Expression of apoptosis-regulatory genes in lung tumour cell lines: Relationship to p53 expression and relevance to acquired drug resistance

British Journal of Cancer

Volumn 73, Issue 10, 1996, Pages 1193-1200

  Reeve, J G ^a   Xiong, J ^a   Morgan, J ^a   Bleehen, N M ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Apoptosis; Drug resistance; Lung neoplasm

Indexed keywords

MESSENGER RNA;

APOPTOSIS; ARTICLE; BRAIN; CARCINOGENESIS; CHEMOTHERAPY; CONTROLLED STUDY; DRUG RESISTANCE; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LUNG TUMOR; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; TUMOR CELL; TUMOR SUPPRESSOR GENE;

EID: 0029943186     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.230     Document Type: Article

References (32)

1. BAILLIE-JOHNSON H, TWENTYMAN PR, FOX NE, WALLS GA, WORKMAN P, WATSON JV, JOHNSON N, REEVE JG AND BLEEHEN NM. (1985). Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma). Br. J. Cancer, 52, 495-504.
2. BEN-EZRA JM, KORNSTEIN MJ, GRIMES MM AND KRYSTAL G. (1994). Small cell carcinomas of the lung express the Bcl-2 protein. Am. J. Pathol., 145, 1036-1040.
3. BOISE LH, GONZÁLEZ GARCIA M, POSTEMA CE, DING L, LINDSTEN T, TURKA LA, MAO X, NUÑEZ G AND THOMPSON CB. (1993). Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
4. CAMPOS L, ROVALULT JP, SABIDO O, ORIOL P, ROUBI N, VASSELON C, ARCHIMBAUD E, MAGAUD JP AND GUYOTAT D. (1993). High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood, 18, 3091-3096.
5. COTTER FE, JOHNSON P, HALL P, POCOCK C, AL MAHDI N, COWELL JK AND MORGAN G. (1994). Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene, 9, 3049-3055.
6. DOLE M, NUÑEZ G, MERCHANT AK, MAYBAUM J, RODE CK, BLOCH CA AND CASTLE VP. (1994). Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res., 54, 3253-3259.
7. FISHER TC, MILNER AE, GREGORY CD, JACKMAN AL, AHERNE GW, HARTLEY JA, DIVE C AND HICKMAN JA. (1993). Bcl-2 modulation of apoptosis induced by anticancer drugs-resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53, 3321-3326.
8. HALDAR S, NEGRINI M, MONNE M, SABBIONI S AND CROCE CM. (1994). Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res., 54, 2095-2097.
9. HENNET T, BERTONI G, RICHTER C AND PETERHANS E. (1993). Expression of Bcl-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor mediated cytotoxicity. Cancer Res., 53, 1456-1460.
10. HOLLSTEIN M, SIDRANSKY D, VOGELSTEIN B AND HARRIS CC. (1991). P53 mutations in human cancers. Science, 253, 49-53.
11. IGEGAKI N, KATSUMA M, MINNA J AND TSUJIMOTO Y. (1994). Expression of Bcl-2 in small cell lung carcinoma cells. Cancer Res., 54, 6-8.
12. KAMESAKI S, KAMESAKI H, JORGENSEN TJ, TANIZAWA A, POMMIER Y AND CROSSMAN J. (1993). Bcl-2 protein inhibits etoposide-induced apoptosis through its effect on events subsequent to topoisomerase-II induced DNA strand breaks and their repair. Cancer Res., 53, 4251-4256.
13. KITADA S, TAKAYAMA S. AND DERIEL K. (1994). Reduction of chemoresistance and induction of apoptosis by antisense downregulation of Bcl-2. Proc. Am. Assoc. Cancer Res., 35, 318.
14. LOWE SW, RULEY HE, JACKS T AND HOUSEMAN DE. (1993). p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967.
15. LU Q-L, ELIA G, LUCAS S AND THOMAS JA. (1993). Bcl-2 protooncogene expression in Epstein-Barr virus associated nasopharyngeal carcinoma. Int. J. Cancer. 53, 29-35.
16. MCDONNELL T, TRONCOSO P, BRISBARY S, LOGOTHETIS C, CHUNG LWK, HSIEH JT, TU SM AND CAMPBELL ML. (1992). Expression of the proto-oncogene BCL-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res., 52, 6940-6944.
17. MCDONNELL TJ. (1993). Cell division versus cell death: a functional model of multistep neoplasia. Mol. Carcinogenesis, 8, 209-213.
18. MANOME Y, WEICHSELBAUM RR, KUFE DW AND FINE HA. (1993). Effect of bcl-2 on ionizing radiation and 1-bd-arabinofuranosylcytosine-induced internucleosomal DNA fragmentation and cell survival in human myeloid leukaemia cells. Oncol. Res., 5, 139-144.
19. MATLASHEWSKI GJ, TUCK S, PIM D, LAMB P, SCHNEIDER J AND CRAWFORD LV. (1987). Primary structure polymorphism at amino acid residue 72 of human p53. Mol. Cell. Biol., 7, 961-963.
20. MIYASHITA T AND REED JC. (1992). Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res., 52, 5407-5411.
21. MIYASHITA T AND REED JC. (1993). Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81, 151-157.
22. MIYASHITA T, KRAJEWSKI S, KRAJEWSKA M, WANG HG, LIN HK, LIEBERMANN DA, HOFFMAN B AND REED JC. (1994a). Tumour suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
23. MIYASHITA T, HARIGAI M, HANADA M AND REED JC. (1994b). Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res., 54, 3131-3135.
24. OHMORI T, PODACK ER, NISHIO K, TAKAHASHI M, MIYAHARA Y, TAKEDA Y, KUBOTA N, KUNAYAMA Y, OGASAWARA H, OHIRO T, OHTA S AND SALIO N. (1993). Apoptosis of lung cancer cells caused by some anticancer agents (MMC, CPT-11, ADM) is inhibited by Bcl-2. Biochem. Biophys. Res. Commun., 192, 30-36.
25. OLTVAI ZN, MILLIMAN CL AND KORSMEYER SJ. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
26. PEZZELLA F, TURLEY H, KUZU I, TUNGEKAR MF, DUNNILL MS, PIERCE CB, HARRIS A, GATTER KC AND MASON DY. (1993). Bcl-2 protein in non-small cell lung carcinoma. N. Engl. J. Med., 329, 690-694.
27. REED JC. (1994). Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6.
28. REED JC, MEISTER L, TANAKA S, CUDDY M, YUM S, GEYER C AND PLEASURE D. (1991). Differential expression of bcl-2 protooncogene in neuroblastoma and other tumor cell lines of neural origin. Cancer Res., 51, 6529-6538.
29. REEVE JG, MORGAN J, SCHWANDER J AND BLEEHEN NM. (1993). Role for membrane and secreted insulin-like growth factor binding protein-2 in the regulation of insulin-like growth factor action in lung tumors. Cancer Res., 53, 4680-4685.
30. TWENTYMAN PR, FOX NE, WRIGHT K AND BLEEHEN NM. (1986). Derivation and preliminary characterisation of adriamycin resistant cell lines of human lung cancer cells. Br. J. Cancer, 53, 529-537.
31. WALTON MI, WHYSONG D, O'CONNOR PM, HOCKENBERRY D, KORSMEYER SJ AND KOHN KW. (1993). Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res., 53, 1853-1861.
32. WILLIAMS GT AND SMITH CA. (1993). Molecular regulation of apoptosis: genetic controls on cell death. Cell, 74, 777-779.