Recent Developments of Achiral HPLC Methods in Pharmaceuticals Using Various Detection Modes

Journal of Liquid Chromatography and Related Technologies

Volumn 27, Issue 7-9, 2004, Pages 1237-1316

  Natishan, Theresa K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Active pharmaceutical ingredient; Electrochemical detectors; Fast HPLC; Formulation; Impurity profile method; Reverse phase HPLC; Stability indicating method

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICAL APPLICATIONS; SPECTROSCOPIC ANALYSIS;

DRUG DISCOVERY; SPECTROSCOPIC DETECTORS;

DRUG PRODUCTS;

AUTOMATION; CHEMICAL ANALYSIS; CHIRALITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; REVIEW; SPECTROSCOPY;

EID: 2342629272     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120030603     Document Type: Review

References (244)

1. Snyder, L.R.; Kirkland, J.J.; Glajch, J.L. Practical HPLC Method Development, 2nd Ed.; John Wiley & Sons, Inc.; 1997; 765.
2. Wulff, G. Molecular imprinting in cross-linked materials with the aid of molecular templates - a way towards artificial antibodies. Angew. Chem. Int. Ed. Engl. 1995, 34, 1812-1832.
3. Wilson, I.D.; Brinkman, U.A.Th. Hyphenation and hypernation. The practice and prospects of multiple hyphenation. J. Chromatogr. A 2003, 1000, 325-356.
4. Qi, M.L.; Wang, P.; Wang, L.J.; Fu, R.N. LC method for the determination of oxcarbazepine in pharmaceutical preparations. J. Pharm. Biomed. Anal. 2003, 31, 57-62.
5. Zawilla, N.H.; Mohammad, M.A.; El Kousy, N.M.; El-Moghazy Aly, S.M. Determination of meloxicam in bulk and pharmaceutical formulations. J. Pharm. Biomed. Anal. 2003, 32, 1135-1144.
6. Youngvises, N.; Liawruangrath, B.; Liawruangrath, S. Simultaneous micellar LC determination of lidocaine and tolperisone. J. Pharm. Biomed. Anal. 2003, 31, 629-638.
7. Choi, D.W.; Kim, M.J.; Kim, H.S.; Chang, S.H.; Jung, G.S.; Shin, K.Y.; Chang, S.Y. A size-exclusion HPLC method for the determination of sodium chondroitin sulfate in pharmaceutical preparations. J. Pharm. Biomed. Anal. 2003, 31, 1229-1236.
8. Li, J.; Jaworsky, M.S.; Stirling, D.I. The determination of a potential impurity in thalidomide drug substance and product by HPLC with indirect UV detection. J. Pharm. Biomed. Anal. 2003, 31, 19-27.
9. Gandhimathi, M.; Ravi, T.K.; Abraham, A.; Thomas, R. Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography. J. Pharm. Biomed. Anal. 2003, 32, 1145-1148.
10. Radhakrishna, T.; Narasaraju, A.; Ramakrishna, M.; Satyanarayana, A. Simultaneous determination of montelukast and loratadine by HPLC and derivative spectrophotometric methods. J. Pharm. Biomed. Anal. 2003, 31, 359-368.
11. Burge, L.J.; Raches, D.W. A rapid HPLC assay for the determination of dextro-propoxyphene related substances in combination with aspirin, acetaminophen, and caffeine in tablet and capsule formulations. J. Liq. Chromatog. Related Technol. 2003, 26 (12), 1977-1990.
12. Monser, L.; Darghouth, F. Simultaneous determination of naproxen and related compounds by HPLC using porous graphitic carbon column. J. Pharm. Biomed. Anal. 2003, 32, 1087-1092.
13. Erk, N. Rapid and sensitive HPLC method for the simultaneous determination of dorzolamide hydrochloride and timolol maleate in eye drops with diode-array and UV detection. Pharmazie 2003, 58, 491-493.
14. Hamilton Company. EDTA. LCGC N. Am. 2003 (Suppl. S), 44.
15. Hajkova, R.; Solich, P.; Dvorak, J.; Sicha, J. Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC. J. Pharm. Biomed. Anal. 2003, 32, 921-927.
16. Garcia-Alvarez-Coque, M.C.; Simo-Alphonso, E.F.; Ramis-Ramos, G.; Esteve-Romero, J.S. High-performance micellar liquid chromatography determination of sulphonamides in pharmaceuticals after azodye precolumn derivatization. J. Pharm. Biomed. Anal. 1995, 13 (3), 237-245.
17. Gonzalo-Lumbreras, R.; Izquierdo-Hornillos, R. Optimization and validation of conventional and micellar LC methods for the analysis of metyltestosterone in sugar-coated pills. J. Pharm. Biomed. Anal. 2003, 31, 201-208.
18. Molero-Monfort, M.; Martin-Biosca, Y.; Sagrado, S.; Villanueva-Camanas, R.M.; Medina-Hernandez, M.J. Micellar liquid chromatography for prediction of drug transport. J. Chromatogr. A 2000, 870, 1-11.
19. Garcia-Alvarez-Coque, M.C.; Carda Broch, S. Direct injection of physiological fluids in micellar liquid chromatography. J. Chromatogr. B 1999, 736, 1-18.
20. Ruiz-Angel, M.J.; Carda-Broch, S.; Simo-Alfonso, E.F.; Garcia-Alvarez-Coque, M.C. Optimised procedures for the reversed-phase liquid chromatographic analysis of formulations containing tricyclic antidepressants. J. Pharm. Biomed. Anal. 2003, 32, 71-84.
21. Garcia, C.V.; Breier, A.R.; Steppe, M.; Schapoval, E.E.S.; Oppe, T.P. Determination of dexamethasone acetate in cream by HPLC. J. Pharm. Biomed. Anal. 2003, 31, 597-600.
22. Savaser, A.; Ozkan, C.K.; Ozkan, Y.; Uslu, B.; Ozkan, S.A. Development and validation of an RP-HPLC method for the determination of valacyclovir in tablets and human serum and its application to drug dissolution studies. J. Liq. Chromatogr. Related Technol. 2003, 26 (11), 1755-1767.
23. Atay, O.; Tamer, U.; Arikan, D. Determination of cilazapril and hydrochlorothiazide in pharmaceuticals by high performance liquid chromatography. Anal. Lett. 2001, 34 (7), 1153-1161.
24. Glasl, S.; Mucaji, P.; Werner, I.; Jurenitsch, J. TLC and HPLC characteristics of desacetylmatricarin, leucodin, achillin and their 8α-angeloxy-derivatives. Pharmazie 2003, 58, 487-490.
25. Wang, J.; Lu, J.; Zhang, L.; Hu, Y. Determination of cetylpyridinium chloride and tetracaine hydrochloride in buccal tablets by RP-HPLC. J. Pharm. Biomed. Anal. 2003, 32, 381-386.
26. Dincer, Z.; Basan, H.; Goger, N.G. Quantitative determination of ambroxol in tablets by derivative UV spectrophotometric method and HPLC. J. Pharm. Biomed. Anal. 2003, 31, 867-872.
27. Thomas, S.M.; Trone, M.D.; Hooker, T.; Dorwart, J.G.; Morneweck, L.A. Quantitation of propyl gallate in an active pharmaceutical ingredient (API) using high-low chromatography. J. Liq. Chromatogr. Related Technol. 2003, 26 (11), 1743-1753.
28. Supelco, Applications Development Group. Separation of rapamycin and 32-desmethoxyrapmycin on Discovery HS C18. LCGC N. Am. 2003 (Suppl. S), 51.
29. Segall, A.I.; Vitale, M.F.; Perez, V.L.; Pizzorno, M.T. HPLC analysis of 5H-benzo[a]carbazole with antifungal activity. J. Pharm. Biomed. Anal. 2003, 31, 1021-1026.
30. Bauer, S.; Stormer, E.; Kirchheiner, J.; Michael, C.; Brockmoller, J.; Roots, I. Rapid and simple method for the analysis of nateglinide in human plasma using HPLC analysis with UV detection. J. Pharm. Biomed. Anal. 2003, 31, 551-555.
31. Niopas, I.; Daftsios, A.C. Determination of nifedipine in human plasma by solid-phase extraction and high-performance liquid chromatography: validation and application to pharmacokinetic studies. J. Pharm. Biomed. Anal. 2003, 32, 1213-1218.
32. Oh, S.Y.; Kim, K.Y.; Kim, Y.G.; Kim, H.-G. High-performance liquid chromatographic analysis of nitrendipine in human plasma using ultra-violet detection and single-step solid phase sample preparation. J. Pharm. Biomed. Anal. 2003, 32, 387-392.
33. Katori, K.; Homma, M.; Kuga, K.; Yamaguchi, I.; Sugibayashi, K.; Kohda, Y. Liquid chromatographic determination of unbound flecainide in therapeutic drug monitoring. J. Pharm. Biomed. Anal. 2003, 32, 375-380.
34. Suchocka, Z.; Gronostajska, D.; Suchocki, P.; Pachecka, J. New HPLC method for separation of blood plasma phospholipids. J. Pharm. Biomed. Anal. 2003, 32, 859-865.
35. Wang, L.Z.; Ho, P.C.; Lee, H.S.; Vaddi, H.K.; Chan, Y.W.; Yung, C.S. Quantitation of paclitaxel in micro-sample rat plasma by a sensitive reversed-phase HPLC assay. J. Pharm. Biomed. Anal. 2003, 31, 283-289.
36. Imaz, C.; Navajas, R.; Carreras, D.; Rodriquez, C.; Rodriguez, A.F. Composition of various reversed-phase columns for the simultaneous determination of ephedrines in urine by high-performance liquid chromatography. J. Chromatogr. A 2000, 870, 23-28.
37. Bun, S.S.; Ciccolini, J.; Bun, H.; Aubert, C.; Catalin, J. Drug interactions of paclitaxel metabolism in human liver microsomes. J. Chemotherapy 2003, 15 (3), 266-274.
38. Huq, S.; Teuscher, J. Introducing Strata™ X-C, ideal for the extraction of basic drugs from biological matrices. LCGC N. Am. 2003 (Suppl. S), 46-47.
39. Zarghi, A.; Foroutan, S.M.; Shafaait, A.; Khoddam, A. Rapid determination of metformin in human plasma using ion-pair HPLC. J. Pharm. Biomed. Anal. 2003, 31, 197-200.
40. Zainaghi, I.A.; Lanchote, V.L.; Queiroz, R.H.C. Determination of paroxetine in geriatric depression by high-performance liquid chromatography. Pharm. Res. 2003, 48, 217-221.
41. Kowalczuk, D.; Hopkala, H.; Gumieniczek, A. Application of solid-phase extraction of fluoroquinolone derivatives from a biological matrix to their biodetermination by liquid chromatography. J. Liq. Chromatogr. Related Technol. 2003, 26 (11), 1731-1741.
42. Baeyens, W.R.G.; Van der Weken, G.; D'haeninck, E.; Garcia-Campana, A.M. ; Vankeirsbilck, T.; Vercauteren, A.; Deprez, P. Application of an alkyl-diol silica precolumn in a column switching system for the determination of meloxicam in plasma. J. Pharm. Biomed. Anal. 2003, 32, 839-846.
43. Boinpally, R.R.; Polin, L.; Zhou, S.-L.; Jasti, B.R.; Wiegand, R.A.; White, K.; Kushner, J.; Horwitz, J.P.; Corbett, T.H.; Parchment, R.E. Pharmacokinetics and tissue distribution of cryptophycin 52 (C-52) epoxide and cryptophycin 55 (C-55) chlorohydrin in mice with subcutaneous tumors. Cancer Chemother. Pharmacol. 2003, 52, 25-33.
44. Birsan, T.; Dambrin, C.; Klupp, J.; Stalder, M.; Larson, M.J.; Fitzsimmons, W.E.; Morris, R.E. In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates. Transpl. Int. 2003, 16, 354-360.
45. Lal, J.; Mehrotra, N.; Gupta, R.C. Analysis and pharmacokinetics of bulaquine and its major metabolite primaquine in rabbits using an LC-UV method-a pilot study. J. Pharm. Biomed. Anal. 2003, 32, 141-150.
46. Cho, H.; Gallher, D.D.; Csallany, A.S. Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. Anal. Biochem. 2003, 318, 47-51.
47. Sadakane, Y.; Yamazaki, T.; Nakagomi, K.; Akizawa, T.; Fujii, N.; Tanimura, T.; Kaneda, M.; Hatanaka, Y. Quantification of the isomerization of Asp residue in recombinant human ∝A-crystallin by reversed-phase HPLC. J. Pharm. Biomed. Anal. 2003, 30, 1825-1833.
48. Kobayashi, J.; Kikuchi, A.; Sakai, K.; Okano, T. Cross-linked thermoresponsive anionic polymer-grafted surfaces to separate bioactive basic peptides. Anal. Chem. 2003, 75, 3244-3249.
49. Gilar, M.; Fountain, K.J.; Budman, Y.; Neue, U.D.; Yardley, K.R.; Rainville, P.D.; Russell, R.J.; Gebler, J.C. Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides: retention prediction. J. Chromatogr. A 2002, 958, 167-182.
50. ICH Guideline Q3A(R), Impurities in New Drug Substances; February 7, 2002.
51. ICH Guideline Q3B(R), Impurities in New Drug Substances; February 5, 2003.
52. Nagaraju, V.; Sreenath, D.; Rao, J.T.; Rao, R.N. Separation and determination of synthetic impurities of sildnafil (Viagra) by reversed-phase high-performance liquid chromatography. Anal. Sci. 2003, 19, 1007-1011.
53. Wang, X.; Yao, T.; Zeng, S. Determination of diphenytriazol (DL111-IT) and its related impurities by RP-HPLC with DAD. J. Pharm. Biomed. Anal. 2003, 32, 369-374.
54. Hartman, R.; Abrahim, A.; Clausen, A.; Mao, B.; Crocker, L.S.; Ge, Z. Development and validation of an HPLC method for the impurity and quantitative analysis of etoricoxib. J. Liq. Chromatogr. Related Technol. 2003, 26 (15), 2551-2566.
55. Rocheleau, M.-J.; Jean, C.; Bolduc, J.; Carazzato, D. Evaluation of a silica-based monolithic column in the HPLC analysis of taxanes. J. Pharm. Biomed. Anal. 2003, 31, 191-196.
56. Mao, Y.; Carr, P.W. The thermally tuned tandem column approach to optimizing selectivity in HPLC. LC-GC N. Am. 2003, 21 (2), 150-167.
57. Mao, Y.; Carr, P.W. Separation of barbiturates and phenylthiohydantoin amino acids using the thermally tuned tandem column concept. Anal. Chem. 2001, 73, 1821-1830.
58. Khmelnitskaia, E.; Stoll, D.; Carr, P.W. Robust methods with high efficiency, bonded-carbon HPLC columns. LC-GC N. Am. 2002 (Suppl. S), 31.
59. Dolfinger, R.; Locke, D.C. Dependence of selectivity on eluent composition and temperature in the HPLC separation of taxanes using fluorinated and hydrocarbon phases. Anal. Chem. 2003, 75, 1355-1364.
60. van Zomeren, P.V.; Darwinkel, H.; Coenegracht, P.M.J.; de Jong, G.J. Comparison of several curve resolution methods for drug impurity profiling using high-performance liquid chromatography with diode array detection. Anal. Chim. Acta 2003, 487, 155-170.
61. Krishna Reddy, K.V.S.R.; Moses Babu, J.; Ravindra Kumar, Y.; Vishnu Vardhan Reddy, S.; Kishore Kumar, M.; Eswaraiah, S.; Rama Subba Reddy, K.; Sayanarayana Reddy, M.; Vijaya Bhaskar, B.; Dubey, P.K.; Vyas, K. Impurity profile study of loratadine. J. Pharm. Biomed. Anal. 2003, 32, 29-39.
62. Bakshi, M.; Singh, S. Development of validated stability-indicating assay methods-critical review. J. Pharm. Biomed. Anal. 2002, 28, 1011-1040.
63. Sims, J.L.; Roberts, J.K.; Bateman, A.G.; Carreira, J.A.; Hardy, M.J. An automated workstation for forced degradation of active pharmaceutical ingredients. J. Pharm. Sci. 2002, 91 (3), 884-892.
64. Marinkovic, V.D.; Agbaba, D.; Karljikovic-Rajic, K.; Vladimirov, S.; Nedeljkovic, J.M. Photochemical degradation of solid-state nisoldipine monitored by HPLC. J. Pharm. Biomed. Anal. 2003, 32, 929-935.
65. Gaudiano, M.C.; Valvo, L.; Bertocchi, P.; Manna, L. RP-HPLC study of the degradation of diclofenac and piroxicam in the presence of hydroxyl radicals. J. Pharm. Biomed. Anal. 2003, 32, 151-158.
66. Alibrandi, G.; Coppolino, S.; D'Aliberti, S.; Ficarra, R.; Micali, N.; Villari, A. Fast drug stability determination by LC variable-parameter kinetic experiments. J. Pharm. Biomed. Anal. 2003, 32, 1073-1079.
67. Ferlan, A.; Pecar, S.; Schara, M. Dithranol reaction with nitroxide radicals in DMSO, a HPLC study. Pharmazie 2003, 58 (7), 475-479.
68. Chomy, M.; Levy, D.; Schumacher, I.; Lichaa, C.; Gruzman, B.; Livshits, O.; Lomnicky, Y. Development and validation of a stability-indicating high performance liquid chromatographic assay for benoxinate. J. Pharm. Biomed. Anal. 2003, 32, 189-196.
69. Bebawy, L.I.; Moustafa, A.A.; Abo-Talib, N.F. Stability-indicating methods for the determination of sumatriptan succinate. J. Pharm. Biomed. Anal. 2003, 32, 1123-1133.
70. Bouabdallah, S.; Trabelsi, H.; Ben Dhia, T.; Sabbah, S.; Bouzouita, K.; Khaddar, R. RP-HPLC and NMR study of cis-trans isomerization of enalaprilat. J. Pharm. Biomed. Anal. 2003, 31,731-741.
71. Laviana, L.; Femandez-Mari, F.; Bayod, M.; Blanco, D. HPLC for in-process control in the production of sultamicillin. J. Pharm. Biomed. Anal. 2003, 31, 321-328.
72. Laviana, L.; Llorente, I.; Bayod, M.; Blanco, D. In-process control of midazolam synthesis by HPLC. J. Pharm. Biomed. Anal. 2003, 32, 167-174.
73. Trone, M.D.; Pinto, A.M.; Thomas, S.M. Controlling the structure of a trifluoroacylated hydrazino pharmaceutical intermediate for improved HPLC and GC analyses. J. Liq. Chromatogr. Related Technol. 2003, 26 (20), 3365-3380.
74. Office of Regulatory Affairs. Guide to inspections of validation of cleaning processes. In Reference Material for FDA Investigators and Personnel; Food and Drug Administration: Washington, D.C., 1993; 1-6.
75. Nozal, M.J.; Bernal, J.L.; Toribio, L.; Martin, M.T.; Diez, F.J. Development and validation of an LC assay for sumatriptan succinate residues on surfaces in the manufacture of pharmaceuticals. J. Pharm. Biomed. Anal. 2002, 30, 285-291.
76. Klinkenberg, R.; Streel, B.; Ceccato, A. Development and validation of a liquid chromatographic method for the determination of amlodipine residues on manufacturing equipment surfaces. J. Pharm. Biomed. Anal. 2003, 32, 345-352.
77. Nozal, M.J.; Bernal, J.L.; Toribio, L.; Martin, M.T.; Diez, F.J. Validation of a liquid chromatographic method for the determination of ranitidine hydrochloride residues on surfaces in the manufacture of pharmaceuticals. J. Chromatogr. A 2001, 919, 87-93.
78. Nozal, M.J.; Bernal, J.L.; Toribio, L.; Jimenez, J.J.; Martin, M.T. Validation of the removal of acetylsalicylic acid. Recovery and determination of residues on various surfaces by high performance liquid chromatographic. J. Chromatogr. A. 2000, 870, 69-75.
79. Sajonz, P.S.; Natishan, T.K.; Wu, Y.; McGachy, N.T.; DeTora, D. Development and validation of a sensitive and robust wipe-test method for the detection and quantification of the antibiotic ertapenem and its primary degradates in a pharmaceutical manufacturing environment, in press.
80. Wehr, T. Fast LC for high-throughput LC-MS. LC-GC N. Am. 2002, 20 (1), 40-47.
81. Sottani, C.; Turci, R.; Micoli, G.; Fiorentino, M.L.; Minoia, C. Rapid and sensitive determination of paclitaxel (Taxol®) in environmental samples by high-performance liquid chromatography tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2000, 14, 930-935.
82. Hatsis, P.; Lucy, C.A. Ultra-fast HPLC separation of common anions using a monolithic stationary phase. Analyst 2002, 127, 451-454.
83. van Nederkassel, A.M.; Aerts, A.; Dierick, A.; Massart, D.L.; Vander Heyden, Y. Fast separations on monolithic silica columns: method transfer, robustness and column ageing for some case studies. J. Pharm. Biomed. Anal. 2003, 32, 233-249.
84. Smith, J.H.; McNair, H.M. Fast HPLC with a silica-based monolithic ODS column. J. Chromatogr. Sci. 2003, 41, 209-214.
85. Diehl, D.M.; Van Tran, K.; Grumbach, E.S.; Morrison, D.; McCabe, D.R.; Neue, U.D.; Mazzeo, J.R. New intelligent speed (IS) columns for fast separations. LC-GC N. Am. 2003 (Suppl. S), 51.
86. Joseph, M.J. Fast HPLC analysis of antibiotics using columns with sub two-micron particles. LC-GC N. Am. 2003 (Suppl. S), 41.
87. Tiller, P.R.; Romanyshyn, L.A. Implications of matrix effects in ultra-fast gradient or fast isocratic liquid chromatography with mass spectrometry in drug discovery. Rapid Commun. Mass Spectrom. 2002, 16, 92-98.
88. Nguyet, A.N.M.; Tallieu, L.; Plaizer-Vercammen, J.; Massart, D.L.; Van der Heyden, Y. Validation of an HPLC method on short columns to assay ketoconazole and formaldehyde in shampoo. J. Pharm. Biomed. Anal. 2003, 32, 1-19.
89. Lim, J.K.; Riley, M.C.; Watts, S.T. The Hitachi LaChrom Elite HPLC and fast LC pharmaceutical applications: OTC analgesics & steroids. LC-GC N. Am. 2003, (Suppl. S), 47-48.
90. Leinweber, F.C.; Lubda, D.; Cabrera, K.; Tallarek, U. Characterization of silica-based monoliths with bimodal pore size distribution. Anal. Chem. 2002, 74 (11), 2470-2477.
91. Szumski, M.; Buszewski, B. State of the art in miniaturized separation techniques. Crit. Rev. Anal. Chem. 2002, 32 (1), 1-46.
92. Nakashima, K.; Yamamoto, K.; Al-Dirbashi, O.Y.; Kaddoumi, A.; Nakashima, M.N. Semi-micro column HPLC of triazolam in rat plasma and brain microdialysate and its application to drug interaction study with itraconazole. J. Pharm. Biomed. Anal. 2003, 30, 1809-1816.
93. Imaizumi, M.; Saito, Y.; Hayashida, M.; Takeichi, T.; Wada, H.; Jinno, K. Polymer-coated fibrous extraction medium for sample preparation coupled to microcolumn liquid-phase separations. J. Pharm. Biomed. Anal. 2003, 30, 1801-1808.
94. Yasueda, S.; Kimura, M.; Ohtori, A.; Kakehi, K. Analysis of an anti-inflammatory steroidal drug, difluprednate, in aqueous humor by combination of semi-micro HPLC and column switching method. J. Pharm. Biomed. Anal. 2003, 30, 1735-1742.
95. Okamura, N.; Miyauchi, H.; Choshi, T.; Ishizu, T.; Yagi, A. Simultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography. Biol. Pharm. Bull. 2003, 26 (5), 658-661.
96. Tomita, T.; Hamase, K.; Hayashi, H.; Fukuda, H.; Hirano, J.; Zaitsu, K. Determination of endogenous melatonin in the individual pineal glands of inbred mice using precolumn oxidation reversed-phase micro-high-performance liquid chromatography. Anal. Biochem. 2003, 316, 154-161.
97. Baek, S.K.; Choi, S.J.; Kim, J.S.; Park, E.J.; Sohn, D.H.; Lee, H.-Y.; Lee, H.S. Analysis of tofisopam in human serum by column-switching semi-micro high-performance liquid chromatography and evaluation of tofisopam bioequivalency. Biomed. Chromatogr. 2002, 16, 277-281.
98. Baggiani, C.; Giaraudi, G.; Trotta, F.; Giovannoli, C.; Vanni, A. Chromatographic characterization of a molecular imprinted polymer binding cortisol. Talanta 2000, 51, 71-75.
99. Sanbe, H.; Haginaka, J. Uniformly sized molecularly imprinted polymers for bisphenol A and β-estradiol: retention and molecular recognition properties in hydro-organic mobile phases. J. Pharm. Biomed. Anal. 2002, 30, 1835-1844.
100. Chen, W.; Liu, F.; Zhang, X.; Li, K.A.; Tong, S. The specificity of a chlorphenamine-imprinted polymer and its application. Talanta 2001, 55, 29-34.
101. Moring, S.E.; Wong, O.S.; Stobaugh, J.F. Target specific sample preparation from aqueous extracts with molecular imprinted polymers. J. Pharm. Biomed. Anal. 2002, 27, 719-728.
102. Anderson, J.L.; Armstrong, D.W. High-stability ionic liquids. A new class of stationary phases for gas chromatography. Anal. Chem. 2003, 75, 4851-4858.
103. Armstrong, D.W.; Zhang, L.-K.; He, L.; Gross, M.L. Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2001, 73, 3679-3686.
104. Alfassi, Z.B.; Huie, R.E.; Milman, B.L.; Neta, P. Electrospray ionization mass spectrometry of ionic liquids and determination of their solubility in water. Anal. Bioanal. Chem. 2003, 377, 159-164.
105. Wei, G.-T.; Yang, Z.; Chen, C.-J. Room temperature ionic liquid as a novel medium for liquid/liquid extraction of metal ions. Anal. Chim. Acta 2003, 488, 183-192.
106. Handy, S.T. Greener solvents: room temperature ionic liquids from biorenewable sources. Chem. Eur. J. 2003, 9, 2938-2944.
107. He, L.; Zhang, W.; Zhao, L.; Xia, L.; Jiang, S. Effect of 1-alkyl-3-methyl-imidazolium-based ionic liquids as the eluent on the separation of ephedrines by liquid chromatography. J. Chromatogr. A 2003, 1007, 39-45.
108. Papac, D.I.; Shahrokh, Z. Mass spectrometric innovations in drug discovery and development. Pharm. Res. 2001, 18 (2), 131-144.
109. Smyth, W.F. Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. Anal. Chim. Acta 2003, 492, 1-16.
110. Cech, N.B.; Enke, C.G. Practical implications of some recent studies in electrospray ionization fundamentals. Mass Spectrom. Rev. 2001, 20, 362-387.
111. Matuszewski, B.K.; Constanzer, M.L.; Chavez-Eng, C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 2003, 75, 3019-3030.
112. Watson, D.G.; Atsriku, C.; Oliveira, E.J. Review role of liquid chromatography-mass spectrometry in the analysis of oxidation products and antioxidants in biological systems. Anal. Chim. Acta 2003, 492, 17-47.
113. Gelpi, E. Contributions of liquid chromatography-mass spectrometry to "highlights" of biomedical research. J. Chromatogr. A 2003, 1000, 567-581.
114. Guan, X.; Hoffman, B.; Dwivedi, C.; Matthees, D. A simultaneous liquid chromatography/mass spectrometric assay of glutathione, cysteine, homocysteine and their disulfides in biological samples. J. Pharm. Biomed. Anal. 2003, 31, 251-261.
115. Kim, H.; Han, S.B. Sensitive determination of oxybutynin and desethyloxybutynin in dog plasma by LC-ESI/MS/MS. J. Pharm. Biomed. Anal. 2003, 31, 341-349.
116. Matsuoka, K.; Kitamura, R.; Matsushima, E.; Kawaguchi, Y. Determination of 3′-C-ethynylcytidine in human plasma and urine by liquid chromatographic-electrospray ionization tandem mass spectrometry. J. Pharm. Biomed. Anal. 2003, 31, 47-55.
117. Nelson, B.C.; Pfeiffer, C.M.; Sniegoski, L.T.; Satterfield, M.B. Development and evaluation of an isotope dilution LC/MS method for the determination of total homocysteine in human plasma. Anal. Chem. 2003, 75, 775-784.
118. Toyo'oka, T.; Kumaki, Y.; Kanbori, M.; Kato, M.; Nakahara, Y. Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid chromatography with electrospray ionization mass spectrometry. J. Pharm. Biomed. Anal. 2003, 30, 1773-1787.
119. Oe, T.; Tian, Y.; O'Dwyer, P.J.; Roberts, D.W.; Malone, M.D.; Bailey, C.J.; Blair, I.A. A validated liquid chromatography/tandem mass spectrometry assay for cis-amminedichloro(2-methylpyridine)platinum(II) in human plasma ultrafiltrate. Anal. Chem. 2002, 74, 591-599.
120. De Baere, S.; Cherlet, M.; Baert, K.; De Backer, P. Quantitative analysis of amoxycillin and its major metabolites in animal tissues by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Anal. Chem. 2002, 74, 1393-1401.
121. Gibson, C.R.; Staubus, A.E.; Barth, R.F.; Yang, W.; Kleinholz, N.M.; Jones, R.B.; Green-Church, K.B.; Tjarks, W.; Soloway, A.H. Electrospray ionization mass spectrometry coupled to reversed-phase ion-pair high-performance liquid chromatography for quantitation of sodium borocaptate and application to pharmacokinetic analysis. Anal. Chem. 2002, 74, 2394-2399.
122. Raices, R.S.L.; Salvadori, M.C.; de Cassia, E. Estrela R.; de Aquino Neto, F.R.; Suarez-Kurtz, G. Determination of stavudine in human serum by on-line solid-phase extraction coupled to high-performance liquid chromatography with electrospray ionization tandem mass spectrometry: application to a bioequivalence study. Rapid Commun. Mass Spectrom. 2003, 17, 1611-1618.
123. Ceccato, A.; Klinkenberg, R.; Hubert, Ph.; Streel, B. Sensitive determination of buprenorphine and its N-dealkylated metabolite norbuprenophine in human plasma by liquid chromatography coupled to tandem mass spectrometry. J. Pharm. Biomed. Anal. 2003, 32, 619-631.
124. Palleschi, L.; Lucentini, L.; Ferretti, E.; Anastasi, F.; Amoroso, M.; Draisci, G. Quantitative determination of sufentanil in human plasma by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2003, 32, 329-336.
125. Kim, H.; Yoo, J.-Y.; Han, S.B.; Lee, H.J.; Lee, K.R. Determination of ambroxol in human plasma using LC-MS/MS. J. Pharm. Biomed. Anal. 2003, 32, 209-216.
126. Zhang, J.Y.; Fast, D.M.; Breau, A.P. A validated SPE-LC-MS/MS assay for eplerenone and its hydrolyzed metabolite in human urine. J. Pharm. Biomed. Anal. 2003, 31, 103-115.
127. Wu, Y.; Farrell, J.T.; Lynn, K.; Euler, D.; Kwei, G.; Hwang, T.-L.; Qin, X-Z. The importance of chromatographic separation in LC/MS/MS quantitation of drugs in biological fluids: detection, characterization, and synthesis of a previously unknown low-level nitrone metabolite of a substance P antagonist. Anal. Chem. 2003, 75, 426-434.
128. Yao, M.; Zhang, H.; Chong, S.; Zhu, M.; Morrison, R. A rapid and sensitive LC/MS/MS assay for quantitative determination of digoxin in rat plasma. J. Pharm. Biomed. Anal. 2003, 32, 1189-1197.
129. Basileo, G.; Breda, M.; Fonte, G.; Pisano, R.; James, C.A. Quantitative determination of paclitaxel in human plasma using semi-automated liquid-liquid extraction in conjunction with liquid chromatography/tandem mass spectrometry. J. Pharm. Biomed. Anal. 2003, 32, 591-600.
130. Chi, J.; Jayewardene, A.L.; Stone, J.A.; Aweeka, F.T. An LC-MS-MS method for the determination of nevirapine, a non-nucleoside reverse transcriptase inhibitor, in human plasma. J. Pharm. Biomed. Anal. 2003, 31, 953-959.
131. Calderoli, S.; Colombo, E.; Frigerio, E.; James, C.A.; Sibum, M. LC-MS-MS determination of brostallicin in human plasma following automated on-line SPE. J. Pharm. Biomed. Anal. 2003, 32, 601-607.
132. Naidong, W.; Addison, T.; Schneider, T.; Jiang, X.; Halls, T.D.J. A sensitive LC/MS/MS method using silica column and aqueous-organic mobile phase for the analysis of loratadine and descarboethoxy-loratadine in human plasma. J. Pharm. Biomed. Anal. 2003, 32, 609-617.
133. Shi, G.; Lloyd, T.L.; Sy, S.K. B.; Jiao, Q.; Wernicki, A.; Mutlib, A.; Emm, T.A.; Unger, S.E.; Pieniaszek, H.J. Jr. Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations. J. Pharm. Biomed. Anal. 2003, 31, 937-951.
134. Mauri, P.; Minoggio, M.; Iemoli, L.; Rossoni, G.; Morazzoni, P.; Bombardelli, E.; Pietta, P. Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of terpene lactones in plasma of animals. J. Pharm. Biomed. Anal. 2003, 32, 633-639.
135. Chavez-Eng, C.M.; Constanzer, M.L.; Matuszewski, B.K. Determination of rofecoxib (MK-0966), a cyclooxygenase-2 inhibitor, in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection. J. Chromatogr. B 2000, 748, 31-39.
136. Dams, R.; Murphy, C.M.; Choo, R.E.; Lambert, W.E.; De Leenheer, A.P.; Huestis, M.A. LC-Atmospheric pressure chemical ionization-MS/MS analysis of multiple illicit drugs, methadone, and their metabolites in oral fluid following protein precipitation. Anal. Chem. 2003, 75, 798-804.
137. Pietta, P.G.; Simonetti, P.; Gardana, C.; Cristoni, S.; Bramati, L.; Mauri, P.L. LC-APCI-MS/MS analysis of urinary 8-hydroxy-2′-deoxyguanosine. J. Pharm. Biomed. Anal. 2003, 32, 657-661.
138. Hsieh, Y.; Wang, G.; Wang, Y.; Chackalamannil, S.; Korfmacher, W.A. Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry. Anal. Chem. 2003, 75, 1812-1818.
139. Hsieh, Y.; Merkle, K.; Wang, G.; Brisson, J.-M.; Korfmacher, W.A. High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometric analysis of small molecules in plasma. Anal. Chem. 2003, 75, 3122-3127.
140. Liu, S.; Griffiths, W.J.; Sjovall, J. Capillary liquid chromatography/electrospray mass spectrometry for analysis of steroid sulfates in biological samples. Anal. Chem. 2003, 75, 791-797.
141. Archakov, A.I.; Govorun, V.M.; Dubanov, A.V.; Ivanov, Y.D.; Veselovsky, A.V.; Lewi, P.; Janssen, P. Protein-protein interactions as a target for drugs in proteomics. Proteomics 2003, 3, 380-391.
142. Righetti, P.G.; Castagna, A.; Antonucci, F.; Piubelli, C.; Cecconi, D.; Campostrini, N.; Zanusso, G.; Monaco, S. The proteome: anno domini 2002. Clin. Chem. Lab. Med. 2003, 41 (4), 425-438.
143. Wang, H.; Hanash, S. Multi-dimensional liquid phase based separations in proteomics. J. Chromatogr. B 2003, 787, 11-18.
144. Andrews, C.L.; Vouros, P.; Harsch, A. Analysis of DNA adducts using high-performance separation techniques coupled to electrospray ionization mass spectrometry. J. Chromatogr. A 1999, 856, 515-526.
145. Washburn, M.P.; Wolters, D.; Yates, J.R. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 2001, 19, 242-247.
146. Link, A.J.; Eng. J.; Schieltz, D.M.; Carmack, E.; Mize, G.J.; Morris, D.R.; Garvik, B.M.; Yates, J.R. Direct analysis of protein complexes using mass spectrometry. Nat. Biotechnol. 1999, 17, 676-682.
147. Laurell, T.; Marko-Varga, G. Miniaturisation is mandatory unravelling the human proteome. Proteomics. 2002, 2, 345-351.
148. Ferguson, P.L.; Smith, R.D. Proteome analysis by mass spectrometry. Annu. Rev. Biophys. Biomol. Struct. 2003, 32, 399-424.
149. Leinweber, F.C.; Schmid, D.G.; Lubda, D.; Wiesmuller, K.-H.; Jung, G.; Tallarek, Y. Rapid Commun. Mass Spectrom. 2003, 17, 1180-1188.
150. Yan, F.; Subramanian, B.; Nakeff, A.; Barder, T.J.; Parus, S.J.; Lubman, D.M. A comparison of drug-treated and untreated HCT-116 human colon adenocarcinoma cells using a 2-D liquid separation mapping method based upon chromatofocusing PI fractionation. Anal. Chem. 2003, 75, 2299-2308.
151. Dihazi, G.H.; Sinz, A. Mapping low-resolution three-dimensional protein structures using chemical cross-linking and Fourier transform ion-cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17, 2005-2014.
152. Craft, D.; Doucette, A.; Li, L. Microcolumn capture and digestion of proteins combined with mass spectrometry for protein identification. J. Proteome Res. 2002, 1, 537-547.
153. Wu, S.-L.; Amato, H.; Biringer, R.; Choudhary, G.; Shieh, P.; Hancock, W.S. Targeted proteomics of low-level proteins in human plasma by LC/MSn: using human growth hormone as a model system. J. Proteome Res. 2002, 1, 459-465.
154. Wu, S.-L.; Choudhary, G.; Ramstrom, M.; Bergquist, J.; Hancock, W.S. Evaluation of shotgun sequencing for proteomic analysis of human plasma using HPLC coupled with either ion trap or fourier transform mass spectrometry. J. Proteome Res. 2003, 2, 383-393.
155. Zhao, Y.; Zhang, W.; White, M.A.; Zhao, Y. Capillary high-performance liquid chromatography/mass spectrometric analysis of proteins from affinity-purified plasma membrane. Anal. Chem. 2003, 75 (15), 3751-3757.
156. Yan, F.; Sreekumar, A.; Laxman, B.; Chinnaiyan, A.M.; Lubman, D.M.; Barder, T.J. Protein microarrays using liquid phase fractionation of cell lysates. Proteomics 2003, 3, 1228-1235.
157. Le Bihan, T.; Duewal, H.S.; Figeys, D. On-line strong cation exchange μ-MPLC-ESI-MS/MS for protein identification and process optimization. J. Am. Soc. Mass. Spectrom. 2003, 14, 719-727.
158. Ihling, C.; Berger, K.; Hofliger, M.M.; Fuhrer, D.; Beck-Sickinger, A.G. ; Sinz, A. Nano-high-performance liquid chromatography in combination with nano-electrospray ionization fourier transform ion-cyclotron resonance mass spectrometry for proteome analysis. Rapid Commun. Mass Spectrom. 2003, 17, 1240-1246.
159. Kachman, M.T.; Wang, H.; Schwartz, D.R.; Cho, K.R.; Lubman, D.M. A 2-D liquid separations/mass mapping method for interlysate comparison of ovarian cancers. Anal. Chem. 2002, 74, 1779-1791.
160. Wu, S.-L.; Hancock, W.S.; Goodrich, G.G.; Kunitake, S.T. An approach to the proteomic analysis of a breast cancer cell line (SKBR-3). Proteomics 2003, 3, 1037-1046.
161. O'Neil, K.A.; Miller, F.R.; Barder, T.J.; Lubman, D.M. Profiling the progression of cancer: separation of microsomal proteins in MCF10 breast epithelial cell lines using nonporous chromatophoresis. Proteomics 2003, 3, 1256-1269.
162. Ohkawa, T.; Norikura, R.; Yoshikawa, T. Rapid LC-TOFMS method for identification of binding sites of covalent acylglucuronide-albumin complexes. J. Pharm. Biomed. Anal. 2003, 31, 1167-1176.
163. Srebalus Barnes, C.A.; Hilderbrand, A.E.; Valentine, S.J.; Clemmer, D.E. Resolving isomeric peptide mixtures: a combined HPLC/ion mobility-TOFMS analysis of a 4000-component combinatorial library. Anal. Chem. 2002, 74, 26-36.
164. Tengvall, U.; Auriola, S.; Antopolsky, M.; Azhayev, A.; Biegelman, L. Characterization of antisense oligonucleotide-peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 2003, 32, 581-590.
165. Kolodsick, K.J.; Rossi, D.T.; Kingsmill, C.A. Breaking down barriers: can LC-MS revolutionize the quantitation of drug product impurities. LC/GC N. Am. 2003, 21 (5), 468-479.
166. Sheldon, E.M. Development of a LC-LC-MS complete heart-cut approach for the characterization of pharmaceutical compounds using standard instrumentation. J. Pharm. Biomed. Anal. 2003, 31, 1153-1166.
167. Li, M.; Ahuja, E.S.; Watkins, D.M. LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride. J. Pharm. Biomed. Anal. 2003, 31, 29-38.
168. Ravindra Kumar, Y.R.; Moses Babu, J.M.; Sarma, M.S.P.; Seshidhar, B.; Srinivasa Reddy, S.; Sudarsan Reddy, G.; Vyas, K. Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug. J. Pharm. Biomed. Anal. 2003, 32, 361-368.
169. Vanderghinste, D.; Van Eeckhoudt, M.; Terwinghe, C.; Mortelmans, L.; Bormans, G.M.; Verbruggen, A.M.; Vanbilloen, H.P. An efficient HPLC method for the analysis of isomeric purity of technetium-99 m-exametazime and identity confirmation using LC-MS. J. Pharm. Biomed. Anal. 2003, 32, 679-685.
170. Dunphy, R.; Burinsky, D.J. Detection of choline and acetylcholine in a pharmaceutical preparation using high-performance liquid chromatography/electrospray ionization mass spectrometry. J. Pharm. Biomed. Anal. 2003, 31, 905-915.
171. Miao, X.-S.; Metcalfe, C.D. Determination of cholesterol-lowering drugs in aqueous samples using liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 2003, 998, 133-141.
172. Ohta, M.; Kawakami, N.; Yamato, S.; Shimada, K. Analysis of acetaminophen glucuronide conjugate accompanied by adduct ion production by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. J. Pharm. Biomed. Anal. 2003, 30, 1759-1764.
173. Abdel-Hamid, M.; Phillips, O.A. LC-MS/MS determination of Synercid® injections. J. Pharm. Biomed. Anal. 2003, 32, 1167-1174.
174. Miao, X.-S.; Metcalfe, C.D. Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography-electrospray tandem mass spectrometry. Anal. Chem. 2003, 75, 3731-3738.
175. Vanbilloen, H.P.; Cleynhens, B.J.; de Groot, T.J.; Maes, A.; Bormans, G.M.; Verbruggen, A.M. RP-HPLC separation of the diastereomers of technetium-99m labelled tropanes and identity confirmation using radio-LC-MS. J. Pharm. Biomed. Anal. 2003, 32, 663-668.
176. 99mTc-ECD using radio-LC-MS. J. Pharm. Biomed. Anal. 2003, 32, 669-678.
177. Nassar, A.E.F.; Bjorge, S.M.; Lee, D.Y. On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal. Chem. 2003, 75, 785-790.
178. Wu, Y. The use of liquid chromatography-mass spectrometry for the identification of drug degradation products in pharmaceutical formulations. Biomed. Chromatogr. 2000, 14, 384-396.
179. Sims, J.L.; Roberts, J.K.; Bateman, A.G.; Carreira, J.A.; Hardy, M.J. An automated workstation for forced degradation of active pharmaceutical ingredients. J. Pharm. Sci. 2002, 91 (3), 884-892.
180. Simmonds, E.L.; Lough, W.J.; Gray, M.R. Evaluation of the use of LC-MS in supporting stability studies for preclinical study formulations. J. Pharm. Biomed. Anal. 2003, 32, 1113-1122.
181. Li, C.-J.; Prasad Kari, U.; Noecker, L.A.; Jones, S.R.; Sabo, A.M.; McCormick, T.J.; Johnston, S.M. Determination of degradation products of squalamine lactate using LC/MS. J. Pharm. Biomed. Anal. 2003, 32, 85-96.
182. Torrealday, N.; Gonzalez, L.; Alonso, R.M.; Jimenez, R.M.; Ortiz Lastra, E. Experimental design approach for the optimisation of a HPLC-fluorimetric method for the quantitation of the angiotensin II receptor antagonist telmisartan in urine. J. Pharm. Biomed. Anal. 2003, 32, 847-857.
183. Rabouan, S.; Olivier, J.C.; Guillenmin, H.; Barthes, D. Validation of HPLC analysis of aspartate and glutamate neurotransmitters following o-phthaldialdehyde-mercaptoethanol derivatization. J. Liq. Chromatogr. Related Technol. 2003, 26 (11), 1797-1808.
184. Rbeida, O.; Christiaens, B.; Chiap, P.; Hubert, P.; Lubda, D.; Boos, K.-S.; Crommen, J. Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up. J. Pharm. Biomed. Anal. 2003, 32, 829-838.
185. Inoue, H.; Fukunaga, K.; Tsuruta, Y. Determination of taurine in plasma by high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent. Anal. Biochem. 2003, 319, 138-142.
186. Nobilis, M.; Kopecky, J.; Kvetina, J.; Svoboda, Z.; Pour, M.; Kunes, J.; Holcapek, M.; Kolarova, L. Comparative biotransformation and disposition studies of nabumetone in humans and minipigs using high-performance liquid chromatography with ultraviolet, fluorescence and mass spectrometric detection. J. Pharm. Biomed. Anal. 2003, 32, 641-656.
187. Kobylinska, K.; Barlinska, M.; Kobylinska, M. Analysis of nabumetone in human plasma by HPLC. Application to single dose pharmacokinetic studies. J. Pharm. Biomed. Anal. 2003, 32, 323-328.
188. Mawatari, K.; Mashiko, S.; Watanabe, M.; Nakagomi, K. Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation. Anal. Sci. 2003, 19, 1071-1073.
189. Yuen, C.-T.; Gee, C.K.; Jones, C. High-performance liquid chromatographic profiling of fluorescent labelled N-glycans on glycoproteins. Biomed. Chromatogr. 2002, 16, 247-254.
190. Kai, M.; Kinoshita, H.; Ohta, K.; Hara, S.; Koo Lee, M.; Lu, J. Sensitive determination of a β-lactam antibiotic, cefaclor by liquid chromatography with chemiluminescence detection. J. Pharm. Biomed. Anal. 2003, 30, 1765-1771.
191. Allgeier, M.C.; Nussbaum, M.A.; Risley, D.S. Comparison of an evaporative light-scattering detector and a chemiluminescent nitrogen detector for analyzing compounds lacking a sufficient UV chromophore. LC-GC N. Am. 2003, 21 (4), 376-381.
192. Park, Y.-J.; Lee, D.W.; Lee, W.-Y. Determination of β-blockers in pharmaceutical preparations and human urine by high-performance liquid chromatography with tris(2,2′-bipyridyl)ruthenium(II) electrogenerated chemiluminescence detection. Anal. Chim. Acta 2002, 471, 51-59.
193. Mondorf, U.; Schmidt, R.; Siegers, J.; Gross, W.; Geiger, H.; Scheuermann, E. Lipid hydroperoxides: elevated levels in patients on haemodialysis and patients with chronic renal failure. Nephrology 2000, 5, 65-70.
194. Chiba, R.; Yamamoto, N.; Tanaka, A. High-performance liquid chromatography with chemiluminescence detection of disopyramide in human serum. Anal. Sci. 1998, 14, 1153-1155.
195. Ridlen, J.S.; Skotty, D.R.; Kissinger, P.T.; Nieman, T.A. Determination of erythromycin in urine and plasma using microbore liquid chromatography with tris(2,2‰-bipyridyl)mthenium(II) electrogenerated chemiluminescence detection. J. Chromatogr. B 1997, 694, 393-400.
196. Skotty, D.R.; Lee, W.-Y.; Nieman, T.A. Determination of dansyl amino acids and oxalate by HPLC with electrogenerated chemiluminescence detection using tris(2,2′-bipyridyl)ruthenium(II) in the mobile phase. Anal. Chem. 1996, 68, 1530-1535.
197. Gerardi, R.D.; Barnett, N.W.; Lewis, S.W. Analytical applications of tris(2,2′-bipyridyl)ruthenium(III) as a chemiluminescent reagent. Anal. Chim. Acta 1999, 378, 1-41.
198. Uchikura, K. tris(2,2′-Bipyridine)ruthenium(II) chemiluminescence detection of carbonyl compounds with methylmalonic acid. Anal. Sci. 2000, 16, 453-454.
199. Trojanowicz, M.; Szewczynska, M.; Wcislo, M. Electronanalytical flow measurements - recent advances. Electroanalysis 2003, 15 (5-6), 347-365.
200. Manna, L.; Valvo, L.; Betto, P. Determination of oxidized and reduced glutathione in pharmaceuticals by reversed-phase high-performance liquid chromatography with dual electrochemical detection. J. Chromatogr. A 1999, 846, 59-64.
201. Legorburu, M.J.; Alonso, R.M.; Jimenez, R.M.; Ortiz, E. Quantitative determination of the loop diuretic bumetanide in urine and pharmaceuticals by high-performance liquid chromatography with amperometric detection. J. Chromatogr. Sci. 2001, 39, 425-430.
202. Alvarez-Lueje, A.; Pujol, S.; Squella, J.A.; Nunez-Vergara, L.J. A selective HPLC method for determination of lercanidipine in tablets. J. Pharm. Biomed. Anal. 2003, 31, 1-9.
203. Wyszecka-Kaszuba, E.; Warowna-Grzeskiewicz, M.; Fijalek, Z. Determination of 4-aminophenol impurities in multi-component analgesic preparations by HPLC with amperometric detection. J. Pharm. Biomed. Anal. 2003, 32, 1081-1086.
204. Bazylak, G.; Nagels, L.J. Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection. J. Pharm. Biomed. Anal. 2003, 32, 887-903.
205. Mo, Y.; Dobberpuhl, D.; Dash, A.K. A simple HPLC method with pulsed EC detection for the analysis of creatine. J. Pharm. Biomed. Anal. 2003, 32, 125-132.
206. Taepavarapruk, P.; Phillips, A.G. Neurochemical correlates of relapse to D-amphetamine self-administration by rats induced by stimulation of the ventral subiculum. Psychopharmacology 2003, 168, 99-108.
207. Verschraagen, M.; Ursula Zwiers, T.H.; Torun, E.; Donker, M.G.; Reinhoud, N.J.; Van der Vijgh, W.J.F. Simultaneous determination of BNP7787 and its metabolite mesna in plasma and tissue by micro-HPLC with a dual electrochemical detector. J. Pharm. Sci. 2003, 92 (5), 1040-1050.
208. Giese, R.W. Measurement of endogenous estrogens: analytical challenges and recent advances. J. Chromatogr. A 2003, 1000, 401-412.
209. Meehan, E.; Saunders, G.; Bullock, S. The benefits of improved detector design for HPLC analysis of pharmaceutical compounds using evaporative light scattering detection. LC/GC N. Am. 2003 (Suppl. S), 48-49.
210. Marsilio, R.; Naturale, M.; Manghi, P.; Montini, G.; Murer, L.; Ros, M.; Bisogno, G.; Andretta, B.; Dussini, N.; Giordano, G.; Zacchello, G.; Dall'Amico, R. Rapid and simple determination of inulin in biological fluids by high-performance liquid chromatography with light-scattering detection. J. Chromatogr. B 2000, 744, 241-247.
211. Ioffe, V.; Kalendarev, T.; Rubinstein, I.; Zupkovitz, G. Reverse phase HPLC for polar lipids. Simple and selective HPLC procedures for analysis of phospholipids-based derivatives of valproic acid and various nonsteroidal anti-inflammatory drugs. J. Pharm. Biomed. Anal. 2002, 30, 391-403.
212. Whelan, M.R.; Ford, J.L.; Powell, M.W. Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HMPC) using HPLC and evaporative light scattering detection. J. Pharm. Biomed. Anal. 2002, 30, 1355-1359.
213. Moore, D.E.; Liu, T.X.; Miao, W.G.; Edwards, A.; Elliss, R. A RP-LC method with evaporative light scattering detection for the assay of simethicone in pharmaceutical formulations. J. Pharm. Biomed. Anal. 2002, 30, 273-278.
214. Nair, L.M.; Stephens, N.V.; Vincent, S.; Raghavan, N.; Sand, P.J. Determination of polysorbate 80 in parenteral formulations by high-performance liquid chromatography and evaporative light scattering detection. J. Chromatogr. A 2003, 1012, 81-86.
215. Liu, Y.; Hu, C.-Q. RP-HPLC determination of midecamycin and related impurities. Chromatographia 2003, 57 (3-4), 143-146.
216. de Beer, T.; Velthorst, N.H.; Brinkman, U.A. Th.; Gooijer, C. Laser-based non-fluorescence detection techniques for liquid separation systems. J. Chromatogr. A 2002, 971, 1-35.
217. Erlandsson, B.; Wittgren, B.; Brinkmalm, G. Development of a size exclusion chromatography method for the determination of molar mass for poloxamers. J. Pharm. Biomed. Anal. 2003, 31, 845-858.
218. Mendichi, R.; Rizzo, V.; Gigli, M.; Razzano, G.; Angelucci, F.; Giacometti Schieroni, A. Molar mass distribution of a polymer-drug conjugate containing the antitumor drug paclitaxel by size exclusion chromatography and universal calibration. J. Liq. Chrom. Rel. Technol. 1998, 21 (9), 1295-1309.
219. Kinalekar, M.S.; Kulkarni, S.R.; Vavia, P.R. Simultaneous determination of α, β and γ cyclodextrins by LC. J. Pharm. Biomed. Anal. 2000, 22, 661-666.
220. Shaw, C.J.; Huang, A.; Zhang, X. Quantitation and test of enantiomeric purity of the L-ketohexoses by liquid chromatography with dual refractive index and laser-based chiroptical detection. J. Chromatogr. A 2003, 987, 439-443.
221. Guo, Y.; Huang, A. A HILIC method for the analysis of tromethamine as the counter ion in an investigational pharmaceutical salt. J. Pharm. Biomed. Anal. 2003, 31, 1191-1201.
222. Kenmore, C.K.; Erskine, S.R.; Bornhop, D.J. Refractive-index detection by interferometric backscatter in packed-capillary high-performance liquid chromatography. J. Chromatogr. A 1997, 762, 219-225.
223. Cepria, G.; Castillo, J.R. Surface plasmon resonance-based detection. An alternative to refractive index detection in high-performance liquid chromatography. J. Chromatogr. A 1997, 759, 27-35.
224. -7 barrier for RI measurements in nanoliter volumes. Anal. Chem. 2002, 74, 5438-5441.
225. Spraul, M.; Freund, A.S.; Nast, R.E.; Withers, R.S.; Maas, W.E.; Corcoran, O. Advancing NMR sensitivity for LC-NMR-MS using cryoflow probe: application to the analysis of acetaminophen metabolites in urine. Anal. Chem. 2003, 75, 1546-1551.
226. Lindon, J.C.; Nicholson, J.K.; Wilson, I.D. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. J. Chromatogr. B 2000, 748, 233-258.
227. Kim, H.; Feng, W.; Chan, T.-M.; Rindgen, D.; Bryant, M.; Cox, K.A.; Xia, Y.; Reichard, G.; Paliwal, S.; Hesk, D.; Palamanda, J.; White, R.E.; Nomeir, A.A. Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy. J. Sep. Sci. 2002, 25, 877-882.
228. Petritis, K.; Gillaizeau, I.; Elfakir, C.; Dreux, M.; Petit, A.; Bongibault, N.; Luijten, W. Evaporative light scattering detection for in-line monitoring of stopped-flow liquid chromatography-nuclear magnetic resonance analysis of compounds with weak or no chromophore groups. J. Sep. Sci. 2002, 25, 593-600.
229. Tugnait, M.; Lenz, E.M.; Hofmann, M.; Spraul, M.; Wilson, I.D.; Lindon, J.C.; Nicholson, J.K. The metabolism of 2-trifluoromethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy. J. Pharm. Biomed. Anal. 2003, 30, 1561-1574.
230. 13C]-4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR. J. Pharm. Biomed. Anal. 2002, 28, 875-885.
231. Glaser, T.; Albert, K. Unequivocal structural assignment of steroids in galenic emulsions employing HPLC-NMR coupling. J. Sep. Sci. 2002, 25, 393-398.
232. 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-mass spectrometry. J. Chromatogr. B 2000, 748, 311-319.
233. Dear, G.J.; Plumb, R.S.; Sweatman, B.C.; Parry, P.S.; Roberts, A.D.; Lindon, J.C.; Nicholson, J.K.; Ismail, I.M. Use of directly coupled ion-exchange liquid chromatography-mass spectrometry and liquid chromatography-nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification. J. Chromatogr. B 2000, 748, 295-309.
234. Dear, G.J.; Plumb, R.S.; Sweatman, B.C.; Ayrton, J.; Lindon, J.C.; Nicholson, J.K.; Ismail, I.M. Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy. J. Chromatogr. B 2000, 748, 281-293.
235. Shockor, J.P.; Unger, S.E.; Savina, P.; Nicholson, J.K.; Lindon, J.C. Application of directly coupled LC-NMR-MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83. J. Chromatogr. B 2000, 748, 269-279.
236. Montes-Bayon, M.; DeNicola, K.; Caruso, J.A. Liquid chromatography-inductively coupled plasma mass spectrometry. J. Chromatogr. A 2003, 1000, 457-476.
237. Peters, H.L.; Jones, B.T. Determination of non-metals by high performance liquid chromatography with inductively coupled plasma detection. Appl. Spectrosc. Rev. 2003, 38 (1), 71-99.
238. Hill, S.J.; Pitts, L.J.; Fisher, A.S. High-performance liquid chromatography-isotope dilution inductively coupled plasma mass spectrometry for speciation studies: an overview. Trends Anal. Chem. 2000, 19 (2-3), 120-126.
239. Nagaoka, M.H.; Maitani, T. Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution ICP-MS. Analyst 2000, 125 (11), 1962-1965.
240. Sariego Muniz, C.; Marchante Gayon, J.M.; Ignacio Garcia Alonso, J.; SanzMedel, A. Speciation of essential elements in human serum using anionexchange chromatography coupled to postcolumn isotope dilution analysis with double focusing ICPMS. J. Anal. At. Spectrom. 2001, 16 (6), 587-592.
241. Smith, C.J.; Wilson, I.D.; Abou-Shakra, F.; Payne, R.; Parry, T.C.; Sinclair, P.; Roberts, D.W. A comparison of the quantitative methods for the analysis of the platinum-containing anticancer drug {cis-[amminedichloro(2-methylpyridine)]-platinum(II)} (ZD0473) by HPLC coupled to either a triple quadrupole mass spectrometer of an inductively coupled plasma mass spectrometer. Anal. Chem. 2003, 75, 1463-1469.
242. Somsen, G.W.; Gooijer, C.; Brinkman, U.A. Th. Liquid chromatography-Fourier transform infrared spectrometry. J. Chromatogr. A 1999, 856, 213-242.
243. Geldart, S. LC-IR of pharmaceuticals. Am. Lab. 2000, 32 (Jan), 32-37.
244. Li, Y.; Brown, P.R. On-line detection for the HPLC analysis of water-soluble vitamins in multivitamin tablets. J. Liq. Chrom. Related Technol. 2003, 26 (11), 1769-1786.