Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants

Cell Death and Differentiation

Volumn 9, Issue 9, 2002, Pages 893-904

  Brognard, J ^a   Dennis, P A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Chemotherapy; ERK; Kinase; Lung cancer

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; ONCOPROTEIN; PACLITAXEL; PROTEIN P21; PROTEIN P27; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSTASIS; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MUTANT; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; G0 PHASE; HUMANS; LUNG NEOPLASMS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION; VARIATION (GENETICS);

EID: 0036719080     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401054     Document Type: Article

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