Plant molecular farming: Systems and products

Plant Cell Reports

Volumn 22, Issue 10, 2004, Pages 711-720

  Horn, M E ^a   Woodard, S L ^a   Howard, J A ^a  

^a Prodigene Inc   (United States)

Author keywords

Edible vaccine; Monoclonal antibody; Pharmaceuticals; Recombinant protein

Indexed keywords

BIOTECHNOLOGY; DRUG PRODUCTS; PRODUCT DEVELOPMENT; PROTEINS;

BIOFACTORIES; INDUSTRIAL USES; MOLECULAR FARMING; PLANT SYSTEMS;

CELLS;

BIOLOGICAL PRODUCT; RECOMBINANT PROTEIN; VEGETABLE PROTEIN;

BIOSYNTHESIS; BIOTECHNOLOGY; DRUG INDUSTRY; ECONOMICS; HUMAN; METABOLISM; METHODOLOGY; PUBLIC OPINION; REVIEW; TRANSGENIC PLANT;

BIOLOGICAL PRODUCTS; BIOTECHNOLOGY; DRUG INDUSTRY; HUMANS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; PUBLIC OPINION; RECOMBINANT PROTEINS;

EID: 2442590941     PISSN: 07217714     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00299-004-0767-1     Document Type: Review

References (57)

1. Arakawa T, Yu J, Chong DKX, Hough J, Engen PC, Langridge WHR (1998) A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat Biotechnol 16:934-938
2. Arakawa T, Yu J, Langridge WHR (2001) Synthesis of a cholera toxin B subunit-rotavirus NSP4 fusion protein in potato. Plant Cell Rep 20:343-348
3. Azzoni AR, Kusnadi AR, Miranda EA, Nikolov ZL (2002) Recombinant aprotinin produced in transgenic corn seed: extraction and purification studies. Biotechnol Bioeng 80:268-276
4. Bailey MR, Woodard SL, Callaway E, Beifuss K, Magallanes-Lundback M, Lane JR, Horn ME, Mallubhotla H, Delaney DD, Ward M, Van Gastel F, Howard JA, Hood EE (2004) Improved recovery of active recombinant laccase from maize seed. Appl Microbiol Biotechnol 63:390-397
5. Cabanes-Macheteau M, Fitchette-Laine A-C, Loutelier-Bourhis C, Lange C, Vine ND, Ma JK-C, Lerouge P, Faye L (1999) N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants. Glycobiology 9:365-372
6. Carter JE III, Langridge WHR (2002) Plant-based vaccines for protection against infectious and autoimmune diseases. Crit Rev Plant Sci 21:93-109
7. Conneely OM, Headon DR, O'Malley BW, May GS (2001) Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms. US Patent 6 228 614
8. Daniell H, Streatfield SJ, Wycoff K (2001) Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 6:219-226
9. Daniell H, Khan MS, Allison L (2002) Milestones in chloroplast genetic engineering: an environmentally friendly era in biotechnology. Trends Plant Sci 7:84-91
10. Delaney DE (2002) Choice of crop species and development of transgenic product lines. In: Hood EE, Howard JA (eds) Plants as factories for protein production. Kluwer, Dordrecht, pp 139-158
11. Delaney D, Jilka J, Barker D, Irwin P, Poage M, Woodard S, Horn M, Vinas A, Beifuss K, Barker M, Wiggins B, Drees C, Harkey R, Nikolov Z, Hood E, Howard J (2002) Production of aprotinin in transgenic maize seeds for the pharmaceutical and cell culture markets. In: Vasil IK (ed) Plant biotechnology 2002 and beyond. Kluwer, Dordrecht, pp 393-394
12. During K (1988) Wound-inducible expression and secretion of T4 lysozyme and monoclonal antibodies in Nicotiana tabacum. Ph.D Thesis. Mathematisch-Naturwissenschaftlichen Fakultat der Universität zu Köln
13. During K, Hippe S, Kreuzaler F, Schell J (1990) Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Mol Biol 15:281-293
14. Evangelista RL, Kusnadi AR, Howard JA, Nikolov ZL (1998) Process and economic evaluation of the extraction and purification of recombinant β-glucuronidase from transgenic corn. Biotechnol Prog 14:607-614
15. Fraley RT, Rogers SG, Horsch RB, Sanders PR, Flick JS, Adams SP, Bittner ML, Brand LA, Fink CL, Fry JS, Galluppi GR, Goldberg SB, Hoffman NL, Woo SC (1983) Expression of bacterial genes in plant cells. Proc Natl Acad Sci USA 80:4803-4807
16. Frigerio L, Vine ND, Pedrazzini E, Hein MB, Wang F, Ma JK-C, Vitale A (2000) Assembly, secretion, and vacuolar delivery of a hybrid immunoglobulin in plants. Plant Physiol 123:1483-1493
17. Gruber V, Berna PP, Arnaud T, Bournat P, Clément C, Mison D, Olagnier B, Philippe L, Theisen M, Baudino S, Bénicourt C, Cudrey C, Bloës C, Duchateau N, Dufour S, Gueguen C, Jacquet S, Ollivo C, Poncetta C, Zorn N, Ludevid P, Van Dorsselaer A, Verger R, Doherty A, Mérot B, Danzin C (2001) Large-scale production of a therapeutic protein in transgenic tobacco plants: effect of subcellular targeting on quality of a recombinant dog gastric lipase. Mol Breed 7:329-340
18. Hiatt A, Cafferkey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature 342:76-78
19. Hirel PH, Schmitter JM, Dessen P, Fayat G, Blanquet S (1989) Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid. Proc Natl Acad Sci USA 86:8247-8251
20. Hood EE, Howard JA (2002) Plants as factories for protein production. Kluwer, Dordrecht
21. Hood EE, Jilka JM (1999) Plant-based production of xenogenic proteins. Curr Opin Biotechnol 10:382-386
22. Hood EE, Witcher DR, Maddock S, Meyer T, Baszczynski C, Bailey M, Flynn P, Register J, Marshall L, Bond D, Kulisek E, Kusnadi A, Evangelista R, Nikolov Z, Wooge C, Mehigh RJ, Hernan R, Kappel WK, Ritland D, Li CP, Howard JA (1997) Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification. Mol Breed 3:291-306
23. Hood EE, Kusnadi A, Nikolov Z, Howard JA (1999) Molecular farming of industrial proteins from transgenic maize. In: Shahidi F, Kolodziejczyk P, Whitaker JR, Munguia AL, Fuller G (eds) Chemicals via higher plant bioengineering. Kluwer/Plenum, New York, pp 127-147
24. Hood EE, Woodard SL, Horn ME (2002) Monoclonal antibody manufacturing in transgenic plants - myths and realities. Curr Opin Biotechnol 13:630-635
25. Hood EE, Bailey MR, Beifuss K, Magallanes-Lundback M, Horn ME, Callaway E, Drees C, Delaney DE, Clough R, Howard JA (2003) Criteria for high-level expression of a fungal laccase gene in transgenic maize. Plant Biotechnol J 1:129-140
26. Horn ME, Pappu KM, Bailey MR, Clough RC, Barker M, Jilka JM, Howard JA, Streatfield SJ (2004) Advantageous features of plant-based systems for the development of HIV vaccines. J Drug Targeting (in press)
27. Horsch RB, Fraley RT, Rogers SC, Sanders PR, Lloyd A, Hoffman N (1984) Inheritance of functional foreign genes in plants. Science 223:496-498
28. Jefferson RA, Kavanaugh TA, Bevan MW (1987) GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J 6:3901-3907
29. Korban SS, Krasnyanski SF, Buetow DE (2002) Foods as production and delivery vehicles for human vaccines. J Am Coll Nutr 21:212S-217S
30. Kusnadi AR, Hood EE, Witcher DR, Howard JA, Nikolov ZL (1998) Production and purification of two recombinant proteins from transgenic corn. Biotechnol Prog 14:149-155
31. Lamphear BJ, Streatfield SJ, Jilka JM, Brooks CA, Barker DK, Turner DD, Delaney DE, Garcia M, Wiggins B, Woodard SL, Hood EE, Tizard IR, Lawhorn B, Howard JA (2002) Delivery of subunit vaccines in maize seed. J Control Release 85:169-180
32. Lamphear BJ, Jilka JM, Kesl L, Welter M, Howard JA, Streatfield SJ (2004) A corn-based delivery system for animal vaccines: an oral transmissable gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine (in press)
33. Larrick JW, Yu L, Naftzger C, Jaiswal S, Wycoff K (2001) Production of secretory IgA antibodies in plants. Biomol Eng 18:87-94
34. Legrand D, Salmon V, Spik G, Gruber V, Bournat P, Merot B (2003) Recombinant lactoferrin, methods of production from plants and uses. US Patent 6 569 831
35. Lerouge P, Cabanes-Macheteau M, Rayon C, Fischette-Laine A-C, Gomord V, Faye L (1998) N-Glycoprotein biosynthesis in plants: recent developments and future trends. Plant Mol Biol 38:31-48
36. Masarik M, Kizek R, Kramer KJ, Billova S, Brazdova M, Vacek J, Bailey M, Jelen F, Howard JA (2003) Application of avidin-biotin technology and adsorptive transfer stripping square-wave voltammetry for detection of DNA hybridization and avidin in transgenic avidin maize. Anal Chem 75:2663-2669
37. Mitra A, Zhang Z (1994) Expression of a human lactoferrin cDNA in tobacco cells produces antibacterial protein(s). Plant Physiol 106:997-981
38. Nandi S, Suzuki YA, Huang J, Yalda D, Pham P, Wu L, Bartley G, Huang N, Lönnerdal B (2002) Expression of human lactoferrin in transgenic rice grains for the application in infant formula. Plant Sci 163:713-722
39. Nikolov Z, Hammes D (2002) Production of recombinant proteins from transgenic crops. In: Hood EE, Howard JA (eds) Plants as factories for protein production, Kluwer, Dordrecht, pp 159-174
40. Raskin I (2000) Methods for recovering polypeptides from plants and portions thereof. US Patent 6 096 546
41. Ruggiero F, Exposito J-Y, Bournat P, Gruber V, Perret S, Comte J, Olagnier B, Garrone R, Thiesen M (2000) Triple helix assembly and processing of human collagen produced in transgenic tobacco plants. FEBS Lett 469:132-136
42. Samyn-Petit B, Gruber V, Flahaut C, Wajda-Dubos J-P, Farrer S, Pone A, Desmaizieres G, Slomianny M-C, Theisen M, Delannoy P (2001) N-Glycosylation potential of maize: the human lactoferrin used as a model. Glycoconjugate J 18:519-527
43. Schillberg S, Emans N, Fischer R (2002) Antibody molecular farming in plants and plant cells. Phytochem Rev 1:45-54
44. Stoger E, Sack M, Perrin Y, Vaquero C, Torres E, Twyman RM, Christou P, Fischer R (2002a) Practical considerations for pharmaceutical antibody production in different crop systems. Mol Breed 9:149-158
45. Stoger E, Sack M, Fischer R, Christou P (2002b) Plantibodies: applications, advantages and bottlenecks. Curr Opin Biotechnol 13:161-166
46. Streatfield SJ (2002) The greening of vaccine technology. Curr Drug Discovery Nov:15-18
47. Streatfield SJ, Howard JA (2003) Plant-based vaccines. Int J Parasitol 33:479-493
48. Streatfield SJ, Lane JR, Brooks CA, Barker DK, Poage ML, Mayor JM, Lamphear BJ, Drees CF, Jilka JM, Hood EE, Howard JA (2003) Corn as a production system for human and animal vaccines. Vaccine 21:812-815
49. Svab Z, Maliga P (1993) High-frequency plastid transformation in tobacco by selection for a chimeric aaadA gene. Proc Natl Acad Sci USA 90:913-917
50. Svab Z, Hajdukiewicz P, Maliga P (1990) Stable transformation of plastids in higher plants. Proc Natl Acad Sci USA 87:8526-8530
51. Tacket CO, Clements JD, Wasserman SS, Streatfield S (2003) Immunogenicity of a recombinant bacterial antigen delivered in transgenic corn. Abstract S4, 6th Annual Vaccine Conference, 5-7 May 2003, Arlington, Va.
52. Verch T, Yusibov V, Koprowski H (1998) Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector. J Immunol Methods 220:69-75
53. Witcher DR, Hood EE, Petersen D, Bailey M, Bond D, Kusnadi A, Evangelista R, Nikolov Z, Wooge C, Mehigh R, Kappel W, Register J, Howard JA (1998) Commercial production of β-glucuronidase (GUS): a model system for the production of proteins in plants. Mol Breed 4:301-312
54. Woodard SL, Mayor JM, Bailey MR, Barker DK, Love RT, Lane JR, Delaney DE, McComas-Wagner JM, Mallubhotla HD, Hood EE, Dangott LJ, Tichy SE, Howard JA (2003) Maize-derived bovine trypsin: characterization of the first large-scale, commercial protein product from transgenic plants. Biotechnol Appl Biochem 38:123-130
55. Yu J, Langridge WHR (2001) A plant-based multicomponent vaccine protects mice from enteric diseases. Nat Biotechnol 19:548-552
56. Zeitlin L, Olmsted SS, Moench TR, Co MS, Martinell BJ, Paradkar VM, Russell DR, Queen C, Cone RA, Whaley KJ (1998) A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nat Biotechnol 16:1361-1364
57. Zhong G-Y, Peterson D, Delaney DE, Bailey M, Witcher DR, Register JC III, Bond D, Li C-P, Marshall L, Kulisek E, Ritland D, Meyer T, Hood EE, Howard JA (1999) Commercial production of aprotinin in transgenic maize seeds. Mol Breed 5:345-356