Molecular pharmacology and physiology of glutamate transporters in the central nervous system

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 6, 1998, Pages 393-400

  Vandenberg, Robert J ^a  

^a University of Sydney   (Australia)

Author keywords

EAAT1 5; Glutamate transport; Ion coupling

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; CELL SURFACE RECEPTOR; CHLORIDE CHANNEL; COMPLEMENTARY DNA; DEXTRO ASPARTIC ACID; DIHYDROKAINIC ACID; EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR; NEUROTOXIN; NEUROTRANSMITTER; SERINE;

AMINO ACID SEQUENCE; CELL MEMBRANE; CELL SURFACE; CENTRAL NERVOUS SYSTEM; ELECTROPHYSIOLOGY; GLIA CELL; ION CONDUCTANCE; MEMBRANE TRANSPORT; NEUROTRANSMISSION; PROTEIN ANALYSIS; PROTEIN TRANSPORT; REVIEW; SYNAPSE; SYNAPSE VESICLE;

EID: 0031833248     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02221.x     Document Type: Review

References (65)

1. Balcar VJ, Johnston GAR. The structural specificity of the high affinity of L-glutamate and L-aspartate uptake systems in the rat CNS. J. Neurochem. 1972; 19: 2657-66.
2. Fletcher EJ, Johnston GAR. Regional heterogeneity of L-glutamate and L-aspartate high affinity uptake systems in the rat CNS. J. Neurochem. 1991; 57: 911-14.
3. 3H]-glutamate transport process in the rat brain. Brain Res. 1991; 544: 196-202.
4. 3H]-glutamate transport activity: Pharmacological specificity and regulation by sodium and potassium. J. Neurochem. 1993; 60: 167-79.
5. +-dependent glutamate/aspartate transporter from rat brain. Proc. Natl Acad. Sci. USA 1992; 89: 10955-9.
6. Pines G, Danbolt NC, Borjoras M et al. Cloning and expression of a L-glutamate transporter. Nature 1992; 360: 464-7.
7. Kanai Y, Hediger MA. Primary structure and functional characterisation of a high affinity glutamate transporter. Nature 1992; 360: 467-71.
8. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino acid transporter with properties of a ligand-gated chloride channel. Nature 1995; 375: 599-603.
9. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl Acad. Sci. USA 1997; 94: 4155-60.
10. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG. Functional comparisons of three glutamate transporters cloned from human motor cortex. J. Neurosci. 1994; 14: 5559-69.
11. Rothstein JD, Martin L, Levey AI et al. Localization of neuronal and glial glutamate transporters. Neuron 1994; 13: 713-25.
12. Torp R, Danbolt NC, Babaie E et al. Differential expression of two glial glutamate transporters in the rat brain: An in situ hybridization study. Eur. J. Neurosci. 1994; 6: 936-42.
13. Chaudhry FA, Lehre KP, van Lookeren Campagne M, Ottersen OP, Danbolt NC, Storm-Mathisen J. Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 1995; 15: 711-20.
14. Yamada K, Watanabe M, Shibata T, Tanaka K, Wada K, Inoue Y. EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. Neuroreport 1996; 7: 2013-17.
15. Eliasof S, Arriza JL, Amara SG, Kavanaugh MP. Immunocytochemical localization of 5 glutamate transporters cloned from salamander retina. Invest. Ophthalmol. Vis. Sci. 1997; (Suppl.): Abstract 1434.
16. Seal B, Arriza JL, Amara SG. Topological studies of the sodium-dependent glutamate transporter family. Soc. Neurosci. Abstr. 1995; 21: 1861.
17. Wahle S, Stoffel C. Membrane topology of the high affinity L-glutamate transporter (GLAST-1) of the central nervous system. J. Cell Biol. 1996; 135: 1867-77.
18. +)-coupled glutamate transporter from rat brain. J. Biol. Chem. 1995; 270: 17093-7.
19. Vandenberg RJ, Arriza JL, Amara SG, Kavanaugh MP. Constitutive ion fluxes and substrate binding domains of human glutamate transporters. J. Biol. Chem. 1995; 270: 17668-71.
20. Kavanaugh MP, Bendahan A, Zerangue N, Zhang Y, Kanner BI. Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange J. Biol. Chem. 1996; 272: 1703-8.
21. Slotboom DJ, Lolkema JS, Konings WN. Membrane topology of the C-terminal half of the neuronal, glial and bacterial glutamate transporter family. J. Biol. Chem. 1996; 271: 31 317-21.
22. Haugeto O, Ullensvang K, Levy LM et al. Brain glutamate transporter proteins form homomultimers. J. Biol. Chem. 1996; 271: 27 715-22.
23. Kanner BI, Sharon I. Active transport of L-glutamate by membrane vesicles isolated from rat brain. Biochemistry 1978; 17: 3949-53.
24. Barbour B, Brew H, Attwell D. Electrogenic glutamate uptake in glial cells is activated by intracellular potassium. Nature 1988; 335: 433-5.
25. Bouvier M, Szatkowski M, Amato A, Attwell D. The glial cell glutamate uptake carrier counter-transports pH-changing anions. Nature 1992; 360: 471-4.
26. Zerangue N, Kavanaugh MP. Flux coupling in a neuronal glutamate transporter. Nature 1996; 383: 634-7.
27. Nicholls D, Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 1990; 11: 462-8.
28. Siesjö BK. Calcium, excitotoxins and brain damage. News Physiol. Sci. 1990; 5: 120-5.
29. Szatkowski M, Barbour B, Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 1990; 348: 443-6.
30. Marc RE, Liu W-LS, Kalloniatis M, Raiguel SF, Van Haesendonck E. Patterns of glutamate immunoreactivity in the goldfish retina. J. Neurosci. 1990; 10: 4006-34.
31. Bramham CR, Torp R, Zhang N, Storm-Mathisen J, Ottersen OP. Distribution of glutamate-like immunoreactivity in excitatory hippocampul pathways: A semi-quantitative electron microscopy study. Neuroscience 1990; 39: 405-17.
32. Storm-Mathisen J, Danbolt NC, Rothe F et al. Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue. Prog. Brain Res. 1992; 94: 225-41.
33. Ottersen OP. Quantitative electromicroscopic immunoreactivity of neuroactive amino acids. Anat. Embryol. 1989; 180: 1-15.
34. Attwell D, Barbour B, Szatkowski M. Non-vesicular release of neurotransmitters. Neuron 1993; 11: 401-7.
35. Wadiche JI, Amara SG, Kavanaugh MP. Ion fluxes associated with excitatory amino acid transport. Neuron 1995; 15: 721-8.
36. Eliasof S, Jahr C. Retinal glial glutamate transporters coupled to an anionic conductance. Proc. Natl Acad. Sci. USA 1996; 93: 4153-8.
37. Billups B, Rossi D, Attwell D. Anion conductance behaviour of the glutamate uptake carrier in salamander glial cells. J. Neurosci. 1996; 16: 6722-31.
38. Frenguelli BG, Blake JF, Brown MW, Collingridge GL. Electrogenic uptake contributes a major component of the depolarizing action of L-glutamate in rat hippocampal slices. Br. J. Pharmacol. 1991; 102: 355-62.
39. Barbour B, Szatkowski M, Ingledew N, Attwell D. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 1989; 342: 918-20.
40. Attwell D, Miller B, Sarantis M. Arachidonic acid as a messenger in the central nervous system. Semin. Neurosci. 1993; 5: 159-69.
41. Zerangue N, Arriza JL, Amara SG, Kavanaugh MP. Differential modulation of human glutamate transporter subtypes by arachidonic acid. J. Biol. Chem. 1994; 270: 6433-5.
42. Trotti D, Volterra A, Lehre KP et al. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane. J. Biol. Chem. 1995; 270: 9890-5.
43. 2+ antagonize NMDA and GABA responses of hippocampul neurons. Nature 1987; 328: 640-3.
44. Peters S, Koh J, Choi DW. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 1987; 236: 589-93.
45. Spiridon M, Kamm D, Billups B, Mobbs P, Attwell D. Modulation by zinc of the glutamate transporter in glial cells isolated from the tiger salamander retina J. Physiol. 1998; 506: 363-76.
46. Howell GA, Welch MG, Fredrickson CJ. Stimulation-induced uptake and releases of zinc in hippocampul slices. Nature 1984; 308: 736-8.
47. Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 1986; 31: 145-238.
48. Gabrielsson B, Robson T, Norris D, Chung SH. Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions. Brain Res. 1986; 384: 218-23.
49. Hexum TD. Studies of the reaction catalysed by transport (Na, K) adenosine triphosphate I. Effects of divalent metals. Biochem. Pharmacol. 1974; 23: 3441-7.
50. Vandenberg RJ, Mitrovic AD, Johnston GAR. Molecular basis for differential inhibiton of glutamate transporter subtypes by zinc ions. Mol. Pharmacol. 1998 (in press).
51. Clements JD, Lester RAJ, Tong G, Jahr CE, Westbrook GL. The time course of glutamate in the synaptic cleft. Science 1992; 258: 1498-501.
52. Wadiche JI, Arriza JL, Amara SG, Kavanaugh MP. Kinetics of a human glutamate transporter. Neuron 1995; 14: 1019-27.
53. Tong G, Jahr CE. Block of glutamate transporters potentiates postsynaptic excitation. Neuron 1994; 13: 1195-203.
54. Takahashi M, Sarantis M, Attwell D. Postsynaptic glutamate uptake in rat cerebellar Purkinje cells. J. Physiol. 1996; 497: 523-30.
55. Otis TS, Kavanaugh MP, Jahr CE. Postsynaptic glutamate transport at the climbing fibre-Purkinje cell synapse. Science 1997; 277: 1515-18.
56. Robinson MB, Dowd LA. Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the central nervous system. Adv. Pharmacol. 1997; 37: 69-115.
57. Vandenberg RJ, Mitrovic AD, Johnston GAR. Serine-O-sulfate transport by the human glutamate transporter EAAT2. Br. J. Pharmacol. 1998 (in press).
58. Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GAR. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol. Pharmacol. 1997; 51: 809-15.
59. Lebrun B, Sakaitani M, Shimamoto H, Yasuda-Kamatani Y, Nakajima T. New β-hydroxyaspartate derivatives are competitive antagonists for bovine glutamate/aspartate transporter. J. Biol. Chem. 1997; 272: 20 336-9.
60. Rothstein JD, Van Kammen BA, Levey AI, Martin IJ, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 1995; 38: 73-84.
61. Rothstein JD, Dykes-Hoberg M, Pardo CA et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996; 16: 675-86.
62. Tanaka K, Watase K, Manabe T et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter, GLT-1. Science 1997; 276: 1699-702.
63. Choi DW, Maulucci-Gedde M, Kriefstein AR. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 1987; 7: 357-68.
64. Toru M, Kurumaji A, Ishmaru M. Excitatory amino acids: Implications for psychiatric disorders research. Life Sci. 1994; 5: 1683-99.
65. Ishimaru M, Kuramaji A, Toru M. Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis. Biol. Psychiatry 1996; 35: 84-95.