Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo

Epilepsia

Volumn 44, Issue 6, 2003, Pages 752-760

  Bough, Kristopher J ^a   Schwartzkroin, Philip A ^b   Rho, Jong M ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Hydroxybutyrate; Calorie restriction; Dentate gyrus; Epilepsy; Ketogenic diet

Indexed keywords

3 HYDROXYBUTYRIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DENTATE GYRUS; ELECTROGRAPHY; EPILEPTOGENESIS; IN VIVO STUDY; INTRACTABLE EPILEPSY; KETOGENIC DIET; MALE; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE THRESHOLD;

ANIMALS; CALORIC RESTRICTION; DENTATE GYRUS; DIETARY CARBOHYDRATES; DIETARY FATS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; ELECTROPHYSIOLOGY; EPILEPSY; FOOD, FORMULATED; HUMANS; KETONE BODIES; KETOSIS; KINDLING, NEUROLOGIC; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0038305724     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.55502.x     Document Type: Article

References (47)

1. Brodie MJ, French JA. Management of epilepsy in adolescents and adults. Lancet 2000;356:323-9.
2. Vining EP, Freeman JM, Ballaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998;55:1433-7.
3. Livingston S. Dietary treatment of epilepsy. In: Livingston S, ed. Comprehensive management of epilepsy in infancy, childhood and adolescence. Springfield IL: Charles C Thomas, 1972:378-405.
4. Freeman JM, Vining EPG, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:358-63.
5. Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Bull 1921;2:307-8.
6. Cahill GF. Starvation in man. Clin Endocrinol Metab 1976;5:397-415.
7. Huttenlocher P. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:536-40.
8. Freeman JM, Freeman JB, Kelly MT. The ketogenic diet: a treatment for epilepsy. 3rd ed. New York: Demos Medical Publishing, 2000.
9. Uhlemann ER, Neims AH. Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther 1972;180:231-8.
10. Otani K, Yamatodani A, Wada H, et al. Effect of ketogenic diet on convulsive threshold and brain monoamine levels in young mice. No Tu Hattatsu 1984;16:196-204.
11. Appleton DB, De Vivo DC. An animal model for the ketogenic diet. Epilepsia 1974;15:211-7.
12. Hori A, Tandon P, Holmes GL, et al. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 1997;38:750-8.
13. Lothman EW, Stringer JL, Bertram EH. The dentate gyrus as a control point for seizures in the hippocampus and beyond. Epilepsy Res 1992;7(suppl):301-13.
14. McNamara JO. Emerging insights into the genesis of epilepsy. Nature 1999;399(suppl):A15-22.
15. Tuff LP, Racine RJ, Adamec R. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat, I: paired-pulse depression. Brain Res 1983;277:79-90.
16. de Jonge M, Racine RJ. The development and decay of kindling-induced increases in paired-pulse depression in the dentate gyrus. Brain Res 1987;412:318-28.
17. Stringer JL, Lothman EW. Maximal dentate gyrus activation: characteristics and alterations after repeated seizures. J Neurophysiol 1989;62:136-43.
18. Bough KJ, Emmi A, Rejniak SX, et al. Paired-pulse inhibition and maximal dentate activation protocols suggest decreased excitability in ketogenic diet-fed rats in vivo. Epilepsia 2001;42(suppl 7):264.
19. Rogers AE. Nutrition. In: Baker HJ, Lindsey JR, Weisbroth SH, eds. The laboratory rat. Orlando, FL: Academic Press, 1979:123-52.
20. Bough KJ, Eagles DA. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 1999;40:138-43.
21. Sloviter RS. Feedforward and feedback inhibition of hippocampal principal cell activity evoked by perforant path stimulation: GABA-mediated mechanisms that regulate excitability in vivo. Hippocampus 1991;1:31-40.
22. Stringer JL, Williamson JM, Lothman EW. Induction of paroxysmal discharges in the dentate gyrus: frequency dependence and relationship to afterdischarge production. J Neurophysiol 1989;62:126-35.
23. Stringer JL, Lothman EW. Maximal dentate activation: a tool to screen compounds for activity against limbic seizures. Epilepsy Res 1990;5:169-76.
24. Likhodii SS, Musa K, Mendonca A, et al. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia 2000;41:1400-19.
25. Rho JM, Kim DW, Robbins CA, et al. Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet. Epilepsy Res 1999;37:233-40.
26. Buckmaster PS, Schwartzkroin PA. Hyperexcitability in the dentate gyrus of the epileptic mongolian gerbil. Epilepsy Res 1994;18:23-8.
27. Muller-Schwarze AB, Tandon P, Liu Z, et al. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. Neuroreport 1999;10:1517-22.
28. Su SW, Cilio MR, Sogawa Y, et al. Timing of ketogenic diet initiation in an experimental epilepsy model. Brain Res Dev Brain Res 2000;125:131-8.
29. Croll SD, Suri C, Compton DL, et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 1999;93:1491-506.
30. Michelson HB, Kapur J, Lothman EW. Reduction of paired pulse inhibition in the CA1 region of the hippocampus by pilocarpine in naive and in amygdala-kindled rats. Exp Neurol 1989;104:264-71.
31. A receptor-mediated inhibition in adult rat somatosensory cortex. J Neurophysiol 1996;75:1589-600.
32. Stafstrom CE, Wang C, Jensen FE. Electrophysiological observations in hippocampal slices from rats treated with the ketogenic diet. Dev Neurosci 1999;21:393-9.
33. Kapur J, Stringer JL, Lothman EW. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. J Neurophysiol 1989;61:417-26.
34. Erecinska M, Nelson D, Daikhin Y, et al. Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects on glutamate, calcium, and ketone bodies. J Neurochem 1996;67:2325-34.
35. Yudkoff M, Daikhin Y, Nissim I, et al. Brain amino acid metabolism and ketosis. J Neurosci Res 2001;66:272-81.
36. Stringer JL, Lothman EW. Use of maximal dentate activation to study the effect of drugs on kindling and kindled responses. Epilepsy Res 1990;6:180-6.
37. Stringer JL. A comparison of topiramate and acetazolamide on seizure duration and paired-pulse inhibition in the dentate gyrus of the rat. Epilepsy Res 2000;40:147-53.
38. Stringer JL, Taylor CP. The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine. Epilepsy Res 2000;41:155-62.
39. Greene AE, Todorova MT, McGowan R, et al. Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia 2001;42:1371-8.
40. Bough KJ, Matthews PJ, Eagles DA. A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. Epilepsy Res 2000;38:105-14.
41. Stringer JL. Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus. Epilepsy Res 1993;16:99-109.
42. Stringer JL. Repeated seizures cause a generalized increase in excitability in the hippocampus. Neurosci Lett 1993;150:223-6.
43. Stringer JL. Repeated seizures increase GFAP and vimentin in the hippocampus. Brain Res 1996;717:147-53.
44. Stringer JL, Agarwal KS, Dure LS. Is cell death necessary for hippocampal mossy fiber sprouting? Epilepsy Res 1997;27:67-76.
45. White HS. Animal models of epileptogenesis. Neurology 2002;59(suppl 5):S7-14.
46. Kashiwaya Y, Takeshima T, Mori N, et al. D-β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A 2000;97:5440-4.
47. Bruce-Keller AJ, Umberger G, McFall R, et al. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol 1999;45:8-15.