Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: Roles of conserved active site residues

Journal of Biological Chemistry

Volumn 276, Issue 26, 2001, Pages 23929-23936

  Boehr, David D ^a   Thompson, Paul R ^a   Wright, Gerard D ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CATALYSIS; ENZYMES; MUTAGENESIS; SYNTHESIS (CHEMICAL);

LIGANDS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; AMIKACIN; AMINO ACID DERIVATIVE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOGLYCOSIDE ANTIBIOTIC KINASE APH(3') IIIA; ASPARAGINE; ASPARTIC ACID; BUTIROSIN; ENZYME; FRAMYCETIN; GLUTAMIC ACID; GLUTAMINE; ISOTOPE; KANAMYCIN B; LIGAND; LIVIDOMYCIN; LYSINE; MAGNESIUM; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBOSTAMYCIN; SOLVENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; KANAMYCIN; KANAMYCIN KINASE; PROTEINASE;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CATALYSIS; CATION TRANSPORT; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; IN VIVO STUDY; MOLECULAR MECHANICS; NONHUMAN; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN VARIANT; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; VISCOSITY; ANIMAL; CHEMICAL MODEL; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; NUCLEOTIDE SEQUENCE;

ANIMALIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; DRUG RESISTANCE, MICROBIAL; ENDOPEPTIDASES; KANAMYCIN; KANAMYCIN KINASE; KINETICS; MAGNESIUM; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; VISCOSITY;

EID: 0035968312     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100540200     Document Type: Article

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