Tissue architecture and breast cancer: The role of extracellular matrix and steroid hormones

Endocrine-Related Cancer

Volumn 7, Issue 2, 2000, Pages 95-113

  Hansen, R K ^a   Bissell, M J ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; PROGESTERONE; PROGESTERONE RECEPTOR; STEROID HORMONE;

ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST DEVELOPMENT; CELL ADHESION; DISEASE MODEL; EXTRACELLULAR MATRIX; HORMONE ACTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0033867148     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0070095     Document Type: Article

References (213)

1. Adam L, Crepin M, Lelong JC, Spanakis E & Israel L 1994 Selective interactions between mammary epithelial cells and fibroblasts in co-culture. International Journal of Cancer 59 262-268.
2. Adams JC & Watt FM 1993 Regulation of development and differentiation by the extracellular matrix. Development 117 1183-1198.
3. van Agthoven T, Timmermans M, Foekens JA, Dorssers LC & Henzen-Logmans SC 1994 Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry. American Journal of Pathology 144 1238-1246.
4. Alford D & Taylor-Papadimitriou J 1996 Cell adhesion molecules in the normal and cancerous mammary gland. Journal of Mammary Gland Biology and Neoplasia 1 207-218.
5. Ali S, Metzger D, Bornert JM & Chambon P 1993 Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBO Journal 12 1153-1160.
6. Altmannsberger M, Dirk T, Droese M, Weber K & Osborn M 1986 Keratin polypeptide distribution in benign and malignant breast tumors: subdivision of ductal carcinomas using monoclonal antibodies. Virchows Archiv B. Cell Pathology Including Molecular Pathology 51 265-275.
7. Andres JL, Stanley K, Cheifetz S & Massague J 1989 Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta. Journal of Cell Biology 109 3137-3145.
8. Arnold SF, Obourn JD, Jaffe H & Notides AC 1994 Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Molecular Endocrinology 8 1208-1214.
9. Arnold SF, Melamed M, Vorojeikina DP, Notides AC & Sasson S 1997 Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation. Molecular Endocrinology 11 48-53.
10. Band V, Zajchowski D, Swisshelm K, Trask D, Kulesa V, Cohen C, Connolly J & Sager R 1990 Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Research 50 7351-7357.
11. Bani D, Riva A, Bigazzi M & Bani Sacchi T 1994 Differentiation of breast cancer cells in vitro is promoted by the concurrent influence of myoepithelial cells and relaxin. British Journal of Cancer 70 900-904.
12. Barcellos-Hoff MH, Aggeler J, Ram TG & Bissell MJ 1989 Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105 223-235.
13. Bartek J, Bartkova J, Kyprianou N, Lalani EN, Staskova Z, Shearer M, Chang S & Taylor-Papadimitriou J 1991 Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus. PNAS 88 3520-3524.
14. Beardmore JM & Richards RC 1983 Concentrations of epidermal growth factor in mouse milk throughout lactation. Journal of Endocrinology 96 287-292.
15. Beato M & Sanchez-Pacheco A 1996 Interaction of steroid hormone receptors with the transcription initiation complex. Endocrine Reviews 17 587-609.
16. Beckmann MW, Niederacher D, Schnurch HG, Gusterson BA & Bender HG 1997 Multistep carcinogenesis of breast cancer and tumour heterogeneity. Journal of Molecular Medicine 75 429-439.
17. Benaud C, Dickson RB & Thompson EW 1998 Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Research and Treatment 50 97-116.
18. Berdichevsky F, Alford D, D'Souza B & Taylor-Papadimitriou J 1994 Branching morphogenesis of human mammary epithelial cells in collagen gels. Journal of Cell Science 107 3557-3568.
19. Berthois Y, Dong XF & Martin PM 1989 Regulation of epidermal growth factor-receptor by estrogen and antiestrogen in the human breast cancer cell line MCF-7. Biochemical and Biophysical Research Communications 159 126-131.
20. Bissell MJ & Hall HG 1987 Form and function in the mammary gland: the role of extracellular matrix. In The Mammary Gland, pp 97-146. Eds MC Neville & CW Daniel. New York, Plenum Publishing Corporation.
21. Bissell MJ, Hall HG & Parry G 1982 How does the extracellular matrix direct gene expression? Journal of Theoretical Biology 99 31-68.
22. Bissell MJ, Weaver VM, Lelievre SA, Wang F, Petersen OW & Schmeichel KL 1999 Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Research 59 1757-1763s; discussion 1763s-1764s.
23. Bocchinfuso WP & Korach KS 1997 Mammary gland development and tumorigenesis in estrogen receptor knockout mice. Journal of Mammary Gland Biology and Neoplasia 2 323-334.
24. Bocker W, Bier B, Freytag G, Brommelkamp B, Jarasch ED, Edel G, Dockhorn-Dwomiczak B & Schmid KW 1992 An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: epitheliosis and ductal carcinoma in situ. Virchows Archiv A. Pathological Anatomy and Histopathology 421 323-330.
25. Briand P, Petersen OW & Van Deurs B 1987 A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cellular and Developmental Biology 23 181-188.
26. Briand P, Nielsen KV, Madsen MW & Petersen OW 1996 Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal. Cancer Research 56 2039-2044.
27. Bunone G, Briand PA, Miksicek RJ & Picard D 1996 Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO Journal 15 2174-2183.
28. Carpenter G 1980 Epidermal growth factor is a major growth-promoting agent in human milk. Science 210 198-199.
29. Chalbos D & Galtier F 1994 Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription. Journal of Biological Chemistry 269 23007-23012.
30. Chambers AF & Matrisian LM 1997 Changing views of the role of matrix metalloproteinases in metastasis. Journal of the National Cancer Institute 89 1260-1270.
31. Chrysogelos SA, Yarden RI, Lauber AH & Murphy JM 1994 Mechanisms of EGF receptor regulation in breast cancer cells. Breast Cancer Research and Treatment 31 227-236.
32. Clark EA & Brugge JS 1995 Integrins and signal transduction pathways: the road taken. Science 268 233-239.
33. Clark R, Stampfer MR, Milley R, O'Rourke E, Walen KH, Kriegler M, Kopplin J & McCormick F 1988 Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Research 48 4689-4694.
34. Cowley SM, Hoare S, Mosselman S & Parker MG 1997 Estrogen receptors alpha and beta form heterodimers on DNA. Journal of Biological Chemistry 272 19858-19862.
35. Cunha GR, Young P, Hom YK, Coole PS, Taylor JA & Lubahn DR 1997 Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombination experiments. Journal of Mammary Gland Biology and Neoplasia 2 393-402.
36. Dairkee SH, Puett L & Hackett AJ 1988 Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. Journal of the National Cancer Institute 80 691-695.
37. Dedhar S & Hannigan GE 1996 Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Current Opinion in Cell Biology 8 657-669.
38. Delcommenne M & Streuli CH 1995 Control of integrin expression by extracellular matrix. Journal of Biological Chemistry 270 26794-26801.
39. Deng G, Lu Y, Zlotnikov G, Thor AD & Smith HS 1996 Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274 2057-2059.
40. Dotzlaw H, Miller T, Karvelas J & Murphy LC 1990 Epidermal growth factor gene expression in human breast cancer biopsy samples: relationship to estrogen and progesterone receptor gene expression. Cancer Research 50 4204-4208.
41. Dotzlaw H, Leygue E, Watson PH & Murphy LC 1997 Expression of estrogen receptor-beta in human breast tumors. Journal of Clinical Endocrinology and Metabolism 82 2371-2374.
42. Du X, Gu M, Weisel JW, Nagaswami C, Bennett JS, Bowditch R & Ginsberg MH 1993 Long range propagation of conformational changes in integrin alpha IIb beta 3. Journal of Biological Chemistry 268 23087-23092.
43. Durbeej M, Henry MD & Campbell KP 1998 Dystroglycan in development and disease. Current Opinion in Cell Biology 10 594-601.
44. Dvorak HF 1986 Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. New England Journal of Medicine 315 1650-1659.
45. Earp HS, Dawson TL, Li X & Yu H 1995 Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research. Breast Cancer Research and Treatment 35 115-132.
46. Emerman JT & Pitelka DR 1977 Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro 13 316-328.
47. Emerman JT, Enami J, Pitelka DR & Nandi S 1977 Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes. PNAS 74 4466-4470.
48. Enmark E & Gustafsson JA 1998 Estrogen receptor beta - a novel receptor opens up new possibilities for cancer diagnosis and treatment. Endocrine-Related Cancer 5 213-222.
49. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240 889-895.
50. Fitzpatrick SL, Brightwell J, Wittliff JL, Barrows GH & Schultz GS 1984 Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels. Cancer Research 44 3448-3453.
51. Foster CS, Smith CA, Dinsdale EA, Monaghan P & Neville AM 1983 Human mammary gland morphogenesis in vitro: the growth and differentiation of normal breast epithelium in collagen gel cultures defined by electron microscopy, monoclonal antibodies, and autoradiography. Developmental Biology 96 197-216.
52. Fox SB & Harris AL 1997 The epidermal growth factor receptor in breast cancer. Journal of Mammary Gland Biology and Neoplasia 2 131-141.
53. Fuqua SA, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley BW & McGuire WL 1991 Variant human breast tumor estrogen receptor with constitutive rranscriptional activity. Cancer Research 51 105-109.
54. Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH & Matrisian LM 1994 Structure and expression of the human gene for the matrix metalloproteinase matrilysin. Journal of Biological Chemistry 269 2032-2040.
55. Gaub MP, Bellard M, Scheuer I, Chambon P & Sassone-Corsi P 1990 Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell 63 126-1276.
56. Giancotti FG & Ruoslahti E 1999 Integrin signaling. Science 285 1028-1032.
57. Giangrande PH & McDonnell DP 1999 The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Progress in Hormone Research 54 291-313.
58. Glass CK, Rose DW & Rosenfeld MG 1996 Nuclear receptor coactivators. Current Opinion in Cell Biology 9 222-232.
59. Glukhova M, Koteliansky V, Sastre X & Thiery JP 1995 Adhesion systems in normal breast and in invasive breast carcinoma. American Journal of Pathology 146 706-716.
60. Gompel A, Martin A, Simon P, Schoevaert D, Plu-Bureau G, Hugol D, Audouin J, Leygue E, True JB & Poitout P 1996 Epidermal growth factor receptor and c-erbB-2 expression in normal breast tissue during the menstrual cycle. Breast Cancer Research and Treatment 38 227-235.
61. Gould MN 1993 Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats. Seminars in Cancer Biology 4 161-169.
62. Green S, Walter P, Greene G, Krust A, Goffin C, Jensen E, Scrace G, Waterfield M & Chambon P 1986 Cloning of the human oestrogen receptor cDNA. Journal of Steroid Biochemistry 24 77-83.
63. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y & Shine J 1986 Sequence and expression of human estrogen receptor complementary DNA. Science 231 1150-1154.
64. Grobstein C 1967 Mechanisms of organogenetic tissue interaction. National Cancer Institute Monographs 26 279-299.
65. Groshong SD, Owen GI, Grimison B, Schauer IE, Todd MC, Langan TA, Sclafani RA, Lange CA & Horwitz KB 1997 Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p 21 and p 27(Kipl). Molecular Endocrinology 11 1593-1607.
66. Guelstein VI, Tchypysheva TA, Ermilova VD, Litvinova LV, Troyanovsky SM & Bannikov GA 1988 Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. International Journal of Cancer 42 147-153.
67. Gui GP, Wells CA, Browne PD, Yeomans P, Jordan S, Puddefoot JR, Vinson GP & Carpenter R 1995 Integrin expression in primary breast cancer and its relation to axillary nodal status. Surgery 117 102-108.
68. Gusterson BA, Warburton MJ, Mitchell D, Ellison M, Neville AM & Rudland PS 1982 Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Research 42 4763-1770.
69. Hallowes RC, Bone EJ & Jones W 1980 A new dimension in the culture of human breast. In Tissue Culture in Medical Research (II). Proceedings of the Second International Symposium, Cardiff, Wales, UK, pp 213-220. Eds J Richards & KT Rajan. London: Pergamon.
70. Hansen RK & Fuqua SAW 1999 The estrogen receptor and breast cancer. In Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics, pp 1-30. Ed AM Bowcock. Totowa, New Jersey: Humana Press.
71. Haslam SZ 1986 Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro. Cancer Research 46 310-316.
72. Haslam SZ & Shyamala G 1981 Relative distribution of estrogen and progesterone receptors among the epithelial, adipose, and connective tissue components of the normal mammary gland. Endocrinology 108 825-830.
73. Haslam SZ & Nummy KA 1992 The ontogeny and cellular distribution of estrogen receptors in normal mouse mammary gland. Journal of Steroid Biochemistry and Molecular Biology 42 589-595.
74. Haslam SZ, Counterman LJ & Nummy KA 1992 EGF receptor regulation in normal mouse mammary gland. Journal of Cellular Physiology 152 553-557.
75. Haslam SZ, Counterman LJ & Nummy KA 1993 Effects of epidermal growth factor, estrogen, and progestin on DNA synthesis in mammary cells in vivo are determined by the developmental state of the gland. Journal of Cellular Physiology 155 72-78.
76. Henry MD & Campbell KP 1999 Dystroglycan inside and out. Current Opinion in Cell Biology 11 602-607.
77. Herrera-Gayol A & Jothy S 1999 Adhesion proteins in the biology of breast cancer: contribution of CD44. Experimental and Molecular Pathology 66 149-156.
78. Hissom JR & Moore MR 1987 Progestin effects on growth in the human breast cancer cell line T-47D - possible therapeutic implications. Biochemical and Biophysical Research Communications 145 706-711.
79. Hopp TA & Fuqua SAW 1998 Estrogen receptor variants. Journal of Mammary Gland Biology and Neoplasia 3 73-83.
80. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS & Tung L 1996 Nuclear receptor coactivators and corepressors. Molecular Endocrinology 10 1167-1177.
81. Hewlett AR & Bissell MJ 1993 The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium. Epithelial Cell Biology 2 79-89.
82. Howlett AR, Bailey N, Damsky C, Petersen OW & Bissell MJ 1995 Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. Journal of Cell Science 108 1945-1957.
83. Humphreys RC, Lydon JP, O'Malley BW & Rosen JM 1997 Use of PRKO mice to study the role of progesterone in mammary gland development. Journal of Mammary Gland Biology and Neoplasia 2 343-354.
84. Hynes RO 1992 Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69 11-25.
85. Ignar-Trowbridge DM, Nelson KG, Bidwell MC, Curtis SW, Washburn TF, McLachlan JA & Korach KS 1992 Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. PNAS 89 4658-4662.
86. Ignotz RA & Massague J 1986 Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Journal of Biological Chemistry 261 4337-4345.
87. Imagawa W, Bandyopadhyay GK & Nandi S 1990 Regulation of mammary epithelial cell growth in mice and rats. Endocrine Reviews 11 494-523.
88. Katzenellenbogen BS, Kendra KL, Norman MJ & Berthois Y 1987 Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Research 47 4355-4360.
89. Kenney NJ & Dickson RB 1996 Growth factor and sex steroid interactions in breast cancer. Journal of Mammary Gland Biology and Neoplasia 1 189-198.
90. Klijn JG, Berns PM, Schmitz PI & Foekens JA 1992 The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocrine Reviews 13 3-17.
91. Knudsen KA, Frankowski C, Johnson KR & Wheelock MJ 1998 A role for cadherins in cellular signaling and differentiation. Journal of Cellular Biochemistry (Suppl) 31 168-176.
92. Koenders PG, Faverly D, Beex LV, Bruggink ED, Kienhuis CB & Benraad TJ 1992 Epidermal growth factor receptors in human breast cancer: a plea for standardisation of assay methodology. European Journal of Cancer 28 693-697.
93. Kosmehl H, Berndt A & Katenkamp D 1996 Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects. Virchows Archiv 429 311-322.
94. Kraus WL, Weis KE & Katzenellenbogen BS 1995 Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- and antagonist-occupied progestin receptors. Molecular and Cellular Biology 15 1847-1857.
95. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA & Smithies O 1998 Generation and reproductive phenotypes of mice lacking estrogen receptor beta. PNAS 95 15677-15682.
96. Kubota S, Ito H, Ishibashi Y & Seyama Y 1997 Anti-alpha3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells. International Journal of Cancer 70 106-111.
97. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S & Gustafsson JA 1996 Cloning of a novel receptor expressed in rat prostate and ovary. PNAS 93 5925-5930.
98. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S & Gustafsson JA 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138 863-870.
99. Lambe M, Hsieh CC, Chan HW, Ekbom A, Trichopoulos D & Adami HO 1996 Parity, age at first and last birth, and risk of breast cancer: a population-based study in Sweden. Breast Cancer Research and Treatment 38 305-311.
100. Langholz O, Rockel D, Mauch C, Kozlowska E, Bank I, Krieg T & Eckes B 1995 Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. Journal of Cell Biology 131 1903-1915.
101. Lanzafame S, Emmanuele C & Torrisi A 1996 Correlation of alpha 2 beta 1 integrin expression with histological type and hormonal receptor status in breast carcinomas. Pathology, Research and Practice 192 1031-1038.
102. Lapidus RG, Nass SJ & Davidson NE 1998 The loss of estrogen and progesterone receptor gene expression in human breast cancer. Journal of Mammary Gland Biology and Neoplasia 3 85-94.
103. LaRochelle WJ, May-Siroff M, Robbins KC & Aaronson SA 1991 A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain. Genes and Development 5 1191-1199.
104. Le Goff P, Montano MM, Schodin DJ & Katzenellenbogen BS 1994 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. Journal of Biological Chemistry 269 4458-4466.
105. Leygue E, Dotzlaw H, Watson PH & Murphy LC 1999 Altered expression of exon 6 deleted progesterone receptor variant mRNA between normal human breast and breast tumour tissues. British Journal of Cancer 80 379-382.
106. Liu QY, Niranjan B, Gomes P, Gomm JJ, Davies D, Coombes RC & Buluwela L 1996 Inhibitory effects of activin on the growth and morphogenesis of primary and transformed mammary epithelial cells. Cancer Research 56 1155-1163.
107. Lochter A & Bissell MJ 1995 Involvement of extracellular matrix constituents in breast cancer. Seminars in Cancer Biology 6 165-173.
108. Lochter A, Galosy S, Muschler J, Freedman N, Werb Z & Bissell MJ 1997 Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. Journal of Cell Biology 139 1861-1872.
109. Lochter A, Sternlicht MD, Werb Z & Bissell MJ 1998 The significance of matrix metalloproteinases during early stages of tumor progression. Annals of the New York Academy of Sciences 857 180-193.
110. Lundholt BK, Madsen MW, Lykkesfeldt AE, Petersen OW & Briand P 1996 Characterization of a nontumorigenic human breast epithelial cell line stably transfected with the human estrogen receptor (ER) cDNA. Molecular and Cellular Endocrinology 119 47-59.
111. Lundy J, Schuss A, Stanick D, McCormack ES, Kramer S & Sorvillo JM 1991 Expression of neu protein, epidermal growth factor receptor, and transforming growth factor alpha in breast cancer. Correlation with clinicopathologic parameters. American Journal of Pathology 138 1527-1534.
112. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA Jr, Shyamala G, Conneely OM & O'Malley BW 1995 Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes and Development 9 2266-2278.
113. McCarty KS Jr, Szabo E, Flowers JL, Cox EB, Leight GS, Miller L, Konrath J, Soper JT, Budwit DA, Creasman WT et al. 1986 Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors. Cancer Research 46 4244s-4248s.
114. McDonnell DP 1995 Unraveling the human progesterone receptor signal transduction pathway: insights into anti-progestin action. Trends in Endocrinology and Metabolism 6 133-138.
115. McDonnell DP & Goldman ME 1994 RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. Journal of Biological Chemistry 269 11945-11949.
116. McGrath CM 1983 Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma. Cancer Research 43 1355-1360.
117. McGuire WL 1978 Hormone receptors: their role in predicting prognosis and response to endocrine therapy. Seminars in Oncology 5 428-433.
118. McGuire WL & Clark GM 1992 Prognostic factors and treatment decisions in axillary-node-negative breast cancer. New England Journal of Medicine 326 1756-1761.
119. Maemura M, Akiyama SK, Woods VL Jr & Dickson RB 1995 Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells. Clinical and Experimental Metastasis 13 223-235.
120. Malet C, Compel A, Yaneva H, Cren H, Fidji N, Mowszowicz I, Kuttenn F & Mauvais-Jarvis P 1991 Estradiol and progesterone receptors in cultured normal human breast epithelial cells and fibroblasts: immunocytochemical studies. Journal of Clinical Endocrinology and Metabolism 73 8-17.
121. Mansour EG, Ravdin PM & Dressler L 1994 Prognostic factors in early breast carcinoma. Cancer 74 381-400.
122. Marbaix E, Donnez J, Courtoy PJ & Eeckhout Y 1992 Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. PNAS 89 11789-11793.
123. Markopoulos C, Berger U, Wilson P, Gazet JC & Coombes RC 1988 Oestrogen receptor content of normal breast cells and breast carcinomas throughout the menstrual cycle. British Medical Journal 296 1349-1351.
124. Masters JR, Drife JO & Scarisbrick JJ 1977 Cyclic variation of DNA synthesis in human breast epithelium. Journal of the National Cancer Institute 58 1263-1265.
125. Meyer JS 1977 Cell proliferation in normal human breast ducts. fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Effects of menstrual phase, age, and oral contraceptive hormones. Human Pathology 8 67-81.
126. Miller FR, Soule HD, Tait L, Pauley RJ, Wolman SR, Dawson PJ & Heppner GH 1993 Xenograft model of progressive human proliferative breast disease. Journal of the National Cancer Institute 85 1725-1732.
127. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK & Yamada KM 1995 Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. Journal of Cell Biology 131 791-805.
128. Miyamoto S, Teramoto H, Gutkind JS & Yamada KM 1996 Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. Journal of Cell Biology 135 1633-1642.
129. Mizukami Y, Nonomura A, Noguchi M, Taniya T, Koyasaki N, Saito Y, Hashimoto T, Matsubara F & Yanaihara N 1991 Immunohistochemical study of oncogene product ras p21, c-myc and growth factor EGF in breast carcinomas. Anticancer Research 11 1485-1494.
130. Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G & Defilippi P 1998 Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO Journal 17 6622-6632.
131. Nagle RB, Bocker W, Davis JR, Heid HW, Kaufmann M, Lucas DO & Jarasch ED 1986 Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. Journal of Histochemistry and Cytochemistry 34 869-881.
132. Natali PG, Nicotra MR, Botti C, Mottolese M, Bigotti A & Segatto O 1992 Changes in expression of alpha 6/beta 4 integrin heterodimer in primary and metastatic breast cancer. British Journal of Cancer 66 318-322.
133. Nicholson RI, McClelland RA, Robertson JFR & Gee JMW 1999 Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer. Endocrine-Related Cancer 6 373-387.
134. Nishida K, Kitazawa R, Mizuno K, Maeda S & Kitazawa S 1997 Identification of regulatory elements of human alpha 6 integrin subunit gene. Biochemical and Biophysical Research Communications 241 258-263.
135. Normanno N & Ciardiello F 1997 EGF-related peptides in the pathophysiology of the mammary gland. Journal of Mammary Gland Biology and Neoplasia 2 143-151.
136. Osborne CK, Hobbs K & Clark GM 1985 Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Research 45 584-590.
137. O'Toole TE, Mandelman D, Forsyth J, Shattil SJ, Plow EF & Ginsberg MH 1991 Modulation of the affinity of integrin alpha lib beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science 254 845-847.
138. Pace P, Taylor J, Suntharalingam S, Coombes RC & Ali S 1997 Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha. Journal of Biological Chemistry 272 25832-25838.
139. Pechoux C, Gudjonsson T, Ronnov-Jessen L, Bissell MJ & Petersen OW 1999 Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Developmental Biology 206 88-99.
140. Petersen OW & van Deurs B 1988 Growth factor control of myoepithelial cell differentiation in cultures of human mammary gland. Differentiation 39 197-215.
141. Petersen OW, Hoyer PE & van Deurs B 1987 Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. Cancer Research 47 5748-5751.
142. Petersen OW, Ronnov-Jessen L, Howlett AR & Bissell MJ 1992 Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. PNAS 89 9064-9068.
143. Pettersson K, Grandien K, Kuiper GG & Gustafsson JA 1997 Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha. Molecular Endocrinology 11 1486-1496.
144. Philips A, Chalbos D & Rochefort H 1993 Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis. Journal of Biological Chemistry 268 14103-14108.
145. Pilat MJ, Christman JK & Brooks SC 1996 Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6. Breast Cancer Research and Treatment 37 253-266.
146. Pinkas-Kramarski R, Alroy I & Yarden Y 1997 ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling. Journal of Mammary Gland Biology and Neoplasia 2 97-107.
147. Press MF & Greene GL 1988 Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinology 122 1165-1175.
148. Ricketts D, Turnbull L, Ryall G, Bakhshi R, Rawson NS, Gazet JC, Nolan C & Coombes RC 1991 Estrogen and progesterone receptors in the normal female breast. Cancer Research 51 1817-1822.
149. Robinson SP & Jordan VC 1987 Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model. Cancer Research 47 5386-5390.
150. Ronnov-Jessen L, Petersen OW & Bissell MJ 1996 Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiological Reviews 76 69-125.
151. Rosfjord EC & Dickson RB 1999 Growth factors, apoptosis, and survival of mammary epithelial cells. Journal of Mammary Gland Biology and Neoplasia 4 229-237.
152. Roskelley CD, Srebrow A & Bissell MJ 1995 A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Current Opinion in Cell Biology 7 736-747.
153. Rousseau-Merck MF, Misrahi M, Loosfelt H, Milgrom E & Berger R 1987 Localization of the human progesterone receptor gene to chromosome 11q22-q23. Human Genetics 77 280-282.
154. Rudland PS 1993 Epithelial stem cells and their possible role in the development of the normal and diseased human breast. Histology and Histopathology 8 385-404.
155. Rudland PS, Femig DG & Smith JA 1995 Growth factors and their receptors in neoplastic mammary glands. Biomedicine and Pharmacotherapy 49 389-399.
156. Russo IH & Russo J 1998 Role of hormones in mammary cancer initiation and progression. Journal of Mammary Gland Biology and Neoplasia 3 49-61.
157. Sainsbury JR, Farndon JR, Sherbet GV & Harris AL 1985 Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer. Lancet 1 364-366.
158. Saji S, Jensen EV, Nilsson S, Rylander T, Warner M & Gustafsson JA 2000 Estrogen receptors alpha and beta in the rodent mammary gland. PNAS 97 337-342.
159. Sakakura T 1983 Epithelial-mesenchymal interactions in mammary gland development and its perturbation in relation to tumorigenesis. In Understanding Breast Cancer: Clinical and Laboratory Concepts, pp 261-284. Eds MA Rich, JC Hager & P Furmanski. New York: Marcel Dekker, Inc.
160. Sastry SK, Lakonishok M, Thomas DA, Muschler J & Horwitz AF 1996 Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation. Journal of Cell Biology 133 169-184.
161. Schoenenberger CA, Zuk A, Zinkl GM, Kendall D & Matlin KS 1994 Integrin expression and localization in normal MDCK cells and transformed MDCK cells lacking apical polarity. Journal of Cell Science 107 527-541.
162. Schroeder JA & Lee DC 1998 Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland. Cell Growth and Differentiation 9 451-164.
163. Schroen DJ & Brinckerhoff CE 1996 Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. Gene Expression 6 197-207.
164. Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR & DiAugustine RP 1998 Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. Cell Growth and Differentiation 9 777-785.
165. Shearer M, Bartkova J, Bartek J, Berdichevsky F, Barnes D, Millis R & Taylor-Papadimitriou J 1992 Studies of clonal cell lines developed from primary breast cancers indicate that the ability to undergo morphogenesis in vitro is lost early in malignancy. International Journal of Cancer 51 602-612.
166. Shyamala G, Barcellos-Hoff MH, Toft D & Yang X 1997 In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium. Journal of Steroid Biochemistry and Molecular Biology 63 251-259.
167. Shyamala G, Yang X, Silberstein G, Barcellos-Hoff MH & Dale E 1998 Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands. PNAS 95 696-701.
168. Shyamala G, Louie SG, Camarillo IG & Talamantes F 1999 The progesterone receptor and its isoforms in mammary development. Molecular Genetics and Metabolism 68 182-190.
169. Silberstein GB, Van Horn K, Shyamala G & Daniel CW 1996 Progesterone receptors in the mouse mammary duct: distribution and developmental regulation. Cell Growth and Differentiation 7 945-952.
170. Simian M, Vigil A, Bissell MJ & Shyamala G 2000 Involvement of progesterone receptor (PR) in the organization of basement membrane integrity in mammary glands. Proceedings of the American Association for Cancer Research 91 139.
171. Spinardi L, Einheber S, Cullen T, Milner TA & Giancotti FG 1995 A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. Journal of Cell Biology 129 473-487.
172. Stampfer MR & Bartley JC 1985 Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. PNAS 82 2394-2398.
173. Stampfer MR & Yaswen P 1993 Culture systems for study of human mammary epithelial cell proliferation, differentiation and transformation. Cancer Surveys 18 7-34.
174. Staszewski J 1971 Age at menarche and breast cancer. Journal of the National Cancer Institute 47 935-940.
175. Stemlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ & Werb Z 1999 The stromal proteinase MMP3/stromelysin-l promotes mammary carcinogenesis. Cell 98 137-146.
176. Stoker AW, Streuli CH, Martins-Green M & Bissell MJ 1990 Designer microenvironments for the analysis of cell and tissue function. Current Opinion in Cell Biology 2 864-874.
177. Streuli C 1999 Extracellular matrix remodelling and cellular differentiation. Current Opinion in Cell Biology 11 634-640.
178. Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ & Derynck R 1993 Extracellular matrix regulates expression of the TGF-beta 1 gene. Journal of Cell Biology 120 253-260.
179. Sugiura T & Berditchevski F 1999 Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2). Journal of Cell Biology 146 1375-1389.
180. Sympson CJ, Talhouk RS, Alexander CM, Chin JR, Clift SM, Bissell MJ & Werb Z 1994 Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. Journal of Cell Biology 125 681-693.
181. Taylor-Papadimitriou J, Fentiman IS & Burchell J 1980 Markers for malignancy in human mammary epithelial cells in vitro: problems and directions. In Cell Biology of Breast Cancer, pp 347-362. Eds C McGrath, MJ Brennan & MA Rich. New York: Academic Press.
182. Thomasset N, Lochter A, Sympson CJ, Lund LR, Williams DR, Behrendtsen O, Werb Z & Bissell MJ 1998 Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. American Journal of Pathology 153 457-467.
183. Tora L, Gronemeyer H, Turcotte B, Gaub MP & Chambon P 1988 The N-terminal region of the chicken progesterone receptor specifies target gene activation. Nature 333 185-188.
184. Trichopoulos D, MacMahon B & Cole P 1972 Menopause and breast cancer risk. Journal of the National Cancer Institute 48 605-613.
185. Tsai MJ & O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annual Review of Biochemistry 63 451-486.
186. Tsai YC, Lu Y, Nichols PW, Zlotnikov G, Jones PA & Smith HS 1996 Contiguous patches of normal human mammary epithelium derived from a single stem cell: Implications for breast carcinogenesis. Cancer Research 56 402-404.
187. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS & Horwitz KB 1993 Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Molecular Endocrinology 7 1256-1265.
188. Umayahara Y, Kawamori R, Watada H, Imano E, Iwama N, Morishima T, Yamasaki Y, Kajimoto Y & Kamada T 1994 Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. Journal of Biological Chemistry 269 16433-16442.
189. Umekita Y, Enokizono N, Sagara Y, Kuriwaki K, Takasaki T, Yoshida A & Yoshida H 1992 Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-alpha) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status. Virchows Archiv A. Pathological Anatomy and Histopathohgy 420 345-351.
190. Unden AB, Sandstedt B, Bruce K, Hedblad M & Stahle-Backdahl M 1996 Stromelysin-3 mRNA associated with myofibroblasts is overexpressed in aggressive basal cell carcinoma and in dermatofibroma but not in dermatofibrosarcoma. Journal of Investigative Dermatology 107 147-153.
191. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW & McDonnell DP 1993 Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Molecular Endocrinology 7 1244-1255.
192. Vonderhaar BK 1999 Prolactin involvement in breast cancer. Endocrine-Related Cancer 6 389-404.
193. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R & Bissell MJ 1998 Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. PNAS 95 14821-14826.
194. Wasylyk C, Gutman A, Nicholson R & Wasylyk B 1991 The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO Journal 10 1127-1134.
195. Wazer DE, Chu Q, Liu XL, Gao Q, Safaii H & Band V 1994 Loss of p53 protein during radiation transformation of primary human mammary epithelial cells. Molecular and Cellular Biology 14 2468-2478.
196. Weaver VM, Fischer AH, Peterson OW & Bissell MJ 1996 The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochemistry and Cell Biology 74 833-851.
197. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C & Bissell MJ 1997 Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. Journal of Cell Biology 137 231-245.
198. Wei LL, Gonzalez-Aller C, Wood WM, Miller LA & Horwitz KB 1990 5'-Heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated 'C'-receptor and unique A-receptor messages. Molecular Endocrinology 4 1833-1840.
199. Wei LL, Hawkins P, Baker C, Norris B, Sheridan PL & Quinn PG 1996 An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Molecular Endocrinology 10 1379-1387.
200. Wellings SR, Jensen HM & Marcum RG 1975 An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. Journal of the National Cancer Institute 55 231-273.
201. White R & Parker MG 1998 Molecular mechanisms of steroid hormone action. Endocrine-Related Cancer 5 1-14.
202. Wiesen JF, Young P, Werb Z & Cunha GR 1999 Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126 335-344.
203. Witty JP, Wright JH & Matrisian LM 1995 Matrix metallo-proteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Molecular Biology of the Cell 6 1287-1303.
204. Wolf C, Rouyer N, Lutz Y, Adida C, Loriot M, Bellocq JP, Chambon P & Basset P 1993 Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. PNAS 90 1843-1847.
205. Woodward TL, Xie JW & Haslam SZ 1998 The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland. Journal of Mammary Gland Biology and Neoplasia 3 117-131.
206. Xie J & Haslam SZ 1997 Extracellular matrix regulates ovarian hormone-dependent proliferation of mouse mammary epithelial cells. Endocrinology 138 2466-2473.
207. Yamaguchi Y, Mann DM & Ruoslahti E 1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346 281-284.
208. Yang J, Richards J, Guzman R, Imagawa W & Nandi S 1980 Sustained growth in primary culture of normal mammary epithelial cells embedded in collagen gels. PNAS 77 2088-2092.
209. Yang J, Liu A, Dougherty C, Chen X, Guzman R & Nandi S 2000 Estrogen and progesterone receptors can be maintained in normal human breast epithelial cells in primary culture and after transplantation into nude mice. Oncology Reports 7 17-21.
210. Zajchowski DA, Sager R & Webster L 1993 Estrogen inhibits the growth of estrogen receptor-negative, but not estrogen receptor-positive, human mammary epithelial cells expressing a recombinant estrogen receptor. Cancer Research 53 5004-5011.
211. Zhang QX, Hilsenbeck SG, Fuqua SA & Borg A 1996 Multiple splicing variants of the estrogen receptor are present in individual human breast tumors. Journal of Steroid Biochemistry and Molecular Biology 59 251-260.
212. Zutter MM, Santoro SA, Painter AS, Tsung YL & Gafford A 1994 The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression. Journal of Biological Chemistry 269 463-469.
213. Zutter MM, Santoro SA, Staatz WD & Tsung YL 1995 Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. PNAS 92 7411-7415.