Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma

Clinical Cancer Research

Volumn 5, Issue 11, 1999, Pages 3508-3515

  Soini, Ylermi ^a,b   Kinnula, Vuokko ^a,b   Kaarteenaho Wiik, Riitta ^a,b   Kurttila, Esko ^a,b   Linnainmaa, Kaija ^a,b   Pääkkö, Paavo ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN MCL 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MESOTHELIOMA; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MESOTHELIOMA; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PLEURAL NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR CELLS, CULTURED;

EID: 0032758427     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Walz, R., and Koch, H. K. Malignant pleural mesothelioma: some aspects of epidemiology, differential diagnosis, and prognosis. Histological and immunohistochemical evaluation and follow-up of mesotheliomas diagnosed from 1964 to January 1985. Pathol. Res. Pract., 186: 124-134, 1990.
2. Mossman, B. T., Kamp, D. W., and Weitzman, S. A. Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. Cancer Investig., 14: 466-480, 1996.
3. Broaddus, V. C., Yang, I., Scavo, L. M., Ernst, J. D., and Boylan, A. M. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J. Clin. Investig., 98: 2050-2059, 1996.
4. Broaddus, V. C., Yang, I., Scavo, L. M., Ernst, J. D., and Boylan, A. M. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environ. Health Perspect., 105: 1147-1152, 1997.
5. Adams, J. M., and Cory, S. The Bcl-2 protein family: arbiters of cell survival. Science (Washington DC), 281: 1322-1326, 1998.
6. Thornberry, N. A., and Lazebnik, Y. Caspases. Enemies within. Science (Washington DC), 281: 1312-1316, 1998.
7. Yang, E., and Korsmeyer, S. J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
8. Green, D. R., and Reed, J. C. Mitochondria and apoptosis. Science (Washington DC), 281: 1309-1312, 1998.
9. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T-I., Jones, D. P., and Wang, X. Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science (Washington DC), 275: 1129-1132, 1997.
10. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.
11. L. FEBS Lett., 415: 29-32, 1997.
12. Mustonen, M., Raunio, H., Pääkkö, P., and Soini Y. The extent of apoptosis is inversely associated with bcl-2 expression in premalignant and malignant breast lesions. Histopathology, 31: 347-354, 1997.
13. Saegusa, M., Kamata, Y., Isono, M., and Okayasu, I. Bcl-2 expression is correlated with a low apoptotic index and associated with progesterone receptor immunoreactivity in endometrial carcinomas. J. Pathol., 180: 275-282, 1996.
14. Törmänen, U., Eerola, A-K., Rainio, P., Vähäkangas, K., Soini, Y., Sormunen, R., Bloigu, R., Lehto, V-P., and Pääkkö, P. Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res., 55: 5595-5602. 1995.
15. Krajewska, M., Krajewski, S., Epstein, J. I., Shabaik, A., Sauvageot, J., Song, K., Kitada, S., and Reed, J. C. Immunohistochemical analysis of bcl-2, bax, bcl-X and mcl-1 expression in prostate cancers. Am. J. Pathol., 148: 1567-1576, 1996.
16. Virkajärvi, N., Pääkkö, P., and Soini, Y. Apoptotic index and apoptosis influencing proteins bcl-2, mcl-1, bax and caspases 3, 6 and 8 in pancreatic carcinoma. Histopathology, 33: 432-439, 1998.
17. Krajewski, S., Bodrug, S., Krajewska, M., Shabaik, A., Gascoyne, R., Berean, K., and Reed, J. C. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am. J. Pathol., 146: 1309-1319, 1995.
18. Krajewska, M., Fenoglio-Preiser, C. M., Krajewski, S., Song, K., MacDonald, J. S., Stemmerman, J. S., and Reed, J. C. Immunohistochemical analysis of bcl-2 family proteins in adenocarcinomas of the stomach. Am. J. Pathol., 149: 1449-1457, 1996.
19. Soini, Y., Raunio, H., and Pääkkö, P. High grade malignant non-Hodgkin's lymphomas differ from low grade lymphomas in the extent of apoptosis and their expression of bcl-2, mcl-1, bax and p53. Tumor Biol., 19: 176-185, 1998.
20. Soini, Y., Törmänen, U., and Pääkkö, P. Apoptosis is inversely related to bcl-2 but not to bax expression in salivary gland tumours. Histopathology, 32: 28-34, 1998.
21. Chilosi, M., Facchetti, F., Dei Tos, A. P., Lestani, M., Morassi, M. L., Martignoni, G., Sorio, C., Benedetti, A., Morelli, L., Doglioni, C., Barberis, M., Menestrina, F., and Viale, G. Bcl-2 expression in pleural and extrapleural solitary fibrous tumours. J. Pathol., 181: 362-367, 1997.
22. Segers, K., Ramael, M., Singh, S. K., Weyler, J., Van Meerbeeck, J., Vermeire, P., and Van Marck, E. Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium. Virchows Arch., 424: 631-634, 1994.
23. Narasimhan. S. R., Yang, L., Gerwin, B. I., and Broaddus, V. C. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of bcl-2 and bax. Am. J. Physiol., 275: L165-L171, 1998.
24. Krajewski, S., Blomqvist, C., Franssila, K., Krajewska, M., Wasenius, V-M., Niskanen, E., Nordling, S., and Reed, J. C. Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res., 55: 4471-4478, 1995.
25. Battifora, H., and McCaughet, W. T. E. Tumors of the serosal membranes. Atlas of Tumor Pathology, Third Series, Fascicle 15, pp. 15-88. Washington, DC: Armed Forces Institute of Pathology, 1994.
26. Dail, D. H., and Hammar, S. P. Pulmonary Pathology, Ed. 2, Vol. 18-19, pp. 597-645. New York: Springer-Verlag, 1994.
27. van der Kwast, T. H., Versnel, M. A., Delahaye, M., de Jong, A., Zondervan, P. E., and Hoogsteden, H. Expression of epithelial membrane antigen on malignant mesothelial cells. An immunohistochemical and immunoelectron microscopic study. Acta Cytol., 32: 169-174, 1988.
28. Pelin, K., Hirvonen, A., and Linnainmaa, K. Expression of cell adhesion molecules and connexins in gap junctional intercellular communication deficient human mesothelioma tumour cell lines and communication competent primary mesothelial cells. Carcinogenesis (Lond.), 15: 2673-2675, 1994.
29. Pelin-Enlund, K., Husgafvel-Pursiainen, K., Tammilehto, L., Klockars, M., Jantunen, K., Gerwin, B. I., Harris, C. C., Tuomi, T., Vanhala, E., Mattson, K., and Linnainmaa, K. Asbestos-related malignant mesothelioma: growth, cytology, tumorigenicity, and consistent chromosome findings in cell lines from five patients. Carcinogenesis (Lond.), 11: 673-681, 1990.
30. Ungar, S., van de Meeren, A., Tammilehto, L., Linnainmaa, K., Mattson, K., and Gerwin, B. I. High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines. Br. J. Cancer, 74: 1534-1540, 1994.
31. Ke, Y., Reddel, R. R., Gervin, B. I., Reddel, H. K., Somers, N. A., McMenamin, M. G., Laveck, M. A., Stahel, R. A., Lechner, J. F., and Harris, C. C. Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am. J. Pathol., 134: 979-991, 1989.
32. Soini, Y., Virkajärvi, N., Lehto, V-P., and Pääkkö, P. Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br. J. Cancer, 73: 1025-1030, 1996.
33. Eerola, A-K., Törmänen, U., Rainio, P., Sormunen, R., Bloigu, R., Vähäkangas, K., Lehto, V-P., Soini, Y., and Pääkkö, P. Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivity. J. Pathol., 181: 172-177, 1997.
34. Laemmli, V. K. Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature (Lond.), 227: 680-684, 1970.
35. Bradford, M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principal of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
36. Soini, Y., Pääkkö, P., and Lehto, V. P. Histopathological evaluation of apoptosis in cancer. A review. Am. J. Pathol., 153: 1041-1053, 1998.
37. Lipponen, P., Pietiläinen, T., Kosma, V-M., Aaltomaa, S., Eskelinen, M., and Syrjänen, K. Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. J. Pathol., 177: 49-55, 1995.
38. Bhargava, V., Kell, D. L., van de Rijn, M., and Warnke, R. A. Bcl-2 immunoreactivity in breast carcinoma correlates with hormone receptor positivity. Am. J. Pathol., 145: 535-540, 1994