Determination of hypnotic benzodiazepines (alprazolam, estazolam, and midazolam) and their metabolites in rat hair and plasma by reversed-phase liquid-chromatography with electrospray ionization mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 30, Issue 6, 2003, Pages 1773-1787

  Toyo'oka, Toshimasa ^a   Kumaki, Yusuke ^a   Kanbori, Masayoshi ^a   Kato, Masaru ^a   Nakahara, Yuji ^b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Benzodiazepines; Electrospray ionization mass spectrometry; Hair analysis; HPLC; Metabolic study

Indexed keywords

1 HYDROXYALPRAZOLAM; 1 HYDROXYMIDAZOLAM; 4 HYDROXYALPRAZOLAM; 4 HYDROXYMIDAZOLAM; 8 CHLORO 6 PHENYL 4H [1,2,4]TRIAZOLO[4,3 A][1,4]BENZODIAZEPIN 4 ONE; ACETIC ACID; ACETIC ANHYDRIDE; ACETONITRILE; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; DRUG METABOLITE; ESTAZOLAM; MIDAZOLAM; PYRIDINE; UNCLASSIFIED DRUG; WATER;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG HAIR LEVEL; HAIR; HAIR ROOT; ION MONITORING; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; RAT STRAIN; REVERSED PHASE LIQUID CHROMATOGRAPHY; SAMPLING; STRUCTURE ANALYSIS; TIME; ANIMAL; BLOOD; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY;

ALPRAZOLAM; ANIMALS; BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTAZOLAM; HAIR; MALE; MIDAZOLAM; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0037437691     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00520-4     Document Type: Article

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