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Volumn 2, Issue 3, 2005, Pages 313-324

Development of adjunctive therapies for bacterial meningitis and lessons from knockout mice

Author keywords

Animal model; Bacterial meningitis; CNS; Inflammation; Knockout mice

Indexed keywords

CYTOKINE; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FAS LIGAND; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; METALLOPROTEINASE; MYELOID DIFFERENTIATION FACTOR 88; OXIDIZING AGENT; PADGEM PROTEIN; PROTEIN P47; PROTEINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 23444457928     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1385/NCC:2:3:313     Document Type: Review
Times cited : (11)

References (131)
  • 1
    • 0037408190 scopus 로고    scopus 로고
    • Pneumococcal meningitis in adults: Spectrum of complications and prognostic factors in a series of 87 cases
    • Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: Spectrum of complications and prognostic factors in a series of 87 cases. Brain 2003;126(Pt 5):1015-1025.
    • (2003) Brain , vol.126 , Issue.5 PART , pp. 1015-1025
    • Kastenbauer, S.1    Pfister, H.W.2
  • 2
    • 0031657220 scopus 로고    scopus 로고
    • Enhanced surveillance of invasive Haemophilus influenza disease in England, 1990 to 1996: Impact of conjugate vaccines
    • Slack MP, Azzopardi HJ, Hargreaves RM, Ramsay ME. Enhanced surveillance of invasive Haemophilus influenza disease in England, 1990 to 1996: impact of conjugate vaccines. Pediatr Infect Dis J 1998;17(9 Suppl):S204-S207.
    • (1998) Pediatr Infect Dis J , vol.17 , Issue.9 SUPPL.
    • Slack, M.P.1    Azzopardi, H.J.2    Hargreaves, R.M.3    Ramsay, M.E.4
  • 3
    • 0031689122 scopus 로고    scopus 로고
    • Epidemiology of Haemophilus influenzae type b disease and impact of Haemophilus influenzae type b conjugate vaccines in the United States and Canada
    • Wenger JD. Epidemiology of Haemophilus influenzae type b disease and impact of Haemophilus influenzae type b conjugate vaccines in the United States and Canada. Pediatr Infect Dis J 1998;17(Suppl 9):S132-S136.
    • (1998) Pediatr Infect Dis J , vol.17 , Issue.9 SUPPL.
    • Wenger, J.D.1
  • 4
    • 0033529442 scopus 로고    scopus 로고
    • Geographic variation in penicillin resistance in Streptococcus pneumoniae - Selected sites, United States, 1997
    • Geographic variation in penicillin resistance in Streptococcus pneumoniae - selected sites, United States, 1997. MMWR 1999; 48(30):656-661.
    • (1999) MMWR , vol.48 , Issue.30 , pp. 656-661
  • 5
    • 0142165971 scopus 로고    scopus 로고
    • Antimicrobial resistance among isolates of respiratory tract infection pathogens from the southern United States: Data from the PROTEKT US surveillance program 2000/2001
    • Waites K, Brown S. Antimicrobial resistance among isolates of respiratory tract infection pathogens from the southern United States: data from the PROTEKT US surveillance program 2000/2001. South Med J 2003;96(10):974-985.
    • (2003) South Med J , vol.96 , Issue.10 , pp. 974-985
    • Waites, K.1    Brown, S.2
  • 6
    • 0035904366 scopus 로고    scopus 로고
    • Macrolide resistance among invasive Streptococcus pneumoniae isolates
    • Hyde TB, Gay K, Stephens DS, et al. Macrolide resistance among invasive Streptococcus pneumoniae isolates. JAMA 2001; 286(15):1857-1862.
    • (2001) JAMA , vol.286 , Issue.15 , pp. 1857-1862
    • Hyde, T.B.1    Gay, K.2    Stephens, D.S.3
  • 7
    • 0345668474 scopus 로고    scopus 로고
    • Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
    • McCormick AW, Whitney CG, Farley MM, et al. Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States. Nat Med 2003;9(4):424-430.
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 424-430
    • McCormick, A.W.1    Whitney, C.G.2    Farley, M.M.3
  • 8
    • 0036900042 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of pneumococcal meningitis
    • Koedel U, Scheld WM, Pfister HW. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis 2002;2(12):721-736.
    • (2002) Lancet Infect Dis , vol.2 , Issue.12 , pp. 721-736
    • Koedel, U.1    Scheld, W.M.2    Pfister, H.W.3
  • 9
    • 0037079004 scopus 로고    scopus 로고
    • Dexamethasone in adults with bacterial meningitis
    • de Gans J, van de BD. Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002;347(20):1549-1556.
    • (2002) N Engl J Med , vol.347 , Issue.20 , pp. 1549-1556
    • De Gans, J.1    Van De, B.D.2
  • 10
    • 1442299474 scopus 로고    scopus 로고
    • Steroids in adults with acute bacterial meningitis: A systematic review
    • van de BD, de Gans J, McIntyre P, Prasad K. Steroids in adults with acute bacterial meningitis: a systematic review. Lancet Infect Dis 2004;4(3):139-143.
    • (2004) Lancet Infect Dis , vol.4 , Issue.3 , pp. 139-143
    • Van De, B.D.1    De Gans, J.2    McIntyre, P.3    Prasad, K.4
  • 11
    • 0032783349 scopus 로고    scopus 로고
    • Models of experimental bacterial meningitis. Role and limitations
    • Koedel U, Pfister HW. Models of experimental bacterial meningitis. Role and limitations. Infect Dis Clin N Am 1999;13(3):549-577.
    • (1999) Infect Dis Clin N Am , vol.13 , Issue.3 , pp. 549-577
    • Koedel, U.1    Pfister, H.W.2
  • 12
    • 0016114674 scopus 로고
    • Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives
    • Dacey RG, Sande MA. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives. Antimicrob Agents Chemother 1974;6(4):437-441.
    • (1974) Antimicrob Agents Chemother , vol.6 , Issue.4 , pp. 437-441
    • Dacey, R.G.1    Sande, M.A.2
  • 13
    • 0022553324 scopus 로고
    • Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation
    • Quagliarello VJ, Long WJ, Scheld WM. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. J Clin Invest 1986;77(4):1084-1095.
    • (1986) J Clin Invest , vol.77 , Issue.4 , pp. 1084-1095
    • Quagliarello, V.J.1    Long, W.J.2    Scheld, W.M.3
  • 14
    • 0015955087 scopus 로고
    • Haemophilus influenzae meningitis in infant rats after intranasal inoculation
    • Moxon ER, Smith AL, Averill DR, Smith DH. Haemophilus influenzae meningitis in infant rats after intranasal inoculation. J Infect Dis 1974;129(2):154-162.
    • (1974) J Infect Dis , vol.129 , Issue.2 , pp. 154-162
    • Moxon, E.R.1    Smith, A.L.2    Averill, D.R.3    Smith, D.H.4
  • 15
    • 0015895528 scopus 로고
    • Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation
    • Smith AL, Smith DH, Averill DR Jr., Marino J, Moxon ER. Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation. Infect Immun 1973;8(2):278-290.
    • (1973) Infect Immun , vol.8 , Issue.2 , pp. 278-290
    • Smith, A.L.1    Smith, D.H.2    Averill Jr., D.R.3    Marino, J.4    Moxon, E.R.5
  • 16
    • 0021034540 scopus 로고
    • Efficacy of trimethoprim/sulfamethoxazole in experimental Escherichia coli bacteremia and meningitis
    • Kim KS, Anthony BF. Efficacy of trimethoprim/sulfamethoxazole in experimental Escherichia coli bacteremia and meningitis. Chemotherapy 1983;29(6):428-435.
    • (1983) Chemotherapy , vol.29 , Issue.6 , pp. 428-435
    • Kim, K.S.1    Anthony, B.F.2
  • 17
    • 0018115878 scopus 로고
    • Dynamics of Escherichia coli infection and meningitis in infant rats
    • Bortolussi R, Ferrieri P, Wannamaker LW. Dynamics of Escherichia coli infection and meningitis in infant rats. Infect Immun 1978;22(2):480-185.
    • (1978) Infect Immun , vol.22 , Issue.2 , pp. 480-1185
    • Bortolussi, R.1    Ferrieri, P.2    Wannamaker, L.W.3
  • 18
    • 0023890129 scopus 로고
    • Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients
    • Leist TP, Frei K, Kam-Hansen S, Zinkernagel RM, Fontana A. Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients. J Exp Med 1988;167(5):1743-1748.
    • (1988) J Exp Med , vol.167 , Issue.5 , pp. 1743-1748
    • Leist, T.P.1    Frei, K.2    Kam-Hansen, S.3    Zinkernagel, R.M.4    Fontana, A.5
  • 19
    • 0018833559 scopus 로고
    • A murine model for listerial meningitis and meningoencephalomyelitis: Therapeutic evaluation of drugs in mice
    • Tsai YH, Hirth RS, Leitner F. A murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice. Chemotherapy 1980;26(3):196-206.
    • (1980) Chemotherapy , vol.26 , Issue.3 , pp. 196-206
    • Tsai, Y.H.1    Hirth, R.S.2    Leitner, F.3
  • 21
    • 0023043553 scopus 로고
    • Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene
    • Thomas KR, Capecchi MR. Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature 1986;324(6092):34-38.
    • (1986) Nature , vol.324 , Issue.6092 , pp. 34-38
    • Thomas, K.R.1    Capecchi, M.R.2
  • 22
    • 0024409025 scopus 로고
    • Inactivating the beta2-microglobulin locus in mouse embryonic stem cells by homologous recombination
    • Koller BH, Smithies O. Inactivating the beta2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci USA 1989;86(22):8932-8935.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.22 , pp. 8932-8935
    • Koller, B.H.1    Smithies, O.2
  • 23
    • 0023090920 scopus 로고
    • A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice
    • Kuehn MR, Bradley A, Robertson EJ, Evans MJ. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 1987;326(6110):295-298.
    • (1987) Nature , vol.326 , Issue.6110 , pp. 295-298
    • Kuehn, M.R.1    Bradley, A.2    Robertson, E.J.3    Evans, M.J.4
  • 24
    • 0037015889 scopus 로고    scopus 로고
    • Tools for targeted manipulation of the mouse genome
    • van der WL, Adams DJ, Bradley A. Tools for targeted manipulation of the mouse genome. Physiol Genomics 2002;11(3):133-164.
    • (2002) Physiol Genomics , vol.11 , Issue.3 , pp. 133-164
    • Van Der, W.L.1    Adams, D.J.2    Bradley, A.3
  • 25
    • 0037374524 scopus 로고    scopus 로고
    • Mice, microbes and models of infection
    • Buer J, Balling R. Mice, microbes and models of infection. Nat Rev Genet 2003;4(3):195-205.
    • (2003) Nat Rev Genet , vol.4 , Issue.3 , pp. 195-205
    • Buer, J.1    Balling, R.2
  • 26
    • 0032795777 scopus 로고    scopus 로고
    • Walking through the forest of transgenic models of human disease
    • Eynon EE, Flavell RA. Walking through the forest of transgenic models of human disease. Immunol Rev 1999;169:5-10.
    • (1999) Immunol Rev , vol.169 , pp. 5-10
    • Eynon, E.E.1    Flavell, R.A.2
  • 27
    • 0037299567 scopus 로고    scopus 로고
    • Knock outmodels to dissect chemokine receptor function in vivo
    • Power CA. Knock outmodels to dissect chemokine receptor function in vivo. J Immunol Methods 2003;273(1-2):73-82.
    • (2003) J Immunol Methods , vol.273 , Issue.1-2 , pp. 73-82
    • Power, C.A.1
  • 28
    • 0031722020 scopus 로고    scopus 로고
    • Using knockout and transgenic mice to study neurophysiology and behavior
    • Picciotto MR, Wickman K. Using knockout and transgenic mice to study neurophysiology and behavior. Physiol Rev 1998;78(4):1131-1163.
    • (1998) Physiol Rev , vol.78 , Issue.4 , pp. 1131-1163
    • Picciotto, M.R.1    Wickman, K.2
  • 29
    • 0022001683 scopus 로고
    • The induction of meningeal inflammation by components of the pneumococcal cell wall
    • Tuomanen E, Liu H, Hengstler B, Zak O, Tomasz A. The induction of meningeal inflammation by components of the pneumococcal cell wall. J Infect Dis 1985;151(5):859-868.
    • (1985) J Infect Dis , vol.151 , Issue.5 , pp. 859-868
    • Tuomanen, E.1    Liu, H.2    Hengstler, B.3    Zak, O.4    Tomasz, A.5
  • 30
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989;54:1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , pp. 1-13
    • Janeway Jr., C.A.1
  • 31
    • 0032502682 scopus 로고    scopus 로고
    • Binding of bacterial peptidoglycan to CD14
    • Dziarski R, Tapping RI, Tobias PS. Binding of bacterial peptidoglycan to CD14. J Biol Chem 1998;273(15):8680-8690.
    • (1998) J Biol Chem , vol.273 , Issue.15 , pp. 8680-8690
    • Dziarski, R.1    Tapping, R.I.2    Tobias, P.S.3
  • 32
    • 0343619375 scopus 로고    scopus 로고
    • CD14, new aspects of ligand and signal diversity
    • Landmann R, Muller B, Zimmerli W. CD14, new aspects of ligand and signal diversity. Microbes Infect 2000;2(3):295-304.
    • (2000) Microbes Infect , vol.2 , Issue.3 , pp. 295-304
    • Landmann, R.1    Muller, B.2    Zimmerli, W.3
  • 34
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1(2):135-145.
    • (2001) Nat Rev Immunol , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 35
    • 0033168728 scopus 로고    scopus 로고
    • Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999;163(1):1-5.
    • (1999) J Immunol , vol.163 , Issue.1 , pp. 1-5
    • Yoshimura, A.1    Lien, E.2    Ingalls, R.R.3    Tuomanen, E.4    Dziarski, R.5    Golenbock, D.6
  • 36
    • 0037220060 scopus 로고    scopus 로고
    • Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis
    • Koedel U, Angele B, Rupprecht T, et al. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 2003;170(1):438-444.
    • (2003) J Immunol , vol.170 , Issue.1 , pp. 438-444
    • Koedel, U.1    Angele, B.2    Rupprecht, T.3
  • 37
    • 0037105727 scopus 로고    scopus 로고
    • Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation
    • Echchannaoui H, Frei K, Schnell C, Leib SL, Zimmerli W, Landmann R. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis 2002;186(6):798-806.
    • (2002) J Infect Dis , vol.186 , Issue.6 , pp. 798-806
    • Echchannaoui, H.1    Frei, K.2    Schnell, C.3    Leib, S.L.4    Zimmerli, W.5    Landmann, R.6
  • 38
    • 0036709969 scopus 로고    scopus 로고
    • A universal role for MyD88 in TLR/IL-1R-mediated signaling
    • Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci 2002;27(9):474-482.
    • (2002) Trends Biochem Sci , vol.27 , Issue.9 , pp. 474-482
    • Janssens, S.1    Beyaert, R.2
  • 39
    • 0036448929 scopus 로고    scopus 로고
    • MyD88 as a bottle neck in Toll/IL-1 signaling
    • Takeuchi O, Akira S. MyD88 as a bottle neck in Toll/IL-1 signaling. Curr Top Microbiol Immunol 2002;270:155-67.:155-167.
    • (2002) Curr Top Microbiol Immunol , vol.270 , pp. 155-167
    • Takeuchi, O.1    Akira, S.2
  • 40
    • 2942557102 scopus 로고    scopus 로고
    • MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS
    • Koedel U, Rupprecht T, Angele B, et al. MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Brain 2004;127(pt 6):1437-1445.
    • (2004) Brain , vol.127 , Issue.6 PART , pp. 1437-1445
    • Koedel, U.1    Rupprecht, T.2    Angele, B.3
  • 41
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • Dinarello CA. Proinflammatory cytokines. Chest 2000;118(2):503-508.
    • (2000) Chest , vol.118 , Issue.2 , pp. 503-508
    • Dinarello, C.A.1
  • 42
    • 0036890739 scopus 로고    scopus 로고
    • Pathophysiology of bacterial meningitis: Mechanism(s) of neuronal injury
    • Scheid WM, Koedel U, Nathan B, Pfister HW. Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury. J Infect Dis 2002;186:S225-S233.
    • (2002) J Infect Dis , vol.186
    • Scheid, W.M.1    Koedel, U.2    Nathan, B.3    Pfister, H.W.4
  • 43
    • 0035278914 scopus 로고    scopus 로고
    • Cytokines and the central nervous system
    • Szelenyi J. Cytokines and the central nervous system. Brain Res Bull 2001;54(4):329-338.
    • (2001) Brain Res Bull , vol.54 , Issue.4 , pp. 329-338
    • Szelenyi, J.1
  • 44
    • 0024358178 scopus 로고
    • Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response
    • Waage A, Halstensen A, Shalaby R, Brandtzaeg P, Kierulf P, Espevik T. Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response. J Exp Med 1989;170(6):1859-1867.
    • (1989) J Exp Med , vol.170 , Issue.6 , pp. 1859-1867
    • Waage, A.1    Halstensen, A.2    Shalaby, R.3    Brandtzaeg, P.4    Kierulf, P.5    Espevik, T.6
  • 45
    • 0024334929 scopus 로고
    • Correlation of interleukin-1 beta and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis
    • Mustafa MM, Lebel MH, Ramilo O, et al. Correlation of interleukin-1 beta and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis. J Pediatr 1989;115(2):208-213.
    • (1989) J Pediatr , vol.115 , Issue.2 , pp. 208-213
    • Mustafa, M.M.1    Lebel, M.H.2    Ramilo, O.3
  • 47
    • 0035877050 scopus 로고    scopus 로고
    • Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown
    • Winkler F, Koedel U, Kastenbauer S, Pfister HW. Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown. J Infect Dis 2001;183(12):1749-1759.
    • (2001) J Infect Dis , vol.183 , Issue.12 , pp. 1749-1759
    • Winkler, F.1    Koedel, U.2    Kastenbauer, S.3    Pfister, H.W.4
  • 48
    • 0025910921 scopus 로고
    • Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor
    • Quagliarello VJ, Wispelwey B, Long WJ Jr., Scheld WM. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. J Clin Invest 1991;87(4):1360-1366.
    • (1991) J Clin Invest , vol.87 , Issue.4 , pp. 1360-1366
    • Quagliarello, V.J.1    Wispelwey, B.2    Long Jr., W.J.3    Scheld, W.M.4
  • 49
    • 0034773556 scopus 로고    scopus 로고
    • Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis
    • Wellmer A, Gerber J, Ragheb J, et al. Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis. Infect Immun 2001;69(11):6881-6886.
    • (2001) Infect Immun , vol.69 , Issue.11 , pp. 6881-6886
    • Wellmer, A.1    Gerber, J.2    Ragheb, J.3
  • 50
    • 0032960948 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, Interleukin 6, and other cytokines using the GP130 transducing receptor: Roles in inflammation and injury
    • Gadient RA, PattersonPH. Leukemia inhibitory factor, Interleukin 6, and other cytokines using the GP130 transducing receptor: roles in inflammation and injury. Stem Cells 1999;17(3):127-137.
    • (1999) Stem Cells , vol.17 , Issue.3 , pp. 127-137
    • Gadient, R.A.1    Patterson, P.H.2
  • 51
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) - A molecule with both beneficial and destructive potentials
    • Gadient RA, Otten UH. Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials. Prog Neurobiol 1997;52(5):379-390.
    • (1997) Prog Neurobiol , vol.52 , Issue.5 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 52
    • 0042266296 scopus 로고    scopus 로고
    • Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis
    • Paul R, Koedel U, Winkler F, et al. Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain 2003;126(Pt 8):1873-1882.
    • (2003) Brain , vol.126 , Issue.8 PART , pp. 1873-1882
    • Paul, R.1    Koedel, U.2    Winkler, F.3
  • 53
    • 0242584867 scopus 로고    scopus 로고
    • IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis
    • Zwijnenburg PJ, Van Der PT, Florquin S, Roord JJ, Van Furth AM. IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis. J Immunol 2003;170(9):4724-4730.
    • (2003) J Immunol , vol.170 , Issue.9 , pp. 4724-4730
    • Zwijnenburg, P.J.1    Van Der, P.T.2    Florquin, S.3    Roord, J.J.4    Van Furth, A.M.5
  • 54
    • 0036193998 scopus 로고    scopus 로고
    • Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice
    • Koedel U, Winkler F, Angele B, Fontana A, Flavell RA, Pfister HW. Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. Ann Neurol 2002;51(3):319-329.
    • (2002) Ann Neurol , vol.51 , Issue.3 , pp. 319-329
    • Koedel, U.1    Winkler, F.2    Angele, B.3    Fontana, A.4    Flavell, R.A.5    Pfister, H.W.6
  • 55
    • 0034980448 scopus 로고    scopus 로고
    • Transcriptional regulation of caspases in experimental pneumococcal meningitis
    • von Mering M, Wellmer A, Michel U, et al. Transcriptional regulation of caspases in experimental pneumococcal meningitis. Brain Pathol 2001;11(3):282-295.
    • (2001) Brain Pathol , vol.11 , Issue.3 , pp. 282-295
    • Von Mering, M.1    Wellmer, A.2    Michel, U.3
  • 57
    • 0031749136 scopus 로고    scopus 로고
    • Overview of interleukin-18: More than an interferon-gamma inducing factor
    • Dinarello CA, Novick D, Puren AJ, et al. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol 1998;63(6):658-664.
    • (1998) J Leukoc Biol , vol.63 , Issue.6 , pp. 658-664
    • Dinarello, C.A.1    Novick, D.2    Puren, A.J.3
  • 58
    • 0030293444 scopus 로고    scopus 로고
    • IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
    • Tsutsui H, Nakanishi K, Matsui K, et al. IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol 1996;157(9):3967-3973.
    • (1996) J Immunol , vol.157 , Issue.9 , pp. 3967-3973
    • Tsutsui, H.1    Nakanishi, K.2    Matsui, K.3
  • 59
    • 0242720852 scopus 로고    scopus 로고
    • Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes
    • Stuyt RJ, Netea MG, Geijtenbeek TB, Kullberg BJ, Dinarello CA, Van Der Meer JW. Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes. Immunology 2003;110(3):329-334.
    • (2003) Immunology , vol.110 , Issue.3 , pp. 329-334
    • Stuyt, R.J.1    Netea, M.G.2    Geijtenbeek, T.B.3    Kullberg, B.J.4    Dinarello, C.A.5    Van Der Meer, J.W.6
  • 60
    • 0035451438 scopus 로고    scopus 로고
    • A role for IL-18 in neutrophil activation
    • Leung BP, Culshaw S, Gracie JA, et al. A role for IL-18 in neutrophil activation. J Immunol 2001;167(5):2879-2886.
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2879-2886
    • Leung, B.P.1    Culshaw, S.2    Gracie, J.A.3
  • 61
    • 0038297679 scopus 로고    scopus 로고
    • Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis
    • Zwijnenburg PJ, Van Der PT, Florquin S, et al. Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis. J Neuroimmunol 2003;138(1-2):31-37.
    • (2003) J Neuroimmunol , vol.138 , Issue.1-2 , pp. 31-37
    • Zwijnenburg, P.J.1    Van Der, P.T.2    Florquin, S.3
  • 62
  • 63
    • 0035136359 scopus 로고    scopus 로고
    • Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines
    • Molina-Holgado F, Grencis R, Rothwell NJ. Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines. Glia 2001;33(2):97-106.
    • (2001) Glia , vol.33 , Issue.2 , pp. 97-106
    • Molina-Holgado, F.1    Grencis, R.2    Rothwell, N.J.3
  • 64
    • 0029058650 scopus 로고
    • High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis
    • Van Furth AM, Seijmonsbergen EM, Langermans JA, Groeneveld PH, de Bel CE, van Furth R. High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis. Clin Infect Dis 1995;21(1):220-222.
    • (1995) Clin Infect Dis , vol.21 , Issue.1 , pp. 220-222
    • Van Furth, A.M.1    Seijmonsbergen, E.M.2    Langermans, J.A.3    Groeneveld, P.H.4    De Bel, C.E.5    Van Furth, R.6
  • 65
    • 0030442779 scopus 로고    scopus 로고
    • Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis
    • Koedel U, Bernatowicz A, Frei K, Fontana A, Pfister HW. Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis. J Immunol 1996;157(11):5185-5191.
    • (1996) J Immunol , vol.157 , Issue.11 , pp. 5185-5191
    • Koedel, U.1    Bernatowicz, A.2    Frei, K.3    Fontana, A.4    Pfister, H.W.5
  • 66
    • 0344837298 scopus 로고    scopus 로고
    • Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis
    • Zwijnenburg PJ, Van Der PT, Florquin S, Roord JJ, Van Furth AM. Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis. Infect Immun 2003;71(4):2276-2279.
    • (2003) Infect Immun , vol.71 , Issue.4 , pp. 2276-2279
    • Zwijnenburg, P.J.1    Van Der, P.T.2    Florquin, S.3    Roord, J.J.4    Van Furth, A.M.5
  • 67
    • 0036849026 scopus 로고    scopus 로고
    • Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1
    • Imai Y, Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002;40(2):164-174.
    • (2002) Glia , vol.40 , Issue.2 , pp. 164-174
    • Imai, Y.1    Kohsaka, S.2
  • 68
    • 0025045744 scopus 로고
    • Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid
    • Gallo P, Pagni S, Giometto B, et al. Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid. J Neuroimmunol 1990;29(1-3):105-112.
    • (1990) J Neuroimmunol , vol.29 , Issue.1-3 , pp. 105-112
    • Gallo, P.1    Pagni, S.2    Giometto, B.3
  • 69
    • 0034958369 scopus 로고    scopus 로고
    • A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
    • Berl
    • Gerber J, Raivich G, Wellmer A, et al. A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease. Acta Neuropathol (Berl) 2001;101(5):499-508.
    • (2001) Acta Neuropathol , vol.101 , Issue.5 , pp. 499-508
    • Gerber, J.1    Raivich, G.2    Wellmer, A.3
  • 70
    • 0035653672 scopus 로고    scopus 로고
    • The role of Fas ligand in immune privilege
    • Green DR, Ferguson TA. The role of Fas ligand in immune privilege. Nat Rev Mol Cell Biol 2001;2(12):917-924.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.12 , pp. 917-924
    • Green, D.R.1    Ferguson, T.A.2
  • 71
    • 0031730436 scopus 로고    scopus 로고
    • Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand
    • Miwa K, Asano M, Horai R, Iwakura Y, Nagata S, Suda T. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med 1998;4(11):1287-1292.
    • (1998) Nat Med , vol.4 , Issue.11 , pp. 1287-1292
    • Miwa, K.1    Asano, M.2    Horai, R.3    Iwakura, Y.4    Nagata, S.5    Suda, T.6
  • 72
    • 0029788696 scopus 로고    scopus 로고
    • Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: Implications for the regulation of apoptosis in neutrophils
    • Liles WC, Kiener PA, Ledbetter JA, Aruffo A, Klebanoff SJ. Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med 1996;184(2):429-440.
    • (1996) J Exp Med , vol.184 , Issue.2 , pp. 429-440
    • Liles, W.C.1    Kiener, P.A.2    Ledbetter, J.A.3    Aruffo, A.4    Klebanoff, S.J.5
  • 73
    • 0032916577 scopus 로고    scopus 로고
    • Fas (APO-1/CD95) in inflammatory CNS diseases: Intrathecal release in bacterial meningitis
    • Fassbender K, Eschenfelder C, Hennerici M. Fas (APO-1/CD95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis. J Neuroimmunol 1999;93(1-2):122-125.
    • (1999) J Neuroimmunol , vol.93 , Issue.1-2 , pp. 122-125
    • Fassbender, K.1    Eschenfelder, C.2    Hennerici, M.3
  • 74
    • 3042608293 scopus 로고    scopus 로고
    • Inflammatory response during bacterial meningitis is unchanged in Fas- and Fas Ligand-deficient mice
    • Paul R, Angele B, Sporer B, Pfister HW, Koedel U. Inflammatory response during bacterial meningitis is unchanged in Fas- and Fas Ligand-deficient mice. J Neuroimmunol 2004; 152(1-2):78-82.
    • (2004) J Neuroimmunol , vol.152 , Issue.1-2 , pp. 78-82
    • Paul, R.1    Angele, B.2    Sporer, B.3    Pfister, H.W.4    Koedel, U.5
  • 75
    • 0034987955 scopus 로고    scopus 로고
    • Adhesion molecules and their role in vascular disease
    • Krieglstein CF, Granger DN. Adhesion molecules and their role in vascular disease. Am J Hypertens 2001;14(6 Pt 2):44S-54S.
    • (2001) Am J Hypertens , vol.14 , Issue.6 PART 2
    • Krieglstein, C.F.1    Granger, D.N.2
  • 76
    • 0032753372 scopus 로고    scopus 로고
    • Migration of leukocytes across endothelium and beyond: Molecules involved in the transmigration and fate of monocytes
    • Muller WA, Randolph GJ. Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes. J Leukoc Biol 1999;66(5):698-704.
    • (1999) J Leukoc Biol , vol.66 , Issue.5 , pp. 698-704
    • Muller, W.A.1    Randolph, G.J.2
  • 77
    • 0036667554 scopus 로고    scopus 로고
    • Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: Insights from the IgG immune complex model
    • Guo RF, Ward PA. Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model. Free Radic Biol Med 2002;33(3):303-310.
    • (2002) Free Radic Biol Med , vol.33 , Issue.3 , pp. 303-310
    • Guo, R.F.1    Ward, P.A.2
  • 78
    • 0036024085 scopus 로고    scopus 로고
    • Selectins: Critical mediators of leukocyte recruitment
    • Patel KD, Cuvelier SL, Wiehler S. Selectins: critical mediators of leukocyte recruitment. Semin Immunol 2002;14(2):73-81.
    • (2002) Semin Immunol , vol.14 , Issue.2 , pp. 73-81
    • Patel, K.D.1    Cuvelier, S.L.2    Wiehler, S.3
  • 79
    • 0029893116 scopus 로고    scopus 로고
    • Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins
    • Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest 1996;97(11):2485-2490.
    • (1996) J Clin Invest , vol.97 , Issue.11 , pp. 2485-2490
    • Tang, T.1    Frenette, P.S.2    Hynes, R.O.3    Wagner, D.D.4    Mayadas, T.N.5
  • 80
    • 0028893589 scopus 로고
    • Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model
    • Tan TQ, Smith CW, Hawkins EP, Mason EO Jr., Kaplan SL. Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model. J Infect Dis 1995;171(2):342-349.
    • (1995) J Infect Dis , vol.171 , Issue.2 , pp. 342-349
    • Tan, T.Q.1    Smith, C.W.2    Hawkins, E.P.3    Mason Jr., E.O.4    Kaplan, S.L.5
  • 81
    • 0028788966 scopus 로고
    • Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis
    • Weber JR, Angstwurm K, Burger W, Einhaupl KM, Dirnagl U. Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis. J Neuroimmunol 1995;63(1):63-68.
    • (1995) J Neuroimmunol , vol.63 , Issue.1 , pp. 63-68
    • Weber, J.R.1    Angstwurm, K.2    Burger, W.3    Einhaupl, K.M.4    Dirnagl, U.5
  • 82
    • 0024421227 scopus 로고
    • Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes
    • Tuomanen EI, Saukkonen K, Sande S, Cioffe C, Wright SD. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J Exp Med 1989;170(3):959-969.
    • (1989) J Exp Med , vol.170 , Issue.3 , pp. 959-969
    • Tuomanen, E.I.1    Saukkonen, K.2    Sande, S.3    Cioffe, C.4    Wright, S.D.5
  • 83
    • 0034651848 scopus 로고    scopus 로고
    • The role of integrin-mediated cell adhesion in health and disease: Integrin-based therapy in clinical medicine
    • Smith SJ. The role of integrin-mediated cell adhesion in health and disease: integrin-based therapy in clinical medicine. Ann Intern Med 2000;132(4):333-336.
    • (2000) Ann Intern Med , vol.132 , Issue.4 , pp. 333-336
    • Smith, S.J.1
  • 84
    • 0036728623 scopus 로고    scopus 로고
    • MMPs and TIMPs - An historical perspective
    • Woessner JF Jr. MMPs and TIMPs - an historical perspective. Mol Biotechnol 2002;22(1):33-49.
    • (2002) Mol Biotechnol , vol.22 , Issue.1 , pp. 33-49
    • Woessner Jr., J.F.1
  • 85
    • 0029310597 scopus 로고
    • Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease
    • Ries C, Petrides PE. Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease. Biol Chem Hoppe Seyler 1995;376(6):345-355.
    • (1995) Biol Chem Hoppe Seyler , vol.376 , Issue.6 , pp. 345-355
    • Ries, C.1    Petrides, P.E.2
  • 86
    • 0028872942 scopus 로고
    • Nitric oxide activates metalloprotease enzymes in articular cartilage
    • Murrell GA, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 1995;206(1):15-21.
    • (1995) Biochem Biophys Res Commun , vol.206 , Issue.1 , pp. 15-21
    • Murrell, G.A.1    Jang, D.2    Williams, R.J.3
  • 87
    • 0028860849 scopus 로고
    • Stimulation of matrix metalloproteinase-dependent migration of T cells by eicosanoids
    • Leppert D, Hauser SL, Kishiyama JL, An S, Zeng L, Goetzl EJ. Stimulation of matrix metalloproteinase-dependent migration of T cells by eicosanoids. FASEB J 1995;9(14):1473-1481.
    • (1995) FASEB J , vol.9 , Issue.14 , pp. 1473-1481
    • Leppert, D.1    Hauser, S.L.2    Kishiyama, J.L.3    An, S.4    Zeng, L.5    Goetzl, E.J.6
  • 88
    • 0031831764 scopus 로고    scopus 로고
    • Gelatinase B modulates selective opening of the blood-brain barrier during inflammation
    • Mun-Bryce S, Rosenberg GA. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am J Physiol 1998;274(5 Pt 2):R1203-R1211.
    • (1998) Am J Physiol , vol.274 , Issue.5 PART 2
    • Mun-Bryce, S.1    Rosenberg, G.A.2
  • 89
    • 0029889674 scopus 로고    scopus 로고
    • Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: Relation to blood-brain barrier injury
    • Rosenberg GA, Dencoff JE, Correa N Jr., Reiners M, Ford CC. Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury. Neurology 1996;46(6):1626-1632.
    • (1996) Neurology , vol.46 , Issue.6 , pp. 1626-1632
    • Rosenberg, G.A.1    Dencoff, J.E.2    Correa Jr., N.3    Reiners, M.4    Ford, C.C.5
  • 90
    • 0033942044 scopus 로고    scopus 로고
    • In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse
    • D'Haese A, Wuyts A, Dillen C, et al. In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse. J Interferon Cytokine Res 2000;20(7):667-674.
    • (2000) J Interferon Cytokine Res , vol.20 , Issue.7 , pp. 667-674
    • D'Haese, A.1    Wuyts, A.2    Dillen, C.3
  • 91
    • 0030094287 scopus 로고    scopus 로고
    • Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane
    • Delclaux C, Delacourt C, D'Ortho MP, Boyer V, Lafuma C, Harf A. Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane. Am J Respir Cell Mol Biol 1996;14(3):288-295.
    • (1996) Am J Respir Cell Mol Biol , vol.14 , Issue.3 , pp. 288-295
    • Delclaux, C.1    Delacourt, C.2    D'Ortho, M.P.3    Boyer, V.4    Lafuma, C.5    Harf, A.6
  • 92
    • 0031723106 scopus 로고    scopus 로고
    • Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
    • Paul R, Lorenzl S, Koedel U, et al. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol 1998;44(4):592-600.
    • (1998) Ann Neurol , vol.44 , Issue.4 , pp. 592-600
    • Paul, R.1    Lorenzl, S.2    Koedel, U.3
  • 93
    • 0034845846 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis
    • Leib SL, Clements JM, Lindberg RL, et al. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 2001;124(Pt 9):1734-1742.
    • (2001) Brain , vol.124 , Issue.9 PART , pp. 1734-1742
    • Leib, S.L.1    Clements, J.M.2    Lindberg, R.L.3
  • 94
    • 0032816550 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases in bacterial meningitis
    • Kieseier BC, Paul R, Koedel U, et al. Differential expression of matrix metalloproteinases in bacterial meningitis. Brain 1999;122(Pt 8):1579-1587.
    • (1999) Brain , vol.122 , Issue.8 PART , pp. 1579-1587
    • Kieseier, B.C.1    Paul, R.2    Koedel, U.3
  • 95
    • 0037422243 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis
    • Bottcher T, Spreer A, Azeh I, Nau R, Gerber J. Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis. Neurosci Lett 2003;338(3):201-204.
    • (2003) Neurosci Lett , vol.338 , Issue.3 , pp. 201-204
    • Bottcher, T.1    Spreer, A.2    Azeh, I.3    Nau, R.4    Gerber, J.5
  • 96
  • 97
    • 0033375029 scopus 로고    scopus 로고
    • Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis
    • Kastenbauer S, Koedel U, Pfister HW. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. J Infect Dis 1999;180(4):1164-1170.
    • (1999) J Infect Dis , vol.180 , Issue.4 , pp. 1164-1170
    • Kastenbauer, S.1    Koedel, U.2    Pfister, H.W.3
  • 98
    • 0032957004 scopus 로고    scopus 로고
    • Oxidative stress in bacterial meningitis
    • Koedel U, Pfister HW. Oxidative stress in bacterial meningitis. Brain Pathol 1999;9(1):57-67.
    • (1999) Brain Pathol , vol.9 , Issue.1 , pp. 57-67
    • Koedel, U.1    Pfister, H.W.2
  • 99
    • 0028929617 scopus 로고
    • Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide
    • Koedel U, Bernatowicz A, Paul R, Frei K, Fontana A, Pfister HW. Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. Ann Neurol 1995;37(3):313-323.
    • (1995) Ann Neurol , vol.37 , Issue.3 , pp. 313-323
    • Koedel, U.1    Bernatowicz, A.2    Paul, R.3    Frei, K.4    Fontana, A.5    Pfister, H.W.6
  • 100
    • 0030901966 scopus 로고    scopus 로고
    • Protective effect of the antioxidant N-acetyl-cysteine in pneumococcal meningitis in the rat
    • Koedel U, Pfister HW. Protective effect of the antioxidant N-acetyl-cysteine in pneumococcal meningitis in the rat. Neurosci Lett 1997;225(1):33-36.
    • (1997) Neurosci Lett , vol.225 , Issue.1 , pp. 33-36
    • Koedel, U.1    Pfister, H.W.2
  • 101
    • 0026488234 scopus 로고
    • Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats
    • Pfister HW, Koedel U, Lorenzl S, Tomasz A. Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats. Stroke 1992;23(12):1798-1804.
    • (1992) Stroke , vol.23 , Issue.12 , pp. 1798-1804
    • Pfister, H.W.1    Koedel, U.2    Lorenzl, S.3    Tomasz, A.4
  • 102
    • 0029842366 scopus 로고    scopus 로고
    • Nitrite concentration in cerebrospinal fluid of infants: Evidence for enhanced nitric oxide production in Hemophilus influenzae meningitis
    • Tsukahara H, Hara Y, Tsuchida S, et al. Nitrite concentration in cerebrospinal fluid of infants: evidence for enhanced nitric oxide production in Hemophilus influenzae meningitis. Acta Paediatr Jpn 1996;38(4):420-422.
    • (1996) Acta Paediatr Jpn , vol.38 , Issue.4 , pp. 420-422
    • Tsukahara, H.1    Hara, Y.2    Tsuchida, S.3
  • 103
    • 0030038567 scopus 로고    scopus 로고
    • Levels of nitric oxide correlate with high leels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis
    • Van Furth AM, Seijmonsbergen EM, Groeneveld PH, van Furth R, Langermans JA. Levels of nitric oxide correlate with high leels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis. Clin Infect Dis 1996;22(5): 876-878.
    • (1996) Clin Infect Dis , vol.22 , Issue.5 , pp. 876-878
    • Van Furth, A.M.1    Seijmonsbergen, E.M.2    Groeneveld, P.H.3    Van Furth, R.4    Langermans, J.A.5
  • 104
    • 0344701073 scopus 로고    scopus 로고
    • Nitric oxide and prostaglandin E2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis
    • Jaworowicz DJ, Jr., Korytko PJ, Singh LS, Boje KM. Nitric oxide and prostaglandin E2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis. Brain Res Bull 1998;46(6):541-546.
    • (1998) Brain Res Bull , vol.46 , Issue.6 , pp. 541-546
    • Jaworowicz Jr., D.J.1    Korytko, P.J.2    Singh, L.S.3    Boje, K.M.4
  • 105
    • 0031981875 scopus 로고    scopus 로고
    • Nitric oxide concentrations and cerebrospinal fluid parameters in an experimental animal model of Streptococcus pneumoniae meningitis
    • Destache CJ, Pakiz CB, Dash AK, Larsen C. Nitric oxide concentrations and cerebrospinal fluid parameters in an experimental animal model of Streptococcus pneumoniae meningitis. Pharmacotherapy 1998;18(3):612-619.
    • (1998) Pharmacotherapy , vol.18 , Issue.3 , pp. 612-619
    • Destache, C.J.1    Pakiz, C.B.2    Dash, A.K.3    Larsen, C.4
  • 106
    • 0037972445 scopus 로고    scopus 로고
    • Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis
    • Schaper M, Leib SL, Meli DN, Brandes RP, Tauber MG, Christen S. Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis. Infect Immun 2003;71(7): 4087-4092.
    • (2003) Infect Immun , vol.71 , Issue.7 , pp. 4087-4092
    • Schaper, M.1    Leib, S.L.2    Meli, D.N.3    Brandes, R.P.4    Tauber, M.G.5    Christen, S.6
  • 107
    • 0030282186 scopus 로고    scopus 로고
    • Interactions between the components of the human NADPH oxidase: Intrigues in the phox family
    • Leusen JH, Verhoeven AJ, Roos D. Interactions between the components of the human NADPH oxidase: intrigues in the phox family. J Lab Clin Med 1996;128(5):461-476.
    • (1996) J Lab Clin Med , vol.128 , Issue.5 , pp. 461-476
    • Leusen, J.H.1    Verhoeven, A.J.2    Roos, D.3
  • 108
    • 0042379916 scopus 로고    scopus 로고
    • The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
    • Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci 2003;24(9):471-178.
    • (2003) Trends Pharmacol Sci , vol.24 , Issue.9 , pp. 471-1178
    • Cai, H.1    Griendling, K.K.2    Harrison, D.G.3
  • 109
    • 0035844030 scopus 로고    scopus 로고
    • Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
    • Lassegue B, Sorescu D, Szocs K, et al. Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res 2001;88(9):888-894.
    • (2001) Circ Res , vol.88 , Issue.9 , pp. 888-894
    • Lassegue, B.1    Sorescu, D.2    Szocs, K.3
  • 110
    • 0032930417 scopus 로고    scopus 로고
    • Mammalian nitric oxide synthases
    • Stuehr DJ. Mammalian nitric oxide synthases. Biochim Biophys Acta 1999;1411(2-3):217-230.
    • (1999) Biochim Biophys Acta , vol.1411 , Issue.2-3 , pp. 217-230
    • Stuehr, D.J.1
  • 111
    • 0034090640 scopus 로고    scopus 로고
    • Lessons learned from nitric oxide synthase knockout animals
    • Huang PL. Lessons learned from nitric oxide synthase knockout animals. Semin Perinatol 2000;24(1):87-90.
    • (2000) Semin Perinatol , vol.24 , Issue.1 , pp. 87-90
    • Huang, P.L.1
  • 112
    • 0034091610 scopus 로고    scopus 로고
    • Integrin expression on neutrophils in a rabbit model of Group B Streptococcal meningitis
    • Rowin ME, Xue V, Irazuzta J. Integrin expression on neutrophils in a rabbit model of Group B Streptococcal meningitis. Inflammation 2000;24(2):157-173.
    • (2000) Inflammation , vol.24 , Issue.2 , pp. 157-173
    • Rowin, M.E.1    Xue, V.2    Irazuzta, J.3
  • 113
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996;271(5 Pt 1):C1424-C1437.
    • (1996) Am J Physiol , vol.271 , Issue.5 PART 1
    • Beckman, J.S.1    Koppenol, W.H.2
  • 114
    • 0035910611 scopus 로고    scopus 로고
    • Interactions between nitric oxide and lipid oxidation pathways: Implications for vascular disease
    • O'Donnell VB, Freeman BA. Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease. Circ Res 2001;88(1):12-21.
    • (2001) Circ Res , vol.88 , Issue.1 , pp. 12-21
    • O'Donnell, V.B.1    Freeman, B.A.2
  • 115
    • 0032127666 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
    • Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998;19(7):287-298.
    • (1998) Trends Pharmacol Sci , vol.19 , Issue.7 , pp. 287-298
    • Szabo, C.1    Dawson, V.L.2
  • 116
    • 0036139308 scopus 로고    scopus 로고
    • Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase
    • Koedel U, Winkler F, Angele B, Fontana A, Pfister HW. Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 2002;22(1):39-49.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.1 , pp. 39-49
    • Koedel, U.1    Winkler, F.2    Angele, B.3    Fontana, A.4    Pfister, H.W.5
  • 117
    • 16944365627 scopus 로고    scopus 로고
    • Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis
    • Koedel U, Gorriz C, Lorenzl S, Pfister HW. Increased endothelin levels in cerebrospinal fluid samples from adults with bacterial meningitis. Clin Infect Dis 1997;25(2):329-330.
    • (1997) Clin Infect Dis , vol.25 , Issue.2 , pp. 329-330
    • Koedel, U.1    Gorriz, C.2    Lorenzl, S.3    Pfister, H.W.4
  • 118
    • 0031965481 scopus 로고    scopus 로고
    • Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis
    • Koedel U, Lorenzl S, Gorriz C, Arendt RM, Pfister HW. Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis. J Cereb Blood Flow Metab 1998;18(1):67-74.
    • (1998) J Cereb Blood Flow Metab , vol.18 , Issue.1 , pp. 67-74
    • Koedel, U.1    Lorenzl, S.2    Gorriz, C.3    Arendt, R.M.4    Pfister, H.W.5
  • 119
    • 0031916129 scopus 로고    scopus 로고
    • Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    • Clouthier DE, Hosoda K, Richardson JA, et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998;125(5):813-824.
    • (1998) Development , vol.125 , Issue.5 , pp. 813-824
    • Clouthier, D.E.1    Hosoda, K.2    Richardson, J.A.3
  • 120
    • 0028360062 scopus 로고
    • Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
    • Kurihara Y, Kurihara H, Suzuki H, et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994;368(6473):703-710.
    • (1994) Nature , vol.368 , Issue.6473 , pp. 703-710
    • Kurihara, Y.1    Kurihara, H.2    Suzuki, H.3
  • 121
    • 0028639196 scopus 로고
    • Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
    • Hosoda K, Hammer RE, Richardson JA, et al. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 1994;79(7):1267-1276.
    • (1994) Cell , vol.79 , Issue.7 , pp. 1267-1276
    • Hosoda, K.1    Hammer, R.E.2    Richardson, J.A.3
  • 122
    • 0026632979 scopus 로고
    • Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis
    • Pfister HW, Frei K, Ottnad B, Koedel U, Tomasz A, Fontana A. Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis. J Exp Med 1992;176(1):265-268.
    • (1992) J Exp Med , vol.176 , Issue.1 , pp. 265-268
    • Pfister, H.W.1    Frei, K.2    Ottnad, B.3    Koedel, U.4    Tomasz, A.5    Fontana, A.6
  • 123
    • 0030609894 scopus 로고    scopus 로고
    • TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
    • Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 1997;124(13):2659-2670.
    • (1997) Development , vol.124 , Issue.13 , pp. 2659-2670
    • Sanford, L.P.1    Ormsby, I.2    Gittenberger-de Groot, A.C.3
  • 124
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multi-focal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multi-focal inflammatory disease. Nature 1992;359(6397):693-699.
    • (1992) Nature , vol.359 , Issue.6397 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 125
    • 0035348633 scopus 로고    scopus 로고
    • The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases
    • NY
    • Linder CC. The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab Anim (NY) 2001;30(5):34-39.
    • (2001) Lab Anim , vol.30 , Issue.5 , pp. 34-39
    • Linder, C.C.1
  • 126
    • 0141996262 scopus 로고    scopus 로고
    • First clinical trial of a novel caspase inhibitor: Anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes
    • Valentino KL, Gutierrez M, Sanchez R, Winship MJ, Shapiro DA. First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes. Int J Clin Pharmacol Ther 2003;41(10):441-449.
    • (2003) Int J Clin Pharmacol Ther , vol.41 , Issue.10 , pp. 441-449
    • Valentino, K.L.1    Gutierrez, M.2    Sanchez, R.3    Winship, M.J.4    Shapiro, D.A.5
  • 127
    • 0037295235 scopus 로고    scopus 로고
    • Pralnacasan (vertex pharmaceuticals)
    • Siegmund B, Zeitz M. Pralnacasan (vertex pharmaceuticals). IDrugs 2003;6(2):154-158.
    • (2003) IDrugs , vol.6 , Issue.2 , pp. 154-158
    • Siegmund, B.1    Zeitz, M.2
  • 129
    • 0037239590 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors
    • Southan GJ, Szabo C. Poly(ADP-ribose) polymerase inhibitors. Curr Med Chem 2003;10(4):321-340.
    • (2003) Curr Med Chem , vol.10 , Issue.4 , pp. 321-340
    • Southan, G.J.1    Szabo, C.2
  • 130
    • 33644572374 scopus 로고    scopus 로고
    • Inotek completes enrollment of Phase 1 clinical trial with oral PARP inhibitor
    • Inotek completes enrollment of Phase 1 clinical trial with oral PARP inhibitor. Inotek news 2003; http:/www.inotekcorp.com/news/apr_26_2003.htm. Accessed 06/26/2004.
    • (2003) Inotek News
  • 131
    • 33644578255 scopus 로고    scopus 로고
    • Cancer Research UK - Science and Research
    • Current early clinical trials. Cancer Research UK - Science and Research 2004;http://science.cancerresearchuk.org/tcr/drugdevelopment/curearlycts/? version=1. Accessed 06/26/2004.
    • (2004) Current Early Clinical Trials


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