Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model

Epilepsia

Volumn 45, Issue 12, 2004, Pages 1531-1538

  Rhodes, Madeline E ^a   Frye, Cheryl A ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

3 ,5 THP; Animal Model; Epilepsy; Progesterone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; GESTAGEN; PENTETRAZOLE; PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIESTRUS; FEMALE; HIPPOCAMPUS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROESTRUS; PROGESTERONE BLOOD LEVEL; RAT; SEIZURE;

5-ALPHA-DIHYDROPROGESTERONE; ANIMALS; ANTICONVULSANTS; DIESTRUS; DISEASE MODELS, ANIMAL; FEMALE; HIPPOCAMPUS; MOTOR ACTIVITY; OVARIECTOMY; PENTYLENETETRAZOLE; POSTURE; PROESTRUS; PROGESTERONE; PROGESTINS; RADIOIMMUNOASSAY; RATS; RATS, LONG-EVANS; SEIZURES; SEXUAL BEHAVIOR, ANIMAL;

EID: 10644251771     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0013-9580.2004.16504.x     Document Type: Article

References (46)

1. Spiegel E, Wycis H. Anticonvulsant effects of steroids. J Lab Clin Med 1945;36:947-53.
2. Backstrom T. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol Scand 1976;54:321-47.
3. Frye CA, Bayon LE. Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid, 3α,5α-THP. Neuroendocrinology 1998;68:272-80.
4. Herkes GK, Eadie MJ, Sharbrough F, et al. Patterns of seizure occurrence in catamenial epilepsy. Epilepsy Res 1993;15:47-52.
5. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997;38:1082-8.
6. Morrell MJ. Hormones and epilepsy through the lifetime. Epilepsia 1992;33:S49-61.
7. Pesce ME, Acevedo X, Bustamante D, et al. Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice. Pharmacol Toxicol 2001;89:312-4.
8. Backstrom T, Zetterlund B, Blom S, et al. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol Scand 1984;60:240-8.
9. Edwards HE, Burnham WM, Mendonca A, et al. Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats. Brain Res 1999;838:136-50.
10. Frye CA, Bayon LE. Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures. Pharmacol Biochem Behav 1999;62:315-21.
11. Frye CA, Bayon LE. Prenatal stress reduces the effectiveness of the neurosteroid 3α,5α-THP to block kainic-acid-induced seizures. Dev Psychobiol 1999;34:227-34.
12. Frye CA, Scalise TJ. Anti-seizure effects of progesterone and 3α,5α-THP in kainic acid and perforant pathway models of epilepsy. PsychoNeuroendocrinology 2000;25:407-20.
13. Herzog AG. Intermittent progesterone therapy and frequency of complex partial seizures in women with menstrual disorders. Neurology 1986;36:1607-10.
14. Hoffman GE, Moore N, Fiskum G, et al. Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Exp Neurol 2003;182:124-34.
15. Pesce ME, Acevedo X, Bustamante D, et al. Progesterone and testosterone modulate the convulsant actions of pentylenetetrazol and strychnine in mice. Pharmacol Toxicol 2000;87:116-9.
16. Reddy DS, Rogawski MA. Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia 2001;42:337-44.
17. Frye CA, Scalise TJ, Bayon LE. Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. J Neuroendocrinol 1998;10:291-6.
18. Herzog AG, Frye CA. Seizure exacerbation associated with inhibition of progesterone metabolism. Ann Neurol 2003;53:390-1.
19. Kokate TG, Banks MK, Magee T, et al. Finasteride, a 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J Pharmacol Exp Ther 1999;288:679-84.
20. Rhodes ME, McCormick CM, Frye CA. 3α,5α-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacol Biochem Behav 2004;78:505-12.
21. McEwen BS. Steroid hormones and the brain: cellular mechanisms underlying neural and behavioral plasticity. PsychoNeuroendocrinology 1980;5:1-11.
22. Frye CA, Vongher JM. 3α,5α-THP in the midbrain ventral tegmental area of rats and hamsters is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. J Endocrinol Invest 1999;22:455-64.
23. Mathern GW, Leite JP, Pretorius JK, et al. Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development. Epilepsy Res Suppl 1996;12:33-43.
24. Frye CA. The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res 1995;696:113-20.
25. Pohle W, Becker A, Grecksch G, et al. Piracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits. Seizure 1997;6:467-74.
26. Rigoulot MA, Koning E, Ferrandon A, et al. Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy. J Pharmacol Exp Ther 2004;308:787-95.
27. Long JA, Evans HM. Oestrous cycle in the rat and its associated phenomena. Memoirs of The University of California 1922;6:1-146.
28. Hardy DF, Debold JF. Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat. Physiol Behav 1971;7:643-45.
29. Rhodes ME, Frye CA. Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors. Cogn Affect Behav Neurosci 2001;1:287-96.
30. Davis PG, Krieger MS, Barfield RJ, et al. The site of action of intrahypothalamic estrogen implants in feminine sexual behavior: an autoradiographic analysis. Endocrinology 1982;111:1581-6.
31. Stone WE. Convulsant actions of tetrazole derivatives. Pharmacology 1970;3:367-70.
32. Racine RJ. Modification of seizure activity by electrical stimulation, II: motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-94.
33. Huot J, Radouco-Thomas C. Qualitative and quantitative evaluation of experimentally induced seizures. In: Mercier J, ed. Anticonvulsant drugs. Oxford: Pergamon, 1973;1:123-85.
34. Browning RA. Anatomy of generalized convulsive seizures. In:Malafosse A, Genton P, Hirsch E et al., eds. Idiopathic generalized seizures epilepsies: clinical, experimental and genetic aspects. London: John Libbey, 1994:399-413.
35. Hirsch E, Maton B, Vergnes M, et al. Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats. Epilepsy Res 1992;11:159-66.
36. Hirsch E, Danober L, Simler S, et al. The amygdala is critical for seizure propagation from brainstem to forebrain. Neuroscience 1997;77:975-84.
37. Rhodes ME, Frye CA. Androgens in the hippocampus can alter, and be altered by, ictal activity. Pharmacol Biochem Behav 2004;78:483-93.
38. Rodbard D, Hutt DM. Statistical analysis of radioimmunoassay and immunoradiometric assays: a generalized, weighted iterative, least squares method for logistic curve fitting. In: International Atomic Energy Agency, ed. Symposium on radioimmunoassay and related procedures in medicine. New York: Uniput, 1974:209-33.
39. Finn DA, Gee KW. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther 1994;271:164-70.
40. Lonsdale D, Burnham WM. The anticonvulsant effects of progesterone and 5α-dihydroprogesterone on amygdala-kindled seizures in rats. Epilepsia 2003;44:1494-9.
41. Reddy DS, Castaneda DC, O'Malley BW, et al. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther 2004;310:230-9.
42. Kalkbrenner KA, Standley CA. Estrogen modulation of NMDA-induced seizures in ovariectomized and non-ovariectomized rats. Brain Res 2003;964:244-9.
43. Paul SM, Purdy RH. Neuroactive steroids. FASEB J 1992;6:2311-22.
44. Cunningham GR, Tindall DJ, Means AR. Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor. Steroids 1979;33:261-76.
45. Gee KW. Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Mol Neurobiol 1988;2:291-317.
46. Cyr M, Ghribi O, Thibault C, et al. Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors. Brain Res Brain Res Rev 2001;37:153-61.