Local inner-ear drug delivery and pharmacokinetics

Drug Discovery Today

Volumn 10, Issue 19, 2005, Pages 1299-1306

  Salt, Alec N ^a   Plontke, Stefan K R ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS INHIBITOR; BIOPOLYMER; GENTAMICIN; GLUCOCORTICOID; GROWTH FACTOR; NEUROTRANSMITTER; NEUROTRANSMITTER UPTAKE INHIBITOR;

COCHLEA; COCHLEA FENESTRA; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENDOLYMPH; HUMAN; INNER EAR DISEASE; MENIERE DISEASE; NOISE; NONHUMAN; OSMOTIC PUMP; REVIEW; SENSORY NERVE CELL; TINNITUS; VESTIBULAR SYSTEM;

EID: 26244433867     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03574-9     Document Type: Review

References (94)

1. Ersner M.S. Transtympanic injection of anesthetics for the treatment of Menière's Syndrome AMA Arch. Otolaryngol. 54 1951 43 52
2. Völger G. Beseitigung von Labyrinthliquordruckstörungen bei dem Menièrschen Symptomkomplex durch das Hyaluronidasepräparat Kinetin HNO 3 1952 142 147
3. Schuknecht H.F. Ablation therapy for the relief of Meniere's disease Laryngoscope 66 1956 859 870
4. Nedzelski J.M. Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Meniere's disease Am. J. Otol. 13 1992 18 22
5. Toth A.A., Parnes L.S. Intratympanic gentamicin therapy for Meniere's disease: preliminary comparison of two regimens J. Otolaryngol. 24 1995 340 344
6. Minor L.B. Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy Am. J. Otol. 20 1999 209 219
7. Lange G. Long-term results after interval therapy with intratympanic gentamicin for Meniere's disease Laryngoscope 114 2004 102 105
8. Carey J. Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo Otolaryngol. Clin. North Am. 37 2004 1075 1090
9. Parnes L.S. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application Laryngoscope 109 1999 1 17
10. Kopke R.D. Targeted topical steroid therapy in sudden sensorineural hearing loss Otol. Neurotol. 22 2001 475 479
11. Chandrasekhar S.S. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation Otol. Neurotol. 22 2001 18 23
12. Gianoli G.J., Li J.C. Transtympanic steroids for treatment of sudden hearing loss Otolaryngol. Head Neck Surg 125 2001 142 146
13. Lefebvre P.P., Staecker H. Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study Acta Otolaryngol. 122 2002 698 702
14. Gouveris H. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy Eur. Arch. Otorhinolaryngol. 262 2005 131 134
15. Ho H.G. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment Laryngoscope 114 2004 1184 1189
16. Plontke, S. et al. Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning of randomized controlled trials. Acta Otolaryngol. (in press).
17. Itoh A., Sakata E. Treatment of vestibular disorders Acta Otolaryngol. Suppl. 481 1991 617 623
18. Shea J.J. Jr, Ge X. Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Meniere's disease Otolaryngol. Clin. North Am. 29 1996 353 358
19. Silverstein H. Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial Am. J. Otol. 19 1998 196 201
20. Sennaroglu L. Transtympanic dexamethasone application in Meniere's disease: an alternative treatment for intractable vertigo J. Laryngol. Otol. 113 1999 217 221
21. Coles R.R. Intra-tympanic injections in the treatment of tinnitus Clin. Otolaryngol. 17 1992 240 242
22. Silverstein H. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report) Ear Nose Throat J. 75 1996 468 471 474, 476 passim.
23. Sakata E. Clinical experiences of steroid targeting therapy to inner ear for control of tinnitus Int. Tinnitus J. 3 1997 117 121
24. Shulman A., Goldstein B. Intratympanic drug therapy with steroids for tinnitus control: a preliminary report Int. Tinnitus J. 6 2000 10 20
25. Cesarani A. Intratympanic dexamethasone treatment for control of subjective idiopathic tinnitus: our clinical experience Int. Tinnitus J. 8 2002 111 114
26. Ristow W. Zur Behandlung der Menière-Krankheit mittels temporärer Labyrinthanästhesie Z. Laryngol. Rhinol. Otol. 47 1968 442 448
27. Schwab B. Laryngorhinootologie 83 2004 164 172
28. Keithley E.M. GDNF protects the cochlea against noise damage Neuroreport 9 1998 2183 2187
29. Shoji F. Differential protective effects of neurotrophins in the attenuation of noise-induced hearing loss Hear. Res. 146 2000 134 142
30. Li G. Round window membrane delivery of l-methionine provides protection from cisplatin ototoxicity without compromising chemotherapeutic efficacy Neurotoxicology 22 2001 163 176
31. Korver K.D. Round window application of d-methionine provides complete cisplatin otoprotection Otolaryngol. Head Neck Surg. 126 2002 683 689
32. Wang J. Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig Neuroscience 111 2002 635 648
33. Wang J. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss J. Neurosci. 23 2003 8596 8607
34. Chen Z. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs Audiol. Neurootol. 8 2003 49 56
35. Hight N.G. Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA Hear. Res. 179 2003 21 32
36. Takemura K. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig Hear. Res. 196 2004 58 68
37. Raphael Y. Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo. Neurosci. Lett. 207 1996 137 141
38. Lalwani A.K. Development of in vivo gene therapy for hearing disorders: introduction of adeno-associated virus into the cochlea of the guinea pig Gene Ther. 3 1996 588 592
39. Dazert S. Transfection of neonatal rat cochlear cells in vitro with an adenovirus vector Int. J. Dev. Neurosci. 15 1997 595 600
40. Staecker H. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss Otolaryngol. Head Neck Surg. 119 1998 7 13
41. Stover T. Cochlear gene transfer: round window versus cochleostomy inoculation Hear. Res. 136 1999 124 130
42. Kawamoto K. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity Mol. Ther. 9 2004 173 181
43. Izumikawa M. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals Nat. Med. 11 2005 271 276
44. Tran Ba Huy P. Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs J. Clin. Invest. 77 1986 1492 1500
45. Hoffer M.E. Use of sustained release vehicles in the treatment of Meniere's disease Otolaryngol. Clin. North Am. 30 1997 1159 1166
46. Bachmann G. Permeabilität der runden Fenstermembran für Prednisolon-21-Hydrogensuccinat HNO 49 2001 538 542
47. Hibi T. Perilymphatic concentration of gentamicin administered intratympanically in guinea pigs Acta Otolaryngol. 121 2001 336 341
48. Thomsen J. Preliminary results of a new delivery system for gentamicin to the inner ear in patients with Meniere's disease Eur. Arch. Otorhinolaryngol. 257 2000 362 365
49. Schoendorf J. Continuous intratympanic infusion of gentamicin via a microcatheter in Meniere's disease Otolaryngol. Head Neck Surg. 124 2001 203 207
50. Salt A.N., Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane Hear. Res. 154 2001 88 97
51. Salt A.N. Simulation of methods for drug delivery to the cochlear fluids Adv. Otorhinolaryngol. 59 2002 140 148
52. Hobbie R.K. Transport in an infinite medium Intermediate Physics for Medicine and Biology 1997 Springer 85 90
53. Goycoolea M.V. Clinical aspects of round window membrane permeability under normal and pathological conditions Acta Otolaryngol 121 2001 437 447
54. Chandrasekhar S.S. Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents Otolaryngol. Head Neck Surg. 122 2000 521 528
55. Selivanova O. The effects of Streptolysin-O and sodium hyaluronate on the permeability of the round window membrane in guinea pigs - an electrophysiologic study Laryngorhinootologie 82 2003 235 239
56. Salt A.N. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid Hear. Res. 182 2003 24 33
57. Ohyama K. Volume flow rate of perilymph in the guinea-pig cochlea Hear. Res. 35 1988 119 129
58. Salt A.N. Radial communication between the perilymphatic scalae of the cochlea. II: Estimation by bolus injection of tracer into the sealed cochlea Hear. Res. 56 1991 37 43
59. Plontke S. Analysis of gentamicin kinetics in fluids of the inner ear with round window administration Otol. Neurotol. 23 2002 967 974
60. Saijo S., Kimura R.S. Distribution of HRP in the inner ear after injection into the middle ear cavity Acta Otolaryngol. 97 1984 593 610
61. Salt A.N. Direct measurement of longitudinal endolymph flow rate in the guinea pig cochlea Hear. Res. 23 1986 141 151
62. Plontke S.K., Salt A.N. Quantitative interpretation of corticosteroid pharmacokinetics in inner ear fluids using computer simulations Hear. Res. 182 2003 34 42
63. Laurell G. Local administration of antioxidants to the inner ear. Kinetics and distribution(1) Hear. Res. 173 2002 198 209
64. Hoffer M.E. Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function Laryngoscope 111 2001 1343 1357
65. Arnold W. Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs Audiol. Neurootol. 10 2005 53 63
66. Thorne M. Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images Laryngoscope 109 1999 1661 1668
67. Shinomori Y. Volumetric and dimensional analysis of the guinea pig inner ear Ann. Otol. Rhinol. Laryngol. 110 2001 91 98
68. Scheibe F. On sources of error in the biochemical study of perilymph (guinea pig) Arch. Otorhinolaryngol. 240 1984 43 48
69. Hara A. Perilymph composition in scala tympani of the cochlea: influence of cerebrospinal fluid Hear. Res. 42 1989 265 271
70. Balough B.J. Kinetics of gentamicin uptake in the inner ear of Chinchilla langier after middle-ear administration in a sustained-release vehicle Otolaryngol. Head Neck Surg. 119 1998 427 431
71. Hoffer M.E. Morphologic changes in the inner ear of chinchilla laniger after middle ear administration of gentamicin in a sustained-release vehicle Otolaryngol. Head Neck Surg. 120 1999 643 648
72. th Annual Meeting of the Association for Research in Otolaryngology. 22-27 February 2004, Daytona Beach, FL, USA (Abstract No.1552).
73. Hunter B.A. Estimation of perilymph concentration of agents applied to the round window membrane by microdialysis Acta Otolaryngol. 123 2003 453 458
74. th Annual Meeting of the Association for Research in Otolaryngology. 19-24 February 2005, New Orleans, LA, USA (Abstract No. 874).
75. Becvarovski Z. Round window gentamicin absorption: An in vivo human model Laryngoscope 112 2002 1610 1613
76. Wise D.L. Handbook of pharmaceutical controlled release technology 2000 Marcel Dekker
77. Lange G. 27 years experiences with transtympanic aminoglycoside treatment of Meniere's disease Laryngorhinootologie 74 1995 720 723
78. Schuknecht H.F. Ablation therapy in the management of Meniere's disease Acta Otolaryngol. 47 1957 1 42
79. Arriaga M.A., Goldman S. Hearing results of intratympanic steroid treatment of endolymphatic hydrops Laryngoscope 108 1998 1682 1685
80. Kroath F. Transtympanale Injektion zur Behandlung des Menièreschen Syndroms Z. Laryngol. Rhinol. Otol. 39 1960 190 195
81. Silverstein H. Direct round window membrane application of gentamicin in the treatment of Meniere's disease Otolaryngol. Head Neck Surg. 120 1999 649 655
82. Alzamil K.S., Linthicum F.H. Jr Extraneous round window membranes and plugs: possible effect on intratympanic therapy Ann Otol Rhinol Laryngol 109 2000 30 32
83. Plontke S.K. Transtympanic endoscopy for drug delivery to the inner ear using a new microendoscope Adv. Otorhinolaryngol. 59 2002 149 155
84. Silverstein H. Use of a new device, the Microwick, to deliver medication to the inner ear Ear Nose Throat J. 78 1999 595 598
85. Brown J.N. Osmotic pump implant for chronic infusion of drugs into the inner ear Hear. Res. 70 1993 167 172
86. Prieskorn D.M., Miller J.M. Technical report: chronic and intracochlear infusion in rodents Hear. Res. 140 2000 212 215
87. Lehner R. A totally implantable drug delivery system for local therapy of the middle and inner ear Ear Nose Throat J. 76 1997 567 570
88. Praetorius M. A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model Audiol. Neurootol. 6 2001 250 258
89. Paasche G. Technical report: modification of a cochlear implant electrode for drug delivery to the inner ear Otol. Neurotol. 24 2003 222 227
90. th Annual Meeting of the Association for Research in Otolaryngology. 19-24 February 2005, New Orleans, LA, USA (Abstract No. 158).
91. Park K. Biodegradable hydrogels for drug delivery 1993 Technomic Publishing Company
92. Okano T. Biorelated polymers and gels: controlled release and applications in biomedical engineering 1998 Academic Press
93. th Annual Meeting of the Association for Research in Otolaryngology, 22-27 February 2004, Daytona Beach, FL, USA (Abstract No. 1054).
94. Scarpidis U. Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation Otol. Neurotol. 24 2003 409 417