Advantageous features of plant-based systems for the development of HIV vaccines

Journal of Drug Targeting

Volumn 11, Issue 8-10, 2003, Pages 539-545

  Horn, Michael E ^a   Pappu, Kameshwari M ^a   Bailey, Michele R ^a   Clough, Richard C ^a   Barker, Mark ^a   Jilka, Joseph M ^a   Howard, John A ^a   Streatfield, Stephen J ^a  

^a Prodigene Inc   (United States)

Author keywords

Corn; gp120; gp130; Human immunodeficiency virus; Plant based vaccine; Simian immunodeficiency virus

Indexed keywords

GAG PROTEIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 130; GLYCOPROTEIN GP 160; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; RECOMBINANT PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; ARTICLE; CLINICAL TRIAL; CORN; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TARGETING; EXPRESSION VECTOR; FOOD PROCESSING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT BIOTECHNOLOGY; PLANT SEED; POTATO; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN IMMUNODEFICIENCY VIRUS; TOBACCO; TRANSGENIC PLANT; VIRUS IMMUNITY; VIRUS PATHOGENESIS;

ADMINISTRATION, ORAL; AIDS VACCINES; GENE PRODUCTS, ENV; HIV ANTIGENS; PLANTS, GENETICALLY MODIFIED; ZEA MAYS;

EID: 1942475249     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860410001669992     Document Type: Article

References (36)

1. Bakker, H., Bardor, M., Molthoff, J.W., Gomord, V., Elbers, I., Stevens, L.H., Jordi, W., Lommen, A., Faye, L., Lerouge, P. and Bosch, D. (2001) "Galactose-extended glycans of antibodies produced by transgenic plants", Proc. Natl Acad. Sci. USA 98, 2899-2904.
2. Bradford, M.M. (1976) "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding", Anal. Biochem, 72, 248-254.
3. Chickwamba, R., Cunnick, J., Hathaway, D., McMurray, J., Mason, H. and Wang, K. (2002) "A functional antigen in a practical crop: LT-B producing maize protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT)", Transgenic Res. 11, 479-493.
4. Daniell, H., Streatfield, S.J. and Wycoff, K. (2001a) "Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants", Trends Plant Sci. 6, 219-226.
5. Daniell, H., Lee, S.-B., Panchai, T. and Wiebe, P.O. (2001b) "Expression of the native cholera toxin B subunit gene and assembly of functional oligomers in transgenic tobacco chloroplasts", J. Mol. Biol. 311, 1001-1009.
6. Durrani, Z., McInerney, T.L., McLain, L., Jones, T., Bellaby, T., Brennan, F.R. and Dimmock, N.J. (1998) "Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization", J. Immunol. Methods 220, 93-103.
7. Fischer, R., Vaquero-Martin, C., Sack, M., Drossard, J., Emans, N. and Commandeur, U. (1999) "Towards molecular farming in the future: transient protein expression in plants", Biotechnol. Appl. Biochem. 30, 113-116.
8. Hamilton, S.R., Bobrowicz, P., Bobrowicz, B., Davidson, R.C., Huijuan, L., Mitchell, T., Nett, J.H., Rausch, S., Stadheim, T.A., Wischnewski, H., Wildt, S. and Gerngross, T.U. (2003) "Production of complex human glycoproteins in yeast", Science 301, 1244-1246.
9. Haq, T.A., Mason, H.S., Clements, J.D. and Arntzen, C.J. (1995) "Oral immunization with a recombinant bacterial antigen produced in transgenic plants", Science 268, 714-716.
10. Hood, E.E., Witcher, D.R., Maddock, S., Meyer, T., Baszczynski, C., Bailey, M., Flynn, P., Register, J., Marshall, L., Bond, D., Kulisek, E., Kusnadi, A., Evangelista, R., Nikolov, Z., Wooge, C., Mehigh, R.J., Hernan, R., Kappel, W.K., Ritland, D., Li, C.-P. and Howard, J.A. (1997) "Commercial production of avidin from transgenic maize: characterization of transformant, production, processing, extraction and purification", Mol. Breed. 3, 291-306.
11. Hood, E.E., Woodard, S.L. and Horn, M.E. (2002) "Monoclonal antibody manufacturing in transgenic plants - myths and realities", Curr. Opin. Biotechnol. 13, 630-635.
12. Ishida, Y., Saito, H., Ohta, S., Hiei, Y., Komari, T. and Kumashiro, T. (1996) "High efficiency transformation of maize (Zea mays L.) mediated by Agrobacterium tumefaciens", Nat. Biotechnol. 14, 745-750.
13. Joelson, T., Akerblom, L., Oxelfelt, P., Strandberg, B., Tomenius, K. and Morris, T.J. (1997) "Presentation of a foreign peptide on the surface of tomato bushy stunt virus", J. Gen. Virol. 78, 1213-1217.
14. Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yubisov, V., Koprowski, H., Plucienniczak, A. and Legocki, A.B. (1999) "A plant-derived edible vaccine against hepatitis B virus", FASEB J. 13, 1796-1799.
15. Lamphear, B.J., Streatfield, S.J., Jilka, J.M., Brooks, C.A., Barker, D.K., Turner, D.D., Delaney, D.E., Garcia, M., Wiggins, B., Woodard, S.L., Hood, E.E., Tizard, I.R., Lawhorn, B. and Howard, J.A. (2002) "Delivery of subunit vaccines in maize seed", J. Control. Release 85, 169-180.
16. Lamphear, B.J., Jilka, J.M., Kesl, L., Welter, M., Howard, J.A. and Streatfield, S.J. (2004) "A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine", Vaccine, In press.
17. Lerouge, P., Cabanes-Macheteau, M., Rayon, C., Fischette-Laine, A.C., Gomord, V. and Faye, L. (1998) " N-glycoprotein biosynthesis in plants: recent developments and future trends", Plant Mol. Biol, 38, 31-48.
18. Marusic, C., Rizza, P., Lattanzi, L., Mancini, C., Spada, M., Belardelli, F., Benvenuto, E. and Capone, I. (2001) "Chimeric plant virus particles as immunogens for inducing murine and human responses against human immunodeficiency virus type 1", J. Virol. 75, 8434-8439.
19. Mason, H.S., Lam, D.M. and Arntzen, C.J. (1992) "Expression of hepatitis B surface antigen in transgenic plants", Proc. Natl Acad. Sci. USA 89, 11745-11749.
20. McInerney, T.L., Brennan, F.R., Jones, T.D. and Dimmock, N.J. (1999) "Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide", Vaccine 17, 1359-1368.
21. McLain, L., Durrani, Z., Wisniewski, L.A., Porta, C., Lomonossoff, G.P. and Dimmock, N.J. (1996) "Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus", Vaccine 14, 799-810.
22. Moore, J.P. (1990) "Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4", AIDS 4, 297-305.
23. Porta, C., Spall, V.E., Loveland, J., Johnson, J.E., Barker, P.J. and Lomonossoff, G.P. (1994) "Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides", Virology 202, 949-955.
24. Samyn-Petit, B., Gruber, V., Flahaut, C., Wajda-Dubos, J.P., Farrer, S., Pons, A., Desmaizieres, G., Slomianny, M.C., Theisen, M. and Delannoy, P. (2001) "N-glycosylation potential of maize: the human lactoferrin used as a model", Glycoconjugates J. 18, 519-527.
25. Streatfield, S.J., Jilka, J.M., Hood, E.E., Turner, D.D., Bailey, M.R., Mayor, J.M., Woodard, S.L., Beifuss, K., Horn, M.E., Delaney, D.E., Tizard, I.R. and Howard, J.A. (2001) "Plant-based vaccines: unique advantages", Vaccine 19, 2742-2748.
26. Streatfield, S.J., Mayor, J.M., Barker, D.K., Brooks, C., Lamphear, B.J., Woodard, S.L., Beifuss, K.K., Vicuna, D.V., Massey, L.A., Horn, M.E., Delaney, D.D., Nikolov, Z.L., Hood, E.E., Jilka, J.M. and Howard, J.A. (2002) "Development of an edible subunit vaccine in corn against enterotoxigenic strains of Escherichia coli", In Vitro Cell. Dev. Biol.-Plant 38, 11-17.
27. Streatfield, S.J. and Howard, J.A. (2003) "Plant-based vaccines", Int. J. Parasitol. 33, 479-493.
28. Streatfield, S.J., Lane, J.R., Brooks, C.A., Barker, D.K., Poage, M.L., Mayor, J.M., Lamphear, B.J., Drees, C.F., Jilka, J.M., Hood, E.E. and Howard, J.A. (2003) "Corn as a production system for human and animal vaccines", Vaccine 21, 812-815.
29. Tacket, C.O., Mason, H.S., Losonsky, G., Clements, J.D., Levine, M.M. and Arntzen, C.J. (1998) "Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato", Nat. Med. 4, 607-609.
30. Tacket, C.O., Mason, H.S., Losonsky, G., Estes, M.K., Levine, M.M. and Arntzen, C.J. (2000) "Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes", J. Infect. Dis. 182, 302-305.
31. Woodard, S.L., Mayor, J.M., Bailey, M.R., Barker, D.K., Love, R.T., Lane, J.R., Delaney, D.E., McComas-Wagner, J.M., Mallubhotla, H.D., Hood, E.E., Dangott, L.J., Tichy, S.E. and Howard, J.A. (2003) "Maize-derived bovine trypsin: characterization of the first large-scale, commercial protein product from transgenic plants", Biotechnol. Appl. Biochem. 38, 123-130.
32. Yu, J. and Langridge, W.H.R. (2001) "A plant-based multicomponent vaccine protects mice from enteric diseases", Nat. Biotechnol. 19, 548-552.
33. Yusibov, V., Modelska, A., Steplewski, K., Agadjanyan, M., Weiner, D., Hooper, D.C. and Koprowski, H. (1997) "Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1", Proc. Natl Acad. Sci. USA 94, 5784-5788.
34. Yusibov, V., Hooper, D.C., Spitsin, S.V., Fleysh, N., Kean, R.B., Mikheeva, T., Deka, D., Karasev, A., Cox, S., Randall, J. and Koprowski, H. (2002) "Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine", Vaccine 20, 3155-3164.
35. Zhang, G., Leung, C., Murdin, L., Rovinski, B. and White, K.A. (2000) "In planta expression of HIV-1 p24 protein using an RNA plant virus-based expression vector", Mol. Biotechnol. 14, 99-107.
36. Zhang, G.G., Rodrigues, L., Rovinski, B. and White, K.A. (2002) "Production of HIV-1 p24 protein in transgenic tobacco plants", Mol. Biotechnol. 20, 131-136.