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Volumn 10, Issue 19, 2005, Pages 1269-1282

Keynote review: The auditory system, hearing loss and potential targets for drug development

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR; GAP JUNCTION PROTEIN; GLUTAMIC ACID; NEUROTROPHIN; PROTEIN KINASE INHIBITOR; RETINOBLASTOMA PROTEIN;

EID: 26244455518     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03595-6     Document Type: Review
Times cited : (74)

References (184)
  • 1
    • 0033950613 scopus 로고    scopus 로고
    • Redefining the survival of the fittest: Communication disorders in the 21st century
    • Ruben R.J. Redefining the survival of the fittest: communication disorders in the 21st century Laryngoscope 110 2000 241 245
    • (2000) Laryngoscope , vol.110 , pp. 241-245
    • Ruben, R.J.1
  • 3
    • 0347087332 scopus 로고    scopus 로고
    • Epidemiology of hearing impairment
    • Ludman H. Wright A. Arnold
    • Davis A. Epidemiology of hearing impairment Ludman H. Wright A. Diseases of the Ear 1998 Arnold 129 137
    • (1998) Diseases of the Ear , pp. 129-137
    • Davis, A.1
  • 4
    • 0036398267 scopus 로고    scopus 로고
    • Mechanisms of tinnitus
    • Baguley D.M. Mechanisms of tinnitus Br. Med. Bull. 63 2002 195 212
    • (2002) Br. Med. Bull. , vol.63 , pp. 195-212
    • Baguley, D.M.1
  • 5
    • 26244449281 scopus 로고    scopus 로고
    • Tinnitus: Neurobiological substrates
    • Eggermont J. Tinnitus: neurobiological substrates Drug Discov. Today 10 2005 1283 1290
    • (2005) Drug Discov. Today , vol.10 , pp. 1283-1290
    • Eggermont, J.1
  • 6
    • 26244433867 scopus 로고    scopus 로고
    • Local inner-ear drug delivery and pharmacokinetics
    • Salt A., Plontke S. Local inner-ear drug delivery and pharmacokinetics Drug Discov. Today 10 2005 1299 1306
    • (2005) Drug Discov. Today , vol.10 , pp. 1299-1306
    • Salt, A.1    Plontke, S.2
  • 7
    • 26244450737 scopus 로고    scopus 로고
    • Applied anatomy and physiology of the ear
    • Ludman H. Wright A. Arnold
    • Wright A. Applied anatomy and physiology of the ear Ludman H. Wright A. Diseases of the Ear 1998 Arnold 32 47
    • (1998) Diseases of the Ear , pp. 32-47
    • Wright, A.1
  • 8
    • 0037364602 scopus 로고    scopus 로고
    • Auditory amplification: Outer hair cells pres the issue
    • Geleoc G.S., Holt J.R. Auditory amplification: outer hair cells pres the issue Trends Neurosci. 26 2003 115 117
    • (2003) Trends Neurosci. , vol.26 , pp. 115-117
    • Geleoc, G.S.1    Holt, J.R.2
  • 10
    • 0036396925 scopus 로고    scopus 로고
    • The molecular architecture of the inner ear
    • Forge A., Wright T. The molecular architecture of the inner ear Br. Med. Bull. 63 2002 5 24
    • (2002) Br. Med. Bull. , vol.63 , pp. 5-24
    • Forge, A.1    Wright, T.2
  • 11
    • 13544276525 scopus 로고    scopus 로고
    • Interactions in the network of Usher syndrome type 1 proteins
    • Adato A. Interactions in the network of Usher syndrome type 1 proteins Hum. Mol. Genet. 14 2005 347 356
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 347-356
    • Adato, A.1
  • 12
    • 2342421512 scopus 로고    scopus 로고
    • Cadherin 23 is a component of the tip link in hair-cell stereocilia
    • Siemens J. Cadherin 23 is a component of the tip link in hair-cell stereocilia Nature 428 2004 950 955
    • (2004) Nature , vol.428 , pp. 950-955
    • Siemens, J.1
  • 13
    • 10644290199 scopus 로고    scopus 로고
    • TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
    • Corey D.P. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells Nature 432 2004 723 730
    • (2004) Nature , vol.432 , pp. 723-730
    • Corey, D.P.1
  • 14
    • 14544269417 scopus 로고    scopus 로고
    • Force generation by mammalian hair bundles supports a role in cochlear amplification
    • Kennedy H.J. Force generation by mammalian hair bundles supports a role in cochlear amplification Nature 433 2005 880 883
    • (2005) Nature , vol.433 , pp. 880-883
    • Kennedy, H.J.1
  • 15
    • 17244366230 scopus 로고    scopus 로고
    • Hair cell synaptic ribbons are essential for synchronous auditory signalling
    • Khimich D. Hair cell synaptic ribbons are essential for synchronous auditory signalling Nature 434 2005 889 894
    • (2005) Nature , vol.434 , pp. 889-894
    • Khimich, D.1
  • 16
    • 0037136582 scopus 로고    scopus 로고
    • Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    • Liberman M.C. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier Nature 419 2002 300 304
    • (2002) Nature , vol.419 , pp. 300-304
    • Liberman, M.C.1
  • 18
    • 0141885144 scopus 로고    scopus 로고
    • Prestin and the dynamic stiffness of cochlear outer hair cells
    • He D.Z. Prestin and the dynamic stiffness of cochlear outer hair cells J. Neurosci. 23 2003 9089 9096
    • (2003) J. Neurosci. , vol.23 , pp. 9089-9096
    • He, D.Z.1
  • 19
    • 26244461179 scopus 로고    scopus 로고
    • Compounds for the prevention and treatment of noise-induced hearing loss
    • Lynch E., Kil J. Compounds for the prevention and treatment of noise-induced hearing loss Drug Discov. Today 10 2005 1291 1298
    • (2005) Drug Discov. Today , vol.10 , pp. 1291-1298
    • Lynch, E.1    Kil, J.2
  • 20
    • 5044233739 scopus 로고    scopus 로고
    • Intratympanic treatment of hearing loss with novel and traditional agents
    • Seidman M.D., Vivek P. Intratympanic treatment of hearing loss with novel and traditional agents Otolaryngol. Clin. North Am. 37 2004 973 990
    • (2004) Otolaryngol. Clin. North Am. , vol.37 , pp. 973-990
    • Seidman, M.D.1    Vivek, P.2
  • 21
    • 18844416858 scopus 로고    scopus 로고
    • Therapeutic promise of JNK ATP-noncompetitive inhibitors
    • Bogoyevitch M.A. Therapeutic promise of JNK ATP-noncompetitive inhibitors Trends Mol. Med. 11 2005 232 239
    • (2005) Trends Mol. Med. , vol.11 , pp. 232-239
    • Bogoyevitch, M.A.1
  • 22
    • 0141457877 scopus 로고    scopus 로고
    • A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss
    • Wang J. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss J. Neurosci. 23 2003 8596 8607
    • (2003) J. Neurosci. , vol.23 , pp. 8596-8607
    • Wang, J.1
  • 23
    • 0036398266 scopus 로고    scopus 로고
    • Cochlear implants and brain stem implants
    • Ramsden R.T. Cochlear implants and brain stem implants Br. Med. Bull. 63 2002 183 193
    • (2002) Br. Med. Bull. , vol.63 , pp. 183-193
    • Ramsden, R.T.1
  • 24
    • 26244453706 scopus 로고    scopus 로고
    • Regeneration and replacement in the vertebrate inner ear
    • Matsui J. Regeneration and replacement in the vertebrate inner ear Drug Discov. Today 10 2005 1307 1312
    • (2005) Drug Discov. Today , vol.10 , pp. 1307-1312
    • Matsui, J.1
  • 26
    • 0036370532 scopus 로고    scopus 로고
    • The inner hair cell afferent/efferent synapses revisited: A basis for new therapeutic strategies
    • Puel J.L. The inner hair cell afferent/efferent synapses revisited: a basis for new therapeutic strategies Adv. Otorhinolaryngol. 59 2002 124 130
    • (2002) Adv. Otorhinolaryngol. , vol.59 , pp. 124-130
    • Puel, J.L.1
  • 27
    • 0026011768 scopus 로고
    • Scar formation after drug-induced cochlear insult
    • Raphael Y., Altschuler R.A. Scar formation after drug-induced cochlear insult Hear. Res. 51 1991 173 183
    • (1991) Hear. Res. , vol.51 , pp. 173-183
    • Raphael, Y.1    Altschuler, R.A.2
  • 28
    • 0022405232 scopus 로고
    • Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment
    • Forge A. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment Hear. Res. 19 1985 171 182
    • (1985) Hear. Res. , vol.19 , pp. 171-182
    • Forge, A.1
  • 29
    • 0346725077 scopus 로고    scopus 로고
    • Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla
    • McFadden S.L. Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla Brain Res. 997 2004 40 51
    • (2004) Brain Res. , vol.997 , pp. 40-51
    • McFadden, S.L.1
  • 30
    • 4143053717 scopus 로고    scopus 로고
    • Calpain activity in the amikacin-damaged rat cochlea
    • Ladrech S. Calpain activity in the amikacin-damaged rat cochlea J. Comp. Neurol. 477 2004 149 160
    • (2004) J. Comp. Neurol. , vol.477 , pp. 149-160
    • Ladrech, S.1
  • 31
    • 0037972264 scopus 로고    scopus 로고
    • Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas
    • Imamura S., Adams J.C. Changes in cytochemistry of sensory and nonsensory cells in gentamicin-treated cochleas J. Assoc. Res. Otolaryngol. 4 2003 196 218
    • (2003) J. Assoc. Res. Otolaryngol. , vol.4 , pp. 196-218
    • Imamura, S.1    Adams, J.C.2
  • 32
    • 23844552101 scopus 로고    scopus 로고
    • The human spiral ganglion: New insights into ultrastructure, survival rate and implications for cochlear implants
    • Glueckert R. The human spiral ganglion: new insights into ultrastructure, survival rate and implications for cochlear implants Audiol. Neurootol. 10 2005 258 273
    • (2005) Audiol. Neurootol. , vol.10 , pp. 258-273
    • Glueckert, R.1
  • 33
    • 0030868270 scopus 로고    scopus 로고
    • Patterns of neural degeneration in the human cochlea and auditory nerve: Implications for cochlear implantation
    • Nadol J.B. Jr Patterns of neural degeneration in the human cochlea and auditory nerve: implications for cochlear implantation Otolaryngol. Head Neck Surg. 117 1997 220 228
    • (1997) Otolaryngol. Head Neck Surg. , vol.117 , pp. 220-228
    • Nadol Jr., J.B.1
  • 34
    • 0037039823 scopus 로고    scopus 로고
    • Repairing the injured spinal cord
    • Schwab M.E. Repairing the injured spinal cord Science 295 2002 1029 1031
    • (2002) Science , vol.295 , pp. 1029-1031
    • Schwab, M.E.1
  • 35
    • 4644346915 scopus 로고    scopus 로고
    • Age-related hearing loss: The status of Schuknecht's typology
    • Ohlemiller K.K. Age-related hearing loss: the status of Schuknecht's typology Curr. Opin. Otolaryngol. Head Neck Surg. 12 2004 439 443
    • (2004) Curr. Opin. Otolaryngol. Head Neck Surg. , vol.12 , pp. 439-443
    • Ohlemiller, K.K.1
  • 36
    • 4644240438 scopus 로고    scopus 로고
    • Apical-to-basal gradients in age-related cochlear degeneration and their relationship to "primary" loss of cochlear neurons
    • Ohlemiller K.K., Gagnon P.M. Apical-to-basal gradients in age-related cochlear degeneration and their relationship to "primary" loss of cochlear neurons J. Comp. Neurol. 479 2004 103 116
    • (2004) J. Comp. Neurol. , vol.479 , pp. 103-116
    • Ohlemiller, K.K.1    Gagnon, P.M.2
  • 37
    • 12344304163 scopus 로고    scopus 로고
    • Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness
    • Beltramello M. Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness Nat. Cell Biol. 7 2005 63 69
    • (2005) Nat. Cell Biol. , vol.7 , pp. 63-69
    • Beltramello, M.1
  • 38
    • 0242684552 scopus 로고    scopus 로고
    • Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30
    • Marziano N.K. Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30 Hum. Mol. Genet. 12 2003 805 812
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 805-812
    • Marziano, N.K.1
  • 39
    • 0035132449 scopus 로고    scopus 로고
    • A genetic approach to understanding auditory function
    • Steel K.P., Kros C.J. A genetic approach to understanding auditory function Nat. Genet. 27 2001 143 149
    • (2001) Nat. Genet. , vol.27 , pp. 143-149
    • Steel, K.P.1    Kros, C.J.2
  • 40
    • 0037046804 scopus 로고    scopus 로고
    • Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death
    • Cohen-Salmon M. Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death Curr. Biol. 12 2002 1106 1111
    • (2002) Curr. Biol. , vol.12 , pp. 1106-1111
    • Cohen-Salmon, M.1
  • 41
    • 11844301284 scopus 로고    scopus 로고
    • Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin
    • Delprat B. Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin Mol. Cell. Biol. 25 2005 847 853
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 847-853
    • Delprat, B.1
  • 42
    • 0034941877 scopus 로고    scopus 로고
    • Spiral ligament pathology: A major aspect of age-related cochlear degeneration in C57BL/6 mice
    • Hequembourg S., Liberman M.C. Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice J. Assoc. Res. Otolaryngol. 2 2001 118 129
    • (2001) J. Assoc. Res. Otolaryngol. , vol.2 , pp. 118-129
    • Hequembourg, S.1    Liberman, M.C.2
  • 43
    • 0036154529 scopus 로고    scopus 로고
    • Effects of age on the distortion product otoacoustic emission growth functions
    • Gates G.A. Effects of age on the distortion product otoacoustic emission growth functions Hear. Res. 163 2002 53 60
    • (2002) Hear. Res. , vol.163 , pp. 53-60
    • Gates, G.A.1
  • 44
    • 1642530939 scopus 로고    scopus 로고
    • Acquired sensorineural hearing loss
    • Ludman H. Wright A. Arnold
    • Jones N., Ludman H. Acquired sensorineural hearing loss Ludman H. Wright A. Diseases of the Ear 1998 Arnold
    • (1998) Diseases of the Ear
    • Jones, N.1    Ludman, H.2
  • 45
    • 0027395835 scopus 로고
    • The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors
    • Gates G.A. The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors Arch. Otolaryngol. Head Neck Surg. 119 1993 156 161
    • (1993) Arch. Otolaryngol. Head Neck Surg. , vol.119 , pp. 156-161
    • Gates, G.A.1
  • 46
    • 0035675828 scopus 로고    scopus 로고
    • Molecular genetics of hearing loss
    • Petit C. Molecular genetics of hearing loss Annu. Rev. Genet. 35 2001 589 646
    • (2001) Annu. Rev. Genet. , vol.35 , pp. 589-646
    • Petit, C.1
  • 47
    • 26244434985 scopus 로고    scopus 로고
    • The genetics of deafness
    • Avraham K.B. The genetics of deafness Drug Discov. Today 10 2005 1323 1330
    • (2005) Drug Discov. Today , vol.10 , pp. 1323-1330
    • Avraham, K.B.1
  • 48
    • 20044386893 scopus 로고    scopus 로고
    • Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss
    • Nemoto M. Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss Biochem. Biophys. Res. Commun. 324 2004 1283 1288
    • (2004) Biochem. Biophys. Res. Commun. , vol.324 , pp. 1283-1288
    • Nemoto, M.1
  • 49
    • 0036638824 scopus 로고    scopus 로고
    • Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene
    • Li S. Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene Development 129 2002 3523 3532
    • (2002) Development , vol.129 , pp. 3523-3532
    • Li, S.1
  • 50
    • 0242607215 scopus 로고    scopus 로고
    • Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26)
    • Zhu M. Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26) Am. J. Hum. Genet. 73 2003 1082 1091
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1082-1091
    • Zhu, M.1
  • 51
    • 0037321225 scopus 로고    scopus 로고
    • Hair cell regeneration: Winging our way towards a sound future
    • Bermingham-McDonogh O., Rubel E.W. Hair cell regeneration: winging our way towards a sound future Curr. Opin. Neurobiol. 13 2003 119 126
    • (2003) Curr. Opin. Neurobiol. , vol.13 , pp. 119-126
    • Bermingham-Mcdonogh, O.1    Rubel, E.W.2
  • 52
    • 0034710917 scopus 로고    scopus 로고
    • Cellular studies of auditory hair cell regeneration in birds
    • Stone J.S., Rubel E.W. Cellular studies of auditory hair cell regeneration in birds Proc. Natl. Acad. Sci. U. S. A. 97 2000 11714 11721
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11714-11721
    • Stone, J.S.1    Rubel, E.W.2
  • 53
    • 0032188820 scopus 로고    scopus 로고
    • Hair cells and supporting cells share a common progenitor in the avian inner ear
    • Fekete D.M. Hair cells and supporting cells share a common progenitor in the avian inner ear J. Neurosci. 18 1998 7811 7821
    • (1998) J. Neurosci. , vol.18 , pp. 7811-7821
    • Fekete, D.M.1
  • 54
    • 0034710913 scopus 로고    scopus 로고
    • Hair cell recovery in mitotically blocked cultures of the bullfrog saccule
    • Baird R.A. Hair cell recovery in mitotically blocked cultures of the bullfrog saccule Proc. Natl. Acad. Sci. U. S. A. 97 2000 11722 11729
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11722-11729
    • Baird, R.A.1
  • 55
    • 14644393078 scopus 로고    scopus 로고
    • Hair cell regeneration in sensory epithelia from the inner ear of a urodele amphibian
    • Taylor R.R., Forge A. Hair cell regeneration in sensory epithelia from the inner ear of a urodele amphibian J. Comp. Neurol. 484 2005 105 120
    • (2005) J. Comp. Neurol. , vol.484 , pp. 105-120
    • Taylor, R.R.1    Forge, A.2
  • 56
    • 8844256181 scopus 로고    scopus 로고
    • Regeneration of the inner ear as a model of neural plasticity
    • Morest D.K., Cotanche D.A. Regeneration of the inner ear as a model of neural plasticity J. Neurosci. Res. 78 2004 455 460
    • (2004) J. Neurosci. Res. , vol.78 , pp. 455-460
    • Morest, D.K.1    Cotanche, D.A.2
  • 57
    • 0027531639 scopus 로고
    • Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans
    • Warchol M.E. Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans Science 259 1993 1619 1622
    • (1993) Science , vol.259 , pp. 1619-1622
    • Warchol, M.E.1
  • 58
    • 0029827693 scopus 로고    scopus 로고
    • Regenerative proliferation in organ cultures of the avian cochlea: Identification of the initial progenitors and determination of the latency of the proliferative response
    • Warchol M.E., Corwin J.T. Regenerative proliferation in organ cultures of the avian cochlea: identification of the initial progenitors and determination of the latency of the proliferative response J. Neurosci. 16 1996 5466 5477
    • (1996) J. Neurosci. , vol.16 , pp. 5466-5477
    • Warchol, M.E.1    Corwin, J.T.2
  • 59
    • 0030040342 scopus 로고    scopus 로고
    • Regeneration of sensory cells after laser ablation in the lateral line system: Hair cell lineage and macrophage behavior revealed by time-lapse video microscopy
    • Jones J.E., Corwin J.T. Regeneration of sensory cells after laser ablation in the lateral line system: hair cell lineage and macrophage behavior revealed by time-lapse video microscopy J. Neurosci. 16 1996 649 662
    • (1996) J. Neurosci. , vol.16 , pp. 649-662
    • Jones, J.E.1    Corwin, J.T.2
  • 60
    • 0343416372 scopus 로고    scopus 로고
    • Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula
    • Li L., Forge A. Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula Int. J. Dev. Neurosci. 15 1997 433 446
    • (1997) Int. J. Dev. Neurosci. , vol.15 , pp. 433-446
    • Li, L.1    Forge, A.2
  • 61
    • 0027404833 scopus 로고
    • Ultrastructural evidence for hair cell regeneration in the mammalian inner ear
    • Forge A. Ultrastructural evidence for hair cell regeneration in the mammalian inner ear Science 259 1993 1616 1619
    • (1993) Science , vol.259 , pp. 1616-1619
    • Forge, A.1
  • 62
    • 0032551516 scopus 로고    scopus 로고
    • Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs
    • Forge A. Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs J. Comp. Neurol. 397 1998 69 88
    • (1998) J. Comp. Neurol. , vol.397 , pp. 69-88
    • Forge, A.1
  • 63
    • 0027976601 scopus 로고
    • Cell division in the gerbil cochlea after acoustic trauma
    • Roberson D.W., Rubel E.W. Cell division in the gerbil cochlea after acoustic trauma Am. J. Otol. 15 1994 28 34
    • (1994) Am. J. Otol. , vol.15 , pp. 28-34
    • Roberson, D.W.1    Rubel, E.W.2
  • 64
    • 0033049426 scopus 로고    scopus 로고
    • Development of the vertebrate ear: Insights from knockouts and mutants
    • Fekete D.M. Development of the vertebrate ear: insights from knockouts and mutants Trends Neurosci. 22 1999 263 269
    • (1999) Trends Neurosci. , vol.22 , pp. 263-269
    • Fekete, D.M.1
  • 65
    • 0036471398 scopus 로고    scopus 로고
    • Revisiting cell fate specification in the inner ear
    • Fekete D.M., Wu D.K. Revisiting cell fate specification in the inner ear Curr. Opin. Neurobiol. 12 2002 35 42
    • (2002) Curr. Opin. Neurobiol. , vol.12 , pp. 35-42
    • Fekete, D.M.1    Wu, D.K.2
  • 66
    • 0027493926 scopus 로고
    • The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture
    • Kelley M.W. The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture Development 119 1993 1041 1053
    • (1993) Development , vol.119 , pp. 1041-1053
    • Kelley, M.W.1
  • 67
    • 0036398351 scopus 로고    scopus 로고
    • Sensory organ development in the inner ear: Molecular and cellular mechanisms
    • Bryant J. Sensory organ development in the inner ear: molecular and cellular mechanisms Br. Med. Bull. 63 2002 39 57
    • (2002) Br. Med. Bull. , vol.63 , pp. 39-57
    • Bryant, J.1
  • 68
    • 0032538906 scopus 로고    scopus 로고
    • Characterization of atypical cells in the juvenile rat organ of corti after aminoglycoside ototoxicity
    • Daudet N. Characterization of atypical cells in the juvenile rat organ of corti after aminoglycoside ototoxicity J. Comp. Neurol. 401 1998 145 162
    • (1998) J. Comp. Neurol. , vol.401 , pp. 145-162
    • Daudet, N.1
  • 69
    • 0030882545 scopus 로고    scopus 로고
    • Apoptosis and hair cell degeneration in the vestibular sensory epithelia of the guinea pig following a gentamicin insult
    • Lang H., Liu C. Apoptosis and hair cell degeneration in the vestibular sensory epithelia of the guinea pig following a gentamicin insult Hear. Res. 111 1997 177 184
    • (1997) Hear. Res. , vol.111 , pp. 177-184
    • Lang, H.1    Liu, C.2
  • 70
    • 0038118296 scopus 로고    scopus 로고
    • Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo.
    • Kawamoto K. Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J. Neurosci. 23 2003 4395 4400
    • (2003) J. Neurosci. , vol.23 , pp. 4395-4400
    • Kawamoto, K.1
  • 71
    • 0036090708 scopus 로고    scopus 로고
    • Role of trophic factors in the development, survival and repair of primary auditory neurons
    • Marzella P.L., Gillespie L.N. Role of trophic factors in the development, survival and repair of primary auditory neurons Clin. Exp. Pharmacol. Physiol. 29 2002 363 371
    • (2002) Clin. Exp. Pharmacol. Physiol. , vol.29 , pp. 363-371
    • Marzella, P.L.1    Gillespie, L.N.2
  • 72
    • 19544383410 scopus 로고    scopus 로고
    • Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3
    • Wise A.K. Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 J. Comp. Neurol. 487 2005 147 165
    • (2005) J. Comp. Neurol. , vol.487 , pp. 147-165
    • Wise, A.K.1
  • 73
    • 3042756199 scopus 로고    scopus 로고
    • Stem cells as therapy for hearing loss
    • Li H. Stem cells as therapy for hearing loss Trends Mol. Med. 10 2004 309 315
    • (2004) Trends Mol. Med. , vol.10 , pp. 309-315
    • Li, H.1
  • 74
    • 11844284903 scopus 로고    scopus 로고
    • NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear
    • Hu Z. NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear Neurobiol. Dis. 18 2005 184 192
    • (2005) Neurobiol. Dis. , vol.18 , pp. 184-192
    • Hu, Z.1
  • 75
    • 8344260567 scopus 로고    scopus 로고
    • Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear
    • Hu Z. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear Exp. Cell Res. 302 2005 40 47
    • (2005) Exp. Cell Res. , vol.302 , pp. 40-47
    • Hu, Z.1
  • 76
    • 1642270497 scopus 로고    scopus 로고
    • Transplantation of neural stem cells into explants of rat inner ear
    • Fujino K. Transplantation of neural stem cells into explants of rat inner ear Acta Otolaryngol Suppl. 551 2004 31 33
    • (2004) Acta Otolaryngol Suppl. , vol.551 , pp. 31-33
    • Fujino, K.1
  • 77
    • 1642304642 scopus 로고    scopus 로고
    • Application of cell therapy to inner ear diseases
    • Nakagawa T., Ito J. Application of cell therapy to inner ear diseases Acta Otolaryngol Suppl 551 2004 6 9
    • (2004) Acta Otolaryngol Suppl , Issue.551 , pp. 6-9
    • Nakagawa, T.1    Ito, J.2
  • 78
    • 1642393952 scopus 로고    scopus 로고
    • Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens
    • Sakamoto T. Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens Acta Otolaryngol Suppl. 551 2004 48 52
    • (2004) Acta Otolaryngol Suppl. , vol.551 , pp. 48-52
    • Sakamoto, T.1
  • 79
    • 18144389828 scopus 로고    scopus 로고
    • Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve
    • Regala C. Xenografted fetal dorsal root ganglion, embryonic stem cell and adult neural stem cell survival following implantation into the adult vestibulocochlear nerve Exp. Neurol. 193 2005 326 333
    • (2005) Exp. Neurol. , vol.193 , pp. 326-333
    • Regala, C.1
  • 80
    • 3042819733 scopus 로고    scopus 로고
    • Transplantation of bone marrow stromal cells into the cochlea of chinchillas
    • Naito Y. Transplantation of bone marrow stromal cells into the cochlea of chinchillas Neuroreport 15 2004 1 4
    • (2004) Neuroreport , vol.15 , pp. 1-4
    • Naito, Y.1
  • 81
    • 1642368061 scopus 로고    scopus 로고
    • Survival of fetal rat otocyst cells grafted into the damaged inner ear
    • Kojima K. Survival of fetal rat otocyst cells grafted into the damaged inner ear Acta Otolaryngol Suppl. 551 2004 53 55
    • (2004) Acta Otolaryngol Suppl. , vol.551 , pp. 53-55
    • Kojima, K.1
  • 82
    • 0142218376 scopus 로고    scopus 로고
    • Fate of neural stem cells grafted into injured inner ears of mice
    • Tateya I. Fate of neural stem cells grafted into injured inner ears of mice Neuroreport 14 2003 1677 1681
    • (2003) Neuroreport , vol.14 , pp. 1677-1681
    • Tateya, I.1
  • 83
    • 13144259693 scopus 로고    scopus 로고
    • Cell transplantation in Parkinson's disease: How can we make it work?
    • Winkler C. Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci. 28 2005 86 92
    • (2005) Trends Neurosci. , vol.28 , pp. 86-92
    • Winkler, C.1
  • 84
    • 68549122853 scopus 로고    scopus 로고
    • Generation of inner ear hair cell immunophenotypes from neurospheres obtained from fetal rat central nervous system in vitro
    • Kojima K. Generation of inner ear hair cell immunophenotypes from neurospheres obtained from fetal rat central nervous system in vitro Acta Otolaryngol Suppl. 551 2004 26 30
    • (2004) Acta Otolaryngol Suppl. , vol.551 , pp. 26-30
    • Kojima, K.1
  • 85
    • 1342301594 scopus 로고    scopus 로고
    • The potential use of stem cells for cochlear repair
    • Parker M.A., Cotanche D.A. The potential use of stem cells for cochlear repair Audiol. Neurootol. 9 2004 72 80
    • (2004) Audiol. Neurootol. , vol.9 , pp. 72-80
    • Parker, M.A.1    Cotanche, D.A.2
  • 86
    • 0037454942 scopus 로고    scopus 로고
    • Trophic support of mouse inner ear by neural stem cell transplantation
    • Iguchi F. Trophic support of mouse inner ear by neural stem cell transplantation Neuroreport 14 2003 77 80
    • (2003) Neuroreport , vol.14 , pp. 77-80
    • Iguchi, F.1
  • 87
    • 0037162691 scopus 로고    scopus 로고
    • Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi H. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors Cell 110 2002 429 441
    • (2002) Cell , vol.110 , pp. 429-441
    • Nakatomi, H.1
  • 88
    • 0141785164 scopus 로고    scopus 로고
    • A niche for adult neural stem cells
    • Doetsch F. A niche for adult neural stem cells Curr. Opin. Genet. Dev. 13 2003 543 550
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , pp. 543-550
    • Doetsch, F.1
  • 89
    • 0034677891 scopus 로고    scopus 로고
    • Retinal stem cells in the adult mammalian eye
    • Tropepe V. Retinal stem cells in the adult mammalian eye Science 287 2000 2032 2036
    • (2000) Science , vol.287 , pp. 2032-2036
    • Tropepe, V.1
  • 90
    • 0142073815 scopus 로고    scopus 로고
    • Pluripotent stem cells from the adult mouse inner ear
    • Li H. Pluripotent stem cells from the adult mouse inner ear Nat. Med. 9 2003 1293 1299
    • (2003) Nat. Med. , vol.9 , pp. 1293-1299
    • Li, H.1
  • 91
    • 0344633590 scopus 로고    scopus 로고
    • Generation of hair cells by stepwise differentiation of embryonic stem cells
    • Li H. Generation of hair cells by stepwise differentiation of embryonic stem cells Proc. Natl. Acad. Sci. U. S. A. 100 2003 13495 13500
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 13495-13500
    • Li, H.1
  • 92
    • 18044363648 scopus 로고    scopus 로고
    • Regeneration of human auditory nerve. in vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion
    • Rask-Andersen H. Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion Hear. Res. 203 2005 180 191
    • (2005) Hear. Res. , vol.203 , pp. 180-191
    • Rask-Andersen, H.1
  • 93
    • 0014040729 scopus 로고
    • Development of the inner ear of the mouse: A radioautographic study of terminal mitoses
    • Ruben R.J. Development of the inner ear of the mouse: a radioautographic study of terminal mitoses Acta Otolaryngol. Suppl. 220 1967 221 244
    • (1967) Acta Otolaryngol. Suppl. , vol.220 , pp. 221-244
    • Ruben, R.J.1
  • 94
    • 0032007713 scopus 로고    scopus 로고
    • The development of the vertebrate inner ear
    • Torres M., Giraldez F. The development of the vertebrate inner ear Mech. Dev. 71 1998 5 21
    • (1998) Mech. Dev. , vol.71 , pp. 5-21
    • Torres, M.1    Giraldez, F.2
  • 95
    • 0032933174 scopus 로고    scopus 로고
    • P27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    • Chen P., Segil N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti Development 126 1999 1581 1590
    • (1999) Development , vol.126 , pp. 1581-1590
    • Chen, P.1    Segil, N.2
  • 96
    • 0037936843 scopus 로고    scopus 로고
    • Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    • Chen P. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d Nat. Cell Biol. 5 2003 422 426
    • (2003) Nat. Cell Biol. , vol.5 , pp. 422-426
    • Chen, P.1
  • 97
    • 21044454607 scopus 로고    scopus 로고
    • The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    • Mantela J. The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear Development 132 2005 2377 2388
    • (2005) Development , vol.132 , pp. 2377-2388
    • Mantela, J.1
  • 98
    • 13844309351 scopus 로고    scopus 로고
    • Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein
    • Sage C. Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein Science 307 2005 1114 1118
    • (2005) Science , vol.307 , pp. 1114-1118
    • Sage, C.1
  • 99
    • 0033616695 scopus 로고    scopus 로고
    • Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti
    • Lowenheim H. Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti Proc. Natl. Acad. Sci. U. S. A. 96 1999 4084 4088
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 4084-4088
    • Lowenheim, H.1
  • 100
    • 0038440704 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors
    • Fischer P.M. Cyclin-dependent kinase inhibitors Prog. Cell Cycle Res. 5 2003 235 248
    • (2003) Prog. Cell Cycle Res. , vol.5 , pp. 235-248
    • Fischer, P.M.1
  • 101
    • 0347917093 scopus 로고    scopus 로고
    • Cell-cycle targeted therapies
    • Swanton C. Cell-cycle targeted therapies Lancet Oncol. 5 2004 27 36
    • (2004) Lancet Oncol. , vol.5 , pp. 27-36
    • Swanton, C.1
  • 102
    • 0344393019 scopus 로고    scopus 로고
    • Perspectives on cancer therapy: Cell cycle blockers and perturbators
    • Dobashi Y. Perspectives on cancer therapy: cell cycle blockers and perturbators Curr. Med. Chem. 10 2003 2549 2558
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2549-2558
    • Dobashi, Y.1
  • 103
    • 0030070984 scopus 로고    scopus 로고
    • An RT-PCR analysis of mRNA for growth factor receptors in damaged and control sensory epithelia of rat utricles
    • Saffer L.D. An RT-PCR analysis of mRNA for growth factor receptors in damaged and control sensory epithelia of rat utricles Hear. Res. 94 1996 14 23
    • (1996) Hear. Res. , vol.94 , pp. 14-23
    • Saffer, L.D.1
  • 104
    • 0031032087 scopus 로고    scopus 로고
    • Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures
    • Zheng J.L. Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures J. Neurosci. 17 1997 216 226
    • (1997) J. Neurosci. , vol.17 , pp. 216-226
    • Zheng, J.L.1
  • 105
    • 0037684905 scopus 로고    scopus 로고
    • Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants
    • Berggren D. Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants Hear. Res. 180 2003 114 125
    • (2003) Hear. Res. , vol.180 , pp. 114-125
    • Berggren, D.1
  • 106
    • 0035863080 scopus 로고    scopus 로고
    • Intracellular signals that control cell proliferation in mammalian balance epithelia: Key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated protein kinase
    • Montcouquiol M., Corwin J.T. Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated protein kinase J. Neurosci. 21 2001 570 580
    • (2001) J. Neurosci. , vol.21 , pp. 570-580
    • Montcouquiol, M.1    Corwin, J.T.2
  • 107
    • 0035109615 scopus 로고    scopus 로고
    • Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats
    • Montcouquiol M., Corwin J.T. Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats J. Neurosci. 21 2001 974 982
    • (2001) J. Neurosci. , vol.21 , pp. 974-982
    • Montcouquiol, M.1    Corwin, J.T.2
  • 108
    • 3042613348 scopus 로고    scopus 로고
    • Actual targets in cytodifferentiation cancer therapy
    • Gomez-Vidal J.A. Actual targets in cytodifferentiation cancer therapy Curr. Top. Med. Chem. 4 2004 175 202
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 175-202
    • Gomez-Vidal, J.A.1
  • 109
    • 0642349266 scopus 로고    scopus 로고
    • Cell adhesion molecules during inner ear and hair cell development, including notch and its ligands
    • Kelley M.W. Cell adhesion molecules during inner ear and hair cell development, including notch and its ligands Curr. Top. Dev. Biol. 57 2003 321 356
    • (2003) Curr. Top. Dev. Biol. , vol.57 , pp. 321-356
    • Kelley, M.W.1
  • 110
    • 14044258714 scopus 로고    scopus 로고
    • Two contrasting roles for Notch activity in chick inner ear development: Specification of prosensory patches and lateral inhibition of hair-cell differentiation
    • Daudet N., Lewis J. Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development 132 2005 541 551
    • (2005) Development , vol.132 , pp. 541-551
    • Daudet, N.1    Lewis, J.2
  • 111
    • 0037672576 scopus 로고    scopus 로고
    • Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea
    • Zine A. Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea Mol. Neurobiol. 27 2003 223 238
    • (2003) Mol. Neurobiol. , vol.27 , pp. 223-238
    • Zine, A.1
  • 112
    • 0032427792 scopus 로고    scopus 로고
    • Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: Parallels with Drosophila sense-organ development
    • Adam J. Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development Development 125 1998 4645 4654
    • (1998) Development , vol.125 , pp. 4645-4654
    • Adam, J.1
  • 113
    • 0034231601 scopus 로고    scopus 로고
    • Toward the rational design of cell fate modifiers: Notch signaling as a target for novel biopharmaceuticals
    • Zlobin A. Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticals Curr. Pharm. Biotechnol. 1 2000 83 106
    • (2000) Curr. Pharm. Biotechnol. , vol.1 , pp. 83-106
    • Zlobin, A.1
  • 114
    • 0034791336 scopus 로고    scopus 로고
    • SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
    • Wu G. SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation Mol. Cell. Biol. 21 2001 7403 7415
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7403-7415
    • Wu, G.1
  • 115
    • 0032995894 scopus 로고    scopus 로고
    • Delta1 expression during avian hair cell regeneration
    • Stone J.S., Rubel E.W. Delta1 expression during avian hair cell regeneration Development 126 1999 961 973
    • (1999) Development , vol.126 , pp. 961-973
    • Stone, J.S.1    Rubel, E.W.2
  • 116
    • 15844384249 scopus 로고    scopus 로고
    • Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
    • Erkman L. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development Nature 381 1996 603 606
    • (1996) Nature , vol.381 , pp. 603-606
    • Erkman, L.1
  • 117
    • 0031770385 scopus 로고    scopus 로고
    • Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells
    • Xiang M. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells Development 125 1998 3935 3946
    • (1998) Development , vol.125 , pp. 3935-3946
    • Xiang, M.1
  • 118
    • 4744376084 scopus 로고    scopus 로고
    • Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene
    • Hertzano R. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene Hum. Mol. Genet. 13 2004 2143 2153
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2143-2153
    • Hertzano, R.1
  • 119
    • 4744371464 scopus 로고    scopus 로고
    • Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
    • Clough R.L. Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity Biochem. Biophys. Res. Commun. 324 2004 372 381
    • (2004) Biochem. Biophys. Res. Commun. , vol.324 , pp. 372-381
    • Clough, R.L.1
  • 120
    • 0033546004 scopus 로고    scopus 로고
    • Math1: An essential gene for the generation of inner ear hair cells
    • Bermingham N.A. Math1: an essential gene for the generation of inner ear hair cells Science 284 1999 1837 1841
    • (1999) Science , vol.284 , pp. 1837-1841
    • Bermingham, N.A.1
  • 121
    • 13744263559 scopus 로고    scopus 로고
    • Math1 regulates development of the sensory epithelium in the mammalian cochlea
    • Woods C. Math1 regulates development of the sensory epithelium in the mammalian cochlea Nat. Neurosci. 7 2004 1310 1318
    • (2004) Nat. Neurosci. , vol.7 , pp. 1310-1318
    • Woods, C.1
  • 122
    • 0036337481 scopus 로고    scopus 로고
    • The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    • Chen P. The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell fate determination Development 129 2002 2495 2505
    • (2002) Development , vol.129 , pp. 2495-2505
    • Chen, P.1
  • 123
    • 0037705527 scopus 로고    scopus 로고
    • Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1
    • Shou J. Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1 Mol. Cell. Neurosci. 23 2003 169 179
    • (2003) Mol. Cell. Neurosci. , vol.23 , pp. 169-179
    • Shou, J.1
  • 124
    • 0034127584 scopus 로고    scopus 로고
    • Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
    • Zheng J.L., Gao W.Q. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears Nat. Neurosci. 3 2000 580 586
    • (2000) Nat. Neurosci. , vol.3 , pp. 580-586
    • Zheng, J.L.1    Gao, W.Q.2
  • 125
    • 16244411316 scopus 로고    scopus 로고
    • Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
    • Izumikawa M. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals Nat. Med. 11 2005 271 276
    • (2005) Nat. Med. , vol.11 , pp. 271-276
    • Izumikawa, M.1
  • 126
    • 22844435328 scopus 로고    scopus 로고
    • Gene therapy: Cursed or inching towards credibility?
    • Branca M.A. Gene therapy: cursed or inching towards credibility? Nat. Biotechnol. 23 2005 519 521
    • (2005) Nat. Biotechnol. , vol.23 , pp. 519-521
    • Branca, M.A.1
  • 127
    • 0034029614 scopus 로고    scopus 로고
    • Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
    • Helms A.W. Autoregulation and multiple enhancers control Math1 expression in the developing nervous system Development 127 2000 1185 1196
    • (2000) Development , vol.127 , pp. 1185-1196
    • Helms, A.W.1
  • 128
    • 11144262821 scopus 로고    scopus 로고
    • Molecular characterization of conditionally immortalized cell lines derived from mouse early embryonic inner ear
    • Germiller J.A. Molecular characterization of conditionally immortalized cell lines derived from mouse early embryonic inner ear Dev. Dyn. 231 2004 815 827
    • (2004) Dev. Dyn. , vol.231 , pp. 815-827
    • Germiller, J.A.1
  • 129
    • 0037027340 scopus 로고    scopus 로고
    • Cell lines in inner ear research
    • Rivolta M.N., Holley M.C. Cell lines in inner ear research J. Neurobiol. 53 2002 306 318
    • (2002) J. Neurobiol. , vol.53 , pp. 306-318
    • Rivolta, M.N.1    Holley, M.C.2
  • 130
    • 4043183391 scopus 로고    scopus 로고
    • Id genes and proteins as promising targets in cancer therapy
    • Fong S. Id genes and proteins as promising targets in cancer therapy Trends Mol. Med. 10 2004 387 392
    • (2004) Trends Mol. Med. , vol.10 , pp. 387-392
    • Fong, S.1
  • 131
    • 0037228535 scopus 로고    scopus 로고
    • Identification of gene expression profiles in rat ears with cDNA microarrays
    • Lin J. Identification of gene expression profiles in rat ears with cDNA microarrays Hear. Res. 175 2003 2 13
    • (2003) Hear. Res. , vol.175 , pp. 2-13
    • Lin, J.1
  • 132
    • 9444264776 scopus 로고    scopus 로고
    • Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
    • Wine-Lee L. Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord Development 131 2004 5393 5403
    • (2004) Development , vol.131 , pp. 5393-5403
    • Wine-Lee, L.1
  • 133
    • 17844388072 scopus 로고    scopus 로고
    • Sox2 is required for sensory organ development in the mammalian inner ear
    • Kiernan A.E. Sox2 is required for sensory organ development in the mammalian inner ear Nature 434 2005 1031 1035
    • (2005) Nature , vol.434 , pp. 1031-1035
    • Kiernan, A.E.1
  • 134
    • 18444385403 scopus 로고    scopus 로고
    • Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency
    • Palmqvist L. Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency Stem Cells 23 2005 663 680
    • (2005) Stem Cells , vol.23 , pp. 663-680
    • Palmqvist, L.1
  • 135
    • 0037104646 scopus 로고    scopus 로고
    • FGFR1 is required for the development of the auditory sensory epithelium
    • Pirvola U. FGFR1 is required for the development of the auditory sensory epithelium Neuron 35 2002 671 680
    • (2002) Neuron , vol.35 , pp. 671-680
    • Pirvola, U.1
  • 136
    • 0030030195 scopus 로고    scopus 로고
    • Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells
    • Lee K.H., Cotanche D.A. Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells Hear. Res. 94 1996 1 13
    • (1996) Hear. Res. , vol.94 , pp. 1-13
    • Lee, K.H.1    Cotanche, D.A.2
  • 137
    • 16244423015 scopus 로고    scopus 로고
    • Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    • Shim K. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling Dev. Cell 8 2005 553 564
    • (2005) Dev. Cell , vol.8 , pp. 553-564
    • Shim, K.1
  • 138
    • 0042162894 scopus 로고    scopus 로고
    • Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear
    • Stevens C.B. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear Dev. Biol. 261 2003 149 164
    • (2003) Dev. Biol. , vol.261 , pp. 149-164
    • Stevens, C.B.1
  • 139
    • 0642287956 scopus 로고    scopus 로고
    • Neurotrophic factors during inner ear development
    • Pirvola U., Ylikoski J. Neurotrophic factors during inner ear development Curr. Top. Dev. Biol. 57 2003 207 223
    • (2003) Curr. Top. Dev. Biol. , vol.57 , pp. 207-223
    • Pirvola, U.1    Ylikoski, J.2
  • 140
    • 0037347806 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils
    • Hakuba N. Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils Gene Ther. 10 2003 426 433
    • (2003) Gene Ther. , vol.10 , pp. 426-433
    • Hakuba, N.1
  • 141
    • 0035826693 scopus 로고    scopus 로고
    • Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function
    • Kopke R.D. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function Proc. Natl. Acad. Sci. U. S. A. 98 2001 5886 5891
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5886-5891
    • Kopke, R.D.1
  • 142
    • 0032575993 scopus 로고    scopus 로고
    • Transforming growth factor alpha with insulin stimulates cell proliferation in vivo in adult rat vestibular sensory epithelium
    • Kuntz A.L., Oesterle E.C. Transforming growth factor alpha with insulin stimulates cell proliferation in vivo in adult rat vestibular sensory epithelium J. Comp. Neurol. 399 1998 413 423
    • (1998) J. Comp. Neurol. , vol.399 , pp. 413-423
    • Kuntz, A.L.1    Oesterle, E.C.2
  • 143
    • 0037399412 scopus 로고    scopus 로고
    • Tyrosine kinases as targets in cancer therapy - Successes and failures
    • Traxler P. Tyrosine kinases as targets in cancer therapy - successes and failures Expert Opin. Ther. Targets 7 2003 215 234
    • (2003) Expert Opin. Ther. Targets , vol.7 , pp. 215-234
    • Traxler, P.1
  • 144
    • 0037195556 scopus 로고    scopus 로고
    • In vitro activation of extracellular signal-regulated kinase1/2 in the inner ear of guinea pigs
    • Hess A. In vitro activation of extracellular signal-regulated kinase1/2 in the inner ear of guinea pigs Brain Res. 956 2002 236 245
    • (2002) Brain Res. , vol.956 , pp. 236-245
    • Hess, A.1
  • 145
    • 0036421826 scopus 로고    scopus 로고
    • Regeneration in avian hair cell epithelia: Identification of intracellular signals required for S-phase entry
    • Witte M.C. Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry Eur. J. Neurosci. 14 2001 829 838
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 829-838
    • Witte, M.C.1
  • 146
    • 0032032016 scopus 로고    scopus 로고
    • Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
    • Ma Q. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia Neuron 20 1998 469 482
    • (1998) Neuron , vol.20 , pp. 469-482
    • Ma, Q.1
  • 147
    • 0034446983 scopus 로고    scopus 로고
    • Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation
    • Ma Q. Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation J. Assoc. Res. Otolaryngol. 1 2000 129 143
    • (2000) J. Assoc. Res. Otolaryngol. , vol.1 , pp. 129-143
    • Ma, Q.1
  • 148
    • 0034669030 scopus 로고    scopus 로고
    • Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
    • Liu M. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems Genes Dev. 14 2000 2839 2854
    • (2000) Genes Dev. , vol.14 , pp. 2839-2854
    • Liu, M.1
  • 149
    • 0035123017 scopus 로고    scopus 로고
    • NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development
    • Kim W.Y. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development Development 128 2001 417 426
    • (2001) Development , vol.128 , pp. 417-426
    • Kim, W.Y.1
  • 150
    • 2342419491 scopus 로고    scopus 로고
    • Suppression of neural fate and control of inner ear morphogenesis by Tbx1
    • Raft S. Suppression of neural fate and control of inner ear morphogenesis by Tbx1 Development 131 2004 1801 1812
    • (2004) Development , vol.131 , pp. 1801-1812
    • Raft, S.1
  • 151
    • 3843138284 scopus 로고    scopus 로고
    • Islet-1 expression in the developing chicken inner ear
    • Li H. Islet-1 expression in the developing chicken inner ear J. Comp. Neurol. 477 2004 1 10
    • (2004) J. Comp. Neurol. , vol.477 , pp. 1-10
    • Li, H.1
  • 152
    • 0034915989 scopus 로고    scopus 로고
    • Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons
    • Huang E.J. Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons Development 128 2001 2421 2432
    • (2001) Development , vol.128 , pp. 2421-2432
    • Huang, E.J.1
  • 153
    • 0037147757 scopus 로고    scopus 로고
    • Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear
    • Lawoko-Kerali G. Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear J. Comp. Neurol. 442 2002 378 391
    • (2002) J. Comp. Neurol. , vol.442 , pp. 378-391
    • Lawoko-Kerali, G.1
  • 154
    • 1442274674 scopus 로고    scopus 로고
    • GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
    • Lawoko-Kerali G. GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear Mech. Dev. 121 2004 287 299
    • (2004) Mech. Dev. , vol.121 , pp. 287-299
    • Lawoko-Kerali, G.1
  • 155
    • 0035931676 scopus 로고    scopus 로고
    • Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
    • Karis A. Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear J. Comp. Neurol. 429 2001 615 630
    • (2001) J. Comp. Neurol. , vol.429 , pp. 615-630
    • Karis, A.1
  • 156
    • 0033770129 scopus 로고    scopus 로고
    • Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: Immunohistochemistry and antibody perturbation
    • Hossain W.A., Morest D.K. Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: immunohistochemistry and antibody perturbation J. Neurosci. Res. 62 2000 40 55
    • (2000) J. Neurosci. Res. , vol.62 , pp. 40-55
    • Hossain, W.A.1    Morest, D.K.2
  • 157
    • 0034122764 scopus 로고    scopus 로고
    • Role for basic fibroblast growth factor (FGF-2) in tyrosine kinase (TrkB) expression in the early development and innervation of the auditory receptor: In vitro and in situ studies
    • Brumwell C.L. Role for basic fibroblast growth factor (FGF-2) in tyrosine kinase (TrkB) expression in the early development and innervation of the auditory receptor: in vitro and in situ studies Exp. Neurol. 162 2000 121 145
    • (2000) Exp. Neurol. , vol.162 , pp. 121-145
    • Brumwell, C.L.1
  • 158
    • 3242795675 scopus 로고    scopus 로고
    • Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear
    • Varela-Nieto I. Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear Hear. Res. 196 2004 19 25
    • (2004) Hear. Res. , vol.196 , pp. 19-25
    • Varela-Nieto, I.1
  • 159
    • 0035478673 scopus 로고    scopus 로고
    • Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice
    • Camarero G. Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice J. Neurosci. 21 2001 7630 7641
    • (2001) J. Neurosci. , vol.21 , pp. 7630-7641
    • Camarero, G.1
  • 161
    • 0036305336 scopus 로고    scopus 로고
    • Auditory system development: Primary auditory neurons and their targets
    • Rubel E.W., Fritzsch B. Auditory system development: primary auditory neurons and their targets Annu. Rev. Neurosci. 25 2002 51 101
    • (2002) Annu. Rev. Neurosci. , vol.25 , pp. 51-101
    • Rubel, E.W.1    Fritzsch, B.2
  • 162
    • 0346849766 scopus 로고    scopus 로고
    • Neurotrophins in the ear: Their roles in sensory neuron survival and fiber guidance
    • Fritzsch B. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance Prog. Brain Res. 146 2004 265 278
    • (2004) Prog. Brain Res. , vol.146 , pp. 265-278
    • Fritzsch, B.1
  • 163
    • 1542267744 scopus 로고    scopus 로고
    • NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea
    • Tessarollo L. NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea J. Neurosci. 24 2004 2575 2584
    • (2004) J. Neurosci. , vol.24 , pp. 2575-2584
    • Tessarollo, L.1
  • 164
    • 0029014667 scopus 로고
    • Complementary roles of BDNF and NT-3 in vestibular and auditory development
    • Ernfors P. Complementary roles of BDNF and NT-3 in vestibular and auditory development Neuron 14 1995 1153 1164
    • (1995) Neuron , vol.14 , pp. 1153-1164
    • Ernfors, P.1
  • 165
    • 0141676513 scopus 로고    scopus 로고
    • Gradients of neurotrophins, ion channels, and tuning in the cochlea
    • Davis R.L. Gradients of neurotrophins, ion channels, and tuning in the cochlea Neuroscientist 9 2003 311 316
    • (2003) Neuroscientist , vol.9 , pp. 311-316
    • Davis, R.L.1
  • 166
    • 0037083380 scopus 로고    scopus 로고
    • Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons
    • Adamson C.L. Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons J. Neurosci. 22 2002 1385 1396
    • (2002) J. Neurosci. , vol.22 , pp. 1385-1396
    • Adamson, C.L.1
  • 167
    • 5444243357 scopus 로고    scopus 로고
    • Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear
    • Stankovic K. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear J. Neurosci. 24 2004 8651 8661
    • (2004) J. Neurosci. , vol.24 , pp. 8651-8661
    • Stankovic, K.1
  • 168
    • 0037027314 scopus 로고    scopus 로고
    • Understanding inner ear development with gene expression profiling
    • Chen Z.Y., Corey D.P. Understanding inner ear development with gene expression profiling J. Neurobiol. 53 2002 276 285
    • (2002) J. Neurobiol. , vol.53 , pp. 276-285
    • Chen, Z.Y.1    Corey, D.P.2
  • 169
    • 1642310205 scopus 로고    scopus 로고
    • Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization
    • Powles N. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization Dev. Biol. 268 2004 24 38
    • (2004) Dev. Biol. , vol.268 , pp. 24-38
    • Powles, N.1
  • 170
    • 0038006781 scopus 로고    scopus 로고
    • Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: Implications for human hearing and balance disorders
    • Hawkins R.D. Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders Hum. Mol. Genet. 12 2003 1261 1272
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1261-1272
    • Hawkins, R.D.1
  • 171
    • 0035985508 scopus 로고    scopus 로고
    • Gene expression profiles of the rat cochlea, cochlear nucleus, and inferior colliculus
    • Cho Y. Gene expression profiles of the rat cochlea, cochlear nucleus, and inferior colliculus J. Assoc. Res. Otolaryngol. 3 2002 54 67
    • (2002) J. Assoc. Res. Otolaryngol. , vol.3 , pp. 54-67
    • Cho, Y.1
  • 172
    • 0033846660 scopus 로고    scopus 로고
    • Differential display and gene arrays to examine auditory plasticity
    • Lomax M.I. Differential display and gene arrays to examine auditory plasticity Hear. Res. 147 2000 293 302
    • (2000) Hear. Res. , vol.147 , pp. 293-302
    • Lomax, M.I.1
  • 173
    • 0033101832 scopus 로고    scopus 로고
    • Establishment and characterization of conditionally immortalized organ of corti cell lines
    • Kalinec F. Establishment and characterization of conditionally immortalized organ of corti cell lines Cell Biol. Int. 23 1999 175 184
    • (1999) Cell Biol. Int. , vol.23 , pp. 175-184
    • Kalinec, F.1
  • 174
    • 0031916949 scopus 로고    scopus 로고
    • Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus-mediated gene transfer technique
    • Zheng J.L. Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus-mediated gene transfer technique Hear. Res. 117 1998 13 23
    • (1998) Hear. Res. , vol.117 , pp. 13-23
    • Zheng, J.L.1
  • 175
    • 0033232748 scopus 로고    scopus 로고
    • Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells
    • Lawlor P. Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells J. Neurosci. 19 1999 9445 9458
    • (1999) J. Neurosci. , vol.19 , pp. 9445-9458
    • Lawlor, P.1
  • 176
    • 0030859145 scopus 로고    scopus 로고
    • Immortalized cell lines from embryonic avian and murine otocysts: Tools for molecular studies of the developing inner ear
    • Barald K.F. Immortalized cell lines from embryonic avian and murine otocysts: tools for molecular studies of the developing inner ear Int. J. Dev. Neurosci. 15 1997 523 540
    • (1997) Int. J. Dev. Neurosci. , vol.15 , pp. 523-540
    • Barald, K.F.1
  • 177
    • 11144337805 scopus 로고    scopus 로고
    • Ventral otic cell lines as developmental models of auditory epithelial and neural precursors
    • Lawoko-Kerali G. Ventral otic cell lines as developmental models of auditory epithelial and neural precursors Dev. Dyn. 231 2004 801 814
    • (2004) Dev. Dyn. , vol.231 , pp. 801-814
    • Lawoko-Kerali, G.1
  • 178
    • 0036069213 scopus 로고    scopus 로고
    • Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line
    • Rivolta M.N. Transcript profiling of functionally related groups of genes during conditional differentiation of a mammalian cochlear hair cell line Genome Res. 12 2002 1091 1099
    • (2002) Genome Res. , vol.12 , pp. 1091-1099
    • Rivolta, M.N.1
  • 179
    • 0038308411 scopus 로고    scopus 로고
    • A cochlear cell line as an in vitro system for drug ototoxicity screening
    • Kalinec G.M. A cochlear cell line as an in vitro system for drug ototoxicity screening Audiol. Neurootol. 8 2003 177 189
    • (2003) Audiol. Neurootol. , vol.8 , pp. 177-189
    • Kalinec, G.M.1
  • 180
    • 0035660042 scopus 로고    scopus 로고
    • Proteomics and the inner ear
    • Thalmann I. Proteomics and the inner ear Dis. Markers 17 2001 259 270
    • (2001) Dis. Markers , vol.17 , pp. 259-270
    • Thalmann, I.1
  • 181
    • 4544241674 scopus 로고    scopus 로고
    • Proteomics: A primer for otologists
    • McGuire J.F., Casado B. Proteomics: a primer for otologists Otol. Neurotol. 25 2004 842 849
    • (2004) Otol. Neurotol. , vol.25 , pp. 842-849
    • McGuire, J.F.1    Casado, B.2
  • 183
    • 0035810962 scopus 로고    scopus 로고
    • Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes
    • Velloso C.P. Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes Curr. Biol. 11 2001 855 858
    • (2001) Curr. Biol. , vol.11 , pp. 855-858
    • Velloso, C.P.1
  • 184
    • 0033637206 scopus 로고    scopus 로고
    • A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback
    • Legan P.K. A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback Neuron 28 2000 273 285
    • (2000) Neuron , vol.28 , pp. 273-285
    • Legan, P.K.1


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