Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV- 2 replication by antagonism of the chemokine receptor CXCR4

Journal of Medicinal Chemistry

Volumn 42, Issue 19, 1999, Pages 3971-3981

  Bridger, Gary J ^a   Skerlj, Renato T ^a   Padmanabhan, Sreenivasan ^b   Martellucci, Stephen A ^b   Henson, Geoffrey W ^a   Struyf, Sofie ^c   Witvrouw, Myriam ^c   Schols, Dominique ^c   De Clercq, Erik ^c  

^a GENZYME CORPORATION   (United States)

^b Johnson Matthey Pharmaceutical Res   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENE BIS(METHYLENE)] BIS 1,4,8,11 TETRA AZACYCLOTETRADECANE; 7,7' [1,4 PHENYLENEBIS(METHYLENE)]BIS[4,7,10,17 TETRAAZABICYCLO[13.3.1]HEPTADECA 1(17),13,15 TRIENE]; CHEMOKINE RECEPTOR CXCR4; CYCLAM DERIVATIVE; MACROCYCLIC COMPOUND; MONOCLONAL ANTIBODY; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LIGAND BINDING; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYNCYTIUM; VIRUS INHIBITION;

ANTI-HIV AGENTS; CALCIUM; CELL LINE; FURA-2; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 2-RING; HIV-1; HIV-2; HUMANS; MODELS, CHEMICAL; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 0033598379     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990211i     Document Type: Article

References (21)

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