Role of nitric oxide in the regulation of HIF-1α expression during hypoxia

American Journal of Physiology - Cell Physiology

Volumn 283, Issue 1 52-1, 2002, Pages

  Agani, Faton H ^a   Puchowicz, Michelle ^a   Chavez, Juan Carlos ^a   Pichiule, Paola ^a   Lamanna, Joseph ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxia inducible factor 1; Mitochondria; Oxygen sensing

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; NITRIC OXIDE; SCAVENGER; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; ELECTRON TRANSPORT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRIAL ENERGY TRANSFER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RESPIRATORY CHAIN;

LETHRINIDAE; MAMMALIA;

EID: 0036089548     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00381.2001     Document Type: Article

References (52)

1. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
2. Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury
3. Nitric oxide-induced necrosis and apoptosis in PC12 cell is mediated by mitochondria
4. Oxidative stress and S-nitrosylation of proteins in cells
5. Lactate dehydrogenase UV-assay with pyruvate and NADH
6. Roles of nitric oxide in brain hypoxia-ischemia
7. Nitric oxide mediates brain mitochondrial damage during perinatal anoxia
8. Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols
9. Nitric oxide and mitochondrial respiration
10. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
11. 2 sensing
12. Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
13. On the mechanism by which vascular endothelial cells regulate their oxygen consumption
14. Stationary-state oxidized platinum microsensor for selective and on-line monitoring of nitric oxide in biological preparations
15. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
16. Role of hydrogen peroxide in hypoxia-induced erythropoietin production
17. Nitric oxide affects the production of reactive oxygen species in hepatoma cells: Implications for the process of oxygen sensing
18. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
19. Interactions of nitric oxide with hemoproteins: Roles of nitric oxide in mitochondria
20. Rac-1 activity is required for activation of hypoxia-inducible factor 1
21. Cloning of a factor required for activity of the Ah (dioxin) receptor
22. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
23. 2-dependent degradation domain via the ubiquitin-proteasome pathway
24. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
25. 2 sensing
26. 2-regulated prolyl hydroxylation
27. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: Implications for Parkinson's disease
28. Regulation of hypoxia-inducible factor 1α by the ubiquitinproteasome pathway
29. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
30. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
31. Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking
32. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
33. The enzymatic measurement of adenine nucleotides and P-creatine in picomole amounts
34. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
35. Ubiquitination of hypoxia-inducible factor requires direct binding to the betadomain of the von Hippel-Lindau protein
36. Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium
37. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: Redox-dependent effect of nitrogen oxides
38. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
39. Accumulation of HIF-1α under the influence of nitric oxide
40. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
41. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
42. 2 homeostasis by hypoxia-inducible factor 1
43. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
44. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
45. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway
46. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
47. Regulation of HIF-1 is preserved in the absence of a functioning mitochondrial respiratory chain
48. 2 tension
49. Identification and characterization of transcription factors from mammalian cells
50. Purification and characterization of hypoxia-inducible factor 1
51. Mammalian oxygen sensing, signaling and gene regulation
52. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila