메뉴 건너뛰기




Volumn 16, Issue 1, 2004, Pages 19-27

The role of Bcl-2 family members in non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

A 385358; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; DACARBAZINE; DOCETAXEL; FOMIVIRSEN; HA 141; MITOXANTRONE; OBLIMERSEN; PACLITAXEL; PHOSPHOROTHIOIC ACID; PROTEIN BCL 2; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 2642555698     PISSN: 10430679     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semtcvs.2004.01.002     Document Type: Review
Times cited : (22)

References (66)
  • 1
    • 0031726887 scopus 로고    scopus 로고
    • Apoptosis: Who was first
    • Degli EM: Apoptosis: Who was first. Cell Death Diff 5:719, 1998
    • (1998) Cell Death Diff. , vol.5 , pp. 719
    • Degli, E.M.1
  • 2
    • 0015383455 scopus 로고
    • Apoptosis: A Basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currei AR: Apoptosis: a Basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currei, A.R.3
  • 3
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenberry D, Nunex G, Milliman C, et al: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenberry, D.1    Nunex, G.2    Milliman, C.3
  • 4
    • 9044225527 scopus 로고    scopus 로고
    • BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer resistance to Therapy
    • Reed JC, Miyashita T, Takayama S, et al: BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer resistance to Therapy. J Cell Biochem 60:23-32, 1996
    • (1996) J. Cell Biochem. , vol.60 , pp. 23-32
    • Reed, J.C.1    Miyashita, T.2    Takayama, S.3
  • 5
    • 0037050735 scopus 로고    scopus 로고
    • Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines
    • Sartorius UA, Krammer PH: Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer 97:584-592, 2002
    • (2002) Int. J. Cancer , vol.97 , pp. 584-592
    • Sartorius, U.A.1    Krammer, P.H.2
  • 6
    • 0031032294 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-xl antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
    • Decaudin D, Geley S, Hirsch T, et al: Bcl-2 and Bcl-xl antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57:62-67, 1997
    • (1997) Cancer Res. , vol.57 , pp. 62-67
    • Decaudin, D.1    Geley, S.2    Hirsch, T.3
  • 7
    • 0032575688 scopus 로고    scopus 로고
    • The bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S: The bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326, 1998
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 9
    • 0028857747 scopus 로고
    • Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas
    • Jiang SX, Sato Y, Kuwao S, et al: Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas J Pathol 177:135-138, 1995
    • (1995) J. Pathol. , vol.177 , pp. 135-138
    • Jiang, S.X.1    Sato, Y.2    Kuwao, S.3
  • 10
    • 0029940427 scopus 로고    scopus 로고
    • Bcl-2 and p53 protein expression in non-small cell lung cancers: Correlation with survival time
    • Ohsaki Y, Toyoshima E, Fujiuchi S, et al: Bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time. Clin Cancer Res 2:915-920, 1996
    • (1996) Clin. Cancer Res. , vol.2 , pp. 915-920
    • Ohsaki, Y.1    Toyoshima, E.2    Fujiuchi, S.3
  • 11
    • 0027186201 scopus 로고
    • bcl-2 protein in non-small cell lung carcinoma
    • Pezzella F, Turley H, Kuzu I, et al: bcl-2 protein in non-small cell lung carcinoma. N Engl J Med 329:690-694, 1993
    • (1993) N. Engl. J. Med. , vol.329 , pp. 690-694
    • Pezzella, F.1    Turley, H.2    Kuzu, I.3
  • 12
    • 0031049786 scopus 로고    scopus 로고
    • Bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis
    • Higashiyama M, Doi O, Kodama K, et al: Bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis. J Surg Oncol 64:48-54, 1997
    • (1997) J. Surg. Oncol. , vol.64 , pp. 48-54
    • Higashiyama, M.1    Doi, O.2    Kodama, K.3
  • 13
    • 0035157618 scopus 로고    scopus 로고
    • Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer
    • Cox G, Jones JL, Andi A, et al: Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer. Lung Cancer 34:417-426, 2001
    • (2001) Lung Cancer , vol.34 , pp. 417-426
    • Cox, G.1    Jones, J.L.2    Andi, A.3
  • 14
    • 0034100054 scopus 로고    scopus 로고
    • Predictive survival markers in patients with surgically resected non-small cell lung carcinoma
    • Moldvay J, Scheid P, Wild P, et al: Predictive survival markers in patients with surgically resected non-small cell lung carcinoma. Clin Cancer Res 6:1125-1134, 2000
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1125-1134
    • Moldvay, J.1    Scheid, P.2    Wild, P.3
  • 15
    • 0033031921 scopus 로고    scopus 로고
    • Expression of apoptosis regulatory proteins of the bcl-2 family and p53 in primary resected non-small-cell lung cancer
    • Borner MM, Brousset P, Pfanner-Meyer B, et al: Expression of apoptosis regulatory proteins of the bcl-2 family and p53 in primary resected non-small-cell lung cancer. Br J Cancer 79:952-958, 1999
    • (1999) Br. J. Cancer , vol.79 , pp. 952-958
    • Borner, M.M.1    Brousset, P.2    Pfanner-Meyer, B.3
  • 16
    • 0037790894 scopus 로고    scopus 로고
    • Risk of recurrence in patients with surgically resected stage I non-small cell lung carcinoma
    • Poleri C, Morero JL, Nieva B, et al: Risk of recurrence in patients with surgically resected stage I non-small cell lung carcinoma. Chest 123:1858-1867, 2003
    • (2003) Chest , vol.123 , pp. 1858-1867
    • Poleri, C.1    Morero, J.L.2    Nieva, B.3
  • 17
    • 17444442088 scopus 로고    scopus 로고
    • Immunocytochemical markers in stage I lung cancer: Relevance to prognosis
    • Pastorino U, Andreola S, Tagliabue E, et al: Immunocytochemical markers in stage I lung cancer: Relevance to prognosis J Clin Oncol 15:2858-2865, 1997
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2858-2865
    • Pastorino, U.1    Andreola, S.2    Tagliabue, E.3
  • 18
    • 0038340641 scopus 로고    scopus 로고
    • Expression of bcl-2 protein is associated with shorter survival in non-small cell lung carcinoma
    • Huang C, Neuberg D, Johnson BE, et al: Expression of bcl-2 protein is associated with shorter survival in non-small cell lung carcinoma. Cancer 98:135-143, 2003
    • (2003) Cancer , vol.98 , pp. 135-143
    • Huang, C.1    Neuberg, D.2    Johnson, B.E.3
  • 19
    • 0141885988 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2 expression in resected pN2 non-small cell lung cancer
    • Tomita M, Matsuzaki Y, Edagawa M, et al: Prognostic significance of bcl-2 expression in resected pN2 non-small cell lung cancer. Eur J Surg Oncol 29:654-657, 2003
    • (2003) Eur. J. Surg. Oncol. , vol.29 , pp. 654-657
    • Tomita, M.1    Matsuzaki, Y.2    Edagawa, M.3
  • 20
    • 0037449786 scopus 로고    scopus 로고
    • A functional role for nicotine in bcl2 phosphorylation and suppression of apoptosis
    • Mai H, May WS, Gao F, et al: A functional role for nicotine in bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 278:1886-1891, 2003
    • (2003) J. Biol. Chem. , vol.278 , pp. 1886-1891
    • Mai, H.1    May, W.S.2    Gao, F.3
  • 21
    • 0041343301 scopus 로고    scopus 로고
    • Role of Bcl-2 as a prognostic factor for survival in lung cancer: A systematic review of the literature with meta-analysis
    • Martin B, Pacsmans M, Berghmans T, et al: Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 89:55-64, 2003
    • (2003) Br. J. Cancer , vol.89 , pp. 55-64
    • Martin, B.1    Pacsmans, M.2    Berghmans, T.3
  • 22
    • 0037312094 scopus 로고    scopus 로고
    • Bcl-2 and bax expression in advanced non-small cell lung cancer: Lack of correlation with chemotherapy response or survival in patients treated with docetaxel plus vinorelbine
    • Krug LM, Miller VA, Filippa DA, et al: Bcl-2 and bax expression in advanced non-small cell lung cancer: Lack of correlation with chemotherapy response or survival in patients treated with docetaxel plus vinorelbine. Lung Cancer 39:139-143, 2003
    • (2003) Lung Cancer , vol.39 , pp. 139-143
    • Krug, L.M.1    Miller, V.A.2    Filippa, D.A.3
  • 23
    • 0038676365 scopus 로고    scopus 로고
    • Measurement of chemoresistance markers in patients with stage III non-small cell lung cancer: A novel approach for patient selection
    • Brooks KR, To K, Joshi MB, et al: Measurement of chemoresistance markers in patients with stage III non-small cell lung cancer: a novel approach for patient selection. Ann Thorac Surg 76:187-193, 2003
    • (2003) Ann. Thorac. Surg. , vol.76 , pp. 187-193
    • Brooks, K.R.1    To, K.2    Joshi, M.B.3
  • 24
    • 0031471135 scopus 로고    scopus 로고
    • Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer
    • Koukourakis MI, Giatromanolaki A, O'Byrne KJ, et al: Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer. Int J Cancer 74: 565-570, 1997
    • (1997) Int. J. Cancer , vol.74 , pp. 565-570
    • Koukourakis, M.I.1    Giatromanolaki, A.2    O'Byrne, K.J.3
  • 25
    • 0033534594 scopus 로고    scopus 로고
    • Interleukin-3 induces the phsophorylation of a distinct fraction of bcl-2
    • Poommipanit PB, Chen B, Oltvai ZN: Interleukin-3 induces the phsophorylation of a distinct fraction of bcl-2. J Biol Chem 274:1033-1039, 1999
    • (1999) J. Biol. Chem. , vol.274 , pp. 1033-1039
    • Poommipanit, P.B.1    Chen, B.2    Oltvai, Z.N.3
  • 26
    • 0029943186 scopus 로고    scopus 로고
    • Expression of apoptosis-regulatory genes in lung tumor cell lines: Relationship to p53 expression and relevance to acquired drug resistance
    • Reeve JG, Xiong J, Morgan J, et al: Expression of apoptosis-regulatory genes in lung tumor cell lines: relationship to p53 expression and relevance to acquired drug resistance. Br J Cancer 73:1193-200, 1996
    • (1996) Br. J. Cancer , vol.73 , pp. 1193-1200
    • Reeve, J.G.1    Xiong, J.2    Morgan, J.3
  • 27
    • 0032758427 scopus 로고    scopus 로고
    • Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-x and bax in malignant mesothelioma
    • Soini Y, Kinnula V, Wiik-Kaarteenaho R, et al: Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-x and bax in malignant mesothelioma. Clin Can Res 5:3508-3515, 1999
    • (1999) Clin. Can Res. , vol.5 , pp. 3508-3515
    • Soini, Y.1    Kinnula, V.2    Wiik-Kaarteenaho, R.3
  • 28
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in bcl-xl deficient mice
    • Motoyama N, Wang F, Roth KA, et al: Massive cell death of immature hematopoietic cells and neurons in bcl-xl deficient mice. Science 267:1506-1510, 1995
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3
  • 29
    • 0027427492 scopus 로고
    • Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • Veis DJ, Sorenson CM, Shutter JR, et al: Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240, 1993
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3
  • 30
    • 0032923254 scopus 로고    scopus 로고
    • Frequent high expression of bax pro-apoptotic protein in non-small cell lung cancer
    • Caputi M, Groeger AM, Esposito V, et al: Frequent high expression of bax pro-apoptotic protein in non-small cell lung cancer. Anticancer Res 19:825-827, 1999
    • (1999) Anticancer Res. , vol.19 , pp. 825-827
    • Caputi, M.1    Groeger, A.M.2    Esposito, V.3
  • 31
    • 0030940210 scopus 로고    scopus 로고
    • Prognostic value of the expression of p53, bcl-2 and bax oncoproteins, and neovascularization in patients with radically resected non-small cell lung cancer
    • Apolinario RM, Van der valk P, De Jong JS, et al: Prognostic value of the expression of p53, bcl-2 and bax oncoproteins, and neovascularization in patients with radically resected non-small cell lung cancer. J Clin Oncol 15:2456-2466, 1997
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2456-2466
    • Apolinario, R.M.1    Van der valk, P.2    De Jong, J.S.3
  • 32
    • 0036007249 scopus 로고    scopus 로고
    • Bax and p16INK4A are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer
    • Gessner C, Lieber U, Kuhn H, et al: Bax and p16INK4A are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer. Eur Respir J 19:134-140, 2002
    • (2002) Eur. Respir. J. , vol.19 , pp. 134-140
    • Gessner, C.1    Lieber, U.2    Kuhn, H.3
  • 33
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucledotide
    • Zamecnik PC, Stephenson ML: Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucledotide. Proc Natl Acad Sci USA 75: 280-284, 1978
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 34
    • 0033046750 scopus 로고    scopus 로고
    • Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines
    • Koty PP, Zhang H, Levitt M: Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines. Lung Cancer 23:115-127, 1999
    • (1999) Lung Cancer , vol.23 , pp. 115-127
    • Koty, P.P.1    Zhang, H.2    Levitt, M.3
  • 35
    • 4243735676 scopus 로고    scopus 로고
    • Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells
    • Koty PP, Tyurina YY, Tyurin VA, et al: Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells. Mol Cell Biochem 234(-235):125-133, 2002
    • (2002) Mol. Cell Biochem. , vol.234 , Issue.235 , pp. 125-133
    • Koty, P.P.1    Tyurina, Y.Y.2    Tyurin, V.A.3
  • 36
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by bcl2 antisense therapy
    • Jansen B, Wacheck V, Heere-Ress E, et al: Chemosensitisation of malignant melanoma by bcl2 antisense therapy. Lancet 356:1728-1733, 2000
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1    Wacheck, V.2    Heere-Ress, E.3
  • 37
    • 0031664988 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
    • Zangemeister-Wittke U, Schenker T, Luedke GH, et al: Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines. Br J Cancer 78:1035-1042, 1998
    • (1998) Br. J. Cancer , vol.78 , pp. 1035-1042
    • Zangemeister-Wittke, U.1    Schenker, T.2    Luedke, G.H.3
  • 38
    • 0034071150 scopus 로고    scopus 로고
    • Induction of apoptosis in lung cancer cells following bcl-xl antisense treatment
    • Leech SH, Olie RA, Gautschi O, et al: Induction of apoptosis in lung cancer cells following bcl-xl antisense treatment. Int J Cancer 86:570-576, 2000
    • (2000) Int. J. Cancer , vol.86 , pp. 570-576
    • Leech, S.H.1    Olie, R.A.2    Gautschi, O.3
  • 39
    • 0036621573 scopus 로고    scopus 로고
    • Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product
    • Smythe WR, Mohuiddin I, Ozveran M, et al: Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product. J Thorac Cardiovasc Surg 123:1191-1198, 2002
    • (2002) J. Thorac. Cardiovasc. Surg. , vol.123 , pp. 1191-1198
    • Smythe, W.R.1    Mohuiddin, I.2    Ozveran, M.3
  • 40
    • 0003826861 scopus 로고    scopus 로고
    • Induction of endogenous bcl-xs through the control of bcl-x pre-mRNA splicing by antisense oligonucleotides
    • Taylor JK, Qing QZ, Wyatt JR, et al: Induction of endogenous bcl-xs through the control of bcl-x pre-mRNA splicing by antisense oligonucleotides. Nature Bio 17:1097-1100, 1999
    • (1999) Nature Bio. , vol.17 , pp. 1097-1100
    • Taylor, J.K.1    Qing, Q.Z.2    Wyatt, J.R.3
  • 41
    • 0034096268 scopus 로고    scopus 로고
    • A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xl expression efficiently induces apoptosis in tumor cells
    • Zangemeister-Wittke U, Leech SH, Olie RA, et al: A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xl expression efficiently induces apoptosis in tumor cells. Clin Can Res 6:2547-2555, 2000
    • (2000) Clin. Can. Res. , vol.6 , pp. 2547-2555
    • Zangemeister-Wittke, U.1    Leech, S.H.2    Olie, R.A.3
  • 42
    • 0035925537 scopus 로고    scopus 로고
    • Activity of a novel bcl-2/bcl-xl-bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • Gautschi O, Tschopp S, Olie R, et al: Activity of a novel bcl-2/bcl-xl-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J Natl Can Inst 93: 463-471, 2001
    • (2001) J. Natl. Can. Inst. , vol.93 , pp. 463-471
    • Gautschi, O.1    Tschopp, S.2    Olie, R.3
  • 43
    • 85030885662 scopus 로고    scopus 로고
    • A bcl-xl antisense adenoviral vector: A novel and effective pro-apoptolic gene therapy construct
    • Boston, MA, June
    • Cao X, Gu J, Miller SD, et al: A bcl-xl antisense adenoviral vector: a novel and effective pro-apoptolic gene therapy construct. 5th Annual Meeting of the American Society of Gene Therapy, Boston, MA, June, 2002
    • (2002) 5th Annual Meeting of the American Society of Gene Therapy
    • Cao, X.1    Gu, J.2    Miller, S.D.3
  • 44
    • 0034163805 scopus 로고    scopus 로고
    • Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53 resistance cancer lines
    • Kagawa S, Gu J, Swisher S, et al: Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53 resistance cancer lines. Cancer Res 60:1157-1161, 2000
    • (2000) Cancer Res. , vol.60 , pp. 1157-1161
    • Kagawa, S.1    Gu, J.2    Swisher, S.3
  • 45
    • 0035568892 scopus 로고    scopus 로고
    • A model of Bax gene delivery to human lung cancer
    • Groeger AM, Esposito V, Cassandro R, et al: A model of Bax gene delivery to human lung cancer. Anticancer Res 21:3627-30, 2001
    • (2001) Anticancer Res. , vol.21 , pp. 3627-3630
    • Groeger, A.M.1    Esposito, V.2    Cassandro, R.3
  • 46
    • 0036664443 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of Bax driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells
    • Kaliberov SA, Buchsbaum DJ, Gillespie GY, et al: Adenovirus-mediated transfer of Bax driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells. Mol Ther 6:190-198, 2002
    • (2002) Mol. Ther. , vol.6 , pp. 190-198
    • Kaliberov, S.A.1    Buchsbaum, D.J.2    Gillespie, G.Y.3
  • 48
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619, 1993
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 49
    • 0037199456 scopus 로고    scopus 로고
    • Peptides derived from BH3 domains of Bcl-2 family members: A comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death
    • Shangary S, Johnson DE: Peptides derived from BH3 domains of Bcl-2 family members: A comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death. Biochemistry 4:9485-9495, 2002
    • (2002) Biochemistry , vol.4 , pp. 9485-9495
    • Shangary, S.1    Johnson, D.E.2
  • 50
    • 0035150803 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of interaction between the BH3 domain and bcl-xl
    • Degterev A, Lugovskoy A, Cardone M, et al: Identification of small-molecule inhibitors of interaction between the BH3 domain and bcl-xl. Nat Cell Biol 3:173-182, 2001
    • (2001) Nat. Cell Biol. , vol.3 , pp. 173-182
    • Degterev, A.1    Lugovskoy, A.2    Cardone, M.3
  • 51
    • 0038217076 scopus 로고    scopus 로고
    • BH3-domain mimetic compound BH3I-2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria
    • Feng W, Liu F, Patwari Y, et al: BH3-domain mimetic compound BH3I-2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria. Brit J Hem 121:332-340, 2003
    • (2003) Brit. J. Hem. , vol.121 , pp. 332-340
    • Feng, W.1    Liu, F.2    Patwari, Y.3
  • 52
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that hinds Bcl-2 protein and induces apoptosis of tumor cells
    • Wang J, Liu D, Zhang Z, et al: Structure-based discovery of an organic compound that hinds Bcl-2 protein and induces apoptosis of tumor cells. Proc Nat Acad Sci 97: 7124-7129, 2000
    • (2000) Proc. Nat. Acad. Sci. , vol.97 , pp. 7124-7129
    • Wang, J.1    Liu, D.2    Zhang, Z.3
  • 53
    • 2642566181 scopus 로고    scopus 로고
    • Anti-tumor activity of A-385358: A small molecule inhibitor of Bcl-xl
    • abstr
    • Shoemaker A, Oleksijew A, Qing W, et al: Anti-tumor activity of A-385358: A small molecule inhibitor of Bcl-xl. Proc Am Assoc Can Res 44:1317abstr, 2003
    • (2003) Proc. Am. Assoc. Can. Res. , vol.44 , pp. 1317
    • Shoemaker, A.1    Oleksijew, A.2    Qing, W.3
  • 55
    • 0036918738 scopus 로고    scopus 로고
    • Clinical trials of gene therapy for atherosclerotic cardiovascular disease
    • Freedman SB: Clinical trials of gene therapy for atherosclerotic cardiovascular disease. Curr Opin Lipidol 13: 653-661, 2002
    • (2002) Curr. Opin. Lipidol. , vol.13 , pp. 653-661
    • Freedman, S.B.1
  • 56
    • 0036202847 scopus 로고    scopus 로고
    • Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS
    • Vitravene Study Group
    • Vitravene Study Group. Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS. Am J Opthalmol 133:484-498, 2002
    • (2002) Am. J. Opthalmol. , vol.133 , pp. 484-498
  • 57
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non Hodgkin's lymphoma
    • Waters J, Webb A, Cunningham D, et al: Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non Hodgkin's lymphoma. J Clin Oncol 18:1812-1823, 2000
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1812-1823
    • Waters, J.1    Webb, A.2    Cunningham, D.3
  • 58
    • 0036303535 scopus 로고    scopus 로고
    • Phase I trial of Bcl-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer
    • Morris MJ, Tong WP, Cardo-Cordon C, et al: Phase I trial of Bcl-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer. Clin Cancer Res 8:679-683, 2002
    • (2002) Clin. Cancer Res. , vol.8 , pp. 679-683
    • Morris, M.J.1    Tong, W.P.2    Cardo-Cordon, C.3
  • 59
    • 0031907428 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
    • Jansen B, Schlagbauer-Wadl H, Brown BD, et al: Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med 4:232-234, 1998
    • (1998) Nat. Med. , vol.4 , pp. 232-234
    • Jansen, B.1    Schlagbauer-Wadl, H.2    Brown, B.D.3
  • 60
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by BCL-2 antisense therapy
    • Jansen B, Wacheck V, Heere-Ress E, et al: Chemosensitisation of malignant melanoma by BCL-2 antisense therapy. Lancet 356:1728-33, 2000
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1    Wacheck, V.2    Heere-Ress, E.3
  • 61
    • 0036236808 scopus 로고    scopus 로고
    • A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer
    • Rudin CM, Otterson GA, Mauer AM, et al: A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer. Ann Oncol 13:539-545, 2002
    • (2002) Ann. Oncol. , vol.13 , pp. 539-545
    • Rudin, C.M.1    Otterson, G.A.2    Mauer, A.M.3
  • 62
    • 0035678781 scopus 로고    scopus 로고
    • A Phase I dose finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
    • Chi KN, Gleave ME, Klasa R, et al: A Phase I dose finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin Cancer Res 7:3920-3927, 2001
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3920-3927
    • Chi, K.N.1    Gleave, M.E.2    Klasa, R.3
  • 63
    • 0000645010 scopus 로고    scopus 로고
    • A phase I study of BCL-2 antisense G3139 (GENTA) and weekly docetaxel in patients with advanced breast cancer and other solid tumors
    • (abstr)
    • Chen H, Marshall J, Trocky N, et al: A phase I study of BCL-2 antisense G3139 (GENTA) and weekly docetaxel in patients with advanced breast cancer and other solid tumors. Proc Am Soc Clin Oncol 692, 2000 (abstr)
    • (2000) Proc. Am. Soc. Clin. Oncol. , pp. 692
    • Chen, H.1    Marshall, J.2    Trocky, N.3
  • 64
    • 0029899181 scopus 로고    scopus 로고
    • Molecular thanatopsis: A disclosure on the bcl-2 family and cell death
    • Yang E, Korsemeyer SJ: Molecular thanatopsis: a disclosure on the bcl-2 family and cell death. Blood 88:386-401, 1996
    • (1996) Blood , vol.88 , pp. 386-401
    • Yang, E.1    Korsemeyer, S.J.2
  • 65
    • 12244298187 scopus 로고    scopus 로고
    • Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy
    • Swisher SG, Roth JA, Komaki R, et al: Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res 9:93-101, 2003
    • (2003) Clin. Cancer Res. , vol.9 , pp. 93-101
    • Swisher, S.G.1    Roth, J.A.2    Komaki, R.3
  • 66
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, et al: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498, 2001
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.