Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet

Epilepsy Research

Volumn 54, Issue 1, 2003, Pages 41-52

  Eagles, Douglas A ^a   Boyd, Suzanne Jabbour ^a   Kotak, Anandi ^a   Allan, Fiona ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Calorie restriction; Carbohydrate; Diet; Ketogenic diet; Rat; Seizure

Indexed keywords

3 HYDROXYBUTYRIC ACID; MINERAL; PENTETRAZOLE; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CALORIC RESTRICTION; CARBOHYDRATE DIET; CLONIC SEIZURE; CONTROLLED STUDY; DIETARY INTAKE; DRUG INDUCED DISEASE; FOOD COMPOSITION; KETOGENIC DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE THRESHOLD; TEST MEAL;

EID: 0038735542     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(03)00041-X     Document Type: Article

References (72)

1. Al-Mudallal A.S., Levin B.E., Lust W.D., Harik S.I. Effects of unbalanced diets on cerebral glucose metabolism in the adult rat. Neurology. 45:1995;2261-2265.
2. Al-Mudallal A.S., LaManna J.C., Lust W.D., Harik S.I. Diet-induced ketosis does not cause cerebral acidosis. Epilepsia. 37:1996;258-261.
3. Appleton D.B., DeVivo D.C. An animal model of the ketogenic diet. Epilepsia. 15:1974;211-227.
4. Benoit F.L., Martin R.L., Watten R.H. Changes in body composition during weight reduction in obesity. Balance studies comparing effects of fasting and a ketogenic diet. Ann. Int. Med. 63:1965;604-612.
5. Boozer C.N., Schoenback G., Atkinson R.L. Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically. Am. J. Physiol. Endocrinol. Metab. 268(31):1995;E546-E550.
6. Bough K.J., Eagles D.A. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia. 40:1999;138-143.
7. Bough K.J., Chen R.S., Eagles D.A. Path analysis shows that increasing ketogenic ratio, but not β-hydroxybutyrate, elevates seizure threshold in the rat. Dev. Neurosci. 21:1999a;400-406.
8. Bough K.J., Valiyil R., Han F.T., Eagles D.A. Seizure resistance in rats is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res. 35:1999b;21-28.
9. Bough K.J., Yao S.G., Eagles D.A. Higher ketogenic ratios confer protection from seizures without neurotoxicity. Epilepsy Res. 38:2000;15-25.
10. Bruce-Keller A.J., Umberger G., McFall R., Mattson M.P. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 45:1999;8-15.
11. Bukowiecki L.J., Folléa N., Lupien J., Paradis A. Metabolic relationships between lipolysis and respiration in rat brown adipocytes: the role of long chain fatty acids as regulators of mitochondrial respiration and feedback inhibitors of lipolysis. J. Biol. Chem. 256:1981;12840-12848.
12. Cahill G.F. Jr. President's address: starvation. Am. Clin. Climatolog. Assn. 94:1982;1-21.
13. Daniel P.M., Love E.R., Moorhouse S.R., Pratt O.E., Wilson P. Factors influencing utilisation of ketone-bodies by brain in normal rats and rats with ketoacidosis. Lancet. 2(7725):1971;637-638.
14. Davis J.D., Wirtshafter D., Asin K.E., Brief D. Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats. Science. 212:1981;81-83.
15. Dekaban A.S. Plasma lipids in epileptic children treated with the high fat diet. Arch. Neurol. 15:1966;177-184.
16. DeLany J.P., Hansen B.C., Bodkin N.L., Hannah J., Bray G.A. Long-term calorie restriction reduces energy expenditure in aging monkeys. J. Gerontol. Series A: Biol. Sci. Med. Sci. 54:1999;B5-B11.
17. Dell C.A., Likhodii S.S., Musa K., Ryan M.A., Burnham W.M., Cunnane S.C. Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets. Lipids. 36:2001;373-378.
18. DeVivo D.C., Malas K.L., Leckie M.P. Starvation and seizures. Arch. Neurol. 32:1975;755-760.
19. DeVivo D.C., Leckie M.P., Ferrendelli J.S., McDougal D.B. Jr. Chronic ketosis and cerebral metabolism. Ann. Neurol. 3:1978;331-337.
20. Donato K., Hegsted D.M. Efficiency of utilization of various sources of energy for growth. Proc. Natl. Acad. Sci. U.S.A. 82:1985;4866-4870.
21. Dror Y., Sassoon H.F., Watson J.J., Mack D.O., Johnson B.C. Fat versus sucrose as the nonprotein calorie portion of the diet of rats. J. Nutr. 103:1973;342-346.
22. Erecinska M., Nelson D., Daikhin Y., Yudkoff M. Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J. Neurochem. 67:1996;2325-2334.
23. Fery F., Bourdoux P., Christophe J., Balasse E.O. Hormonal and metabolic changes induced by an isocaloric isoproteinic ketogenic diet in healthy subjects. Diabetes Metab. (Paris). 8:1982;299-305.
24. Foote F., Gale K. Proconvulsant effect of morphine on seizures induced by pentylenetetrazol in the rat. Eur. J. Pharmacol. 105:1984;179-184.
25. Freeman J.M., Vining E.P.G. Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch. Pediatr. Adolesc. Med. 153:1999;946-949.
26. Freeman, J.M., Kelly, M.T., Freeman, J.B., 1994. The Epilepsy Diet Treatment: An Introduction to the Ketogenic Diet. Demos, New York.
27. Geyelin R. Fasting as a method for treating epilepsy. Med. Rec. 99:1921;1037-1039.
28. Gjedde A., Crone C. Induction processes in blood-brain transfer of ketone bodies during starvation. Am. J. Physiol. 229:1975;1165-1169.
29. Greene A.E., Todorova M.T., McGowan R., Seyfried T.N. Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia. 42:2001;1371-1378.
30. Hansen B.C., Bodkin N.L., Ortmeyer H.K. Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality. Toxicol. Sci. 52:1999;56-60.
31. Harik S.I., Al-Mudallal A.S., LaManna J.C., Lust W.D., Levin B.E. Ketogenic diet and the brain. Ann. N.Y. Acad. Sci. 835:1997;218-224.
32. Hawkins R.A., Williamson D.H., Krebs H.A. Ketone body utilization by adult and suckling rat brain in vivo. Biochem. J. 122:1971;13-18.
33. Hegardt F.G. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochem. J. 338:1999;569-582.
34. Huttenlocher P.R. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr. Res. 10:1976;536-540.
35. Jéquier E., Tappy L. Regulation of body weight in humans. Physiol. Rev. 79:1999;451-480.
36. Kekwick A., Pawan G.L.S. The effect of high fat and high carbohydrate diets on rates of weight loss in mice. Metabolism. 13:1964;87-97.
37. Kochan Z., Karbowska J., Świerczyński J. Unusual increase of lipogenesis in rat white adipose tissue after multiple cycles of starvation-refeeding. Metabolism. 46:1997;10-17.
38. Lee C.-K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science. 285:1999;1390-1393.
39. Likhodii S.S., Musa K., Mendonca A., Dell C., Burnham W.M., Cunnane S.C. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia. 41:2000;1400-1410.
40. Lin S.J., Kaeberlein M., Andalis A.A., Sturtz L.A., Defossez P.A., Culotta V.C., Fink G.R., Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 418:2002;344-348.
41. Löscher W., Fiedler M. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds. Epilepsy Res. 25:1996;3-10.
42. Mahoney A.W., Hendricks D.G., Bernhard N., Sisson D.V. Fasting and ketogenic diet effects on audiogenic seizure susceptibility of magnesium deficient rats. Pharmacol. Biochem. Behav. 18:1983;683-687.
43. Mhatre M.C., Ticku M.K. Calorie restriction retarded the aging associated changes in gamma-aminobutyric acid A receptor gene expression in rat cerebellum. Brain Res. Mol. Brain Res. 54:1998;270-275.
44. Nakazawa M., Kodama S., Matsuo T. Effects of ketogenic diet on electroconvulsive threshold and brain contents. Brain Dev. 5:1983;375-380.
45. Nordli D.R., DeVivo D.C. The ketogenic diet revisited: back to the future. Epilepsia. 38:1997;743-749.
46. Owen O.E., Morgan A.P., Kemp H.G., Sullivan J.M., Herrera M.G., Cahill G.F. Brain metabolism during fasting. J. Clin. Invest. 46:1967;1589-1595.
47. Owen O.E., Reichard G.A. Jr., Boden G., Shuman C. Comparative measurements of glucose, beta-hydroxybutyrate, acetoacetate, and insulin in blood and cerebrospinal fluid during starvation. Metabolism. 23:1974;7-14.
48. Pariza M.W. Dietary fat, calorie restriction, ad libitum feeding, and cancer risk. Nutr. Rev. 45:1987;107.
49. Peterman M.G. The ketogenic diet in epilepsy. JAMA. 84:1925;1979-1988.
50. Pollack G.M., Shen D.D. A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. J. Pharmacol. Methods. 13:1985;135-146.
51. Portnay G.I., O'Brian J.T., Bush J., Vagenakis A.G., Azizi F., Arky R.A., Ingbar S.H., Braverman L.E. The effect of starvation on the concentration and binding of thyroxine and triiodothyronine in serum on the response to TRH. J. Clin. Endocrinol. Metab. 39:1974;191-194.
52. Rho J.M., Anderson G.D., Donevan S.D., White H.S. Acetoacetate, acetone, and dibenzylamine (a contaminant in 1-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo. Epilepsia. 43:2002;358-361.
53. Riou J.P., Beylot M., Laville M., De Parscau L., Delinger J., Sautot G., Mornex R. Antiketogenic effect of glucose per se in vivo in man and in vitro in isolated rat liver cells. Metabolism. 35:1986;608-613.
54. Roe F.J.C. Are nutritionists worried about the epidemic of tumours in laboratory animals? Proc. Nutr. Soc. 40:1981;57-65.
55. Rogers, A.E., 1979. Nutrition. In: Baker, H.J., Lindsey, J.R., Weisbroth, S.H. (Eds.), The Laboratory Rat, vol. I. Academic Press, Orlando (Chapter 6).
56. Ruderman N.B., Ross P.S., Berger M., Goodman M.N. Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem. J. 138:1974;1-10.
57. Schwartz R.M., Boyes S., Aynsley-Green A. Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev. Med. Child Neurol. 31:1989;152-160.
58. 1H -MRS in patients with epilepsy controlled by ketogenic diet Magn. Reson. Mater. Phys. Biol. Med. 8:1999;33-42.
59. Shouse M.N., da Silva A.M., Sammaritano M. Circadian rhythm, sleep, and epilepsy. J. Clin. Neurophysiol. 13:1996;32-50.
60. Stern J.S., Gades M.D., Wheeldon C.M., Borchers A.T. Calorie restriction in obesity: prevention of kidney disease in rodents. J. Nutr. 131:2001;913S-917S.
61. Sun M., Martin R.J., Edwards G.L. ICV β-hydroxybutyrate: effects on food intake, body composition, and body weight in rats. Physiol. Behav. 61:1997;433-436.
62. Swink T.D., Vining E.P.G., Freeman J.M. The ketogenic diet: 1997. Adv. Pediatr. 44:1997;297-329.
63. Thio L.L., Wong M., Yamada K.A. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology. 54:2000;325-331.
64. Uhlemann E.R., Neims A.H. Anticonvulsant properties of the ketogenic diet in mice. J. Pharmacol. Exp. Ther. 180:1972;231-238.
65. Vagenakis A.G., Burger A., Portnay G.I., Rudolph M., O'Brian J.T., Azizi F., Arky R.A., Nicod P., Ingbar S.H., Braverman L.E. Diversion of peripheral thryroxine metabolism from activating to inactivating pathways during complete fasting. J. Clin. Endocrinol. Metab. 41:1975;191-194.
66. Voskuyl R.A., Vreugdenhil M., Kang J.X., Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur. J. Pharmacol. 341:1998;145-152.
67. Walford R.L., Mock D., Verdery R., MacCallum T. Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J. Gerontol. Series A: Biol. Sci. Med. Sci. 57:2002;B211-B224.
68. Wilder R.M. The effects of ketonemia on the course of epilepsy. Mayo Clin. Bull. 2:1921;307-308.
69. Woolley D.E., Timiras P.S. Estrous and circadian periodicity and electroshock convulsions in rats. Am. J. Physiol. 202:1962;379-382.
70. Yehuda A., Carasso R.L., Mostofsky D.I. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur. J. Pharmacol. 254:1994;193-198.
71. Yudkoff M., Daikhin Y., Nissim I., Grunstein R., Nissim I. Effects of ketone bodies on astrocyte amino acid metabolism. J. Neurochem. 69:1997;682-692.
72. Ziegler D.F., Araújo E., Rotta L.N., Perry M.L., Gonçalves C.A. A ketogenic diet increases protein phosphorylation in brain slices of rats. J. Nutr. 132:2002;483-487.