A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents

Journal of Medicinal Chemistry

Volumn 44, Issue 16, 2001, Pages 2507-2510

  Campiani, G ^a   De Angelis, M ^b   Armaroli, S ^b   Fattorusso, C ^c   Catalanotti, B ^a   Ramunno, A ^a   Nacci, V ^b   Novellino, E ^c   Grewer, C ^d   Ionescu, D ^d   Rauen, T ^e   Griffiths, R ^f   Sinclair, C ^f   Fumagalli, E ^g   Mennini, T ^g  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^e UNIVERSITY OF MÜNSTER   (Germany)

^f UNIVERSITY OF ST ANDREWS   (United Kingdom)

^g MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; ASPARTIC ACID DERIVATIVE; EXCITATORY AMINO ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT;

AMINO ACID TRANSPORT; ARTICLE; CELL VIABILITY; CEREBELLUM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GRANULE CELL; IN VITRO STUDY; MOLECULAR MODEL;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CEREBRAL CORTEX; DRUG DESIGN; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMATES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RATS; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0035797358     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015509z     Document Type: Article

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