Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet

Epilepsy Research

Volumn 35, Issue 1, 1999, Pages 21-28

  Bough, Kristopher J ^a   Valiyil, Ritu ^a   Han, Frederick T ^a   Eagles, Douglas A ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Beta hydroxybutyrate; Ketogenic diet; Rats; Seizure resistance

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CALORIC RESTRICTION; DIETARY INTAKE; KETOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

3-HYDROXYBUTYRIC ACID; AGING; ANIMALS; BEHAVIOR, ANIMAL; CONVULSANTS; DIET; ENERGY INTAKE; GROWTH; KETONE BODIES; KETOSIS; MALE; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0032902642     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(98)00125-9     Document Type: Article

References (40)

1. Adam, P.J., Taiha, N., Rahiala, E., Kekomaki, M., 1975. Oxidation of glucose and D-β-hydroxybutyrate by the early human fetal brain. Acta Paediatr. Scand. 64, 17-24.
2. Al-Mudallal, A.S., Levin, B.E., Lust, W.D., Harik, S.I., 1995. Effects of unbalanced diets on cerebral glucose metabolism in the adult rat. Neurology 45, 2261-2265.
3. Al-Mudallal, A.S., LaManna, J.C., Lust, D., Harik, S.I., 1996. Diet-induced ketosis does not cause cerebral acidosis. Epilepsia 37, 258-261.
4. Appleton, D.B., DeVivo, D.C., 1974. An animal model for the ketogenic diet. Epilepsia 15, 211-227.
5. Blennow, G., Folbergrova, J., Nilsson, B., Siesjö, B.K., 1979. Effects of bicuculline-induced seizures on cerebral metabolism and circulation of rats rendered hypoglycemic by starvation. Ann. Neurol. 5, 139-151.
6. Bough, K.J., Eagles, D.A., 1998. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia (in press).
7. Cremer, J.E., Braun, L.D., Oldendorf, W.H., 1976. Changes during development in transport processes of the blood-brain barrier. Biochim. Biophys. Acta 448, 633-637.
8. Dahlquist, G., Persson, B., 1976. The rate of cerebral utilization of glucose, ketone bodies and oxygen: a comparative in vivo study of infant and adult rats. Pediatr. Res. 10, 910-917.
9. Fisher, R.S., 1989. Animal models of the epilepsies. Brain Res. Rev. 14, 245-278.
10. Freeman, J.M., Kelly, M.T., Freeman, J.B., 1994. The Epilepsy Diet Treatment: An Introduction to the Ketogenic Diet. Demos, New York.
11. Freeman, J.M., 1995. A clinician's look at the developmental neurobiology of epilepsy. In: Schwartzkroin, P.A., Moshe, S.L., Noebels, J.L., Swann, J.W. (Eds.), Brain Development and Epilepsy. Oxford University Press, New York.
12. Hawkins, R.A., Williamson, D.H., Krebs, H.A., 1971. Ketone-body utilization by adult and suckling rat brain in vivo. Biochem. J. 122, 13-18.
13. Haymond, M.W., Howard, C., Ben-Galim, E., De Vivo, D.C., 1983. Effects of ketosis on glucose flux in children and adults. Am. J. Physiol. 245, E373-E378.
14. Holmes, G.L., 1997. Epilepsy in the developing brain: lessons from the laboratory and clinic. Epilepsia 38, 12-30.
15. Hori, A., Tandon, P., Holmes, G.L., Stafstrom, C.E., 1997. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 38, 750-758.
16. Itoh, T., Quastel, J.H., 1970. Acetoacetate metabolism in infant and adult rat brain in vitro. Biochem. J. 116, 641-655.
17. Johnston, M.V., 1996. Developmental aspects of epileptogenesis. Epilepsia 37 (Suppl. 1), S2-S9.
18. Kinsman, S.L., Vining, E.P.G., Quaskey, S.A., Mellits, E.D., Freeman, J.M., 1992. Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 33, 1132-1136.
19. Klee, C.B., Sokoloff, L., 1967. Changes in D(-)-β-hydroxybutyric dehydrogenase activity during brain maturation in the rat. J. Biol. Chem. 242, 3880-3883.
20. Kraus, H., Schlenker, S., Schwedesky, D., 1974. Developmental changes of cerebral ketone body utilization in human infants. Hoppe-Seyler's Z. Physiol. Chem. 355, 164-170.
21. Moore, T.J., Lione, A.P., Sugden, M.C., Regen, D.M., 1976. Hydroxybutyrate transport in rat brain: developmental and dietary modulations. Am. J. Physiol. 230, 619-630.
22. Moshe, S.L., Albala, B.J., Ackermann, R.F., Engel, J. Jr., 1983. Increased seizure susceptibility of the immature brain. Dev. Brain Res. 7, 81-85.
23. Moshe, S.L., 1987. Epileptogenesis and the immature brain. Epilepsia 28 (Suppl. 1), S3-S15.
24. Nehlig, A., deVasconcelos, A.P., 1993. Glucose and ketone body utilization by the brain of neonatal rats. Prog. Neurol. 40, 163-221.
25. Nordli, D.R., DeVivo, D.C., 1997. The ketogenic diet revisited: back to the future. Epilepsia 38, 743-749.
26. Nordli, D.R., Koenigsberger, D., Carroll, J., DeVivo, D.C., 1995. Successful treatment of infants with the ketogenic diet. Ann. Neurol. 38, 523.
27. Otani, K., Yamatodani, A., Wada, H., Mimaki, T., Yabuuchi, H., 1984. Effect of ketogenic diet on convulsive threshold and brain monoamine levels in young mice. No Tu Hattatsu 16, 196-204.
28. Owen, O.E., Morgan, A.P., Kemp, H.G., Sullivan, J.M., Herrera, M.G., Cahill, G.F., 1967. Brain metabolism during fasting. J. Clin. Invest. 46, 1589-1594.
29. Page, M.A., Krebs, H.A., Williamson, D.H., 1971. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Biochem. J. 121, 49-53.
30. Persson, B., Settergren, G., Dahlquist, G., 1972. Cerebral arterio-venous difference of acetoacetate and D-β-hydroxybutyrate in children. Acta Paediatr. Scand. 61, 273-278.
31. Prasad, A.N., Stafstrom, C.F., Holmes, G.L., 1996. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 37 (Suppl. 1), S81-S95.
32. Prince, D.A., Gutnick, M.J., 1972. Neuronal activities in epileptogenic foci of immature cortex. Brain Res. 45, 455-468.
33. Purpura, D.P., Shofer, R.J., Scarff, T., 1965. Properties of synaptic activities and spike potentials of neurons in immature neocortex. J. Neurophysiol. 28, 925-942.
34. Rogers, A.E., 1979. Nutrition. In: Baker, H.J., Lindsey, J.R., Weisbroth, S.H. (Eds.), The Laboratory Rat, vol. I, chapter 6. Academic Press, Orlando, pp. 123
35. Schwartz, R.H., Eaton, J., Bower, B.D., Aynsley-Green, A., 1989. Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev. Med. Child Neurol. 31, 145-151.
36. Spitzer, J.J., Wang, J.T., 1972. Removal and utilization of ketone bodies by the brain of newborn puppies. J. Neurochem. 19, 2169-2173.
37. Spitzer, N.C., 1995. Regulation of excitability in developing neurons. In: Schwartzkroin, P.A., Moshe, S.L., Noebels, J.L., Swann, J.W. (Eds.), Brain Development and Epilepsy. Oxford University Press, New York.
38. Uhlemann, E. R., Neims, A.H., 1972. Anticonvulsant properties of the ketogenic diet in mice. J. Pharmacol. Exp. Ther. 180, 231-238.
39. Wiener, R., Hirsch, H.J., Spitzer, J.J., 1971. Cerebral extraction of ketones and their penetration into CSF in the dog. Am. J. Physiol. 220, 1542-1545.
40. Wooley, D.E., Timiras, P.S., 1962. Estrous and circadian periodicity and electroshock convulsion in rats. Am. J. Physiol. 202, 379-382.