Highly efficient and versatile synthesis of libraries of constrained β- strand mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 17, 1998, Pages 2321-2326

  Ogbu, Cyprian O ^a   Qabar, Maher N ^a   Boatman, P Douglas ^a   Urban, Jan ^a   Meara, Joseph P ^a   Ferguson, Mark D ^a   Tulinsky, John ^a   Lum, Chris ^a   Babu, Suresh ^a   Blaskovich, Mark A ^a   Nakanishi, Hiroshi ^a,b   Ruan, Fuqiang ^a   Cao, Bolong ^a   Minarik, Ryan ^a   Little, Tom ^a   Nelson, Sherry ^a   Nguyen, Minh ^a   Gall, Anna ^a   Kahn, Michael ^a,b  

^a Molecumetics Ltd   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL REACTION; CRYSTAL STRUCTURE; HYDROGEN BOND; PROTEIN SECONDARY STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BICYCLO COMPOUNDS, HETEROCYCLIC; CHYMASES; INDICATORS AND REAGENTS; KALLIKREINS; KINETICS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN INHIBITORS; TRYPTASES;

BETULACEAE;

EID: 0032497355     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00420-X     Document Type: Article

References (24)

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24. 18. All of the inhibitors listed in Table 2 have >5-fold selectivity for the enzyme listed over the others except for the kallikrein inhibitors which were slightly more potent for inhibition of trypsin.