Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 109-119

  Bridger, Gary J ^a   Skerlj, Renato T ^a   Padmanabhan, Sreenivasan ^a   Martellucci, Stephen A ^a   Henson, Geoffrey W ^a   Abrams, Michael J ^a   Joao, Heidi C ^b   Witvrouw, Myriam ^c   De Vreese, Karen ^c   Pauwels, Rudi ^c   De Clercq, Erik ^c  

^a Johnson Matthey Pharmaceutical Res   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTIVIRUS AGENT; CYCLAM DERIVATIVE; FUNCTIONAL GROUP; HETEROCYCLIC COMPOUND; HYDROGEN; JM 2763; MACROCYCLIC COMPOUND; PYRAZINE; PYRIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROGEN BOND; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; AZA COMPOUNDS; CELL LINE; CELL SURVIVAL; HETEROCYCLIC COMPOUNDS; HIV-1; HIV-2; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 0030046536     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950584t     Document Type: Article

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