Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites

Analytica Chimica Acta

Volumn 492, Issue 1-2, 2003, Pages 1-16

  Smyth, W F ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Drugs; Electrospray ionisation mass spectrometry; Fragmentation patterns; Metabolites

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

ELECTROSPRAY IONIZATION MASS SPECTROMETRY;

DRUG PRODUCTS;

7 ETHYL 10 HYDROXYCAMPTOTHECIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHETAMINE DERIVATIVE; ANTHRACYCLINE ANTIBIOTIC AGENT; BENZODIAZEPIN 2 ONE DERIVATIVE; CATECHOL DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CHINESE DRUG; CHLORPROMAZINE; COCAINE; CODEINE; DOMPERIDONE; DRUG METABOLITE; GROWTH PROMOTOR; IMMUNOSUPPRESSIVE AGENT; IRINOTECAN; LIDOCAINE; LYSERGIDE; MACROLIDE; METHAMPHETAMINE; MORPHINE 6 ACETATE; MORPHINE DERIVATIVE; PENICILLIN DERIVATIVE; PHENOTHIAZINE DERIVATIVE; POLYETHER DERIVATIVE; STEROID; SULFONYLUREA DERIVATIVE; TERAZOSIN; UNINDEXED DRUG; VERAPAMIL;

ACTIVATED SLUDGE; ANALYTIC METHOD; ANTIBODY AFFINITY; AUTOPSY; BIODEGRADABILITY; BODY BURDEN; BODY FLUID; CAPILLARY CHROMATOGRAPHY; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; COVALENT BOND; CYTOPATHOGENIC EFFECT; DRUG ADSORPTION; DRUG BRAIN LEVEL; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG HAIR LEVEL; DRUG INTOXICATION; DRUG MONITORING; DRUG STRUCTURE; DRUG URINE LEVEL; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METASTASIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCING BATCH REACTOR; SEWAGE TREATMENT PLANT; TANDEM MASS SPECTROMETRY;

EID: 0042280338     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(02)01474-5     Document Type: Review

References (45)

1. Yamashita M., Fenn J.B. J. Phys. Chem. 88:1984;4671.
2. M.P. Balogh, LC GC, November 1997, p. 728.
3. Kebarle P., Tang L. Anal. Chem. 65:1993;972A.
4. Bruins A.P. J. Chromatogr. A. 794:1998;345.
5. Gaskell S.J. J. Mass Spectrom. 32:1997;677.
6. R.B. Cole (Ed.), Electrospray Ionisation Mass Spectrometry, Wiley, New York, 1997.
7. C. Joyce, V.N. Ramachandran, W.F. Smyth, Rapid Commun. Mass Spectrom. (2002), submitted for publication.
8. H.J. Schulz, Analysis of Pharmacologically Relevant Compounds Using GC/MSD-EI/PCI/NCI by Angilent Technologies, 2002.
9. Sauvage M.F., Marquet P., Rousseau A., Buxeraud J., Raby C., Lachatre G. J. Liq. Chrom. Rel. Technol. 21(20):1998;3173.
10. Van Breemen R.B., Nikolic D., Bolton J.L. Drug Metab. Disposition. 26(2):1998;85.
11. Ragot S., Marquet P., Lachatre F., Rousseau A., Lacassie E., Gaulier J.M., Dupuy J.L., Lachatre G. J. Chromatogr. B. 736:1999;175.
12. Concannon S., Ramachandran V.N., Smyth W.F. Rapid Commun. Mass Spectrom. 14:2000;1157.
13. von Richter O., Eichelbaum M., Schonberger F., Hofmann U. J. Chromatogr. B. 738:2000;137.
14. Ohshima T., Takayasu T. J. Chromatogr. B. 726:1999;185.
15. Abdel-Rehim M., Bielenstein M., Askemark Y., Tyrefors N., Arvidsson T. J. Chromatogr. B. 741:2000;175.
16. Dirikolu L., Lehner A.F., Karpiesiuk W., Harkins J.D., Woods W.E., Carter W.G., Boyles J., Fisher M., Tobin T. J. Vet. Pharmacol. Ther. 23:2000;215.
17. Wu J., Lord H., Pawliszyn J. Talanta. 54:2001;655.
18. Dienes-Nagy A., Rivier L., Giroud C., Augsburger M., Mangin P. J. Chromatogr. A. 854:1999;109.
19. Fuh M.-R., Tai Y.-L., Pan W.H.T. J. Chromatogr. B. 752:2001;107.
20. Fandino A.S., Karas M., Toennes S.W., Kauert G. J. Mass Spectrom. 37:2002;525.
21. Cai Y.J., Henion J. Anal. Chem. 68(1):1996;72.
22. Smyth W.F., McClean S., Ramachandran V.N. Rapid Commun. Mass Spectrom. 14:2000;2061.
23. Benz W., Vane F.M., Rapp V. Org. Mass Spectrom. 14:1979;154.
24. Chen Y.-C., Hu A. Forensic Sci. Int. 103:1999;79.
25. Horie M., Yoshida T., Kikuchi Y., Nakazawa H. J. Food Hyg. Soc. Jpn. 42(6):2001;374.
26. Chaudhary A.K., Nokubo M., Oglesby T.D., Marnett L.J., Blair I.A. J. Mass Spectrom. 30:1995;1157.
27. Davis A.L., Harris J.A., Russell C.A.L., Wilkins J.P.G. Analyst. 124:1999;251.
28. Turnipseed S.B., Roybal J.E., Pfenning A.P., Gonzales S.A., Hurtbut J.A., Madson M.R. J. AOAC Int. 84(3):2001;640.
29. Lopes N.P., Gates P.J., Wilkins J.P.G., Staunton J. Analyst. 127:2002;1224.
30. De Wasch K., De Brabander H.F., Impens S., Vandewiele M., Courtheyn D. J. Chromatogr. A. 912:2001;311.
31. Magni F., Marazzini L., Pereira S., Monti L., Kienle M.G. Anal. Biochem. 282:2000;136.
32. Lachatre F., Marquet P., Ragot S., Gaulier J.M., Cardot P., Dupuy J.L. J. Chromatogr. B. 738:2000;281.
33. Blanchflower W.J., Hewitt S.A., Kennedy D.G. Analyst. 119:1994;2595.
34. Straub R.F., Linder M., Voyksner R.D. Anal. Chem. 66:1994;3651.
35. Keever J., Voyksner R.D., Tyczkowska K.L. J. Chromatogr. A. 794:1998;57.
36. Keski-Hynnila H., Andersin R., Luukkanen L., Taskinen J., Kostiainen R. J. Chromatogr. A. 794:1998;75.
37. Shackleton C.H.L., Chuang H., Kim J., Delatorre X., Segura J. Steriods. 62:1997;523.
38. Codony R., Compano R., Granados M., Garcia-Regueiro J.A., Prat M.D. J. Chromatogr. A. 959(1-2):2002;131.
39. Kirchner G.I., Winkler M., Mueller L., Vidal C., Jacobsen W., Franzke A., Wagner S., Blick S., Manns M.P., Sewing K.-F. Br. J. Clin. Pharmacol. 50:2000;449.
40. Platzer M., Jahn K., Wohlrab J., Neubert R.H.H. J. Chromatogr. B. 755:2001;355.
41. Horie M., Nakazawa H. J. Chromatogr. A. 882:2000;53.
42. Zavitsanos A.P., Alebic-Kolbah T. J. Chromatogr. A. 794:1998;45.
43. Zavitsanos A.P., MacDonald C., Bassoo E., Gopaul D. J. Chromatogr. B. 730(1):1999;9.
44. Song Y., Cheng H.-L., Her G.-R., Wen K.C. J. Chinese Chem. Soc. 47:2000;475.
45. Mohle E., Kempter C., Kern A., Matzger J.W. Acta Hydrochim. Hydrobiol. 27:1999;430.