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Volumn 21, Issue 3, 2003, Pages 196-204

Gene therapy of lung cancer

Author keywords

Angiogenesis; Apoptosis; bcl 2; Clinical trials; Gene therapy delivery; Gene therapy vectors; Growth factors; p53; Prodrug therapy; Thoracic malignancies; Tumor suppressor genes

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ADENOVIRUS VECTOR; ADVEXIN; BEVACIZUMAB; CISPLATIN; GANCICLOVIR; LIPOSOME; PROTEIN BCL 2; PROTEIN P53; RETROVIRUS VECTOR; SCH 58500; THYMIDINE KINASE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0141954118     PISSN: 87560437     EISSN: None     Source Type: Journal    
DOI: 10.1002/ssu.10038     Document Type: Review
Times cited : (11)

References (83)
  • 1
    • 0141962198 scopus 로고
    • DNA breakthrough points way to therapy by virus
    • 13 January
    • Lederberg J: "DNA breakthrough points way to therapy by virus. " Washington Post; 13 January 1968.
    • (1968) Washington Post
    • Lederberg, J.1
  • 2
    • 0027932380 scopus 로고
    • An early history of gene transfer and therapy
    • Lederberg J: An early history of gene transfer and therapy. Hum Gene Ther 1994;5:469-480.
    • (1994) Hum Gene Ther , vol.5 , pp. 469-480
    • Lederberg, J.1
  • 3
    • 0026081764 scopus 로고
    • Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer
    • Culver KW, Osborne WR, Miller AD, et al: Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer. Transplant Proc 1991;23:170-171.
    • (1991) Transplant Proc , vol.23 , pp. 170-171
    • Culver, K.W.1    Osborne, W.R.2    Miller, A.D.3
  • 6
    • 0028815929 scopus 로고
    • Allele specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma
    • Hung J, Kishimoto Y, Sugio K, et al: Allele specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. JAMA 1995;273:558-563.
    • (1995) JAMA , vol.273 , pp. 558-563
    • Hung, J.1    Kishimoto, Y.2    Sugio, K.3
  • 7
    • 0024462655 scopus 로고
    • Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma
    • Mori N, Yokota J, Oshimura M, et al: Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res 1989;49:5130-5135.
    • (1989) Cancer Res , vol.49 , pp. 5130-5135
    • Mori, N.1    Yokota, J.2    Oshimura, M.3
  • 8
    • 0031934761 scopus 로고    scopus 로고
    • Molecular abnormalities in lung cancer
    • Salgia R, Skarin AT: Molecular abnormalities in lung cancer. J Clin Oncol 1998;16:1207-1217.
    • (1998) J Clin Oncol , vol.16 , pp. 1207-1217
    • Salgia, R.1    Skarin, A.T.2
  • 9
    • 0025047766 scopus 로고
    • Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer
    • Lung Cancer Study Group
    • Chiba I, Takahashi T, Nau MM, et al: Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group. Oncogene 1990;5:1603-1610.
    • (1990) Oncogene , vol.5 , pp. 1603-1610
    • Chiba, I.1    Takahashi, T.2    Nau, M.M.3
  • 10
    • 0024452546 scopus 로고
    • p53: A frequent target for genetic abnormalities in lung cancer
    • Takahashi T, Nau MM, Chiba I, et al: p53: a frequent target for genetic abnormalities in lung cancer. Science 1989;246(4929): 491-494.
    • (1989) Science , vol.246 , Issue.4929 , pp. 491-494
    • Takahashi, T.1    Nau, M.M.2    Chiba, I.3
  • 11
    • 14444284332 scopus 로고    scopus 로고
    • Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells
    • Craig C, Kim M, Ohri E, et al: Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. Oncogene 1998;16:265-272.
    • (1998) Oncogene , vol.16 , pp. 265-272
    • Craig, C.1    Kim, M.2    Ohri, E.3
  • 12
    • 0032065130 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth by p21 WAF1 adenoviral gene transfer in lung cancer
    • Joshi US, Chen YQ, Kalemkerian GP, et al: Inhibition of tumor cell growth by p21 WAF1 adenoviral gene transfer in lung cancer. Cancer Gene Ther 1998;5:183-191.
    • (1998) Cancer Gene Ther , vol.5 , pp. 183-191
    • Joshi, U.S.1    Chen, Y.Q.2    Kalemkerian, G.P.3
  • 13
    • 0033623439 scopus 로고    scopus 로고
    • Over-expression of p27kip1 induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines
    • Naruse I, Hoshino H, Dobashi K, et al: Over-expression of p27kip1 induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines. Int J Cancer 2000;88:377-383.
    • (2000) Int J Cancer , vol.88 , pp. 377-383
    • Naruse, I.1    Hoshino, H.2    Dobashi, K.3
  • 14
    • 0028913013 scopus 로고
    • Inhibition of tumor cell proliferation in vitro and in vivo by exogenous p110RB, the retinoblastoma tumor suppressor protein
    • Antelman D, Machemer T, Huyghe BG, et al: Inhibition of tumor cell proliferation in vitro and in vivo by exogenous p110RB, the retinoblastoma tumor suppressor protein. Oncogene 1995;10:697-704.
    • (1995) Oncogene , vol.10 , pp. 697-704
    • Antelman, D.1    Machemer, T.2    Huyghe, B.G.3
  • 15
    • 15444345047 scopus 로고    scopus 로고
    • Absence of FHIT protein in primary lung tumors and cell lines with FHIT gene abnormalities
    • Sozzi G, Tornielli S, Tagliabue E, et al: Absence of FHIT protein in primary lung tumors and cell lines with FHIT gene abnormalities. Cancer Res 1997;57:5207-5212.
    • (1997) Cancer Res , vol.57 , pp. 5207-5212
    • Sozzi, G.1    Tornielli, S.2    Tagliabue, E.3
  • 16
    • 0033214597 scopus 로고    scopus 로고
    • Loss of FHIT is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers
    • Tseng JE, Kemp BL, Khuri FR, et al: Loss of FHIT is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers. Cancer Res 1999;59:4798-4803.
    • (1999) Cancer Res , vol.59 , pp. 4798-4803
    • Tseng, J.E.1    Kemp, B.L.2    Khuri, F.R.3
  • 17
    • 0033565920 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
    • Ji L, Fang B, Yen N, et al: Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res 1999;59:3333-3339.
    • (1999) Cancer Res , vol.59 , pp. 3333-3339
    • Ji, L.1    Fang, B.2    Yen, N.3
  • 18
    • 0035317682 scopus 로고    scopus 로고
    • Melanoma differentiation associated gene-7 (MDA-7): A novel anti-tumor gene for cancer gene therapy
    • Mhashilkar AM, Schrock RD, Hindi M, et al: Melanoma differentiation associated gene-7 (MDA-7): a novel anti-tumor gene for cancer gene therapy. Mol Med 2001;4:271-282.
    • (2001) Mol Med , vol.4 , pp. 271-282
    • Mhashilkar, A.M.1    Schrock, R.D.2    Hindi, M.3
  • 19
    • 0037019174 scopus 로고    scopus 로고
    • Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo
    • Saeki T, Mhasilkar AM, Swanson X, et al: Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002;21:4558-4566.
    • (2002) Oncogene , vol.21 , pp. 4558-4566
    • Saeki, T.1    Mhasilkar, A.M.2    Swanson, X.3
  • 20
    • 0030996171 scopus 로고    scopus 로고
    • Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study
    • Fontanini G, Lucchi M, Vignati S, et al: Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study. J Natl Cancer Inst 1997;89:881-886.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 881-886
    • Fontanini, G.1    Lucchi, M.2    Vignati, S.3
  • 21
    • 0030969559 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma
    • Fontanini G, Vignati S, Boldrini L, et al: Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 1997;3:861-865.
    • (1997) Clin Cancer Res , vol.3 , pp. 861-865
    • Fontanini, G.1    Vignati, S.2    Boldrini, L.3
  • 22
    • 17444378271 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer
    • Giatromanolaki A, Koukourakis MI, Kakolyris S, et al: Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer. Clin Cancer Res 1998;4:3017-3024.
    • (1998) Clin Cancer Res , vol.4 , pp. 3017-3024
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Kakolyris, S.3
  • 23
    • 0000397265 scopus 로고    scopus 로고
    • A randomized phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLS
    • Devore RF, Fehrenbacker RS, Herbst RS, et al: A randomized phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLS [Abstract]. Proc Am Soc Clin Oncol 2000;19:485a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Devore, R.F.1    Fehrenbacker, R.S.2    Herbst, R.S.3
  • 24
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, et al: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219(4587):983-985.
    • (1983) Science , vol.219 , Issue.4587 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 25
    • 0032713925 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions
    • Zebrowski BK, Yano S, Wenbiao L, et al: Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions. Clin Cancer Res 1999;5:3364-3368.
    • (1999) Clin Cancer Res , vol.5 , pp. 3364-3368
    • Zebrowski, B.K.1    Yano, S.2    Wenbiao, L.3
  • 26
    • 0037093969 scopus 로고    scopus 로고
    • HER-2/neu overexpression in patients with radically resected nonsmall cell lung carcinoma. Impact on long-term survival
    • Selvaggi G, Scagliotti GV, Torri V, et al: HER-2/neu overexpression in patients with radically resected nonsmall cell lung carcinoma. Impact on long-term survival. Cancer 2002;94:2669-2674.
    • (2002) Cancer , vol.94 , pp. 2669-2674
    • Selvaggi, G.1    Scagliotti, G.V.2    Torri, V.3
  • 27
    • 0025708183 scopus 로고
    • p185neu expression in human lung adenocarcinomas predicts shortened survival
    • Kern JA, Schwartz DA, Nordberg JE, et al: p185neu expression in human lung adenocarcinomas predicts shortened survival. Cancer Res 1990;50:5184-5187.
    • (1990) Cancer Res , vol.50 , pp. 5184-5187
    • Kern, J.A.1    Schwartz, D.A.2    Nordberg, J.E.3
  • 28
    • 1842416594 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity in lung adenocarcinoma cells by c-erbb2 antisense expression
    • Casalini P, Menard S, Malandrin SM, et al: Inhibition of tumorigenicity in lung adenocarcinoma cells by c-erbb2 antisense expression. Int J Cancer 1997;72:631-636.
    • (1997) Int J Cancer , vol.72 , pp. 631-636
    • Casalini, P.1    Menard, S.2    Malandrin, S.M.3
  • 29
    • 0032891108 scopus 로고    scopus 로고
    • Transfection of anti-sense complementary DNA of human epidermal growth factor receptor attenuates the proliferation of human non-small cell lung cancer cells
    • Fang K, Chen MH: Transfection of anti-sense complementary DNA of human epidermal growth factor receptor attenuates the proliferation of human non-small cell lung cancer cells. Int J Cancer 1999;81:471-478.
    • (1999) Int J Cancer , vol.81 , pp. 471-478
    • Fang, K.1    Chen, M.H.2
  • 30
    • 0036124253 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of non-small cell lung cancer
    • Azzoli CG, Krug LM, Miller VA, et al: Trastuzumab in the treatment of non-small cell lung cancer. Semin Oncol 2002;29(1 Suppl 4):59-65.
    • (2002) Semin Oncol , vol.29 , Issue.1 SUPPL. 4 , pp. 59-65
    • Azzoli, C.G.1    Krug, L.M.2    Miller, V.A.3
  • 31
    • 0025074419 scopus 로고
    • K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
    • Slebos RJ, Kibbelaar RE, Dalesio O, et al: K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 1990;323:561-565.
    • (1990) N Engl J Med , vol.323 , pp. 561-565
    • Slebos, R.J.1    Kibbelaar, R.E.2    Dalesio, O.3
  • 32
    • 0025868669 scopus 로고
    • Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA
    • Mukhopadhyay T, Tainskym Cavender AC, Roth JA: Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res 1991;51:1744-1748.
    • (1991) Cancer Res , vol.51 , pp. 1744-1748
    • Mukhopadhyay, T.1    Tainskym Cavender, A.C.2    Roth, J.A.3
  • 33
    • 0030229218 scopus 로고    scopus 로고
    • Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells
    • Alemany R, Ruan S, Kataoka M, et al: Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells. Cancer Gene Ther 1996;3:296-301.
    • (1996) Cancer Gene Ther , vol.3 , pp. 296-301
    • Alemany, R.1    Ruan, S.2    Kataoka, M.3
  • 34
    • 0002431435 scopus 로고    scopus 로고
    • Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells
    • Zhang Y, Nemunaitis J, Tong A: Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells. Mol Biotechnol 2000;15:39-49.
    • (2000) Mol Biotechnol , vol.15 , pp. 39-49
    • Zhang, Y.1    Nemunaitis, J.2    Tong, A.3
  • 35
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed J: Double identity for proteins of the Bcl-2 family. Nature 1997;387(6356):773-776.
    • (1997) Nature , vol.387 , Issue.6356 , pp. 773-776
    • Reed, J.1
  • 36
    • 0027186201 scopus 로고
    • Bcl-2 protein in non small-cell carcinoma
    • Pezzella F, Turley H, Kuzu I, et al: Bcl-2 protein in non small-cell carcinoma. N Engl J Med 1993;329:690-694.
    • (1993) N Engl J Med , vol.329 , pp. 690-694
    • Pezzella, F.1    Turley, H.2    Kuzu, I.3
  • 37
    • 0032758427 scopus 로고    scopus 로고
    • Apoptosis and expression of apoptosis-regulating proteins bcl-2, mcl-1, bclx and bax in malignant mesothelioma
    • Soini Y, Kinnula V, Kaarteenhaho WR, et al: Apoptosis and expression of apoptosis-regulating proteins bcl-2, mcl-1, bclx and bax in malignant mesothelioma. Clin Cancer Res 1999;5:3508-3515.
    • (1999) Clin Cancer Res , vol.5 , pp. 3508-3515
    • Soini, Y.1    Kinnula, V.2    Kaarteenhaho, W.R.3
  • 38
    • 0034071150 scopus 로고    scopus 로고
    • Induction of apoptosis in lung-cancer cells following bcl-xl anti-sense treatment
    • Leech SH, Olie RA, Gautschi O, et al: Induction of apoptosis in lung-cancer cells following bcl-xl anti-sense treatment. Int J Cancer 2000;86:570-576.
    • (2000) Int J Cancer , vol.86 , pp. 570-576
    • Leech, S.H.1    Olie, R.A.2    Gautschi, O.3
  • 39
    • 0035925537 scopus 로고    scopus 로고
    • Activity of a novel bcl-2/bcl-xl bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • Gautschi O, Tschopp S, Olie RA, et al: Activity of a novel bcl-2/bcl-xl bispecific antisense oligonucleotide against tumors of diverse histologic origins. J Natl Cancer Inst 2001;93:463-471.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 463-471
    • Gautschi, O.1    Tschopp, S.2    Olie, R.A.3
  • 40
    • 0036621573 scopus 로고    scopus 로고
    • Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product
    • Smythe WR, Mohuiddin I, Ozvaran M, Cao X: Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product. J Thorac Cardiovasc Surg 2002;123:1191-1198.
    • (2002) J Thorac Cardiovasc Surg , vol.123 , pp. 1191-1198
    • Smythe, W.R.1    Mohuiddin, I.2    Ozvaran, M.3    Cao, X.4
  • 41
    • 0034874520 scopus 로고    scopus 로고
    • Significant augmentation of proapoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma
    • Mohiuddin I, Cao X, Fang B, et al: Significant augmentation of proapoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther 2001;8:547-554.
    • (2001) Cancer Gene Ther , vol.8 , pp. 547-554
    • Mohiuddin, I.1    Cao, X.2    Fang, B.3
  • 42
    • 0035144922 scopus 로고    scopus 로고
    • Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines
    • Pataer A, Smythe WR, Yu R, et al: Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg 2001;121:61-67.
    • (2001) J Thorac Cardiovasc Surg , vol.121 , pp. 61-67
    • Pataer, A.1    Smythe, W.R.2    Yu, R.3
  • 43
    • 0035870294 scopus 로고    scopus 로고
    • Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene
    • Kagawa S, He C, Gu J, et al: Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. Cancer Res 2001;6:3330-3338.
    • (2001) Cancer Res , vol.6 , pp. 3330-3338
    • Kagawa, S.1    He, C.2    Gu, J.3
  • 44
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986;46:5276-5281.
    • (1986) Cancer Res , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 45
    • 0033732739 scopus 로고    scopus 로고
    • Prodrug/Drug sensitivity gene therapy: Current status
    • Smythe WR: Prodrug/Drug sensitivity gene therapy: current status. Curr Oncol Rep 2000;2:17-22.
    • (2000) Curr Oncol Rep , vol.2 , pp. 17-22
    • Smythe, W.R.1
  • 46
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector producer cells for the treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S, et al: In vivo gene transfer with retroviral vector producer cells for the treatment of experimental brain tumors. Science 1992;256(5063):1550-1552.
    • (1992) Science , vol.256 , Issue.5063 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3
  • 47
    • 0028348372 scopus 로고
    • Use of recombinant adenovirus to transfer the herpes simplex thymidine kinase gene (HSVtk) to thoracic neoplasms: An effective in vitro drug sensitization system
    • Smythe WR, Hwang HC, Amin KM, et al: Use of recombinant adenovirus to transfer the herpes simplex thymidine kinase gene (HSVtk) to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res 1994;54:2055-2059.
    • (1994) Cancer Res , vol.54 , pp. 2055-2059
    • Smythe, W.R.1    Hwang, H.C.2    Amin, K.M.3
  • 48
    • 0029076201 scopus 로고
    • Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene
    • Smythe WR, Hwang HC, Elshami AA, et al: Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann Surg 1995;222:78-86.
    • (1995) Ann Surg , vol.222 , pp. 78-86
    • Smythe, W.R.1    Hwang, H.C.2    Elshami, A.A.3
  • 49
    • 0029340302 scopus 로고
    • Gene therapy using adenovirus carrying the herpes simplex thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer
    • Hwang HC, Smythe WR, Elshami AA, et al: Gene therapy using adenovirus carrying the herpes simplex thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. Am J Respir Cell Mol Biol 1995;13:7-16.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 7-16
    • Hwang, H.C.1    Smythe, W.R.2    Elshami, A.A.3
  • 50
    • 17344365922 scopus 로고    scopus 로고
    • Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a phase I clinical trial in malignant mesothelioma
    • Sterman DH, Treat J, Litzky LA, et al: Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther 1998;9:1083-1092.
    • (1998) Hum Gene Ther , vol.9 , pp. 1083-1092
    • Sterman, D.H.1    Treat, J.2    Litzky, L.A.3
  • 51
    • 12444263241 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of enhanced herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing
    • Wiewrodt R, Kunjlata A, Kiefer M, et al: Adenovirus-mediated gene transfer of enhanced herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing. Cancer Gene Ther 2003;10:353-364.
    • (2003) Cancer Gene Ther , vol.10 , pp. 353-364
    • Wiewrodt, R.1    Kunjlata, A.2    Kiefer, M.3
  • 52
    • 0036186162 scopus 로고    scopus 로고
    • Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer
    • Kurdow R, Boehle AS, Haye S, et al: Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer. Ann Thorac Surg 2002;73:905-910.
    • (2002) Ann Thorac Surg , vol.73 , pp. 905-910
    • Kurdow, R.1    Boehle, A.S.2    Haye, S.3
  • 53
    • 0034294818 scopus 로고    scopus 로고
    • Inhibition of experimental lung metastasis by aerosol delivery of PEI-p53 complexes
    • Gautum A, Densmore CL, Waldrep JC: Inhibition of experimental lung metastasis by aerosol delivery of PEI-p53 complexes. Mol Ther 2000;2:318-323.
    • (2000) Mol Ther , vol.2 , pp. 318-323
    • Gautum, A.1    Densmore, C.L.2    Waldrep, J.C.3
  • 54
    • 0002665408 scopus 로고    scopus 로고
    • Phase I trial of Adenovirus p53 in bronchioalveolar cell lung carcinoma (BAC) administered by bronchoalveolar lavage
    • Kubba S, Adak S, Shiller J, et al: Phase I trial of Adenovirus p53 in bronchioalveolar cell lung carcinoma (BAC) administered by bronchoalveolar lavage [Abstract]. Proc Am Soc Clin Oncol 2000;19:487a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Kubba, S.1    Adak, S.2    Shiller, J.3
  • 55
    • 0032945536 scopus 로고    scopus 로고
    • Bronchial arterial infusion is an effective therapeutic modality for centrally located early-stage lung cancer
    • Osaki T, Hanagiri T, Nakanishi R, et al: Bronchial arterial infusion is an effective therapeutic modality for centrally located early-stage lung cancer. Chest 1999;115:1424-1428.
    • (1999) Chest , vol.115 , pp. 1424-1428
    • Osaki, T.1    Hanagiri, T.2    Nakanishi, R.3
  • 56
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Hacein-Bey-Abina S, von Kalle C, Schmidt M, et al: A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2003;348:255-256.
    • (2003) N Engl J Med , vol.348 , pp. 255-256
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 57
    • 0025279872 scopus 로고
    • Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
    • Miller DG, Adam MA, Miller AD: Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 1990;10:4239-4242.
    • (1990) Mol Cell Biol , vol.10 , pp. 4239-4242
    • Miller, D.G.1    Adam, M.A.2    Miller, A.D.3
  • 58
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas C, Ehrhardt A, Kay M: Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003;4:346-358.
    • (2003) Nat Rev Genet , vol.4 , pp. 346-358
    • Thomas, C.1    Ehrhardt, A.2    Kay, M.3
  • 59
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammallian cell
    • Burns JC, Friedmann T, Driever W, et al: Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammallian cell. Proc Natl Acad Sci USA 1993;90:8033-8037.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8033-8037
    • Burns, J.C.1    Friedmann, T.2    Driever, W.3
  • 60
    • 0032605547 scopus 로고    scopus 로고
    • Expanded-capacity adenoviral vectors - The helper-dependent vectors
    • Morsy MA, Caskey CT: Expanded-capacity adenoviral vectors - the helper-dependent vectors. Mol Med Today 1999;5:18-24.
    • (1999) Mol Med Today , vol.5 , pp. 18-24
    • Morsy, M.A.1    Caskey, C.T.2
  • 61
    • 0035077806 scopus 로고    scopus 로고
    • Polymer-coated adenovirus permits efficient retargeting and evades neutralizing antibodies
    • Fisher KD, Stallwood Y, Green NK, et al: Polymer-coated adenovirus permits efficient retargeting and evades neutralizing antibodies. Gene Ther 2001;8:341-348.
    • (2001) Gene Ther , vol.8 , pp. 341-348
    • Fisher, K.D.1    Stallwood, Y.2    Green, N.K.3
  • 62
    • 0037442441 scopus 로고    scopus 로고
    • Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression
    • Hemminki A, Kanerva A, Liu B, et al: Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression. Cancer Res 2003;63:847-853.
    • (2003) Cancer Res , vol.63 , pp. 847-853
    • Hemminki, A.1    Kanerva, A.2    Liu, B.3
  • 63
    • 0033902946 scopus 로고    scopus 로고
    • Structure and function of lipid-DNA complexes for gene delivery
    • Chesnoy S, Huang L: Structure and function of lipid-DNA complexes for gene delivery. Annu Rev Biophys Biomol Struct 2000;29:27-47.
    • (2000) Annu Rev Biophys Biomol Struct , vol.29 , pp. 27-47
    • Chesnoy, S.1    Huang, L.2
  • 64
    • 0029061020 scopus 로고
    • In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes
    • Mahato RI, Kawabata K, Takakura Y, Hashida M: In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes. J Drug Target 1995;3:149-157.
    • (1995) J Drug Target , vol.3 , pp. 149-157
    • Mahato, R.I.1    Kawabata, K.2    Takakura, Y.3    Hashida, M.4
  • 65
    • 0030760143 scopus 로고    scopus 로고
    • Improved DNA: Liposome complexes for increased systemic delivery and gene expression
    • Templeton NS, Lasic DD, Frederik PM, et al: Improved DNA: Liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 1997;15:547-652.
    • (1997) Nat Biotechnol , vol.15 , pp. 547-652
    • Templeton, N.S.1    Lasic, D.D.2    Frederik, P.M.3
  • 66
    • 0034981225 scopus 로고    scopus 로고
    • Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector
    • Ramesh R, Saeki T, Templeton NS, et al: Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001;3:337-350.
    • (2001) Mol Ther , vol.3 , pp. 337-350
    • Ramesh, R.1    Saeki, T.2    Templeton, N.S.3
  • 67
    • 0034634861 scopus 로고    scopus 로고
    • Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice
    • Tousignant JD, Gates AL, Ingram LA, et al: Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice. Hum Gene Ther 2000;11:2493-2513.
    • (2000) Hum Gene Ther , vol.11 , pp. 2493-2513
    • Tousignant, J.D.1    Gates, A.L.2    Ingram, L.A.3
  • 68
    • 0033199598 scopus 로고    scopus 로고
    • The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo
    • Tan Y, Li S, Pitt BR, Huang L: The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther 1999;10:2153-2161.
    • (1999) Hum Gene Ther , vol.10 , pp. 2153-2161
    • Tan, Y.1    Li, S.2    Pitt, B.R.3    Huang, L.4
  • 69
    • 0034065318 scopus 로고    scopus 로고
    • Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer
    • Zou Y, Zong G, Ling YH, Perez-Soler R: Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer. Cancer Gene Ther 2000;7:683-696.
    • (2000) Cancer Gene Ther , vol.7 , pp. 683-696
    • Zou, Y.1    Zong, G.2    Ling, Y.H.3    Perez-Soler, R.4
  • 70
    • 0029913730 scopus 로고    scopus 로고
    • Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen J, Wu X, Lin J, Levine AJ: Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996;16:2445-2452.
    • (1996) Mol Cell Biol , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 71
    • 0026597191 scopus 로고
    • p53 mutations in non-small cell lung cancer in Japan: Association between mutations and smoking
    • Suzuki H, Takahashi T, Kuoishi T, et al: p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. Cancer Res 1992;52:734-736.
    • (1992) Cancer Res , vol.52 , pp. 734-736
    • Suzuki, H.1    Takahashi, T.2    Kuoishi, T.3
  • 72
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
    • Fugiwara T, Cai DW, Georges RN, et al: Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J Natl Cancer Inst 1994;86:1458-1462.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1458-1462
    • Fugiwara, T.1    Cai, D.W.2    Georges, R.N.3
  • 73
    • 0028403234 scopus 로고
    • High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus
    • Zhang WW, Fang X, Mazur W, et al: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther 1994;1:5-13.
    • (1994) Cancer Gene Ther , vol.1 , pp. 5-13
    • Zhang, W.W.1    Fang, X.2    Mazur, W.3
  • 74
    • 0141927731 scopus 로고    scopus 로고
    • Adenoviral p53 gene therapy strategies in non-small cell lung cancer
    • Choy H (ed). New Jersey: Humana Press
    • Swisher SG, Roth JA: Adenoviral p53 gene therapy strategies in non-small cell lung cancer. In Choy H (ed): "Chemoradiation in cancer therapy." New Jersey: Humana Press; 2002; p. 351-360.
    • (2002) Chemoradiation in Cancer Therapy , pp. 351-360
    • Swisher, S.G.1    Roth, J.A.2
  • 75
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 transfers to tumors of patients with lung cancer
    • Roth JA, Nguyen D, Lawrence DD, et al: Retrovirus-mediated wild-type p53 transfers to tumors of patients with lung cancer. Nat Med 1996;2:985-991.
    • (1996) Nat Med , vol.2 , pp. 985-991
    • Roth, J.A.1    Nguyen, D.2    Lawrence, D.D.3
  • 76
    • 17344365479 scopus 로고    scopus 로고
    • A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer
    • Shuler M, Rochlitz C, Horowitz JA, et al: A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer. Hum Gene Ther 1998;9:2075-2082.
    • (1998) Hum Gene Ther , vol.9 , pp. 2075-2082
    • Shuler, M.1    Rochlitz, C.2    Horowitz, J.A.3
  • 77
    • 0033526357 scopus 로고    scopus 로고
    • Adenovirus-Mediated p53 gene transfer in advanced non-small cell lung cancer
    • Swisher SG, Roth J, Nemunaitis J, et al: Adenovirus-Mediated p53 gene transfer in advanced non-small cell lung cancer. J Natl Cancer Inst 1999;91:763-771.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 763-771
    • Swisher, S.G.1    Roth, J.2    Nemunaitis, J.3
  • 78
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE: P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 79
    • 0028840535 scopus 로고
    • Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer
    • Rusch V, Klimstra D, Venkatraman E, et al: Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 1995;55:5038-5042.
    • (1995) Cancer Res , vol.55 , pp. 5038-5042
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3
  • 80
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T, et al: Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 1994;54:2297-2291.
    • (1994) Cancer Res , vol.54 , pp. 2297-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3
  • 81
    • 0033950285 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer
    • Nemunaitis J, Swisher SG, Timmons T, et al: Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 2000;18:609-622.
    • (2000) J Clin Oncol , vol.18 , pp. 609-622
    • Nemunaitis, J.1    Swisher, S.G.2    Timmons, T.3
  • 82
    • 0035868848 scopus 로고    scopus 로고
    • Adenovirus-Mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small cell lung cancer: Results of a multicenter Phase II study
    • Shuler M, Herrmann R, Jacques LP, et al: Adenovirus-Mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small cell lung cancer: results of a multicenter Phase II study. J Clin Oncol 2001;19:1750-1758.
    • (2001) J Clin Oncol , vol.19 , pp. 1750-1758
    • Shuler, M.1    Herrmann, R.2    Jacques, L.P.3
  • 83
    • 12244298187 scopus 로고    scopus 로고
    • Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy
    • Swisher SG, Roth JA, Komaki R, et al: Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res 2003;9:93-101.
    • (2003) Clin Cancer Res , vol.9 , pp. 93-101
    • Swisher, S.G.1    Roth, J.A.2    Komaki, R.3


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