Precise alignment of sites required for μ enhancer activation in B cells

Molecular and Cellular Biology

Volumn 16, Issue 8, 1996, Pages 4544-4554

  Nikolajczyk, Barbara S ^a   Nelsen, Barbara ^a   Sen, Ranjan ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURVED DNA; IMMUNOGLOBULIN MU CHAIN; NUCLEAR FACTOR;

ARTICLE; B LYMPHOCYTE; CONFORMATIONAL TRANSITION; DNA BINDING; DNA HELIX; ENHANCER REGION; GENE REARRANGEMENT; INTRON; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0029897559     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.16.8.4544     Document Type: Article

References (64)

1. H rearrangement by promoter-enhancer approximation. Mol. Cell. Biol. 11:2096-2107.
2. Bain, G., E. C. R. Maandag, D. J. Izon, D. Amsen, A. M. Kruisbeek, B. C. Weintraub, I. Krop, M. S. Schlissel, A. J. Feeney, M. van Roon, M. van der Valk, H. P. J. ter Riele, A. Berns, and C. Murre. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79:885-892.
3. Beckmann, H., L.-K. Su, and T. Kadesch. 1990. TFE3: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif. Genes Dev. 4:167-179.
4. Blackwell, T. K., J. Huang, A. Ma, L. Kretzner, F. W. Alt, R. N. Eisenman, and H. Weintraub. 1993. Binding of Myc proteins to canonical and noncanonical DNA sequences. Mol. Cell. Biol. 13:5216-5224.
5. Blackwell, T. K., M. W. Moore, G. D. Yancopoulos, H. Suh, S. Lutzker, E. Selsing, and F. W. Alt. 1986. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (London) 324:585-589.
6. Bruggemann, M., J. Free, A. Diamond, J. Howard, S. Cobbold, and H. Waldmann. 1986. Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes. Proc. Natl. Acad. Sci. USA 83:6075-6079.
7. Carr, C. S., and P. A. Sharp. 1990. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell. Biol. 10:4384-4388.
8. H locus. EMBO J. 12:4635-4645.
9. Ephrussi, A., G. M. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134-140.
10. Erman, B. Personal communication.
11. Fernex, C., M. Capone, and P. Ferner. 1995. The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15:3217-3226.
12. Fisher, D. E., L. A. Parent, and P. A. Sharp. 1992. Myc/max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove. Proc. Natl. Acad. Sci. USA 89:11779-11783.
13. Genetta, T., D. Ruezinsky, and T. Kadesch. 1994. Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 14:6153-6163.
14. Giese, K., J. Cox, and R. Grosschedl. 1992. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 69:185-195.
15. Giese, K., C. Kingsley, J. R. Kirshner, and R. Grosschedl. 1995. Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9:995-1008.
16. Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol. 6:4305-4316.
17. Gregor, P. D., M. Sawadogo, and R. G. Roeder. 1990. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 4:1730-1740.
18. Grosschedl, R., and D. Baltimore. 1985. Cell type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41:885-897.
19. Hagman, J., and R. Grosschedl. 1992. An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc. Natl. Acad. Sci. USA 89: 8889-8893.
20. Hanson, R. D., J. L. Grisolano, and T. J. Ley. 1993. Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/ CGL-1) gene synergize to activate transcription. Blood 82:2749-2757.
21. Hayday, A. C., S. D. Gillies, H. Saito, C. Wood, K. Wiman, W. S. Hayward, and S. Tonegawa. 1984. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature (London) 307: 334-340.
22. Hernandez-Munain, C., and M. S. Krangel. 1994. Regulation of the T-cell receptor and enhancer by functional cooperation between c-Myb and core-binding factors. Mol. Cell. Biol. 14:473-483.
23. Ho, I.-C., and J. M. Leiden. 1990. Regulation of the human T-cell receptor a gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements. Mol. Cell. Biol. 19: 4720-4727.
24. Jenuwein, T., W. C. Forrester, R.-G. Qiu, and R. Grosschedl. 1993. The immunoglobulin μ enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev. 7:2016-2032.
25. Kadesch, T., P. Zervos, and D. Ruezinsky. 1986. Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res. 14:8209-8221.
26. Karim, F. D., L. D. Urness, C. S. Thummel, M. J. Klemsz, S. R. McKercher, A. Celada, C. VanBeveren, R. A. Maki, C. V. Gunther, J. A. Nye, and B. J. Graves. 1990. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev. 4:1451-1453.
27. Kerppola, T. K., and T. Curran. 1991. DNA bending by fos and jun: the flexible hinge model. Science 254:1210-1214.
28. Kerppola, T. K., and T. Curran. 1991. Fos-jun heterodimers and jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 66:317-326.
29. Kerppola, T. K., and T. Curran. 1993. Selective DNA bending by a variety of bZIP proteins. Mol. Cell. Biol. 13:5479-5489.
30. Kim, J., C. Zwieb, C. Wu, and S. Adhya. 1989. Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector. Gene 85:15-23.
31. Lee, D.-H., and R. F. Schleif. 1989. In vivo DNA loops in araCBAD: size limits and helical repeat. Proc. Natl. Acad. Sci. USA 86:476-480.
32. Lennon, G. G., and R. P. Perry. 1985. Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon. Nature (London) 318:475-478.
33. Libermann, T. W., and D. Baltimore. 1990. Transcriptional regulation of immunoglobulin gene expression. Mol. Aspects Cell. Regul. 6:399-421.
34. Lim, F., N. Kraut, J. Frampton, and T. Graf. 1992. DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism. EMBO J. 11:643-652.
35. Lu, X. P., N. L. Eberhardt, and M. Pfahl. 1993. DNA bending by retinoid X receptor-containing retinoid and thyroid hormone receptor complexes. Mol. Cell. Biol. 13:6509-6519.
36. Mage, R. G., B. A. Newman, N. Harindranath, K. E. Bernstein, R. S. Becker, and K. L. Knight. 1989. Evolutionary conservation of splice sites in sterile Cμ transcripts and of immunoglobulin heavy chain (IgH) enhancer region sequences. Mol. Immunol. 26:1007-1010.
37. McBroom, L. D., G. Flock, and V. Giguère. 1995. The nonconserved hinge region and distinct amino-terminal domains of the RORa orphan nuclear receptor isoforms are required for proper DNA bending and RORα-DNA interactions. Mol. Cell. Biol. 15:796-808.
38. Murre, C., P. S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777-783.
39. Natesan, S., and M. Z. Gilman. 1993. DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev. 7:2497-2509.
40. Nelsen, B., L. Hellman, and R. Sen. 1988. The NF-κB-hinding site mediates phorbol ester-inducible transcription in non-lymphoid cells. Mol. Cell. Biol. 8:3526-3531.
41. Nelsen, B., T. Kadesch, and R. Sen. 1990. Complex regulation of the immunoglobulin μ heavy-chain gene enhancer: μB, a new determinant of enhancer function. Mol. Cell. Biol. 10:3145-3154.
42. Nelsen, B., and R. Sen. 1992. Regulation of immunoglobulin gene transcription. Int. Rev. Cytol. 133:121-149.
43. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid-specific immunoglobulin μ heavy chain gene enhancer by ETS-domain proteins. Science 261:82-86.
44. Nye, J. A., J. Petersen, C. V. Gunther, M. D. Jonsen, and B. J. Graves. 1992. Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev. 6:975-990.
45. Oltz, E. M., F. W. Alt, W.-C. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. 1993. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol. Cell. Biol. 13:6223-6239.
46. Perkins, N. D., N. L. Edwards, C. S. Duckett, A. B. Agranoff, R. M. Schmid, and G. J. Nabel. 1993. A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12:3551-3558.
47. Rao, E., W. Dang, G. Tian, and R. Sen. A three protein DNA complex defines a functional unit of the lymphoid-specific immunoglobulin μ heavy chain gene enhancer. Submitted for publication.
48. Rivera, R. R., M. H. Stuiver, R. Steenbergen, and C. Murre. 1993. Ets proteins: new factors that regulate immunoglobuin heavy-chain gene expression. Mol. Cell. Biol. 13:7163-7169.
49. Roman, C., L. Cohn, and K. Calame. 1991. A dominant negative form of transcription activator mTFE3 created by differential splicing. Science 254: 94-97.
50. Roman, C., A. G. Matera, C. Cooper, S. Artandi, S. Blain, D. C. Ward, and K. Calame. 1992. mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol. Cell. Biol. 12:817-827.
51. Ruezinsky, D., H. Beckmann, and T. Kadesch. 1991. Modulation of the IgH enhancer's cell type specificity through a genetic switch. Genes Dev. 5:29-37.
52. Schanke, J. T., and B. G. VanNess. 1994. The organization of the transcription factor binding sites in the κ Ig intron enhancer. J. Immunol. 153:4565-4572.
53. Serwe, M., and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321-2327.
54. Shen, L., S. Lieberman, and L. A. Eckhardt. 1993. The octamer/μE4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma X T-lymphoma hybrids. Mol. Cell. Biol. 13:3530-3540.
55. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
56. Sun, S.-H. 1994. Constitutive expression of the IdI gene impairs mouse B cell development. Cell 79:893-900.
57. Takahashi, K., M. Vigneron, H. Mattes, A. Wildeman, M. Zenke, and P. Chambon. 1986. Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (London) 319:121-126.
58. Thompson, J. F., and A. Landy. 1988. Empirical estimation of protein-induced DNA bending angles: applications to X site-specific recombination complexes. Nucleic Acids Res. 16:9687-9705.
59. Vilen, B. J., J. P. Cogswell, and J. P. Ting. 1991. Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol. Cell. Biol. 11:2406-2415.
60. Wasylyk, C., J.-P. Kerckaert, and B. Wasylyk. 1992. A novel modulator domain of Ets transcription factors. Genes Dev. 6:965-974.
61. Werner, M. H., G. M. Clore, C. L. Fisher, R. J. Fisher, L. Trinh, J. Shiloach, and A. M. Gronenborn. 1995. The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation. Cell 83:761-771.
62. Wooton, D., J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1994. Cooperative binding of Ets-1 and core binding factor to DNA. Mol. Cell. Biol. 14:840-850.
63. Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875-884.
64. Zinkel, S. S., and D. M. Crothers. 1991. Catabolite activator protein-induced DNA bending in transcription initiation. J. Mol. Biol. 219:201-215.