Inhibition of either phosphatidylinositol 3-kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer cell lines, but MEK/ERK signaling is critical for cell survival

Breast Cancer Research and Treatment

Volumn 93, Issue 2, 2005, Pages 177-188

  Ripple, Maureen O ^a,b   Kalmadi, Sahana ^a,b   Eastman, Alan ^a,b  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b NORRIS COTTON CANCER CENTER   (United States)

Author keywords

Apoptosis; Bcl 2; Breast cancer cell lines; LY294002; Signal transduction inhibitors; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE B;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER SURVIVAL; CELL DEATH; CELL IMMORTALIZATION; CELL KILLING; CELL PROTECTION; CELL SIZE; CELL VIABILITY; CULTURE MEDIUM; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FUNCTIONAL ASSESSMENT; INCUBATION TIME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; BREAST NEOPLASMS; BUTADIENES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NITRILES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 25844469620     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-005-4794-6     Document Type: Article

References (53)

1. MC Raff 1992 Social controls on cell survival and cell death Nature 356 397 400
2. H Dudek SR Datta MJ Brinbaum R Yao GM Cooper RA Segal DR Kaplan ME Greenberg 1997 Regulation of neuronal survival by the serine-threonine protein kinase Akt Science 275 661 665
3. A Kauffmann-Zeh P Rodriquez-Viciana E Ulrich C Gilbert P Coffer J Downward G Evan 1997 Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB Nature 385 544 548
4. SG Kennedy AJ Wagner SD Conzen J Jordan A Bellacosa PN Tsichlis N Hay 1997 The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes Dev 11 701 713
5. B Vanhaesebroeck DR Alessi 2000 The PI3K-PDK1 connection: more than just a road to PKB Biochem J 346 561 576
6. SR Datta A Brunet ME Greenberg 1999 Cellular survival: a play in three Akts Genes Dev 13 2905 2927
7. ES Kandel N Hay 1999 The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB Exp Cell Res 253 210 229
8. TA Stadheim H Xiao A Eastman 2001 The inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells Cancer Res 61 1533 1540
9. P Blume-Jensen T Hunter 2001 Oncogenic kinase signalling Nature 411 355 365
10. D Harari Y Yarden 2000 Molecular mechanisms underlying Erb2/HER2 action in breast cancer Oncogene 19 6102 6114
11. V Papa V Pexxino A Constantino A Belfiore D Giuffrida L Frittitta GB Vannelli R Brand ID Goldfine R Vigneri 1990 Elevated insulin receptor content in human breast cancer J Clin Invest 86 1503 1510
12. V Papa B Gliozzo GM Clark WL McGuire D Moore Y Fujita-Yamaguchi R Vigneri ID Goldfine V Peaaino 1993 Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer Cancer Res 53 3736 3740
13. MJ Mauro ME O'Dwyer BJ Druker 2000 STI571, a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia: validating the promise of molecularly targeted therapy Cancer Chemother Pharmacol 48 S77 S78
14. GW Sledge KD Miller 2003 Exploiting the hallmarks of cancer. The future conquest of breast cancer Eur J Cancer 39 1668 1675
15. RJ Kreitman WH Wilson K Bergeron M Raggio M Stetler-Stevenson DJ Fitzgerald I Pastan 2001 Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia N Eng J Med 345 241 247
16. A Jemal T Murray A Samuels A Ghafoor E Ward MJ Thun 2003 Cancer statistics CA Cancer J Clin 53 5 26
17. I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-kinase-AKT pathway in human cancer Nature Rev Cancer 2 489 501
18. R Rago J Mitchen G Wilding 1990 DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water Anal Biochem 191 31 34
19. K Yu L Toral-Barza C Discafani WG Zhang J Skotnicki P Frost JJ Gibbons 2001 mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer Endocr Relat Cancer 8 249 258
20. J Brognard AS Clark Y Ni PA Dennis 2001 Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res 61 3986 3997
21. AS Clark K West S Streicher PA Dennis 2002 Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells Mol Cancer Therapat 1 707 717
22. DJ Slamon GM Clark SG Wong WJ Levin A Ullrich WL McGuire 1987 Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 177 181
23. DJ Slamon W Godolphin LA Jones JA Holt SG Wong DE Keith WJ Levin SG Stuart J Udove A Ullrich 1989 Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer Science 244 707 712
24. JRC Sainsbury GV Sherbet JR Farndon AL Harris 1985 Epidermal-growth- factor receptors and oestrogen receptors in human breast cancer Lancet 325 364 366
25. RK Hansen MJ Bissell 2000 Tissue architecture and breast cancer: the role of extracelllular matrix and steroid hormones Endocr Relat Cancer 7 95 113
26. M Hori S Inagawa J Shimazaki M Itabashi 2000 Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage of human breast cancer Pathol Res Pract 196 817 826
27. SC Kozma ME Bogaard K Buser SM Saurer JL Bos B Groner NE Hynes 1987 The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231 Nucl Acids Res 15 5963 5971
28. SP Davies H Reddy M Caivano P Cohen 2000 Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem J 351 95 105
29. N Filippa CL Sable C Filloux B Hemmings E Van Obberghen 1999 Mechanisms of protein kinase B activation by cyclic AMP-dependent protein kinase Mol Cell Biol 19 4989 5000
30. S Yano H Tokumitsu TR Soderling 1998 Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase B pathway Nature 396 584 587
31. U Hermanto CS Zong L-H Wang 2000 Inhibition of mitogen-activated protein kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor 1-mediated mitogen-activated protein kinase activation Cell Growth Differ 11 655 664
32. L, and Mcl-1 and promotes survival of human pancreatic cancer cells J Cell Biochem 79 3555 369
33. E Berra MT Diaz-Mecco J Moscat 1998 The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway J Biol Chem 273 10792 10797
34. J Brognard PA Dennis 2002 Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants Cell Death Differ 9 893 904
35. S Cory JM Adams 2002 The Bcl-2 family: regulators of the cellular life-or-death switch Nature Rev Cancer 2 647 656
36. Y Hu WH Dragowska A Wallis V Duronio L Mayer 2001 Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer Breast Cancer Res Treat 70 11 20
37. S Haldar N Jena CM Croce 1995 Inactivation of Bcl-2 by phosphorylation Proc Natl Acad Sci USA 92 4507 4511
38. T Ito X Deng B Carr WS May 1997 Bcl-2 phosphorylation required for anti-apoptosis function J Biol Chem 272 11671 11673
39. PP Ruvolo X Deng WS May 2001 Phosphorylation of Bcl2 and regulation of apoptosis Leukemia 15 515 522
40. L by the MAPK/Erk kinase J Biol Chem 274 31108 31113
41. SR Datta H Dudek X Tao S Masters H Fu Y Gotoh ME Greenberg 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 231 241
42. N Donovan EBE Becker Y Konishi A Bonni 2002 JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery J Biol Chem 277 40944 40949
43. M Maemura SK Akiyama VL Woods RB Dickson 1995 Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells Clin Exp Metastasis 13 223 235
44. G Zugmaier BW Ennis B Deschauer D Katz C Knabbe G Wilding P Daly ME Lippman RB Dickson 1989 Transforming growth factors type beta 1 and beta 2 are equipotent growth inhibitors of human breast cancer cell lines J Cell Physiol 141 353 361
45. J Filmus MN Pollak R Cailleau RN Buick 1985 MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF Biochem Biophys Res Commun 128 898 905
46. CL Arteaga SD Hurd TC Dugger AR Winnier JB Robertson 1994 Epidermal growth factor receptors in human breast carcinoma cells: a potential selective target for transforming growth factor alpha-Pseudomonas exotoxin 40 fusion protein Cancer Res 54 4703 4709
47. KB Reddy VG Keshamouni YQ Chen 1999 The level of tyrosine kinase activity regulates the expression of p21/WAF1 in cancer cells Int J Oncol 15 301 306
48. A Esparis-Ogando E Diaz-Rodriguez JC Montero L Yuste P Crespo A Pandiella 2002 Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2 Mol Cell Biol 22 270 285
49. W Nieves-Niera 1999 Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways Int J Cancer 82 396 404
50. J Li C Yen D Liaw K Podsyanina S Bose SI Wang J Puc C Miliaresis L Rodgers R McCombie SH Bigner BC Giovanella M Ittmann B Tycko H Hibshoosh MH Wigler R Parsons 1997 PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer Science 275 1876 1878
51. LP Weng WM Smith PL Dahia U Ziebold E Gil JA Lees C Eng 1999 PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death Cancer Res 59 5808 5814
52. Y Lu YZ Lin R LaPushin B Cuevas X Fang SX Yu MA Davies H Khan T Furui M Mao R Zinner MC Hung P Steck K Siminovitch GB Mills 1999 The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells Oncogene 18 7034 7045
53. A Perren LP Weng AH Boag U Ziebold K Thakore PL Dahia P Komminoth JA Lees LM Mulligan GL Mutter C Eng 1999 Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast Am J Pathol 155 1253 1260