Anergy induction by dimeric TCR ligands

Journal of Immunology

Volumn 166, Issue 8, 2001, Pages 5279-5285

  Appel, H ^a   Seth, N P ^a   Gauthier, L ^a   Wucherpfennig, K W ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; HLA DR2 ANTIGEN; HYBRID PROTEIN; IMMUNOGLOBULIN G; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035871624     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.8.5279     Document Type: Article

References (44)

1. The T lymphocyte in experimental allergic encephalomyelitis
2. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
3. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
4. The role of MHC class II molecules in susceptibility and resistance to autoimmunity
5. MHC class-II molecules and autoimmunity
6. Selective binding of self peptides to disease-associated major histocompatibility complex (MI-IC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases
7. The dosage requirements for immunological paralysis by soluble proteins
8. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
9. T cell unresponsiveness in vivo and in vitro: Fine specificity of induction and molecular characterization of the unresponsive state
10. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
11. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T cell clones
12. Human T cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
13. Induction of peripheral T cell tolerance in vivc requires CTLA-4 engagement
14. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g
15. Maintenance of human T cell anergy: Blocking of IL- 2 gene transcription by activated Rapl
16. + T cells
17. + T cell anergy in vitro
18. L
19. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
20. Blocking both signal I and signal 2 of T cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
21. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
22. Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris
23. In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation
24. CD40-activated human B cells: An alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy
25. Expression of recombinant HLA-DR2 molecules: Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR αβ heterodimers
26. Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1 * 1501) and an immunodominant peptide of human myelin basic protein
27. Kinetics of T cell receptor binding by bivalent HLA-DR/peptide complexes that activate antigen-specific human T cells
28. Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones
29. Determination of lymphocyte division by flow cytometry
30. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
31. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: The role of CD4 coreceptor
32. Multivalent structure of an αβ T cell receptor
33. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
34. Erythropoietin receptor activation by a ligand-induced conformation change
35. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
36. Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor
37. Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study
38. Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy: A stereochemical model for tyrosine kinase receptor activation
39. 2 domain of HLA-DR molecules
40. The intestinal T cell response to α-Gliadin in adult Celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
41. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T cell epitope
42. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
43. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
44. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice