Semi-micro column HPLC of triazolam in rat plasma and brain microdialysate and its application to drug interaction study with itraconazole

Journal of Pharmaceutical and Biomedical Analysis

Volumn 30, Issue 6, 2003, Pages 1809-1816

  Nakashima, Kenichiro ^a   Yamamoto, Kazumi ^a   Al Dirbashi, Osama Y ^b   Kaddoumi, Amal ^a   Nakashima, Mihoko N ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b Aventis Pharma Ltd   (Japan)

Author keywords

Drug drug interaction; Itraconazole; Rat brain microdialysis; Rat plasma; Semi micro column HPLC; Triazolam

Indexed keywords

ITRACONAZOLE; TRIAZOLAM;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE CALCULATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONITORING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO; SPIKE; ULTRAVIOLET RADIATION; ANIMAL; BLOOD; DRUG INTERACTION; MALE; METABOLISM; METHODOLOGY; MICRODIALYSIS; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; ITRACONAZOLE; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; TRIAZOLAM;

EID: 0037437682     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00523-X     Document Type: Article

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