Regulation of the cycling of timeless (tim) RNA

Journal of Neurobiology

Volumn 47, Issue 3, 2001, Pages 161-175

  Wang, Garrick K ^a   Ousley, Andrea ^a   Darlington, Thomas K ^b   Chen, Dechun ^b   Chen, Yifeng ^b   Fu, Weili ^a   Hickman, Lesley J ^a   Kay, Steve A ^a   Sehgal, Amita ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Animal behavior; Circadian rhythm; Gene expression; RNA; Transgenes

Indexed keywords

COMPLEMENTARY DNA; HELIX LOOP HELIX PROTEIN; RNA; TRANSCRIPTION FACTOR;

ANIMAL BEHAVIOR; ARTICLE; CIRCADIAN RHYTHM; DROSOPHILA; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BEHAVIOR, ANIMAL; CELLS, CULTURED; CIRCADIAN RHYTHM; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; INSECT PROTEINS; INTRONS; MUTATION; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 0035811195     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/neu.1024     Document Type: Article

References (47)

1. A mutant Drosophila homologue of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
2. dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
3. Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators
4. Light-dependent sequestration of timeless by cryptochrome
5. Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms
6. Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling
7. The period E-box is sufficient to drive circadian oscillation of transcription in vivo
8. Closing the circadian loop: Clock-induced transcription of its own inhibitors per and tim
9. Molecular basis for circadian biological clocks
10. Temporal phosphorylation of the Drosophila period protein
11. Identification and physiology of circadian pacemakers
12. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system
13. Role of the clock protein in the mammalian circadian mechanism
14. Interlocked feedback loops within the Drosophila circadian oscillator
15. A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster
16. The 69 bp circadian regulatory sequence (CRS) mediates per-like developmental, spatial, and circadian expression and behavioral rescue in Drosophila
17. Feedback of the Drosophila period gene on circadian cycling of its messenger RNA levels
18. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
19. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
20. Clock mutants of Drosophila melanogaster
21. Squaring up the E-box
22. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation and interactions with the PER-TIM complex
23. PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1. Heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription
24. Specific sequences outside the E-box are required for proper per expression and behavioral rescue
25. Wild-type circadian rhythmicity is dependent on closely spaced E-boxes in the Drosophila timeless promoter
26. DNA binding specificity of the basic-helix-loop-helix protein MASH-1
27. Positional cloning and sequence analysis of the Drosophila clock gene, timeless
28. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
29. Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies
30. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless
31. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP
32. A stable genomic source of P element transposase in Drosophila melanogaster
33. The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle
34. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
35. SL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants
36. Ontogeny of a biological clock in Drosophila melanogaster
37. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless
38. Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation
39. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling
40. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila
41. Circadian oscillation of a mammalian homologue of the Drosophila period gene
42. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells
43. Role of molecular oscillations in generating behavioral rhythms in Drosophila
44. The regulation of myogenin gene expression during the embryonic development of the mouse
45. Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling
46. A light entrainment mechanism for the Drosophila circadian clock
47. Three period homologues in mammals: Differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain