The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A

Journal of Biological Chemistry

Volumn 279, Issue 22, 2004, Pages 23679-23690

  Gassel, Michael ^a   Breitenlechner, Christine B ^b   König, Norbert ^a   Huber, Robert ^b   Engh, Richard A ^a,b,c   Bossemeyer, Dirk ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CONFORMATIONS; DRUG PRODUCTS; ENZYME INHIBITION; TUMORS;

EUKARYOTIC SIGNAL TRANSDUCTION; THERAPEUTIC DRUGS;

PROTEINS;

ADENOSINE TRIPHOSPHATE; BIM PROTEIN; BISINDOLYLMALEIMIDE; BISINDOLYLMALEIMIDE 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN BIM2; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INDUCTION; ENZYME INHIBITION; MEDIATOR RELEASE; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CATTLE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; INDOLES; MALEIMIDES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE C; RECOMBINANT PROTEINS;

ANIMALIA; EUKARYOTA;

EID: 2542500761     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M314082200     Document Type: Article

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