Transgenesis in rats: Technical aspects and models

Transgenic Research

Volumn 5, Issue 4, 1996, Pages 223-234

  Charreau, Béatrice ^a   Tesson, Laurent ^a   Soulillou, Jean Paul ^a   Pourcel, Christine ^a   Anegon, Ignacio ^a  

^a INSERM   (France)

Author keywords

DNA; embryonic stem cells; rat; transgenic animals; xenotransplantation

Indexed keywords

ANIMALIA; MUS MUSCULUS;

EID: 0030197964     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01972876     Document Type: Review

References (75)

1. Anzai, M., Nakagata, N., Matsumoto, K., Takahash, Y. and Miyata, K. (1994) Cryopreservation of in vitro fertilized embryos from transgenic rats by ultrarapid freezing. Exp. Anim. 43, 247-50.
2. Armstrong, D.T. and Opavski, M.A. (1988) Superovulation of immature rats by continuous infusion of follice-stimulating hormone. Biology Reprod. 39, 511-8.
3. Azimzadeh, A., Wolf, P., Fabre, M., Odeh, M., Charreau, B., Thibadeau, K., Soulillou, J.P. and Anegon, I. (1996) Rat-to-primate heart xenograft hyperacute rejection: model assessment, immunological and histological analysis. Transplantation in press.
4. Bader, M., Zhao, Y., Sander, M., Lee, M. and Bachmann, J. (1992) Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27. Hypertension 19, 681-6.
5. Baker, H.J., Lindsey, J.R. and Weisbroth, M. (1979) The Laboratory Rat. Vols. 1 and 2. New York, Academic Press.
6. Bonnerot, C., Rocancourt, D., Briand, P., Grimber, G. and Nicolas, J.F. (1987) A β-galactosidase hybrid protein targeted to nuclei as marker for developmental studies. Proc. Natl Acad. Sci. USA 84, 6795-9.
7. Bradley, A., Evans, M.J., Kaufman, M.H. and Robertson, E. (1984) Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255-6.
8. Breban, M., Hammer, R.E., Richardson, J.A. and Taurog, J.D. (1993) Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J Exp Med. 178, 1607-16.
9. Brinster, R.L., Chen, H.Y., Trumbauer, M.E., Yagle, M. and Palmiter, R.D. (1985) Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl Acad. Sci USA 82, 4438-42.
10. Canseco, R.S., Sparks, A.E.T., Page, R.L., Russell, C.G., Johnson, J.L., Velander, W.H., Pearson, R.E., Drohan, W.N. and Gwazdauskas, F.C. (1994) Gene transfer efficiency during gestation and the influence of co-transfer of non-manipulated embryos on production of transgenic mice. Transgenic Res. 3, 20-5.
11. Cappechi, M.R. (1989) Altering the genome by homologous recombination. Science 244, 1288-92.
12. Carr, I., Carr, J. and Dreher, B. (1981) Lymphatic metastasis of mammary adenocarcinoma: an experimental study in the rat with a brief review of the literature. Invasion Metastasis 1, 34-53.
13. Cavard, C., Zider, A., Vernet, M., Bennoun, M., Saragosti, S., Grimber, G. and Briand, P. (1990) In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat. J. Clin. Investigation 86, 1369-74.
14. Charlton, B.H.A. and Garrisson Fathman, C. (1994) Mechanisms of transplantation tolerance. Annu. Rev. Immunol. 12, 707-34.
15. Charreau, B., Cassard, A., Tesson, L., Le Mauff, B., Navenot, J.M., Blanchard, D., Soulillou, J.P. and Anegon, I. (1994) Protection of rat endothelial cells from primate complement-mediated lysis by expression of human CD59 and/or decay-accelerating factor. Transplantation 58, 1222-30.
16. Charreau, B., Tesson, L., Buscail, J., Soulillou, J.P. and Anegon, I. (1996) Analysis of human CD59 tissue expression directed by the CMV-IE-1 promoter in transgenic rats. Transgenic Res. in press.
17. Chisari, F., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H., Sell, S., Pinkert, C., Brinster, R. and Palmiter, R. (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59, 1145-56.
18. Depamphilis, M.L., Herman, S.A., Martinez-Salas, E., Chalifour, L., Wirak, D., Cupo, D. and Miranda, M. (1988) Microinjecting DNA into mouse ova to study DNA replication and gene expression and to produce transgenic animals. BioTechniques 6, 662-80.
19. Doetschman, T.C., Williams, P. and Maeda, M. (1988) Establishment of hamster blastocyst-derived embryonic-stem cells. Developmental Biology 127, 224-7.
20. Dunn, C.S., Mehtali, M., Houdebine, L.M., Gut, J.P., Kirn, A. and Aubertin, A.M. (1995) Human immunodeficiency virus type 1 infection of human CD4 transgenic rabbits. J. General Vir. 76, 1327-36.
21. Dycaico, M.J., Provost, G.S., Kretz, P.L., Ransom, S.L., Moores, J.C. and Short, J.M. (1994) The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mittat. Res. 307, 461-78.
22. Efrat, S., Surana, M. and Fleischer, N. (1991) Glucose induces insulin gene transcription in a murine pancreatic beta-cell line. J. Biol. Chem. 266, 11141-3.
23. Evans, M.J. and Kaufman, M.H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 152-6.
24. Fodor, W.L., Williams, B.L., Matis, L.A., Madri, J.A., Rollins, S.A., Knight, J.W., Velander, W. and Squinto, S.P. (1994) Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc. Natl Acad. Sci. USA 91, 11153-7.
25. Fukamizu, A., Seo M., Hatae, T., Yokoyama, M. and Nomura, T. (1989) Tissue-specific expression of the human renin gene in transgenic mice. Biochem. Biophys. Res. Commun. 165, 826-32.
26. Furth, P.A., St. Onge, L., Böger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H. and Hennighausen, L. (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc. Natl Acad. Sci. USA 91, 9302-6.
27. Ganten, D., Wagner, J., Zeh, K., Bader, M., Michel, J.-B., Paul, M., Zimmermann, F., Ruf, P., Hilgenfelt, U., Ganten, U., Kaling M., Bachmann, S., Fukamizu, A., Mullins, J.J. and Murakami, K. (1992) Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc. Natl Acad. Sci. USA 89, 7806-10.
28. Gill, T., Kunz, H.W., Misra, D.N. and Cortese Hassett, A.L. (1987) The major histocompatibility complex of the rat. Transplantation 43, 773-85.
29. Gill, T., Smith, G.J., Wissler, R.W. and Kunz, H.W. (1989) The rat as an experimental animal. Science 245, 269-76.
30. Gould, N.M. (1986) Inheritance and site of expression of genes controlling susceptibility to mammary cancer in an inbred rat model. Cancer Res. 46, 1199-202.
31. Greenwald, R.A. and Diamond H.S., eds (1988) Handbook of Animal Models for The Rheumatic Diseases. Boca Raton, FL, CRC Press.
32. Grosschedl, R., Weaver, D., Baltimore, D. and Constantini, F. (1984) Introduction of an immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38, 647-58.
33. Günthert, U., Hofmann, M., Rudy, W., Reber, S., Zöller, M., Haubmann, I., Matzku, S., Wenzel, A., Ponta, H. and Herrlich, P. (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65, 13-24.
34. 2m: an animal model of HLA-B27-associated human disorders. Cell 63, 1099-112.
35. Harris, A., Pinkert, C., Crawford, M., Langdon, W., Brinster, R. and Adams, J. (1988) The Eμ-myc transgenic mouse: A model for high incidence spontaneous lymphoma and leukemia of early B cells. J. Exp. Med. 167, 353-71.
36. Heideman, J. (1991) Transgenic rats: a discussion. Bio/Technology 16, 325-32.
37. Hochi, S., Ninomiya, T., Homma, M. and Yuki, A. (1990) Successful production of transgenic rats. Anim. Biotechnol. 1, 175-84.
38. Hochi, S.I., Ninomiya, T., Waga-Homma, M., Sagara, J. and Yuji, A. (1992) Secretion of bovine α-lactalbumin into the milk of transgenic rats. Mol. Reprod. Dev. 33, 160-4.
39. Hogan, B., Constantini, F. and Lacy, E. (1986) Manipulating the Mouse Embryo. Cold Spring Harbor, New York; Cold Spring Harbor Laboratory Press.
40. Iannaccone, P.M., Taborn, G.U., Garton, R.L., Caplice, M.D. and Brenin, D.R. (1994) Pluripotent embryonic stem cells from the rat are capable of producing chimeras. Der. Biol. 163, 288-92.
41. Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. and Masaki, T. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl Acad. Sci. USA 86, 2863-7.
42. Jeunemaître, X., Soubrier, F., Kotelevtsev, Y.V., Lifton, R.P. and Williams, C.S. (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71, 169-80.
43. Kajiwara, N., Sugiyama, F., Goto, Y., Sugiyama, Y., Fukamizu, A., Uehara, S., Sugimura, K., Murakami, K., Hokao, R., Akahori, F. and Yagami, K. (1993) Production of transgenic rats using pregnant and pseudopregnant rats prepared at a breeding farm. Jikken Dobutsu 42, 463-6.
44. Lathe, R. and Mullins, J.J. (1993) Transgenic animals as models for human disease - report of an EC study group. Transgenic Res. 2, 286-99.
45. Magee, J.C. and Platt, J.L. (1994) Xenograft rejection-molecular mechanisms and therapeutic implications. Therapeutic Immunology 1, 45-58.
46. Matsumoto, K., Kakidani, H., Takahashi, T., Nakagata, N., Anzai, M., Matsuzaki, Y., Takahashi, Y., Miyata, K., Utsumi, K. and Iritani, A. (1993) Growth retardation in rats whose growth hormone gene expression was suppressed by antisense RNA transgene. Mol. Reprod. Der. 36, 53-8.
47. Mikkelsen, T., Chapman, B., Din, N., Ingerslev, J., Kristensen, P., Poulsen, K. and Hjorth, J.P. (1992) Expression of a cytomegalovirus IE-1-factor VIII cDNA hybrid gene in transgenic mice. Transgenic Res. 1, 164-9.
48. Mullins, J.J., Sigmund, C.D., Kane-Haas, C., McGowan, R.A. and Gross, K.W. (1989) Expression of the murine Ren-2 gene in the adrenal gland of transgenic mice. EMBO J. 8, 4065-72.
49. Mullins, J.J., Peters, J. and Ganten, D. (1990) Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344, 541-4.
50. Nakagata, N. (1993) Production of normal young following transfer of mouse embryos obtained by in vitro fertilization between cryopreserved gametes. J. Reprod. Fert. Steril. 87, 479-83.
51. Notarianni, E., Laurie, S., Moore, R.M. and Evans, M.J. (1990) Maintenance and differentiation in culture of pluripotential embryonic cell lines from pig blastocysts. J. Reprod. Fert. Suppl. 41, 51-6.
52. Paul, M. and Böcker, W. (1995) Transgenic rats expressing endothelin genes - new models for the study of endothelin function in vivo. Submitted.
53. Paul, M., Wagner, J., Hoffmann, S., Urata, H. and Ganten, D. (1994) Transgenic rats: new experimental models for the study of candidate genes in hypertension research. Annu. Rev. Physiol. 56, 811-29.
54. Pinkert, C.A. (1994) Transgenic pig models for xeno-transplantation. Xeno. 2, 10-5.
55. Plump, A.S., Smith, J.D., Hayek, T., Aalto-Setala, K., Walsh, A., Verstuyft, J.G., Rubin, M. and Breslow, J.L. (1991) Severe hypocholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71, 343-53.
56. Overbeek, P.A. (1994) Factors affecting transgenic animal production. In Pinkert, C.A. ed., Transgenic Animal Technology: a Laboratory Handbook, pp. 15 68. San Diego, CA: Academic Press.
57. Robl, J.M. and Heideman, J.K. (1994) Production of transgenic rats and rabbits. In: Pinkert, C.A. ed., Transgenic Animal Technology: a Laboratory Handbook, pp. 265-78. San Diego, CA: Academic Press.
58. Schmidt, E.V. Christoph, G., Zeller, R. and Leder, P. (1990) The cytomegalovirus enhancer: a pan-active control element in transgenic mice. Mol. Cell. Biol. 10, 4406-11.
59. Sigmund, C.D., Jones, C.A., Kane, C.M., Wu, C., Lang, J.A. and Gross, K.W. (1992) Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ. Res. 70, 1070-9.
60. Southard Smith, M., Lechago, J., Wines, D.R., Macdonald, R.J. and Hammer, R.E. (1992) Tissue-specific expression of kallikrein family transgenes in mice and rats. DNA Cell Biology 11, 345-58.
61. Sukoyan, M.A., Golubitas, A.N., Zhelezova, A.L., Shilov, A.G., Vatolin, S.Y., Maximovsky, L.P., Andreeva, L.E., McWhir, J., Pack, S.D. and Bayborodin, S.I. (1992) Isolation and cultivation of blastocyst derived stem cell lines from American mink (Mustela vision). Mol. Reprod. Dev. 33, 418-31.
62. Swanson, M.E., Hughes, T.E., St Denny, I., France, D.S., Paterniti, J.R., Jr, Taparelli, C., Gfeller, P. and Bürki, K. (1992) High level expression of human apolipoprotein A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein A-I. Transgenic Res. 1, 142-7.
63. Szabo, T., Free, S.P., Birkhead, H.A. and Gay, P.E. (1969) Predictibility of pregnancy from various signs of mating in mice and rats. Laboratory Animal Care 19, 822-5.
64. Taketo, M., Schroeder, A.C., Mobraaten, L.E., Gunning, K.B., Hanten, G., Fox, R.R., Roderick, T.H., Stewart, C.L., Lilly, F., Hansen, C.T. and Overbeek, P.A. (1991) FVB/N: an inbred mouse strain preferable for transgenic analysis. Proc. Natl Acad. Sci. USA 88, 2065-9.
65. Taurog, J.D., Hammer, R.E., Maika, S.D., Sams, K.L., El-Zaatari, F.A.K., Stimpson, S.A. and Schwap, J.H. (1990) HLA-B27 transgenic mice as potential models of human disease. In Egorov, I.K. and David, C.S. Transgenic Mice and Mutants in MHC Research, pp. 268-75. Berlin: Springer-Verlag.
66. Taurog, J.D., Maika, S.D., Simmons, W.A., Breban, M. and Hammer, R.E. (1993) Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J. Immunol. 150, 4168-78.
67. Taurog, J.D., Richardson, J.A., Croft, J.T., Simmons, W.A., Zhou, M., Fernandez-Sueiro, J.L., Balish, E. and Hammer, R.E. (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180, 2359-64.
68. Tronik, D., Dreyfus, M., Babinet, C. and Rougeon, F. (1987) Regulated expression of the Ren-2 gene in transgenic mice derived from parental strains carrying only the Ren-1 gene. EMBO J. 6, 983-7.
69. Vilotte, J.E., Soulier, S., Stinnakre, M.G., Massoud, M. and Mercier, J.C. (1989) Efficient tissue-specific expression of bovine α-lactalbumin in transgenic mice. Eur. J. Biochem. 186, 43-8.
70. Walton, E.A., Evans, G. and Armstrong, D.T. (1983) Ovulation response and fertilization failure in immature rats induced to superovulate. Reprod. Fertil. 67, 91-6.
71. Williamson, R., Lee, Hagaman, J. and Maeda, N. (1992) Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc. Natl Acad. Sci. USA 89, 7134-8.
72. Young, W.Y., Yuen, B.H. and Moon, Y.S. (1987) Effects of superovulatory doses of pregnant mare serum gonadotropin on oocyte quality and ovulatory and steroid hormone responses in rats. Gamet. Res. 16, 109-20.
73. Zeng, Q., Carter, D.A. and Murphy, D. (1994a) Cells specific expression of a vasopressin transgene in rats. J. Neuroendocrinol. 6, 469-77.
74. Zeng, Q., Foo, N.C., Funkhouser, J.M., Carter, D.A. and Murphy, D. (1994b) Expression of a rat vasopressin transgene in rat testes. J. Reprod. Fertility 102, 471-81.
75. Zider, A., Mashour, B., Fergelot, P., Grimber, G., Vernet, M., Hazan, U., Couton, D., Briand, P. and Cavard C. (1993) Dispensable role of the NF-κB sites in the UV-induction of the HIV-1 ETR in transgenic mice. Nucl. Acids Res. 21, 79-86.