Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase β

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 24226-24235

  Lund, Ida Katrine ^a   Andersen, Henrik Sune ^a   Iversen, Lars Fogh ^a   Olsen, Ole Hvilsted ^a   Møller, Karin Bach ^a   Pedersen, Anja Kallesøe ^a   Ge, Yu ^b   Holsworth, Daniel D ^b   Newman, Michael J ^b,c   Axe, Frank U ^b   Møller, Niels Peter Hundahl ^a  

^a NOVO NORDISK A S   (Denmark)

^b Ontogen Corporation   (United States)

^c Dihedron Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DRUG PRODUCTS; ENZYME INHIBITION; ENZYMES; MOLECULAR WEIGHT; MUTAGENESIS; TUMORS; X RAY CRYSTALLOGRAPHY;

AUTOIMMUNITY; BIOINFORMATICS; MUTANTS; SIGNAL TRANSDUCTION;

BIOCHEMISTRY;

INSULIN; LEPTIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE BETA; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; BIOINFORMATICS; CANCER; DIABETES MELLITUS; DRUG DESIGN; DRUG STRUCTURE; ENZYME KINETICS; MOLECULAR MODEL; MOLECULAR WEIGHT; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; INSULIN; KINETICS; LEPTIN; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PHTHALIMIDES; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 2642535242     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313027200     Document Type: Article

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