Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats

Epilepsy and Behavior

Volumn 7, Issue 2, 2005, Pages 231-239

  Rhodes, Madeline E ^a,b   Talluri, Jayanth ^a   Harney, Jacob P ^a   Frye, Cheryl A ^b  

^a UNIVERSITY OF HARTFORD   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Androgens; Epilepsy; Ketogenic diet; Nongenomic; Pentylenetetrazole; Progestins; Seizures

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA PREGNANE 3,20 DIONE; ANDROSTANEDIOL; ANDROSTANOLONE; CHOLESTEROL; PENTETRAZOLE; PROGESTERONE; STEROID; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CALORIC INTAKE; CONTROLLED STUDY; DIESTRUS; DIET RESTRICTION; ESTRUS; FEMALE; INCIDENCE; INTRACTABLE EPILEPSY; KETOGENIC DIET; NONHUMAN; RADIOIMMUNOASSAY; RAT; SEIZURE; STEROID BLOOD LEVEL;

ALLYLAMINE; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; DIET; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; ESTROUS CYCLE; FEMALE; MEPERIDINE; PENTYLENETETRAZOLE; RADIOIMMUNOASSAY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STEROIDS; VAGINA;

EID: 23844466237     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yebeh.2005.05.025     Document Type: Article

References (81)

1. R.G. Jarrar J.R. Buchhalter Therapeutics in pediatric epilepsy: Part 1. The new antiepileptic drugs and the ketogenic diet Mayo Clin Proc 78 2003 359-370
2. S.P. Aiken W.M. Brown Treatment of epilepsy: Existing therapies and future developments Front Biosci 5 2000 E124-E152
3. K.J. Bough D.A. Eagles Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet Epilepsia 42 2001 1345-1353
4. P. Murphy S.S. Likhodii K. Nylen W.M. Burnham The antidepressant properties of the ketogenic diet Biol Psychiatry 56 2004 981-983
5. B.C. Albensi A comparison of drug treatment versus electrical stimulation for suppressing seizure activity Drug News Perspect 16 2003 347-352
6. R.D. Sheth C.E. Stafstrom Intractable pediatric epilepsy: Vagal nerve stimulation and the ketogenic diet Neurol Clin 20 2002 1183-1194
7. J.I. Sirven The current treatment of epilepsy: A challenge of choices Curr Neurol 20 2002 1183-1194
8. G. Coppola Treatment of partial seizures in childhood: An overview CNS Drugs 18 2004 133-156
9. R.D. Sheth Metabolic concerns associated with antiepileptic medications Neurology 63 2004 S24-S29
10. J.W. Wheless The ketogenic diet: An effective medical therapy with side effects J Child Neurol 16 2001 633-635
11. P. Kankirawatana P. Jirapinyo S. Kanikirawatana R. Wongarn N. Thamanasiri Ketogenic diet: An alternative treatment for refractory epilepsy in children J Med Assoc Thai 84 2001 1027-1032
12. A. Mandel M. Ballew J.E. Pina-Garza V. Stalmasek L.H. Clemens Medical costs are reduced when children with intractable epilepsy are successfully treated with the ketogenic diet J Am Diet Assoc 102 2002 396-398
13. D.R. Nordli Jr M.M. Kuroda J. Carroll et al. Experience with the ketogenic diet in infants Pediatrics 108 2001 129-133
14. M. Yudkoff Y. Daikhin I. Nissim A. Lazarow I. Nissim Ketogenic diet, amino acid metabolism and seizure control J Neurosci Res 66 2001 931-940
15. M. Yudkoff Y. Daikhin I. Nissim A. Lazarow I. Nissim Brain amino acid metabolism and ketosis J Neurosci Res 66 2001 272-281
16. P.O. Kwiterrovich Jr E.P. Vining P. Pyzik R. Skolasky Jr J.M. Freeman Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children JAMA 290 2003 912-920
17. Q. Zhao C.E. Stafstrom D.D. Fu Y. Hu G.L. Holmes Detrimental effects of the ketogenic diet on cognitive functions in rats Pediatr Res 55 2004 498-506
18. E.H. Kossof More fat and fewer seizures: Dietary therapies for epilepsy Lancet Neurol 3 2004 415-420
19. C. Hemingway J.M. Freeman D.J. Pillas P.L. Pyzik The ketogenic diet: A 3- to 6-year follow -up of 150 children enrolled prospectively Pediatrics 108 2001 898-905
20. M.A. Mady E.H. Kossoff A.L. Mcgregor J.W. Wheless P.L. Pyzik J.M. Freeman The ketogenic diet: Adolescents can do it, too Epilepsia 44 2003 847-851
21. J.I. Sirven B. Whedon D. Caplan et al. Ketogenic diet for intractable epilepsy in adults: Preliminary results Epilepsia 40 1999 1721-1726
22. R.S. El-Mallakh M.E. Paskitti The ketogenic diet may have mood-stabilizing properties Med Hypoth 57 2001 724-726
23. S.R. Benbadis W.O. Tatum Advances in the treatment of epilepsy Am Fam Physician 64 2001 91-98
24. C.E. Stafstrom K.J. Bough The ketogenic diet for the treatment of epilepsy: A challenge for nutritional neuroscientists Nutr Neurosci 6 2003 67-79
25. A.N. Prasad C.F. Stafstrom G.L. Holmes Alternative epilepsy therapies: the ketogenic diet, immunoglobulins and steroids Epilepsia 37 Suppl. 1 1996 S81-S95
26. A.G. Herzog Reproductive endocrine considerations and hormonal therapy for women with epilepsy Epilepsia 32 Suppl. 6 1991 S27-S33
27. D.S. Reddy Newer GABAergic agents for pharmacotherapy of infantile spasms Drugs Today (Barc) 38 2002 657-675
28. A.G. Herzog Progesterone therapy in women with complex partial and secondary generalized seizures Neurology 45 1995 1660-1662
29. D.S. Reddy Role of neurosteroids in catamenial epilepsy Epilepsy Res 62 2004 99-118
30. R.H. Purdy A.L. Morrow P.H. Moore Jr S.M. Paul Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain Proc Natl Acad Sci USA 88 1991 4553-4557
31. D.D. Fraser S. Whiting R.D. Andrew E.A. Macdonald K. Musa-Veloso S.C. Cunnane Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet Neurology 60 2003 1026-1029
32. B.S. McEwen Non-genomic and genomic effects of steroids on neural activity Trends Pharmacol Sci 12 1991 141-147
33. A receptor: Mechanism of action and physiological significance Prog Neurobiol 38 1992 379-395
34. E.V. Lambert D.P. Speechly S.C. Dennis T.D. Noakes Enhanced endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet Eur J Appl Physiol 69 1994 387-393
35. C.A. Frye J.E. Duncan M. Basham M.E. Erskine Behavioral effects of 3α-androstanediol: II. Hypothalamic and preoptic area actions via GABAergic mechanism Behav Brain Res 79 1996 119-130
36. K.W. Gee M.B. Bolger R.D. Brinton H. Coirini B.S. McEwen Steroid modulation of the chloride ionophore in rat brain: Structure-activity requirements, regional dependence and mechanism of action J Pharmacol Exp Ther 246 1998 803-812
37. E.-E. Baulieu P. Robel Neurosteroids: A new brain function J Steroid Biochem Mol Biol 37 1990 395-403
38. C.A. Frye The neurosteroid 3α,5α-THP has anti-seizure and possible neuroprotective effects in an animal model of epilepsy Brain Res 696 1995 113-120
39. C.A. Frye T.A. Reed Androgenic neurosteroids: Anti-seizure effects in an animal model of epilepsy Psychoneuroendocrinology 23 1998 385-399
40. M.E. Rhodes C.A. Frye Androgens in the hippocampus can alter, and be altered by, ictal activity Pharmacol Biochem Behav 78 2004 483-493
41. I. McQuarrie C. Husted W.R. Bloor The lipids of the blood plasma in epilepsy: II. Variations of lipids in relation to occurrence of seizures J Clin Invest 12 1933 255-265
42. K.J. Bough S.G. Yao D.A. Eagles Higher ketogenic diet ratios confer protection from seizures without neurotoxicity Epilepsy Res 38 2000 15-25
43. K.J. Bough K. Gudi F.T. Han A.H. Rathod D.A. Eagles An anticonvulsant profile of the ketogenic diet in the rat Epilepsy Res 50 2002 313-325
44. C.A. Frye L.E. Bayon Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures Pharmacol Biochem Behav 62 1999 315-321
45. C.A. Frye L.E. Bayon Prenatal stress reduces the effectiveness of the neurosteroid 3α,5α-THP to block kainic-acid-induced seizures Dev Psychobiol 34 1999 227-234
46. C.A. Frye C.K. Kellogg Endogenous levels of 5α-THP-reduced progestins and androgens in fetal vs. adult rat brains Dev Brain Res 115 1999 17-24
47. P. Kehoe K. Mallinson C.M. McCormick C.A. Frye Central allopregnanolone is increased in rat pups in response to repeated, short episodes of neonatal isolation Brain Res Dev 124 2000 133-136
48. C.M. McCormick P. Kehoe K. Mallinson L. Cecchi C.A. Frye Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile rats Pharmacol Biochem Behav 73 2002 77-85
49. K.J. Bough R. Valiyil F.T. Han D.A. Eagles Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet Epilepsy Res 35 1999 21-28
50. S.W. Su M.R. Cilio Y. Sogawa D.C. Silveira G.L. Holmes Timing of ketogenic diet initiation in an experimental epilepsy model Dev Brain Res 125 2000 131-138
51. Ginzberg M, Watemberg N, Levi A, et al. Ketogenic diet as antiepileptic therapy: A description of the clinical experience and the multidisciplinary approach at the metabolic-neurogenetic clinic at the Wolfson Medical Center. Harefuah 2004;143:177-81.
52. C.A. Frye C.M. McCormick The neurosteroid, 3α-androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats Brain Res 855 2000 166-170
53. H.S. Noh Y.S. Kim H.P. Lee et al. The protective effect of ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice Epilepsy Res 53 2003 119-128
54. P.A. Schwartzkroin Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet Epilepsy Res 37 1999 171-180
55. J.P. Harney J. Madara J. Madara H. I'Anson Effects of acute inhibition of fatty acid oxidation on latency to seizure and concentrations of beta hydroxybutyrate in plasma of rats maintained on restriction and/or the ketogenic diet Epilepsy Res 49 2002 239-246
56. K.J. Bough P.A. Schwartzkroin J.M. Rho Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo Epilepsia 44 2003 752-760
57. C.A. Frye S.M. Petralia M.E. Rhodes Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP Pharmacol Biochem Behav 67 2000 587-596
58. C.A. Frye L.E. Bayon Seizure activity is increased in endocrine states characterized by decline in endogenous 3α,5α-THP Neuroendocrinology 68 1998 272-280
59. M.E. Rhodes C.A. Frye Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model Epilepsia 45 2004 1531-1538
60. Rodbard D, Hutt DM. Statistical analysis of radioimmunoassay and immunoradiometric assays: A generalized, weighted iterative, least squares method for logistic curve fitting. In: International Atomic Energy Agency (Ed.), Symposium on Radioimmunoassay and Related Procedures in Medicine, New York: Uniput; 1974.
61. C.A. Frye A.A. Walf Hippocampal 3α,5α-THP may alter depressive behavior of pregnant and lactating rats Pharmacol Biochem Behav 78 2004 531-540
62. G.E. Hoffman N. Moore G. Fiskum A.Z. Murphy Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment Exp Neurol 182 2003 124-134
63. A receptor 2003 CRC Press Boca Raton, FL
64. T. Backstrom Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle Acta Neurol Scand 54 1976 321-347
65. A receptor gene regulation in the brain and anxiety behavior Steroids 67 2002 519-528
66. A.G.C. Bergqvist Indications and contraindications of the ketogenic diet In: C.E. Stafstrom J.M. Rho editors. Epilepsy and the ketogenic diet 2004 Humana Press Clifton, NJ 111-121
67. M.E. Rhodes J.P. Harney C.A. Frye Gonadal, adrenal, and neuroactive steroids' role in ictal activity Brain Res 1000 2004 8-18
68. K.J. Bough R.S. Chen D.A. Eagles Path analysis shows that ketogenic diet, but not beta-hydroxybutyrate, elevates seizure threshold in the rat Dev Neurosci 21 1999 400-406
69. S.C. Cunnane K. Musa M.A. Ryan S. Whiting D.D. Fraser Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet Prostaglandins Leukot Essent Fatty Acids 67 2002 131-135
70. M.T. Todorova P. Tandon R.A. Madore C.E. Stafstrom T.N. Seyfried The ketogenic diet inhibits epileptogenesis in EL mice: A genetic model for idiopathic epilepsy Epilepsia 41 2000 933-940
71. D.A. Eagles S.J. Boyd A. Kotak F. Allan Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet Epilepsy Res 54 2003 41-52
72. R. Sankar M. Sotero de Menezes Metabolic and endocrine aspects of the ketogenic diet Epilepsy Res 37 1999 191-201
73. S.S. Likhodii K. Musa A. Mendonca C. Dell W.M. Burnham S.C. Cunnane Dietary fat, ketosis and seizure resistance in rats on the ketogenic diet Epilepsia 41 2004 1400-1410
74. M. Yudkoff Y. Daikhin I. Nissim Ketogenic diet, brain glutamate metabolism and seizure control Prostaglandins Leukot Essent Fatty Acids 70 2004 277-285
75. C.M. Cheng K. Hicks J. Wang D.A. Eagles C.A. Bondy Calorie restriction augments brain glutamic acid decarboxylase-65 and -67 expression J Neurosci Res 77 2004 270-276
76. Z.J. Wang C. Berrqvist J.V. Hunter D. Jin D.J. Wang S. Wehrli R.A. Zimmerman In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy: Exploration of GABA levels in a ketogenic diet Magn Reson Med 49 2003 615-619
77. C.A. Frye The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents Brain Res Rev 37 2001 201-222
78. D.P. Figlewicz Endocrine regulation of neurotransmitter transporters Epilepsy Res 37 1999 203-210
79. H.S. Noh Y.S. Kim H.P. Lee D.W. Kim S.S. Kang G.J. Cho A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet Brain Res Mol Brain 129 2004 80-87
80. Frye CA, Rhodes ME, Petralia SM, Walf AA, Sumida K, Edinger KL. 3α,5α-THP in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neurosci 2005, in press.
81. P. Murphy S.S. Likhodii M. Hatamian W.M. Burnham Effect of the ketogenic diet on the activity level of Wistar rats Pediatr Res 2004