Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2485-2490

  Tang, Tao ^a,b   Frenette, Paul S ^a   Hynes, Richard O ^c   Wagner, Denisa D ^a   Mayadas, Tanya N ^a,b,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d Vascular Research Division   (United States)

Author keywords

blood brain barrier; cerebrospinal fluid; endothelium; inflammation; leukocytes

Indexed keywords

CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; PADGEM PROTEIN; RECOMBINANT INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; GENE MUTATION; GENETIC ENGINEERING; HISTOLOGY; INFLAMMATORY CELL; LEUKOCYTE COUNT; LUMBAR PUNCTURE; MALE; MENINGITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY;

EID: 0029893116     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118695     Document Type: Article

References (37)

1. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:301-314.
2. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
3. Gotsch, U., U. Jager, M. Dominis, and D. Vestweber. 1994. Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo. Cell Adhesion and Communication. 2:7-14.
4. Weller, A., S. Isenmann, and D. Vestweber. 1992. Cloning of the mouse endothelial selectins: expression of both E- and P-selectin is inducible by tumor necrosis factor α. J. Biol. Chem. 267:15176-15183.
5. Mayadas, T.N., R.C. Johnson, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1993. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 74:541-554.
6. Frenette, P.S., T.N. Mayadas, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1996. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectin. Cell. 84:563-574.
7. Labow, M.A., C.R. Norton, J.M. Rumberger, K.M. Lombard-Gillooly, D.J. Shuster, J. Hubbard, R. Bertko, P.A. Knaack, R.W. Terry, M.L. Harbison. et al. 1994. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity. 1:709-720.
8. Quagliarello, V.J., and W.M. Scheid. 1993. New perspectives on bacterial meningitis. Clin. Infect. Dis. 17:603-610.
9. Tuomanen, E. 1992. Adjunctive therapy of experimental meningitis: agents other than steroids. In Bacterial Meningitis. Antibiotic Chemotherapy. H. Schonfeld and H. Helwig, editors. Karger. Basel. 184-191.
10. Tuomanen, E. 1994. Modulation of inflammation in bacterial meningitis. Isr. J. Med. Sci. 30:339-341.
11. Tuomanen, E., K. Saukkonen, S. Sande, C. Cioffe, and S.D. Wright. 1989. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J. Exp. Med. 170:959-968.
12. Sáez-Llorens, X., H.S. Jafari, C. Severien, F. Parras, K.D. Olsen, E.J. Hansen, I.I. Singer, and G.H. McCracken, Jr. 1991. Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilia: meningitis. J. Clin. Invest. 88:2003-2011.
13. Tan, T.Q., C. Wayne Smith, E.P. Hawkins, E.O. Mason, Jr., and S.L. Kaplan. 1995. Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model. J. Infect. Dis. 171:342-349.
14. Rodewald, A.K., A.B. Onderdonk, H.B. Warren, and D.L. Kasper. 1992. Neonatal mouse model of group B streptococcal infection. J. Infect. Dis. 166:635-639.
15. Tsai, Y.H., E.B. Williams, R.S. Hirth, and K.E. Price. 1975. Pneumococcal meningitis: therapeutic studies in mice. Chemotherapy. 21:342-357.
16. Leist, T.P., K. Frei, S. Kam-Hansen, R.M. Zinkernagel, and A. Fontana. 1988. Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients. J. Exp. Med. 167:1743-1748.
17. Quagliarello, V.J., B. Wispelwey, W.J. Long, and W.M. Scheld. 1991. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. J. Clin. Invest. 87:1360-1366.
18. Mustafa, M.M., O. Ramilo, K.D. Olsen, P.S. Franklin, E.J. Hansen, B. Beutler, and G.H. McCracken, Jr. 1989. Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis. J. Clin. Invest. 84:1253-1259.
19. Ramilo, O., X. Saez-Llorens, J. Mertsola, H. Jafari, K.D. Olsen, E.J. Hansen, M. Yoshinaga, S. Ohkawara, H. Nariuchi, and G.H. McCraken, Jr. 1990. Tumor necrosis factor α/cachectin and interleukin 1β initiate meningeal inflammation. J. Exp. Med. 172:497-507.
20. Griffin, D.E. 1981. Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice. J. Immunol. 126:27-31.
21. Kurose, I., T. Yamada, R. Wolf, and D.N. Granger. 1994. P-selectin-dependent leukocyte recruitment and intestinal mucosa injury induced by lacloferrin. J. Leukocyte Biol. 55:771-777.
22. Yam, L.T., C.Y. Li, and W.H. Crosby. 1971. Cytochemical identification of monocytes and granulocytes. Am. J. Clin. Pathol. 55:283-290.
23. McCracken, G.H., Jr., M.M. Mustafa, O. Ramilo, K.D. Olsen, and R.C. Risser. 1989. Cerebrospinal fluid interleukin-1β and tumor necrosis factor concentrations and outcome from neonatal gram-negative enteric bacillary meningitis. Ped. Infect. Dis. J. 8:155-159.
24. Waage, A., A. Halstensen, R. Shalaby, P. Brandtzaeg, P. Kierulf, and T. Espevik. 1989. Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis. Relations to the inflammatory response. J. Exp. Med. 170:1859-1867.
25. Mustafa, M.M., M.H. Lebel, O. Ramilo, K.D. Olsen, J.S. Reisch, B. Beutler, and G.H. McCracken, Jr. 1989. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis. J. Pediatr. 115:208-213.
26. Dinarello, C.A. 1988. Biology of interleukin-1. FASEB (Fed. Am. Soc. Exp. Biol.) J. 2:108-115.
27. Robbins, D.S., Y. Shivazi, B.E. Drysdale, A. Lieberman, H.S. Shin, and M.L. Shin. 1987. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J. Immunol. 139:2593-2597.
28. Frei, K., C. Siepl, P. Groscurth, S. Bodmer, C. Schwerdel, and A. Fontana. 1987. Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur. J. Immunol. 17:1271-1278.
29. Tuomanen, E., and A. Baruch. 1989. New antibodies as adjunctive therapies for gram-positive bacterial meningitis. Ped. Infect. Dis. J. 8:923-928.
30. Barkalow, F.J., M.J. Goodman, and T.N. Mayadas. 1996. Cultured murine cerebral microvascular endothelial cells contain von Willebrand factor positive Weibel-Palade bodies and support rapid cytokine-induced neutrophil adhesion. Microcirculation. 3:19-28.
31. Lo, S.K., S. Lee, R.A. Ramos, R. Lobb, M. Rosa, G. Chi-Rosso, and S.D. Wright. 1991. Endothelial-leukocyte adhesion molecule-1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, αmβ2) on human neutrophils. J. Exp. Med. 173:1493-1500.
32. Cooper, D., C.M. Butcher, M.C. Berndt, and M.A. Vadas. 1994. P-selectin interacts with a β2-integrin to enhance phagocytosis. J. Immunol. 153:3199-3209.
33. Granert, C., J. Raud, X. Xie, L. Lindquist, and L. Lindbom. 1994. Inhibition of leukocyte rolling with polysaccharide fucoidin prevents pleocylosis in experimental meningitis in the rabbit. J. Clin. Invest. 93:929-936.
34. Scheid, W.M., V.J. Quagliarello, and A.J. Lesse. 1987. Selected aspects of the pathogenesis and pathophysiology of bacterial meningitis. In Bacterial Meningitis, J.D. Williams and J. Burnie, editors. Academic Press, Boston. 1-21.
35. Mulligan, M.S., J.C. Paulson, S. De Frees, Z.-L. Zheng, J.B. Lowe, and P.A. Ward. 1993. Protective effects of oligosaccharides in P-selectin-dependem lung injury. Nature (Lond.). 364:149-151.
36. Sharar, S.R., R.K. Winn, C.E. Murry, J.M. Harlan, and C.L. Rice. 1991. A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits. Surgery (St. Louis). 110:213-220.
37. Sharar, S.R., S.S. Sasaki, L.C. Flaherty, J.C. Paulson, J.M. Harlan, and R.K. Winn. 1993. P-selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits. J. Immunol. 151: 4982-4988.