082955 scopus 로고    scopus 로고
    • The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides
    • Vader W, Kooy Y, Van Veelen P, et al. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002;122:1729-1737.
    • (2002) Gastroenterology , vol.122 , pp. 1729-1737
    • Vader, W.1    Kooy, Y.2    Van Veelen, P.3
  • 25
    • 1642447710 scopus 로고    scopus 로고
    • Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    • Kim CY, Quarsten H, Bergseng E, et al. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Nat Acad Sci 2004;101:4175-4179.
    • (2004) Proc Nat Acad Sci , vol.101 , pp. 4175-4179
    • Kim, C.Y.1    Quarsten, H.2    Bergseng, E.3
  • 26
    • 15244344453 scopus 로고    scopus 로고
    • Modelling of HLA-DQ2 and its interaction with gluten peptides to explain molecular recognition in celiac disease
    • Costantini S, Rossi M, Colonna G and Facchiano AM. Modelling of HLA-DQ2 and its interaction with gluten peptides to explain molecular recognition in celiac disease. J Mol Graph Model 2005;23:419-431.
    • (2005) J Mol Graph Model , vol.23 , pp. 419-431
    • Costantini, S.1    Rossi, M.2    Colonna, G.3    Facchiano, A.M.4
  • 27
    • 0031660029 scopus 로고    scopus 로고
    • Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
    • Nilsen EM, Jahnsen FL, Lundin KE, et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998;115:551-563.
    • (1998) Gastroenterology , vol.115 , pp. 551-563
    • Nilsen, E.M.1    Jahnsen, F.L.2    Lundin, K.E.3
  • 28
    • 0031891459 scopus 로고    scopus 로고
    • The majority of gliadin-specific T cell clones from the coeliac small intestinal mucosa produce both γ-interferon and IL-4
    • Troncone R, Gianfrani C, Mazzarela G, et al. The majority of gliadin-specific T cell clones from the coeliac small intestinal mucosa produce both γ-interferon and IL-4. Dig Dis Sci 1998;43:156-161
    • (1998) Dig Dis Sci , vol.43 , pp. 156-161
    • Troncone, R.1    Gianfrani, C.2    Mazzarela, G.3
  • 29
    • 0036728160 scopus 로고    scopus 로고
    • Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease
    • Forsberg G, Hernell O, Melgar S, et al. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 2002;123:667-678.
    • (2002) Gastroenterology , vol.123 , pp. 667-678
    • Forsberg, G.1    Hernell, O.2    Melgar, S.3
  • 30
    • 0035063548 scopus 로고    scopus 로고
    • Role of interferon-α in promoting T helper cell type 1 responses in the small intestine in coeliac disease
    • Monteleone G, Pender SLF, Alstead E, et al. Role of interferon-α in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut 2001;48:425-429.
    • (2001) Gut , vol.48 , pp. 425-429
    • Monteleone, G.1    Pender, S.L.F.2    Alstead, E.3
  • 31
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: New players of T cell responses
    • Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players of T cell responses. Immunity 2003;19:641-644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 32
    • 0036155753 scopus 로고    scopus 로고
    • Interleukin 18 and associated markers of T helper cell type 1 activity in celiac disease
    • Salvati VM, MacDonald TT, Bajaj-Elliot M, et al. Interleukin 18 and associated markers of T helper cell type 1 activity in celiac disease. Gut 2002;50:186-190.
    • (2002) Gut , vol.50 , pp. 186-190
    • Salvati, V.M.1    MacDonald, T.T.2    Bajaj-Elliot, M.3
  • 33
    • 0033778725 scopus 로고    scopus 로고
    • Interleukin-15 mediates epithelial changes in celiac disease
    • Maiuri L, Ciacci C, Auricchio S, et al. Interleukin-15 mediates epithelial changes in celiac disease. Gastroenterology 2000;119:996-1006.
    • (2000) Gastroenterology , vol.119 , pp. 996-1006
    • Maiuri, L.1    Ciacci, C.2    Auricchio, S.3
  • 34
    • 19944368396 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa
    • Salvati VM, Mazzarella G, Gianfrani C, et al. Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa. Gut 2005;54:46-53.
    • (2005) Gut , vol.54 , pp. 46-53
    • Salvati, V.M.1    Mazzarella, G.2    Gianfrani, C.3
  • 35
    • 0030463222 scopus 로고    scopus 로고
    • Analysis of interleukin -4 and interleukin-10 and their association with the lymphatic infiltrate in the small intestine of patients with coeliac disease
    • Beckett CG, Dell'Olio D, Kontakou M, et al. Analysis of interleukin -4 and interleukin-10 and their association with the lymphatic infiltrate in the small intestine of patients with coeliac disease. Gut 1996;39:818-823.
    • (1996) Gut , vol.39 , pp. 818-823
    • Beckett, C.G.1    Dell'Olio, D.2    Kontakou, M.3
  • 36
    • 0033499464 scopus 로고    scopus 로고
    • Differing patterns of TGF-ß expression in normal intestinal mucosa and in active celiac disease
    • Lionetti P, Pazzaglia A, Moriondo M, et al. Differing patterns of TGF-ß expression in normal intestinal mucosa and in active celiac disease. J Pediatr Gastroenterol Nutr 1999;29:308-313.
    • (1999) J Pediatr Gastroenterol Nutr , vol.29 , pp. 308-313
    • Lionetti, P.1    Pazzaglia, A.2    Moriondo, M.3
  • 38
    • 0033034038 scopus 로고    scopus 로고
    • Increased expression of mRNA for matrix metalloproteinase-1 and -3 and tissue inhibitor of metalloproteinase-1 in intestinal biopsy specimens from patients with coeliac disease
    • Daum S, Bauer U, Foss HD, et al. Increased expression of mRNA for matrix metalloproteinase-1 and -3 and tissue inhibitor of metalloproteinase-1 in intestinal biopsy specimens from patients with coeliac disease. Gut 1999;44:17-25.
    • (1999) Gut , vol.44 , pp. 17-25
    • Daum, S.1    Bauer, U.2    Foss, H.D.3
  • 39
    • 14744282884 scopus 로고    scopus 로고
    • Matrix metalloproteinase pattern in celiac duodenal mucosa
    • Ciccocioppo R, Di Sabatino A, Bauer M, et al. Matrix metalloproteinase pattern in celiac duodenal mucosa. Lab Invest 2005;85:397-407.
    • (2005) Lab Invest , vol.85 , pp. 397-407
    • Ciccocioppo, R.1    Di Sabatino, A.2    Bauer, M.3
  • 40
    • 19944433266 scopus 로고    scopus 로고
    • Guideline for the diagnosis and treatment of celiac disease in children
    • Hill ID, et al. Guideline for the diagnosis and treatment of celiac disease in children. J Pediatr Gastroenterol Nutr 2005;40:1-19.
    • (2005) J Pediatr Gastroenterol Nutr , vol.40 , pp. 1-19
    • Hill, I.D.1
  • 41
    • 16244363310 scopus 로고    scopus 로고
    • Follow-up of patients with celiac disease: Achieving compliance with treatment
    • Pietzak MM. Follow-up of patients with celiac disease: achieving compliance with treatment. Gastroenterology 2005;128: S135-S141.
    • (2005) Gastroenterology , vol.128
    • Pietzak, M.M.1
  • 42
    • 16244393674 scopus 로고    scopus 로고
    • The gluten-free diet: How to ptovide effective education and resources
    • Case S. The gluten-free diet: how to ptovide effective education and resources. Gastroenterology 2005;128:S128-S134.
    • (2005) Gastroenterology , vol.128
    • Case, S.1
  • 43
    • 20444489227 scopus 로고    scopus 로고
    • Future therapeutic options for coeliac disease
    • Sollid LM and Khosla C. Future therapeutic options for coeliac disease. Nat Clin Pract 2005;2:140-147.
    • (2005) Nat Clin Pract , vol.2 , pp. 140-147
    • Sollid, L.M.1    Khosla, C.2
  • 45
    • 11844263978 scopus 로고    scopus 로고
    • Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: Chemical and immunological characterization
    • Marti T, Molberg O, Li Q, et al. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization. J Pharmacol Exp Ther 2005;312:19-26.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 19-26
    • Marti, T.1    Molberg, O.2    Li, Q.3
  • 46
    • 0035019083 scopus 로고    scopus 로고
    • T cells from celiac disease lesions recognize gliadin epitopes deaminated in situ by endogenous tissue transglutaminase
    • Molberg O, McAdam SN, Lundin KE, et al. T cells from celiac disease lesions recognize gliadin epitopes deaminated in situ by endogenous tissue transglutaminase. Eur J Immunol 2001;31:1317-1323.
    • (2001) Eur J Immunol , vol.31 , pp. 1317-1323
    • Molberg, O.1    McAdam, S.N.2    Lundin, K.E.3
  • 47
    • 0026195616 scopus 로고
    • MHC-antigen-T cell interactions: An overview
    • Sette A, O'Sullivan D, Krieger JI, et al. MHC-antigen-T cell interactions: an overview. Semin Immunol 1991;3:195-2002.
    • (1991) Semin Immunol , vol.3 , pp. 195-2002
    • Sette, A.1    O'Sullivan, D.2    Krieger, J.I.3
  • 49
    • 0038316325 scopus 로고    scopus 로고
    • Anatomical basis of tolerance and immunity to intestinal antigens
    • Mowat A. McI. Anatomical basis of tolerance and immunity to intestinal antigens. Nature Rev Immunol 2003;3:331-341.
    • (2003) Nature Rev Immunol , vol.3 , pp. 331-341
    • McI Mowat, A.1
  • 50
    • 10744225587 scopus 로고    scopus 로고
    • Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice
    • Senger S, Luongo D, Maurano F, et al. Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice. Immunol Lett 2003;88:127-134.
    • (2003) Immunol Lett , vol.88 , pp. 127-134
    • Senger, S.1    Luongo, D.2    Maurano, F.3
  • 51
    • 0036093570 scopus 로고    scopus 로고
    • Biologic therapy of inflammatory bowel disease
    • Sandborn WJ and Targan SR. Biologic therapy of inflammatory bowel disease. Gastroenterology 2002;122:1592-1608.
    • (2002) Gastroenterology , vol.122 , pp. 1592-1608
    • Sandborn, W.J.1    Targan, S.R.2
  • 52
    • 0042324649 scopus 로고    scopus 로고
    • Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease
    • Mention JJ, Ben Ahmed M, Begue B, et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003;125:730-45.
    • (2003) Gastroenterology , vol.125 , pp. 730-745
    • Mention, J.J.1    Ben Ahmed, M.2    Begue, B.3
  • 53
    • 1842731811 scopus 로고    scopus 로고
    • Acquired and natural memory T cells join forces at the mucosal front line
    • Cheroutre H, Madakamutil L. Acquired and natural memory T cells join forces at the mucosal front line. Nat Rev Immunol 2004;4:290-300.
    • (2004) Nat Rev Immunol , vol.4 , pp. 290-300
    • Cheroutre, H.1    Madakamutil, L.2
  • 54
    • 0344407041 scopus 로고    scopus 로고
    • Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway
    • Giovannini C, Matarrese P, Scazzocchio B, et al. Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway. FEBS Lett 2003;540:117-124
    • (2003) FEBS Lett , vol.540 , pp. 117-124
    • Giovannini, C.1    Matarrese, P.2    Scazzocchio, B.3
  • 55
    • 16844372098 scopus 로고    scopus 로고
    • Gliadin as a stimulator of innate responses in celiac disease
    • Londei M, Ciacci C, Ricciardelli I, et al. Gliadin as a stimulator of innate responses in celiac disease. Mol Immunol 2005;42:913-8.
    • (2005) Mol Immunol , vol.42 , pp. 913-918
    • Londei, M.1    Ciacci, C.2    Ricciardelli, I.3
  • 56
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signalling pathway converts CTL into Lymphokine-activated killer cells in celiac disease
    • Meresse B, Chen Z, Ciszewski C, et al. Coordinated induction by IL15 of a TCR-independent NKG2D signalling pathway converts CTL into Lymphokine-activated killer cells in celiac disease. Immunity 2004;21:357-66.
    • (2004) Immunity , vol.21 , pp. 357-366
    • Meresse, B.1    Chen, Z.2    Ciszewski, C.3


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