Cutting edge: CXCR4-Lo: Molecular cloning and functional expression of a novel human CXCR4 splice variant

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2368-2372

  Gupta, Shalley K ^a   Pillarisetti, Kodandaram ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; MESSENGER RNA;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ARTICLE; BASOPHIL; CHEMOTAXIS; CONTROLLED STUDY; HEART DEVELOPMENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL; LEUKOPOIESIS; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; LEUKEMIA, BASOPHILIC, ACUTE; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, CXCR4; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033198102     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Tashiro, K., H. Tada, R. Heilker, M. Shirozu, T. Nakano, and T. Honjo. 1993. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science 261:600.
2. Oberlin, E., A. Amara, F. Bachelerie, C. Bessia, J.-L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.-L. Heard, I. Clark-Lewis, D. F. Legler, M. Loetscher, M. Baggiolini, and B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833.
3. Shirozu, M., T. Nakano, J. Inazawa, K. Tashiro, H. Tada, T. Shinohara, and T. Honjo. 1995. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 28:495.
4. Rimland, J., W. Xin, P. Sweetnam, K. Saijoh, E. J. Nestler, and R. S. Duman 1991. Sequence and expression of a neuropeptide Y receptor cDNA. Mol. Pharmacol. 40:869.
5. Federsppiel, B., I. G. Melhado, A. M. V. Duncan, A. Delaney, K. Schappert, I. Clark-Lewis, and F. R. Jirik. 1993. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics 16:707.
6. Bleul, C. C., R. C. Fuhlbrigge, J. M. Casanovas, A. Aiuti, and T. A. Springer. 1996. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184:1101.
7. Gupta, S. K., P. G. Lysko, K. Pillarisetti, E. Ohlstein, and J. M. Stadel. 1998. Chemokine receptors in human endothelial cells: functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J. Biol. Chem. 273:4282.
8. Nagasawa, T., S. Hirota, K. Tachibana, N. Takakura, S. Nishikawa, Y. Kitamura, N. Yoshida, H. Kikutani, and T. Kishimoto. 1996. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382:635.
9. Tachibana, K., S. Hirota, H. Iizasa, H. Yoshida, K. Kawabata, Y. Kataoka, Y. Kitamura, K. Matsushima, N. Yoshida, S. Nishikawa, T. Kishimoto, and T. Nagasawa. 1998. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393:591.
10. Zou, Y.-R., A. H. Kottman, M. Kuroda, I. Taniuchi, and D. R. Littman. 1998. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595.
11. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872.
12. Alkhatib, G., C. Comadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E.A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955.
13. LaRosa, G. J., K. M. Thomas, M. E. Kaufmann, R. Mark, M. White, L. Taylor, G. Gray, D. Witt, and J. Navarro. 1992. Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity. J. Biol. Chem. 267:25402.
14. Hebert, C., A. Chuntharapai, M. Smith, T. Colby, J. Kim, and R. Horuk. 1993. Partial functional mapping of the human interleukin-8 type A receptor: identification of a major ligand binding domain. J. Biol. Chem. 268:18549.
15. Monteclaro, F. S., and I. F. Charo. 1996. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1 alpha receptor, confers chemokine selectivity: evidence for a two-step mechanism for MCP-1 receptor activation. J. Biol. Chem. 271:19084.
16. Pease, J. E., J. Wang, P. D. Ponath, and P. M. Murphy. 1998. The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1α and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation. J. Biol. Chem. 273:19972.
17. Ruckers, J., M. Samson, B. J. Doranz, F. Libert, J. F. Berson, C. C. Broder, G. Vassart, R. W. Doms, and M. Parmentier. 1996. Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 87: 437.
18. Heesen, M., M. A. Berman, U. E. Hopken, N. P, Gerard, and M. E. Dorf. 1997. Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1α is a ligand for both CXC chemokine receptor-4 isoforms. J. Immunol. 158:3561.
19. Moepps, B., R. Frodl, H. Rodewald, M. Baggiolini, and P. Gierschik. 1997. Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1α activation of Gi2 are differentially expressed in vivo. Eur. J. Immunol. 27:2102.
20. Wegner, S.A., P. K. Ehrenberg, G. Chang, D. E. Dayhoff, A. L. Sleeker, and N. L. Michael. 1998. Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 273:4754.
21. Caruz, A., M. Samsom, J. M. Alonso, I. Alcami, F. Baleux, J. L. Virelizier, M. Parmentier, and F. Arenzana-Seisdedos. 1998. Genomic organization and promoter characterization of human CXCR4 gene. FEBS Lett. 426:271.
22. Frodl, R., P. Gierschik, and B. Moepps. 1998. Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-b in human tissues. J. Recept. Signal Transduct. Res. 18:321.
23. i distinct rat cell types using fluorimetric imaging. J. Cardiovasc. Phamacol. 31(Suppl. 1):S192.
24. Lupetti, R., P. Pisarra, A. Verrecchia, C. Farina, G. Nicolini, A. Anichini, C. Bordignon, M. Sensi, G. Parmiani, and C. Travesari. 1998. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J. Exp. Med. 188:1005.
25. Crump, P. M., J.-H. Gong, P. Loetscher, K. Rajarathanam, A. Amara, F. Arenzana-Seisdedos, J.-L. Virelizier, M. Baggiolini, B. D. Sykes, and I. Clark-Lewis. 1997. Solution structure and basis for functional activity of stromal cell-derived factor-1: dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J. 16:6996.
26. Cacalano, G., J. Lee, K. Kikly, A. M. Ryan, S. Pitts-Meek, B. Hultgren, W. I. Wood, and M. W. Moore. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265:682.
27. Rothenberg, M. E., J. A. MacLean, E. Pearlman, A. D. Luster, and L. Philip. 1997. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J. Exp. Med. 185:785.
28. -/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394:894.