Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer

Breast Cancer Research and Treatment

Volumn 70, Issue 1, 2001, Pages 11-20

  Hu, Y ^a   Dragowska, W H ^a   Wallis, A ^a   Duronio, V ^b   Mayer, L ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Apoptosis; Bcl 2; Breast cancer; Inhibitors of signal transduction pathway kinases; Mcl 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; DNA FRAGMENT; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN MCL 1; PROTEIN TYROSINE KINASE; STAUROSPORINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL DEATH; CELL STRAIN MCF 7; CELL SURVIVAL; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; BUTADIENES; CHROMONES; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; GENISTEIN; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NEOPLASM PROTEINS; NITRILES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0035193257     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012564620853     Document Type: Article

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